Background. Erosions and ulcers can be observed in many skin diseases. There were 20 patients with chronic dermatoses hospitalised at the Ural Research Institute of Dermatovenerology and Immunopathology (Ekaterinburg). All patients had chronic recurrent dermatoses with disease duration from 7 months to 9 years. During this observation the patients were prescribed standard systemic therapy in accordance with the severity of the skin process, provided by clinical recommendations, as well as external antiseptic agents of the latest generation – gel, which includes a modern antiseptic and surfactant.

Results. The article provides rationale for the use of the gel in external therapy of erosive and ulcerative skin defects in patients with chronic dermatoses. The article presents the results of efficacy and safety evaluation of using Prontosan gel during the topical treatment of patients with pemphigus vulgaris, chronic pyoderma and chronic non-healing trophic ulcers. The duration of the disease ranged from 7 months to 9 years. Clinical observation was conducted for 14 days of applying the medication, both in inpatient facilities and outpatient conditions. The gel proved to be highly effective in prompting the regression of perifocal edema and erythema, in reducing the exudation intensity and the amount of purulent discharge from ulcers and erosive defects. Application of the gel induces complete clearing of erosive and ulcerous surfaces from fibrin, promotes active marginal epithelization of skin defects, reduces total wound surface area by 24.6-66.3%, in particular due to the active forming of the granulation tissue. Evaluation of the dynamics of clinical symptoms such as burning sensation, itching and soreness, as well as monitoring of the dermatologic life quality index demonstrated complete regression of pain and other subjective sensations in patients, as well as almost complete restoration of the patients' quality of life (regression of DLQI by 69.5-77.6%).

Background. Rosacea is a chronic, relapsing dermatological disease that affects the skin of the face. Rosacea is characterized by the occurrence of erythema, papules, telangiectasia, edema, pustules, or a combination of these manifestations. Currently, rosacea is considered a multifactorial disease with a wide range of exogenous and endogenous triggers.

Objective. Purpose of the study: analysis of Russian-language and foreign scientific publications on the influence of trigger factors and concomitant systemic pathology on rosacea.

Materials and methods. During this study, a search and analysis of domestic and foreign literary sources was carried out using electronic databases PubMed, Elibrary, CyberLeninka, ScienceDirect in the field of dermatovenerology, containing information on the etiopathogenesis of rosacea, trigger factors, and concomitant pathologies affecting the disease.

Results. Unfavorable trigger factors for rosacea are pharmacological, immunological, infectious, climatic, thermal and nutritional. Skin with rosacea is most sensitive to temperature changes, especially heat. Various factors play a role in the development of rosacea, including disruption of the protective function of the epidermis, inflammation induced by cathelicidin antimicrobial peptides, changes in vascular reactivity, enhanced innate immunity, neurogenic inflammation, angiogenesis, fibrosis, and hypercolonization by Demodex mites. It is assumed that rosacea is not limited only to the skin, but may be associated with various systemic disorders, such as pathologies of the gastrointestinal tract, cardiovascular diseases, neurological disorders, and endocrinopathies.

Conclusion. Identifying and eliminating triggers is critical to successfully treating and preventing this disease.

Background. Localized scleroderma may be associated with a malignant process occurring in the body. The onset of scleroderma does not always coincide with the onset of clinical manifestations of oncology. The process can have a primary, secondary or independent development. Authors from different countries correspond to cases of both parallel development of both conditions, as well as the development of localized scleroderma against the background of cancer treatment and oncological processes against the background of long-term localized scleroderma. In addition, some substances, apparently, can provoke the development of localized scleroderma of a non-tumor-associated form.

Results. An article presents a clinical case of morphea associated with endometrial cancer and made a debut as a result of medicine intake. A patient who underwent nerve-sparing extended extirpation of the uterus and appendages, with the upper part of the vagina and pelvic lymphadenectomy for endometrioid adenocarcinoma. After one year, increase in uric acid in the blood was found, so allopurinol was prescribed. After three weeks of the drug intake, she noticed itching and painful sensations on the skin of the back. After keeping taking the pills, rashes appeared, gradually occupying most of the skin of the trunk, upper and lower extremities.

