The aim of this work was to study the risk factors for severe COVID-19, comorbid diseases, and the structure of mortality in patients who died in a hospital from a new coronavirus infection. The study included 180 patients with bilateral viral polysegmental pneumonia caused by SARS-CoV-2. In patients with viral pneumonia, the degree of lung tissue damage, the frequency and severity of comorbid diseases were studied: arterial hypertension, coronary heart disease, cerebrovascular diseases (chronic cerebral ischemia, cerebral stroke), atrial fibrillation, chronic heart failure, chronic kidney disease, diabetes mellitus type 2, obesity, malignancy and anemia. In patients with COVID-19-associated pneumonia, severe lung damage was observed – pneumonia with CT3 (36.1%) and CT4 (33.0%) prevailed, less often CT2 (30.9%). A high frequency of comorbid diseases was found in deceased patients with viral pneumonia: arterial hypertension (98.9%), cerebrovascular disease (96.9%), coronary heart disease (83.9%), chronic kidney disease (96.7%), type 2 diabetes mellitus and atrial fibrillation – in almost half of patients (42.2%), and in every third patient – obesity (36.6%). The main causes of death in patients with COVID-19-associated pneumonia were: acute respiratory distress syndrome (83.3%), less often acute myocardial infarction (7.2%), cerebral infarction and edema (5.6%), thromboembolism pulmonary artery (3.9%). In patients with viral pneumonia caused by SARS-CoV-2, there is a high frequency of comorbid conditions leading to a severe course of the disease: arterial hypertension, coronary heart disease, severe chronic heart failure, advanced age (> 75 years), lack of vaccination, chronic kidney disease, obesity of the 3rd degree, diabetes mellitus type 2. Among women who died from COVID-19-associated pneumonia, such risk factors as age over 75 years, type 2 diabetes, lack of vaccination, a history of myocardial infarction with the development of chronic heart failure stages 2A and 2B, and chronic microcytic anemia prevailed; among the dead men – obesity of the third degree, a history of cerebral stroke, lack of vaccination and severe chronic heart failure.

A study of the commitment of Russian scientists to a healthy lifestyle and an assessment of behavioral and social risk factors for reducing their professional activity was fulfilled. A cross-sectional study of a single-stage section of 213 researchers from state scientific institutions in Moscow was carried out. At the age of 23 to 78 years (mean age = 45.48 ± 15.33 years), 116 women, 97 men. It was found that in the group of Russian researchers about a quarter of the respondents did not follow the principles of a healthy lifestyle well enough (25.34%). The main problem was low physical activity, identified in 79.3% of the respondents, as well as: non-compliance with the principles of rational nutrition, primarily among scientists with a teaching load; low stress management skills among doctors who combine clinical practice with science; Difficulties in interpersonal relationships in people engaged only in scientific work. In addition, a high frequency of violations and problems that can lead to a decrease in professional effectiveness has been recorded. In 9.85%, probable cognitive impairments were detected, and not associated with the age of the scientist, in 3.28% there were signs of senile asthenia, in 2.34% – senile depression. Two-thirds lived in a sub-depressive state (74.6%). Only one fifth of the respondents (19.71%, n = 42) had no cognitive impairment, no asthenic syndrome, no depression. It was concluded that risk factors for reducing professional efficiency among scientists, such as: low physical activity, poor nutrition, low stress management skills, subdepressive state, are modifiable and can be corrected, which will lead to a lesser occurrence of asthenia and cognitive impairment. It is necessary to develop and implement programs for the prevention, early diagnosis and correction of risk factors among researchers in order to maintain their effectiveness in their work and prolong their professional longevity.

