The cessation of smoking in terms of the effectiveness of primary and secondary prevention of cardiovascular events is comparable with drug therapy and invasive interventions. Comprehensive assessment of the state of the microcirculatory bed in former smokers with arterial hypertension was performed. 

The results of a clinical comparative study show a statistically significant decrease in the level of NT-proBNP in the blood of patients with decompensated CHF on the background of receiving metabolic adjustment meldonium in comparison with the control group, which leads to improved forecast and reduced likelihood of death, also associated with a decrease in the severity of CHF, reducing the risk of re-hospitalization for decompensated CHF and improving the quality of life of patients. 

The review is devoted to the description of a number of modern technologies called omixes, including genomics, transcriptome, proteomics, metabolomics, lipidomics and multimarker strategy, whose most important goals is the development of biomarkers for the diagnostics of cardiovascular diseases. The article reflects the achievements of these methods to date and the principles of their application in modern clinical practice for the early diagnostics of diseases, unresolved issues and future prospects. 

The risk factors for development of primary breast cancer (BC) were considered. The analysis shows that, within the female population of cardiovascular diseases and BC, there are common modified risk factors, which defines prospects for additional advantages of non-drug interventions. 

The review provides a modern approach to the diagnosis of myocarditis and its applicability for the conditions of routine medicine practice. Diagnostic work-up in myocarditis is multistage and requires integration of clinical symptoms, laboratory and imaging data. However, the results of the endomyocardial biopsy are crucial for the diagnosis of myocarditis. This diagnostic algorithm usually is not possible for the internist. But the impossibility of carrying out endomyocardial biopsy should not lead to the rejection of the clinical diagnosis of myocarditis. 

The paper is devoted to the evaluation of therapeutic possibilities of pharmacopuncture (stimulation of reflexotherapy points by injection of drugs) in case of combined cardiac and metabolic disorders. 

The review is Dedicated to the analysis of modern literature on the definition, classification and diagnostics of Raynaud’s phenomenon, describes the main causes of secondary RP, clinical manifestations of RP, the importance of capillaroscopy in the early diagnostics of rheumatic diseases, principles of treatment of RP. 

This article presents current view on the problem of adherence to self-medication, diets of various kinds, a clinical case of unspecified dyspepsia in reproductive age men and proves the clinical analysis of consequences from the somatic pathology pathogenesis standpoint. 

Analysis of literature data on interconnection of disorders in intestinal microbiocenosis and development of cardiovascular and cerebrovascular diseases was done. Microbiota of gastrointestinal tract, influenced both by genetic and environmental factors, was shown to be a new area of research, which may become a potential target for therapeutic intervention, in order to decrease the risk of cardiovascular and cerebrovascular diseases. 

The article presents the results of the examination and treatment of biliary pancreatitis in children. All children with repeated bouts of abdominal pain, accompanied by vomiting, need to determine the amylase of blood and urine. Recurrent pancreatitis requires the elimination of abnormal development of the ductal system of the liver and pancreas. Endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography are shown. All children with abnormal development of the ductal system of the liver and pancreas, calculous cholecystitis need surgical treatment. 

The article presents the various options of complications of acute intestinal infections (AII) in children and a possibility of their prevention. The paper contains the data of own research. AII are followed by complications at children quite often. The complications can enlarge duration of a disease and risk of an adverse outcome. Enterosorbent, drugs for rehydration, probiotics and, according to the indications, antibacterial or antiviral medicines are the basis for prevention of AII complications. 

Approaches to rehabilitation of patients with post-stroke aphasia of different severity levels were studied. Dynamics of speech and other cognitive function restoration on the background of complex therapy including cholinesterase inhibitor was studied in patients who suffered from first ischemic stroke in the left cerebral hemisphere. 

The frequency of detection of human papilloma virus (HPV) DNA in pregnant women varies in different populations. HPV is a significant factor of spontaneous abortions, preterm labor, pre-eclampsia, low-weight to the period of gestation of the fetus. With HPV, vertical or hematogenous infection of the fetus can occur. The risk of contamination is reduced due to delivery by cesarean section and in case if C-reactive protein levels over 10 mg/dL. 

Clinical observation of lichen planus and universal vitiligo in a patient with a combined lesion of the gastrointestinal tract is described. This case is of interest to clinicians in connection with a rare combination of lichen planus with vitiligo. Considering the leading role of autoimmune theory today, both in the genesis of lichen planus and vitiligo, it is theoretically possible to suggest a single pathogenetic mechanism for the development of these dermatoses. Perhaps the pathology of the gastrointestinal tract in this patient was a factor contributing to the development of lichen planus. 

The article deals with etiologic factors which caused diffusive alopecia, such as: nutritional deficiency, dysfunction of the endocrine system, exogenous and endogenous intoxications, infectious diseases, diffusive diseases of the connective tissue, stress. It is noted that application of vaccines usually does not bring about visible hair loss. A medical case of vaccine-induced diffusive telogen effluvium is demonstrated in a young woman which occurred after a planned tetanus vaccination. The main role in establishing diagnosis of analysis of clinical data, laboratory and pathohistological study is shown. Thus, vaccination can be one of triggers of emergence of nonscarring diffuse alopecia of the hairy part of the head.