Сonclusion. Besides the association of morphea with a malignant process and the possible involvement of allopurinol as a trigger of the skin process, the vastness of the skin lesion and the disease course become interesting. It also remains unclear whether there is a development of localized scleroderma against the background of a malignant process, the trigger was solely taking an anti-gouty drug, or whether there is a combination of all factors that led to the current condition of the patient.

Background. Lichen planus is a chronic inflammatory disease affecting the mucous membranes, skin and its appendages. Nail lesions in lichen planus are quite common, which leads to a negative psychological and physical impact on patients. In addition to nail lesions against the background of the underlying disease, there are also isolated forms in which only the nail plates are affected in patients with lichen planus without involving the skin and mucous membranes. Changes in the nail plates in lichen planus can be irreversible, destroying the nail plate itself and the entire nail apparatus.

Objective. The aim of this article was to study the most common nail lesions in lichen planus.

Materials and methods. In the period from April to July 2024, we analyzed publications from the PubMed and eLibrary databases devoted to nail lesions in lichen planus. The search queries included "Nail lichen planus", "Lichen planus", "Nail lichen planus", "Trachionychia", "Twenty nail dystrophy", "Dermoscopy nail lichen planus".

Results. The study revealed that the most common nail lesions in lichen planus are longitudinal grooves, general dystrophic changes in the nails in the form of their fragility, onychorrhexis and trachyonychia. It was also noted that lichen planus is characterized by severe irreversible changes in the nails, such as anonychia and pterygium. In the course of this work, we noted the evolution of pathological changes in the nails in lichen planus. This observation can be useful in the diagnostic search and choice of treatment tactics in the early stages of the lesion.

Conclusion. Timely diagnosis of pathological changes in the nails in lichen planus is crucial in choosing patient management tactics. The development of irreversible lesions of the nail plates in lichen planus should be prevented by treating earlier pathological changes.

Objective. The purpose of the work was to study the clinical picture of acute brucellosis in patients of brucellosis in the Astrakhan region at the present stage. Due to the presence of epizootic foci of brucellosis in AO and the incidence of brucellosis among people, clinicians should pay attention to the clinical and epidemiological picture and diagnosis of this disease.

Materials and methods. A clinical retrospective analysis of 46 case histories of patients with acute brucellosis who were treated at the regional Infectious Diseases Clinical Hospital named after A. M. Nichoga in 2012-2021 was carried out. A descriptive method was used to study the medical histories of patients with acute brucellosis. The epizootic situation of brucellosis in JSC was studied on the basis of data from Rospotrebnadzor (reporting forms for 2012-2021, form 2).

Results. Among the patients, 38 males (82.6%) prevailed. There were 8 women (17.4%). The age of patients with acute brucellosis ranged from 18 years to 77 years. The patients were mainly young and middle-aged people (under 50 years old) – 36 patients (78.3%). There were 10 patients aged 51-77 years (21.7%). The average age was 41.4 ± 2.39 years. Acute brucellosis was recorded mainly in the spring and summer period of the year. In March-August, 39 cases (84.8%) were detected, in autumn – 6 cases (13.0%), in winter – 1 case (2.2%). In most patients, the disease began acutely with chills (84.8%), in some patients with tremendous chills and a rapid increase in body temperature to high numbers (39-40 °C). Fever was observed in all patients (100%). In most cases (69.6%), the fever was subfebrile, did not exceed 38.0 °C. 11 (23.9%) patients had febrile body temperature (up to 40.0 °C) and 3 patients had hyperpyretic (up to 40.6 °C). However, febrile fever was short-lived and persisted for 5-8 days. Then the body temperature dropped to subfebrile numbers. In general, the fever in patients with brucellosis was undulating and lasted 10-15 days.