Today special attention is paid to the issues of comorbidity of particularly common nosologies due to the active introduction into clinical practice of the principles of an individual approach to the treatment of each patient. This article is devoted to the clinical phenotype «tension-type headache and arterial hypertension». Its timely diagnosis is of great importance, as a timely correct diagnosis will increase the effectiveness and safety of treatment, improve the quality of life of patients, as well as reduce the risk of cardiovascular complications. This article presents a clinical case of a 56-year-old patient who applied to the Department of General Medical Practice of Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University with complaints of increased frequency of attacks of chronic headache. She had a long history of headache and high blood pressure, burdened with a hereditary history on the mother's side of tension-type headache and arterial hypertension. She had been self-medicating for a long time and had low compliance with hypotensive and analgesic therapy. During the examination, which includes neurological examination, the use of specialized scales and questionnaires to assess the presence of cognitive-affective disorders, the assessment of the subjective sensation of pain using a digital analog scale, laboratory and instrumental research methods, night respiratory monitoring, as well as analysis of the headache diary, indices of time lost due to headache, and the effects of headache, daytime sleepiness scales and response to headache therapy, two diseases of tension-type headache and arterial hypertension were identified, proceeding independently and independently of each other, while significantly aggravating the course of each other (i.e. clinical phenotype). Taking into account the results obtained, the therapy was adjusted, the patient was registered with a neurologist, cardiologist. The conclusion is made about the importance of an integrated and interdisciplinary approach in the management of patients with the clinical phenotype «tension-type headache and arterial hypertension».

To study the factors associated with the development of long-term major adverse cardiovascular events (MACE), 94 patients with type 2 diabetes mellitus (T2D) aged 40-65 years (65% of women) with eGFR > 60 ml/min/1,73 m2 and without manifestations of moderate or severe chronic heart failure (CHF) were examined. In patients with T2D clinical and laboratory data were evaluated. A 6-minute walk test (6MWT) and echocardiography were performed. Concentration of N-terminal pro-brain natriuretic peptide (NTproBNP) was determined on an Immulait 2000 Siemens analyzer by immunochemiluminescence assay. Glycemic variability was assessed by calculating the standard deviation (SD) and coefficient of variation (CV) of glycemia during the day according to laboratory measurements of glucose levels at least 3 times a day for at least 3 days. The initial manifestations of CHF according to the clinical examination were detected in 40 out of 94 patients with T2D. According to the discriminant analysis results, they were interconnected with the presence and duration of stable coronary heart disease, an increase in the left ventricle posterior wall thickness and the left atrial (LA) size, an increase in triglyceride level, an increase in duration of diabetes, and a lower estimated glomerular filtration rate. A relationship was found between the initial manifestations of CHF and an increase in CV glycemia during the day and the presence of episodes of hypoglycemia in history. After 8.8 ± 0.72 years MACE were found in 38.6% of patients with T2D (n = 88). There were 12 deaths (10 of them from cardiovascular diseases), 5 cases of myocardial infarction, 9 cases of emergency myocardial revascularization, 4 cases of stroke, 4 cases of hospitalization due to decompensation of CHF. The relationship between MACE and the initial increase in the level of NT-proBNP, an increase in the LA size, and a decrease in 6MWT values was determined according to logistic regression analysis with a percentage of correct prediction of 81.9%. The development of long-term MACE in T2D patients was also influenced by the presence of episodes of hypoglycemia in history and increased glycemic variability. This was confirmed by the logistic regression analysis, which showed the relationship between the development of new cardiovascular complications and death with an initial increase in intraday glycemic CV, an increase in the LA size, and the presence of initial manifestations of CHF with a percentage of correct prediction of 87.8%. After 8.8 ± 0.72 years, 41 patients with type 2 diabetes underwent a repeated clinical and laboratory study and echocardiography with an assessment of left ventricular diastolic function (LV DD) according to the criteria of the RSC for CHF 2020. LV DD was detected in 51,2% of T2DM patients and was correlated with the initial increase in the level of NT-proBNP, especially in combination with the initial increase in the left ventricular myocardial mass index and body mass index according to the results of logistic regression analysis. The level of NT-proBNP more than 31.2 pg/ml can be considered as a prognostic marker of LV DD in T2D patients after 8.8 ± 0.72 years of followup with a sensitivity of 66.7% and a specificity of 100%.

