The problems of physiological need for iodine and its nutritional deficit in the world and in Russia; food sources of iodine; diagnosis of iodine deficiency by rating of ioduria, thyroid gland ultrasound, and assessment of thyroid status; pathological consequences of iodine deficiency and iodine deficiency disorders are discussed in the review article. The possibilities of correction of iodine deficiency in the diet by doctors of various specialties using the appointment of products enriched with iodine and iodine-containing drugs are presented. The advantages of organically bound iodine of marine algae are shown in comparison with inorganic iodine compounds. The use of food products from seaweed laminaria to combat iodine deficiency in the diet is substantiated. The use of foodstuff made from laminaria to combat iodine deficiency in the diet is substantiated. 

Approaches to therapy of distal polyneuropathy (DPN) in a woman patient with 2 type diabetes mellitus were considered. Pathogenetically significant pathology — deficit of vitamins D and B12 was revealed. Against achieving target rates of vitamin D and B12 levels, substantial subjective positive dynamics in DPN manifestations was shown, as well as in general state of health, and quality of life. 

The article summarizes the cases of endocrine drug abuse by patients. 57700 calls for outpatient admission to endocrinologists and admission to endocrinological hospitals were analyzed. It is concluded that it is difficult to manage endocrinological patients who abuse drugs. Solution of this problem requires joint efforts of endocrinologists, drug treatment specialists, psychiatrists and psychologists. 

The article analyzes the aspects of the use of modern rehabilitation technologies aimed at the already developed obesity and its prevention. It is noted that the control of body weight can be achieved by using a multi-component intervention in changing eating habits, lifestyle, physical activity of the child, with the involvement of all members of their family and environment. Compliance with key recommendations on nutrition, physical activity, adequate sleep can also serve as a good means of preventing the development of obesity. 

The review article considers current data on the etiology, pathogenesis, clinical picture, genetic diagnostics of hyperaldosteronism in children and adolescents. Phenotypic signs characteristic of this syndrome are described. Diagnostic methods and treatment strategies are presented. 

Diabetic nephropathy (DN) is the main cause of the adverse prospects on the life of patients with diabetes mellitus and develops equally often in different types of diabetes mellitus. And much more often and faster DN develops in patients with early DM in childhood and puberty. The relevance and importance of this problem led to the active study by scientists of various pathogenic aspects of damage to the structure of the kidneys and microvascular bed. Currently, it is known that DN is a complex multifactorial complication which flows for a long time without clinical manifestations. Renin-angiotensin-aldosterone system makes a significant contribution to its development. These features require the creation of new diagnostic techniques for earlier detection of the pathology. 

Polycystic ovary syndrome (PCOS), which is sufficiently studied in adults, has significant difficulties in diagnostics and treatment when its debut falls on adolescent period. In 2017, international consensus generalizing the available base of evidence in respect of aid to adolescents with PCOS was published. As the PCOS therapy for adolescents, we recommend methods of non-drug lifestyle correction; to reduce clinical symptoms of hyper-androgynism — local cosmetic manipulations. Medical interventions must be limited by application of insulin sensitizers and, according to indications, preparations with anti-androgenic effect. 

Possibilities of efficiency increase of treating patients of late reproductive age with hysteromyoma were studied. In pre-surgery preparation, selective modulators of receptors to progesterone, and ulipristal acetate were used. 

The review provides data on the effectiveness of predictors of preterm labor. The review of publications of the PubMed National Library of Medicine database from 2014 to 2019 was conducted. using the following search conditions: pregnancy, risk factors and prediction of preterm birth. In order to reduce the frequency of preterm birth, predictors of preterm labor have been proposed, making it possible, with a high degree of probability, to assume the term of delivery within 7 days. 

The pregnancy course in women with the nervous system pathology can have a high risk of maternal and perinatal complications. The management of the women in such condition requires a specialist to provide an on-time diagnosis and accurate follow-up supervision of the gestational process with the complex interdisciplinary approach. Our experience in management of pregnant women with the pathology of nervous system at the consultation-and-diagnostic department in a hospital is presented. 

The reasons of primary dysmenorrhea in girls were considered, as well as complex of diagnostic measures in dysmenorrhea, and approaches to treatment. 

Pathological processes of the cervix are the leading issues of modern gynecology due to the high frequency of transformation in cervical cancer. A cross-sectional study was conducted, which included 100 patients. It was found that the development of precancerous cervical pathology has a connection with early sexual debut, number of sexual partners, lack of a permanent sexual partner, long-term use of oral contraceptives (more than 5 years). Smoking is a significant cofactor of the development of cervical intraepithelial neoplasia and cervical cancer. The presence of high-risk oncogenic human papilloma virus 7,4 increases the risk of developing precancerous cervical pathology. 

There is the analysis of the pathogenic therapy of the acute enteric infections in children of early age. The use of gelatin tannat in the treatment of the toxic syndrome and diarrhea in children with gastroenteric infections was very effective. 

The most optimal approach to the problem of managing children with autism spectrum disorders is a complex one that involves a children’s gastroenterologist, a nutritionist, a psychologist, a psychiatrist. The paper presents a comparative analysis of the style of nutrition of children with autism spectrum disorders, depending on whether or not a gluten-free diet is observed. For the early detection of eating disorders in children, a CEBQ questionnaire was used in the study. 

The article reviews literature on the choice of myocardial revascularization method in patients with multivessel coronary disease and also data on the role of randomized research results in clinical guidelines on thi2s problem are presented. 

The article includes analysis of clinical and epidemiological characteristics of patients with acute coronary syndrome at early stationary stage of cardiac rehabilitation. The positive prognostic effect of full three-stage cardiac rehabilitation has been shown. 

In some countries, obesity is growing at the rate of a real epidemics. New epidemiologic studies have shown that antibiotic exposure is connected to increased risk of overweight and obesity. Intestinal microflora disorders take place not only due to antibiotic therapy. Antibiotics are widely used as growth stimulators in agriculture, they are accumulated in animal and poultry meat, and we use it as food. Probiotics are the agents which can modulate and restore intestinal microflora in antibiotic therapy. 

Clamydophyla pneumoniae is one of the leading infectious agents affecting pulmonary system in outpatient conditions. At the same time, complications of diagnostics of acute and chronic C. pneumoniae-infection make it more difficult to define true meaning of this agent and the developed disease.