Conclusion. Thus, in the Astrakhan region, the epidemiological and epizootic situation for brucellosis is unstable. The incidence of brucellosis in cattle and small cattle is registered annually in the region. Acute brucellosis in humans is registered annually in isolated cases and has a moderate course.

Background. Currently, acute intestinal infections are still one of the key health problems both around the world and in Russia. In addition to the obvious health hazards that arise, which are predominantly prevalent among children, these diseases are also an economic problem.

Objective. Analyze the composition of pathogens of acute intestinal diseases in the Arkhangelsk region on the basis of official statistical information and data provided by Primorsky Central District Hospital of Arkhangelsk.

Materials and methods. The method of analyzing data from current literature sources and the provided polyclinic database was used.

Results. Acute intestinal infections are a broad group of diseases, polyetilogical and extremely diverse in their composition, epidemiology and clinical manifestations. One of the key classifications is the division of pathogens into bacterial and viral. At the moment, it is noted that among bacteria the main pathogens are salmonella and shigella. Among viral acute infections, rotaviruses and noroviruses are recognized as the leading etiological agents. According to statistical data, in the Arkhangelsk region there is a tendency to increase the incidence of acute intestinal infections among the entire population: in 2020, 4496 cases were registered, in 2021 and 2022 – 4347 and 5315 cases, respectively. It is cases with an unknown etiology that are rapidly increasing and prevail among all morbidity. In situations where the pathogen is known, the diseases most often recorded in the Arkhangelsk region were salmonellosis (351 cases in 2020, 186 cases in 2021, 190 cases in 2022), shigellosis (10 cases in 2020, 3 and 1 case in 2021 and 2022, respectively), rotavirus (in 2020 65% of the entire structure, in 2021 – 78.8%, in 2022 – 73.5%) and noravirus infection (in 2020 20.9% of cases, in 2021 – 13.6%, in 2022 – 19.1%). The average age of a patient with ACI is 36 years, children make up 9% of the total incidence.

Conclusion. Unfortunately, the diagnosis of pathogens of acute intestinal infections is at a fairly low level, so most often the etiology remains unknown. In cases where the pathogen can be identified, Salmonella spp. dominates among the bacteria that cause this group of diseases, rotaviruses and noroviruses dominate among viruses, and a mixed infection is increasingly observed, requiring carefully selected therapy.

Background. Some of the most tragic pages in human history are associated with periods of epidemic and pandemic spread of infectious diseases. In the process of studying new infections, doctors and scientists used a variety of analysis methods, some of which were associated with a risk to the life and health of not only the researchers themselves, but also those around them.

Objective. Assess the importance and significance of experimental infections in the study of infectious processes.

Materials and methods. The method of analyzing data from literary sources was used. The research material was the most modern scientific publications available on the platforms elibrary.ru, Scholar.ru, etc.

Results. The research work of domestic scientists on the study of infectious diseases is striking in its significance not only for domestic but also world history. Thus, Danila Samoilovich, in the process of his experimental work, determined an effective method of disinfection (fumigation) during the plague epidemic in Moscow in 1771; Stepan Andreevsky in 1788, through self-infection, confirmed that vaccination would help overcome the anthrax epidemic, G. N. Minch in 1874 determined through self-infection that patients were suffering from relapsing fever, not typhus; D. K. Zabolotny proved the effectiveness of cholera vaccination by his own example; Z. V. Ermolyeva proved through an experiment on herself that some cholera-like vibrios, while in the human intestine, can turn into true cholera vibrios, causing the disease cholera; M. P. Chumakov, as part of an expedition in 1937, identified the causative agent of tick-borne encephalitis, established the carrier of the virus, the antigenic properties of the strains and the characteristic signs of the disease; subsequently, in 1959, he, together with A. A. Smorodintsev proved the safety of vaccination with A. B. strains. Sabina against polio; V. A. Znamensky in the second half of the 50s. through self-infection, confirmed that the causative agent of Far Eastern scarlet-like fever is Y. pseudotuberculosis; M. S. Balayan discovered viral hepatitis E through self-infection in 1981.

