The article presents data on the features of antithrombotic therapy in patients with atrial fibrillation in the city of Krasnoyarsk. The volume of antithrombotic therapy was estimated at the prehospital stage, depending on the risk of thromboembolic complications based on patient questioning and analysis of medical records. 

Incidence of chronic heart failure among population of different regions of Russian Federation ranges from 7 to 10%. The part of patients with advanced heart failure during 1998–2014 years increased from 4,9% to 8,8%. Importance of prevention and treatment of basic risk factors and cardiac diseases, leading to destabilized cardiac performance, is of great priority. We discuss current problems of diagnostics, medical, non-pharmacological and endovascular treatment of these patients. Also we show possible ways of their solution. 

The comparison of the variability of left ventricular mass (LVM) calculated from echocardiography, conventional and signalaveraged ECG and evaluation the effectiveness of these methods in the detection of the LVM changes during antihypertensive therapy were performed. It was found that the reproducibility of the signal-averaged ECG method of LVM calculation is significantly higher than the conventional one and echocardiography. The use of this method in clinical practice can provide reliability of individualized assessment of LVM changes on single examination and during follow-up. The use of signal-averaged ECG may reduce groups size or the study duration to achieve statistically significant difference in studies with ECG control. 

87 cases of peripheral artery false aneurysm and pulsating hematoma after endovascular interventions were analyzed. For all patients with pulsating hematoma, the treatment began with local compression with a pressure bandage. The compression efficiency was 89.2%. Attempts of local compression in patients with false aneurysms were not successful and all the patients were operated. Surgical treatment was effective in 100% of false aneurysm cases. The effectiveness of treatment was influenced by: the patient’s intake of anticoagulant and disaggregant drugs, constitutional features of the patient, arterial hypertension, localization and diameter of the postpuncture artery defect. Definitions of pulsating hematoma and false aneurysm of peripheral arteries are formulated. 

The article covers features and difficulties of osteoarthritis therapy in comorbid patients, modern approaches to the therapy of recurrent chronic pain in this group of patients. The results of efficiency and safety study of parenteral administration of chondroitinsulfate in comorbid patients with severe concomitant pathology under outpatient conditions were presented. 

The article presents the results of complex observational program which includes drug and non-drug methods of treatment of recurrent chronic pain in osteoarthritis in comorbid patients. The most important components of this program are application of glycosaminoglycan-peptide complex and physical exercises. Special attention is paid to patients with comorbid diseases as the most widespread group of patients disposed to polypharmacy and having contraindications for NSAID administration. 

In the vast majority of studies devoted to pharmacopuncture (drug injections in the field of reflexology) the priority use of homeopathic remedies is indicated. In this paper, this technology was performed using lumbosacral dorsopathy «model». The facts, obtained at the first stage, fit into the reflex and drug compound framework ideas about the achievement of qualitatively new effects — in our case, vascular ones. At the second stage, the effectiveness advance of the pharmacopuncture was noted due to its combination with the hardware method — low-intensity frequency-wave therapy. This is confirmed by an improvement in the indices of the physical and mental state of patients, which significantly excels the characteristics of the compared groups. 

The article presents detailed analysis of action mechanisms of hydraulic acid derivatives for intra-articular therapy of osteoarthritis, which includes comparative assessment of different characteristics of preparations from this group, such as elasticity, resilience, molecular mass. Special attention is paid to synovial liquid prostheses. 

The effectiveness of the new European chondroprotector in combined therapy in the 1–2 stage of osteoarthritis (OA) of different localization was estimated. The study included 358 patients with knee and hip joint OA, as well as polyosteoartrosis. According to the study, all patients experienced a decrease in the severity of pain, a decrease in need for analgesics, an increase in functional activity and improvement in the quality of life. The drug is well tolerated, and patients demonstrated high adherence to treatment. 

The article considers modern data on etiology, pathogenesis, clinical picture, genetic diagnostics of hypoparathyroidism in adolescents and children. The syndromes flowing with the clinical picture of this disease are described. The methods of examination and modern recommendations for treatment are presented. 

The article covers the new method of diagnostics — microbial markers mass spectrometry in chronic pharyngitis (CPH) with recurrent course. This method is based on quantitative definition of microorganism markers: fatty acids, aldehydes, alcohols and sterols directly in the clinical material (throat smears) in CPH. The technology allows to define, by the level of microbial markers, concentration of 57 microorganisms in the clinical material, within 3 hours after it gets to the laboratory. 

Currently, one of the most discussed issue in medicine is importance of omega-3 fatty acids for human body. There are several types of omega fatty acids: omega-9, omega-6 and omega-3 polyunsaturated lipids. There are clear distinctions among them, both by chemical structure, and by influence on human body. It is the excess of omega-6 that leads to sluggish inflammatory process in the vascular walls, joints, heart and brain. The article covers action mechanisms and effects of omega-3 fatty acids in different diseases. The questions of correlation of omega-6 and omega-3 polyunsaturated fatty acids in nutrition are considered, as well as norms of consuming omega-3 fatty acids in prevention and treatment of different diseases. 

Chronic inducible urticaria (CindU) is a prevalent skin disease characterized by the appearance of recurrent wheals, angioedema or both, as a response to specific and reproducible triggers. Here, we discuss the recently revised EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and treatment of urticaria and review available therapeutic options for CindU. 

Approaches to selection of non-steroidal anti-inflammatory preparations in back pains in patients with comorbid central nervous system pathology were considered, in order to ensure fast, reliable and safe pain relief in the way convenient for the patient.