A prospective comparative controlled study included 100 patients with a confirmed diagnosis of COVID-19 coronavirus infection, randomized into two groups: the main group (MG) – 50 patients receiving interferon alpha-2b preparations, rectal suppositories 3,000,000 IU and gel for external and topical use 36,000 IU/g and standard therapy; comparison group (CG) – 50 patients who received only standard therapy. The total duration of observation was 22 days. Complex therapy of coronavirus infection with the use of interferon alpha-2b in the MG led to a faster dynamics of the reverse development of intoxication symptoms, bronchopulmonary and catarrhal syndromes. Normalization of the total score in the MG occurred faster than in the CG for 2 days (9 vs 11 days). The proportion of persons with normalization of the D-dimer content in the MG exceeded that in the CG by 12% (p > 0.05). Positive dynamics of changes in lung tissue according to the results of computed tomography in the MG was recorded 22.7% more often (p = 0.018). In the CG, 6 (12%) patients died before the end of the follow-up period, no deaths were recorded in the MG. During the entire observation period, no adverse events associated with interferon alpha-2b or other drugs included in the treatment regimen of patients with MG and CG were registered. The results obtained indicate a higher efficiency of standard COVID-19 therapy when using interferon alpha-2b, and confirm the safety of its use in combination with drugs of other groups (antiviral agents, antibiotics, anticoagulants), which makes it possible to recommend it for inclusion in standard treatment regimens for patients with a new coronavirus infection.

The materials of the article at the conceptual level summarize the results of their own research aimed at the scientific substantiation of the use of reflexology. In the course of clarifying the significant mechanisms of the method, the primacy of a nonspecific reaction reproducing adaptation to the repeated action of mild stress was experimentally confirmed for the first time. This phenomenon is fixed in practice, in the form of the identity of reactions to various types of zonal electrical stimulation.In addition to this, the fundamental link, when analyzing individual methods, additional influences can be traced. Thus, with lumbosacral dorsopathies, the reliable superiority of pharmacopuncture (i.e., the introduction of drugs into the area of reflexology points) over the compared methods was also manifested in positive structural-modifying changes in the «affected» intervertebral discs. Another effective technique, including in relation todorsopathies, is spectral phototherapy – irritation of reflexogenic zones and points with low-energy light sources with emission spectra of various chemical elements. Among other priority areas, during the correction of social and stress disorders in persons of dangerous professions – employees of law enforcement agencies involved in local operations, and liquidators of the consequences of the Chernobyl accident, the priority of combining psychological correction and low-frequency electromagnetic effects was noted. In the block of studies on sexology, one third of practically healthy men under 35 years of age recorded a distinct decrease in the sexual activity of persons in the form of a typical pathological condition of humoral, neurotic and vasospastic components. A similar interweaving of links is also revealed in sexual disorders, pathognomonic for men with lumbosacral dorsopathies. In the process of choosing ways to restore sexual activity, experimental data on the stress-limiting effect of various technologies were taken into account. However, in practice, the high effectiveness of spectral phototherapy has been confirmed both in prophylactic and therapeutic terms. These studies are reflected in numerous publications, including monographs, patents for invention and materials of our conferences.

To date, the search for optimal approaches to the conservative treatment of patients with osteoarthritis (OA) is an urgent problem. This is due to the prevalence, multifactorial of the disease, as well as an increase in the incidence of OA among young patients. In the early stages of the disease, as well as in the treatment of young patients, doctors prefer to choose the non-surgical treatment. In OA, the most vulnerable structure of the joint is hyaline cartilage. In degenerative-dystrophic diseases, it becomes thinner, and the synovial fluid in OA tends to lose its elastic properties. To reduce the load on the articular cartilage, (prostheses) of synovial fluid – hyaluronic acid (HA) are actively used. HA is a natural component of synovial fluid, it serves as a lubricant for articular surfaces and provides a number of protective and regulatory effects. The HA injected from the outside takes on the load, compensating for the lost properties of the joint's own synovial fluid. So GC drugs are able to quickly relieve pain and return activity to the patient. During treatment, the choice of the HA drug should depend on the phenotype, age, stage of the disease, concomitant somatic pathology, daily physical activity and individual needs of the patient. The doctor selects a HA drug of different molecular weight, structure and concentration. As a consequence, the number of injections per course of treatment may also vary. It is necessary to evaluate in more detail the criteria for selecting the GC drug to improve the quality of treatment and results in the long term. The analysis of the literature data devoted to the selection of GC drugs presented on the domestic market, depending on the stage of the disease and the age of the patient.