Conclusion. In the history of preventive medicine, experiments with self-infection have become a vivid illustration of the fight against infectious diseases, because Overall, humanity's centuries-long struggle against infectious diseases is a story of courage, struggle and self-sacrifice. The stories of the people presented in the article admire their courage and self-sacrifice, pursuing lofty goals in the form of saving hundreds and thousands of people’s lives.

Background. Typhoid fever remains an urgent problem due to the widespread spread in the world. According to the World Health Organization, the world records from 11 to 21 million cases of typhoid fever per year, of which fatal – from 128,000 to 161,000 cases. Russia belongs to countries with low and very low endemicity, incidence rates from 2014 to 2023 ranged from 0.05-0.01 per 100 thousand population, about 40% of all cases of typhoid fever are recorded among tourists who came from tropical countries.

Results. When analyzing the dynamics of the incidence of typhoid fever in the Novosibirsk Region for the period 2008-2023, it can be noted that it was sporadic, a slight increase in its level was recorded in 2008, 2014, 2017 and 2018. In the period 2019-2022 in the Novosibirsk Region cases of typhoid fever were not detected. The article reflects the epidemiological features of typhoid fever for the period 2014-2023. Despite the decrease in the incidence rate, at present, the possibility of not only importation of this infection by tourists and migrants from disadvantaged regions, but also the occurrence of local cases remains. The article presents the clinical picture of a local case of typhoid fever in a pregnant woman, whose clinic was dominated by prolonged remitting fever and moderately pronounced intoxication syndrome. Isolated from stool Salmonella typhi was resistant to ciprofloxacin.

Background. Tonsillar pathology has long been a general medical problem and is of great interest not only to otorhinolaryngologists, but also to doctors of many other specialties. The central place in the pathology of the palatine tonsils is occupied by chronic tonsillitis, the prevalence of which reaches up to 10-15% among the population. Along with this, chronic tonsillitis is often an interrelated disease and this relationship of chronic tonsillitis is extremely diverse. About the existence of a relationship between diseases of the palatine tonsils and other organs mentioned in ancient times.

Objective. The aim of the work was to study the incidence of chronic tonsillitis in individuals with chronic opisthorchiasis invasion, which is a natural focal infection of the area due to the large proportion of cyprinid fish infected with opisthorchiasis in the diet of the population and the low level of knowledge of preventive measures for this helminthiasis. Materials and methods. Under observation were 106 patients aged 18 to 55 years, among whom were 60 men, 46 women. The observed patients lived in the northern districts of the region from 3 and more than 10 years.

Results. It has been shown that with an invasion duration of more than 10 years, the frequency of registration of chronic tonsillitis was detected in 48.2% of patients, with an invasion duration of up to 5 years – in 19.6% of persons, while with an invasion of up to 3 years – in 7.1% of patients. Tonsillitis-associated process in the palatine tonsils is more often diagnosed in people aged 20 to 39 years, both among men and women, although in men it is 13.2% more common.

Conclusion. Worm infestation, multiplying in the body, causes a number of disturbances in the mechanisms of homeostasis, general immunity, leading to the "disposition" of the body, which in turn weakens the body, allowing the microbial agent to more actively invade the lymphoid tissue.

Background. Currently, there is an increase in the proportion of HIV-infected women of childbearing age. Infection can occur both before pregnancy, during pregnancy, and in the postpartum period. This creates risks of vertical transmission of the disease from mother to child. If infection of the mother occurs in the postpartum period against the background of lactation, the baby is infected through breast milk. Infants infected perinatally are delayed in development, suffer more often and more severely from opportunistic infections and oncological diseases, and their HIV infection rapidly progresses with the early development of immunodeficiency. Early diagnosis and perinatal prevention of infection are crucial.

Objective. To analyze the clinical, epidemiological and laboratory features of acute HIV infection in a mother and perinatally infected infant.

Materials and methods. We studied the medical records of an inpatient (form 003/y) and the results of our own clinical observation of the mother and baby who were treated at the Novokuznetsk City Clinical Infectious Diseases Hospital.

Results. A case of acute HIV infection in a mother and infant with clinical manifestations is presented. The mother was diagnosed for the first time 8 months after giving birth, the infection was associated with a change of sexual partner during lactation. The child was breastfed from birth. Symptoms of the disease in the child appeared 1 month after the onset of clinical manifestations in the mother, during the time when she stayed in the infectious diseases hospital. The child was diagnosed with HIV infection based on the detection of human immunodeficiency virus RNA in the blood.

Conclusion. In the above observation, a vertical route of infection of an infant was realized through the breast milk of a mother infected through sexual contact. The established HIV status of the mother was the reason for testing the child for HIV. The existing risk of infection of women during lactation with subsequent infection of the child during breastfeeding poses the task of organizing their periodic screening for HIV.

Background. The epidemic situation regarding measles both in Russia and in the world makes it extremely urgent to introduce highly sensitive molecular methods, such as polymerase chain reaction, into diagnostics, in addition to existing serological ones. This paper describes the experience of using the polymerase chain reaction method for diagnosing measles in the Russian Federation using the example of the Republic of Dagestan.

Objective. Early detection of measles virus using a highly sensitive polymerase chain reaction method in various types of biomaterial.

Materials and methods. The study was carried out using the polymerase chain reaction method on biomaterial samples from 208 patients diagnosed with measles and 30 apparently healthy volunteers in the control group. The diagnosis of measles was established based on a combination of clinical manifestations and confirmed by the results of laboratory testing with the detection of IgM class antibodies using enzyme linked immunosorbent assay.

Results. Patients admitted to the hospital before 4 days from the onset of the rash were found to be positive by polymerase chain reaction testing for measles virus RNA. The viral load in urine samples and swabs from the nasopharynx and oropharynx was 10³-10⁹ GE/ml, of which in 67.5% of cases it was 10⁶-10⁹ GE/ml; while a much smaller amount of viral RNA was detected in the blood serum – 10³-10⁵ GE/ml.

Conclusion. The possibility of early detection of measles using the polymerase chain reaction method has been shown, which will improve the process of differential diagnosis of diseases that have a similar clinical picture when introducing polymerase chain reaction tests for measles into practical healthcare. This approach involves testing not only sick people, but also contact persons.

Background. Food allergy is a serious, life-threatening condition that negatively impacts the quality of life of patients and their families, especially among children. In Europe, approximately 7 million people suffer from food allergy, while in Russia, the prevalence varies from 5% to 30%. Accurate diagnosis and treatment of food allergy are crucial to preventing complications and improving quality of life. Primary diagnostic methods include medical history, laboratory tests, and elimination diets, though each has its limitations. Globally, oral food challenges are considered the "gold standard" for food allergy diagnosis. It helps to establish a precise connection between the allergen and the reaction, reducing anxiety for patients and their families.

Objective. To evaluate the feasibility of using oral food challenges as a diagnostic method for food allergies in children.

Materials and methods. This single-center, prospective, interventional, non-randomized, uncontrolled study is being conducted from January 1, 2022, to December 31, 2024, at the G. N. Speransky Children’s Hospital No. 9 in Moscow. Children aged 6 months to 17 years, suspected of having an immediate allergic reaction to cow's milk protein and/or egg protein by a doctor or legal guardian, were invited to participate. The study involves using an open food challenge for diagnosing food allergies. An open food challenge involves consuming increasing amounts of the suspected allergen (milk, egg, etc.) in its natural form under medical supervision. To determine the necessity of a provocation test, a consultation is conducted, including a physical examination, medical history, and allergy testing (specific IgE blood tests, component diagnostics for milk and egg, and a prick test with the native allergen). Additionally, during the consultation, questionnaires on anxiety and quality of life were completed. Our patient selection and test procedure algorithm is an adapted version of existing protocols from international allergology organizations.