Back pain is an interdisciplinary medical problem, but, nevertheless, the primary appeal of these patients is to therapists and general practitioners, who are responsible for timely differential diagnosis and prescribing a full range of therapy in cases where back pain is not a manifestation of serious or life-threatening illness. In the vast majority of cases, back pain is non-specific, i.e., its development is not associated with a life-threatening systemic disease or injury. The term «non-specific back pain» means that it was not possible to identify a serious pathology (disease) that caused the pain. In addition, there should be no specific signs of involvement in the process of the roots of the spinal nerves and stenosis of the spinal canal. The most urgent tasks in the work of a therapist or general practitioner are the correct differentiation of the causes of back pain, the identification of «red flags» and the referral of the patient for treatment to a specialist in case of establishing specific causes of pain. The article considers the standard of examination with the participation of therapists, general practitioners, offers a specially developed algorithm for managing patients with back pain. The formation of the skills of curation of patients with back pain by primary outpatient physicians is necessary for the appointment of a full-fledged complex of therapy in case of its non-specific nature and timely referral to a specialist in case of specific reasons for its detection. The general principles of the treatment of back pain include informing the patient about the main causes of back pain, the role of an active lifestyle and dosed physical activity, avoiding prolonged bed rest. The general therapy of back pain syndrome involves the use of agents that affect the pathogenetic underlying mechanisms: inflammation, painful muscle hypertonicity, impaired trophism of the nervous tissue, etc. The ineffectiveness of non-drug therapy is an indication for the appointment of non-steroidal anti-inflammatory drugs, primarily for external use in the form of ointments, creams or gel and / or their systemic use, as well as symptomatic slow-acting drugs for osteoarthritis (SYSADOA).

Diagnosis of Crohn's disease is a complex, often lengthy process, which is based on a consistent differential diagnostic search. A significant proportion of patients with Crohn's disease may develop extraintestinal manifestations. Often, skin lesions precede the manifestation of intestinal symptoms or occur in parallel with intestinal manifestations. Their spectrum is quite wide, and the mechanism of occurrence is heterogeneous. In particular, autoimmune extraintestinal manifestations associated with the activity of the inflammatory process are isolated, which appear along with the main intestinal symptoms of exacerbation and, with the modern appointment of adequate pathogenetic therapy, are resolved in parallel with a decrease in the degree of activity of intestinal inflammation. Skin lesions in inflammatory bowel diseases, according to various authors, occur in 6-43% of cases. Skin changes in inflammatory bowel diseases are explained by common pathogenetic mechanisms: hyperproduction of IL-12 and interferon-gamma synthesized by Th1-lymphocytes, IL-5 and IL-13 produced by Th2-lymphocytes, IL-17 by Th17-lymphocytes. One of the severe skin lesions in Crohn's disease is pyoderma gangrenosum, an inflammatory neutrophilic dermatosis characterized by painful ulcerative skin defects (ulcers of polycyclic outlines with raised edges and covered with necrotic masses) and often associated with diseases of the internal organs. The article describes a clinical case of a patient with Crohn's disease and pyoderma gangrenosum. The stages of differential diagnostic search and treatment are described. The interleukin 12/23 inhibitor ustekinumab has been shown to be highly effective in achieving clinical, laboratory and endoscopic effects already at early stages of treatment. At the same time, in parallel with the healing of the mucosa of the terminal ileum, skin manifestations were also reduced. This clinical case also confirms the importance of such factors as the severity of the course of the disease and the presence of extraintestinal manifestations when choosing the first biological drug for the treatment of Crohn's disease.

The relevance of the problem of metabolic syndrome is beyond doubt and is associated with its high prevalence and the fact that it precedes the occurrence of cardiovascular diseases and diabetes mellitus. The metabolic syndrome is a multifactorial disease, and the organs of the gastrointestinal tract are both target organs in the metabolic syndrome and active participants in the pathogenesis of obesity and associated diseases. Against the background of obesity, the size of adipocytes increases, which leads to an increase in the concentration of inflammatory mediators and the development of insulin resistance, and can also contribute to carcinogenesis. In obese patients, chronic inflammation was found in the gastrointestinal tract, liver, blood vessels, and pancreas. The article presents known and new information about changes in the intestines in patients with metabolic syndrome, describes the mutual influence of microbiota, intestinal motility and obesity. The intestinal microbiota is involved in many metabolic processes in the human body, which suggests the existence of a relationship between changes in the intestinal microbiota and the development and/or progression of various pathological conditions, including the metabolic syndrome. The increase in the prevalence of obesity cannot be attributed solely to changes in the human genome, eating habits, or a decrease in physical activity in our daily lives. Gut microbiota must be considered as an important environmental factor. A diet poor in fiber and cellular membranes, a sedentary lifestyle contribute to the development of both constipation and obesity. Changes in the functional state of the intestine, revealed in the metabolic syndrome, occupy an important place in the mechanism of development of endotoxemia and disorders of the intestinal microbiota in the metabolic syndrome. Enriching the diet with dietary fiber, including in the composition of functional foods, opens up new prospects for non-drug correction of both the functional activity of the intestinal microbiota and the components of the metabolic syndrome. We present literature and our own data on effective multipurpose therapy with psyllium in patients with metabolic syndrome and diseases of the digestive system.

It is vital to maintain iron metabolism within strict limits. Both the deficiency and excess of this metal in the body is manifested by numerous pathologies. Of interest is the comparison of iron metabolism in premature infants born using in vitro fertilization technology and premature infants born after conventional conception, because. such studies are being conducted for the first time and may contribute to improving the quality of care for such children. The purpose of the study is to conduct a comparative study of iron metabolism indicators, in particular, serum transferrin receptor (sTfR), ferritin, ferritin index (sTfR/logFer) and others in children born using IVF technology and children born after traditional conception. The main indicators of the hemogram and the main indicators of ferrokinetics have been studied. There were no significant differences in iron metabolism in full-term after traditional conception and as a result of the in vitro fertilization procedure. In premature infants born as a result of the IVF procedure, the hemoglobin level was 13.35 ± 0.55 g/dl, and the serum iron level was 16.16 ± 0.97 μmmol/l. ferritin level 128.64 ± 11.22 μg/l, level of soluble transferrin receptor 10.34 ± 0.57 mg/l, transferrin iron saturation 52.14 ± 3.27%, ferritin index 4.98 ± 0.1. According to the data obtained, premature babies born through the in vitro fertilization procedure had significant differences with premature babies born as a result of traditional conception in four indicators. 1. The level of ferritin in these children is significantly lower. 2. The ferritin index is significantly higher than in premature babies born as a result of traditional conception of the same gestational age. 3. the level of soluble transferrin receptor is significantly higher than in preterm infants born as a result of traditional conception of the same gestational age. 4. The percentage of transferrin saturation with iron in preterm infants born under the in vitro fertilization procedure does not differ from the percentage of transferrin saturation with iron in full-term healthy children, in contrast to premature children born as a result of traditional conception, in which this percentage is significantly lower.

Palliative care for children is a unique and separately developing service from adult palliative care and is aimed at improving the quality of life of a child with severe chronic diseases in which the rehabilitation potential is reduced or absent. The purpose of this study was to analyze the structure of palliative pathology in children of the Voronezh region. The Palliative Pathology Register can be used to accumulate, analyze data, and compile a report on the nosology of palliative pathology in the Voronezh Region. Data were collected from 47 medical institutions of the Voronezh region providing medical care to children: 15 children's polyclinics in Voronezh and Novovoronezh and 32 central district children's hospitals. Data were obtained on the number of children in need of both inpatient and outpatient palliative care, the area of residence, the social status of the family, the main and concomitant diagnoses. The type of nutrition of the child, the type of breathing of the child, the need for additional oxygen therapy, artificial ventilation, psychological and social assistance, information about the type of rehabilitation measures and medications received by the child were also evaluated. Based on the data obtained, it was revealed that directly in the districts of the city of Voronezh, the largest number of palliative patients was detected in the Levoberezhny district. In the Voronezh region, the largest number of patients with palliative pathology is located in the Novousmansky district, which can be attributed to the immediate proximity of the district to the city. According to the structure of the detected palliative pathologies, non-oncological diseases prevail in children of the Voronezh region, which is compared with statistical data for Russia. Also, acquired neurological diseases are most common – cerebral palsy and congenital malformations, in particular brain malformations. Oncological diseases in children, according to our data, occupy a small proportion (4%). In the Voronezh Region, depending on the probability of a fatal outcome, irreversible but not progressive conditions with severe disability and the patient's exposure to complications prevail, which requires the organization of a multidisciplinary approach to palliative therapy, the introduction of new diagnostic methods and rehabilitation measures.