Conclusions. Preliminary results indicate that the provocation test is a safe diagnostic method when following a strict patient selection and test procedure algorithm. Notably, parents of children undergoing these tests exhibit high anxiety levels. We plan to continue this study and assess personal and situational anxiety levels over time post oral food challenges.

Background. Asthenic syndrome is a morbid condition manifested by increased physical and mental fatigue and exhaustion with mood instability, irritability, sleep disturbance, accompanied by weakening of self-control, impatience, restlessness, intolerance to loud sounds, bright light, strong odours. Clinical manifestations of asthenic syndrome differ from the state of physiological fatigue and overwork in that fatigue or exhaustion arise spontaneously, in the absence of physical or mental effort. In addition, asthenic syndrome is not a physiological phenomenon, is not corrected as a result of rest and requires medical intervention. According to literature data, the frequency of occurrence of asthenic syndrome in the population ranges from 12 to 18%, at the appointment of a general practitioner – from 20 to 25%, in the presence of somatic diseases – from 50 to 100%. The most common tool for diagnosing AS is currently the Multidimensional Fatigue Inventory (MFI-20) questionnaire, and the L. D. Malkova Asthenic Scale is also widely used in the Russian Federation.

Results. The review article outlines the relevant problems of the terminology of asthenic syndrome, its classification, location, and statistical coding. Asthenic syndrome is presented as a polyetiological disease, for the prevention of which it is advisable to correct modifiable risk factors for its development. Some mechanisms of the formation of asthenic syndrome as a result of COVID-19 infection are considered, and the common pathogenesis of a number of pathogenetic links of these diseases is emphasized. An innovative direction in the treatment and prevention of asthenic syndrome is modulation of the function of the "gut-brain" axis. For this purpose, the use of a biologically active food supplement containing in its composition the product of meat and bone meal distillation seems to be quite promising.

Background. Gastroesophageal reflux disease is a multifactorial disease that is quite common in clinical practice. High prevalence, a clear trend towards increasing incidence not only in Russia, but also in all countries of the world, chronic relapsing course and significant impact on the quality of life of patients, the complexity of managing patients with gastroesophageal reflux disease, especially in comorbid patients, often distinguish it from other types of organ pathologies digestion. A significant contribution to the development of gastroesophageal reflux disease in a comorbid patient is made by obesity, hiatal hernia, duodenogastroesophageal reflux, etc.

Results. First-line therapy for gastroesophageal reflux disease is proton pump inhibitors. Often, it is in a comorbid patient that an incomplete response to roton pump inhibitor monotherapy may occur, when the clinician faces the difficult problem of diagnosing the causes of nonresponse, as well as approaches to the treatment of refractory gastroesophageal reflux disease. An integrated approach to the treatment of gastroesophageal reflux disease in a comorbid patient allows for relief of the symptoms of the disease. At the same time, it is important to take into account the risks of drug-drug interactions of prescribed drugs, given the fact that comorbid patients initially receive a considerable number of medications for other diseases. In this regard, an effective approach to the treatment of gastroesophageal reflux disease may be the administration of alginic acid in combination with proton pump inhibitors. Аlginic acid, being a universal antireflux drug, has sorption properties, which is important for mixed reflux. In addition, the use of alginates is compatible with proton pump inhibitors. The alginic acid containing drug, due to its composition and mechanism of action, is effective and safe in comorbid patients.

Background. Gamma rhythm plays an important role in enabling cognitive processes. Studies confirm the association of gamma activity with visual and auditory perception, time perception, attention, consciousness and processing of semantic information, inner speech, and memory.

Objective. The purpose of the study is to evaluate gamma activity in patients with hemispheric ischemic stroke in the acute and acute periods in comparison with cognitive and anxiety-depressive disorders.

Materials and methods. A study was carried out on 32 patients with hemispheric ischemic stroke. All patients underwent comprehensive clinical-neurological, laboratory-instrumental and neurophysiological studies. The EEG was analyzed visually and using mathematical analysis. Using the method of mathematical analysis, we assessed the average values of the gamma rhythm power spectrum in the range of 30-45, 50-70 and 80-100 Hz in all leads and the peak frequency of the γ rhythm of the background EEG. The NIHSS, Rankin, Rivermead, Montreal Cognitive Assessment Scale, Hospital Anxiety and Depression Scale, Spielberger – Hanin Reactive and Personal Anxiety Scales, and Beck Depression Scales were used.

Results. Mathematical analysis of bioelectrical activity of the brain of patients with hemispheric ischemic stroke showed deviations in the gamma rhythm in the range of 30-100 Hz, compared with the control group. Statistically significant correlations were established between cognitive, anxiety-depressive disorders and the gamma rhythm index in the frontal and central-temporal regions in the frequency range of 30-100 Hz.

Conclusion. Mathematical analysis of the bioelectrical activity of the brain, along with clinical and neuropsychological studies, is recommended to be used for the diagnosis and identification of cognitive and anxiety-depressive disorders in patients with hemispheric ischemic stroke already in the acute and acute periods, which is especially important for prescribing adequate, pathogenetically based therapy and determining the prognosis of the disease.

Introduction. From September 26 to 28, 2024, the Russian National Congress of Cardiologists, one of the key annual events for cardiologists and specialists from related fields, took place in St. Petersburg. The goal of the Congress is to promote the modernization of the healthcare system, improve the quality of specialized care, and reduce morbidity and mortality from cardiovascular diseases. A satellite symposium, "Solving Complex Issues in Lipidology: 2+3!", chaired by Doctors of Medical Sciences G. P. Arutyunov and M. V. Ezhov, was dedicated to the challenges of modern treatments of dyslipidemia, one of the key risk factors for cardiovascular diseases.

Objective. The aim of this work is to review the presentations given at the symposium, to inform medical specialists about the latest developments in lipid-lowering therapy and the positions of international and new Russian clinical guidelines on the management of patients with lipid metabolism disorders. The review focuses on the issues and evidence regarding the efficacy, tolerability, and safety of statin therapy across various patient groups.

Background. On 26-28 September, the Russian National Congress of Cardiologists 2024 was held in St. Petersburg. The event was accompanied by a satellite symposium supported by RECORDATI dedicated to practical aspects of personalised therapy. The focus was on modern approaches to the prevention of atherosclerotic cardiovascular diseases, the possibility of taking into account individual risk factors in comorbid patients and the safest options of drug therapy.

Conclusion. Modern prophylactic and therapeutic measures, improvement of patients’ and doctor’ knowledge about statins therapy allow using them effectively and safely both in primary and secondary prevention of cardiovascular complications in all groups of patients.

Background. Participants of the breakout session "Yesterday, Today, Tomorrow: Approaches to the Therapy of Obesity and Carbohydrate Metabolism Disorders" organised by Pharmstandard JSC within the framework of the II International Congress "Obesity and Metabolic Disorders: Conscious Reloading" held on 10-12 October 2024 in Moscow discussed the problems of obese patients and modern aspects of drug therapy selection. Special attention was drawn to such a complication as diabetic polyneuropathy.

Conclusion. Comprehensive treatment of diabetic neuropathy is an extremely important component of therapy of patients with diabetes mellitus and should include both drug and non-drug therapies.

Background. The participants of the breakout session "Role of nutritional support in the process of recovery of patients with acute cerebral circulatory failure", organised with the support of Nutricia Company within the framework of the II All-Russian Neurocongress with international participation, held on 10-12 October 2024 in Moscow, discussed the problems and approaches to the recovery of patients with acute cerebral circulatory failure.

Conclusion. Close attention of the participants was focused on the issues of adequate replenishment of nutritional needs of the patients' organism, without which rehabilitation is impossible.