Recently, there has been a tendency to increase the incidence of hereditary diseases in children around the world. Norrie's disease is a rare genetic disease that is characterized by an abnormality in the development of the retina and congenital blindness. The article presents a clinical case of Norrie's disease in a child aged 4 years and 2 months. From the anamnesis of life it is known that the patient is from 1 pathologically proceeding pregnancy and childbirth. During pregnancy, the mother of the child had gestosis, a threat of abortion, a high titer of antibodies to Chlamydia trachomatis. At the age of 1 month, an ophthalmologist was first diagnosed with: Norrie's disease? Repeatedly examined at the Research Institute of Eye Diseases named Helmholtz (Moscow). Surgical treatment of retinal detachment is considered futile. For the first time, the diagnosis of Norrie's disease was confirmed by the molecular genetic method at the age of the patient 9 months. At the age of 11 months, the child was hospitalized in the Children's Clinical Hospital (St. Petersburg), where he underwent 1 stage of surgery on his left eye – lensvitrshvartectomy, subretinal fluid drainage, and iris plastic surgery. After 2 months, surgical treatment was performed on the right eye – lensvitrshvartectomy, drainage of the subretinal fluid, plastic iris. The postoperative period was uneventful, but the prognosis of specialists regarding vision is unpromising. After a year, the child underwent repeated organ-sparing surgeries in the right eye. Positive dynamics was noted, consisting in a decrease in the degree of pathological displacement anteriorly of the equatorial sections of the retinal tissue. The article notes the main stages of the diagnosis of Norrie's disease in a patient, presents the features of the clinical course of the disease and monitoring the sick child in dynamics. The disease of the organs of vision was probably formed as a result of complex antenatal pathology during the first half of pregnancy in the mother of the child.

The aim of the study was to determine the clinical and laboratory features of the course of herpetic infection in married couples with impaired reproductive function. Patients and methods. The study by continuous screening included 149 married couples who complained of reproductive dysfunction. The main group included 80 married couples who had signs of urogenital herpetic infection, and the comparison group consisted of 69 married couples who did not have markers of HSV-1, 2 infection. Clinical, laboratory and ultrasound deviations were evaluated in the compared groups. It was revealed that 58.75% of patients from the main group and 38.75% in the comparison group had various complaints when assessing the symptoms among women. 43.75% of patients complained among men of the main group, and in the comparison group – 6.25%. Gynecological examination of women with HSV-1, 2 more often revealed cracks in the posterior adhesions, vesicular erosive elements of the external genitalia, contact bleeding, enlargement of the uterus and enlargement of inguinal lymph nodes. Laboratory examination of the spermogram in the vast majority of patients of the main group revealed teratozoospermia. Detection of HSV-1, 2 by the culture method in 100% of cases, along with the detection of antibodies of class IgA or IgM (less often) confirms infection. It was concluded that it is necessary to take into account the probability of damage to the urogenital tract of HSV-1, 2 when examining couples with reproductive disorders in the form of infertility or undeveloped pregnancy. Complaints, anamnesis and examination data should be taken into account to confirm or exclude significant infection with herpes simplex virus. The most informative are the culture method, as well as serological with the detection of IgA class antibodies among the laboratory methods for assessing the significance of infection associated with HSV-1, 2. Couples should be prescribed antiherpetic therapy if infection is confirmed.

4th international educational forum «Russian Days of the Heart» took place in St. Petersburg, 22 June 2022. Its program included a satellite symposium «Actual cardioneurology: cardiovascular risk factors and polymorbidity» that was held with the support of the «Grindex» company. Therapeutic arsenal in the context of cardioprotection is represented by a relatively large number of drugs, among which the greatest attention was paid to piperazine derivatives (ranolazine etc.) and gamma-butyrobetaine hydroxylase inhibitors (Mildronate): the evidence base, indications and pharmacodynamics. Pathogenetic features of comorbidity determine the basic principles of the treatment of cardiovascular diseases in patients with type 2 diabetes. Partial fatty acid oxidation (pFOX) inhibitors (ranolazine, trimetazidine, meldonium) are indicated as cardiac cytoprotectors for this group of patients. Nervous system affected by type 2 diabetes was also issued. Drugs that can be used to slow the progression of diabetic neuropathy are ipidacrine and meldonium. As a final report, the results of the study «Asthenic disorders in patients of a cardiologist and neurologist – in the wake of one study» were presented. Due to the multidisciplinary nature of reports the speakers were able to comprehend a complex comorbid patient at all stages of the cardiovascular disease continuum, as well as demonstrate numerous possibilities for the therapeutic correction of cardiovascular disorders, including through Mildronate pharmacodynamics and broad indications.