Treatment and rehabilitation of children with cleft lip and palate, who suffered from acute recurrent viral and bacterial respiratory tract and ENT-organs infections is one of the most complicated tasks. The local therapy by interferon was used both before and after surgical treatment: lubrication of the nasal passages and oral mucosa were carried out during 40 days ( 10 days before and 30days after surgical treatment). The priority in treating children with such diseases is given to the gradually increasing efficacy of rehabilitation and lowering post-operative complications and restoring the immune system functional activity. 

Approaches to the therapy of non-lactation mastitis in adolescent girls were considered. Clinical picture, methods of patient examination were described, as well as treatment of serous and purulent mastitis. 

Infant formula with probiotics has an important influence on the formation of the intestinal microbiocenosis in children deprived of breast milk. Special attention should be given to baby milk formula. which in the process of milk fermentation, gets unique properties which allows to prescribe them with therapeutic and preventive purposes, including for relief of functional disorders of the digestive system. 

The randomized clinical study included 120 children aged 6–18 years after they were exposed to radio-wave tonsillotomy, who received nonsteroidal anti-inflammatory preparations as symptomatic therapy in the early post-operative period. It was defined that in the early post-operative period, course application of ketoprofen lysine salt solution for intake in patients has an advantage over single application of the similar preparation, ibuprofen syrup and ketoprofen lysine salt solution for gargling. 

In the survey article, modern data on etiology, pathogenesis, clinics, genetics and diagnostics of pheochromocytomas/ paragangliomas are analyzed. It also presents methods of instrumental examination and current recommendations for treatment. 

The problems of obesity in children and adolescents, and approaches to the therapy of this pathology were considered. It is highlighted that the most accessible and effective way of both prevention, and treatment of obesity in children and adolescents is non-drug therapy directed to formation/ modification of lifestyle not only for the patient, but also for all his/her environment. 

Premature ventricular contractions is a frequent disorder of heart rhythm in children. The clinical course and the forecast for the disease is defined by the presence of cardiovascular system pathology, stability and presence of arrhythmia, and therapy efficiency. The article gives classification of premature ventricular contractions, approaches to prescription of anti-arrhythmic therapy and radiofrequency ablation based on the available national and international guidelines. 

Acute respiratory viral infections is the most common cause of illness in children and adults. Their clinical symptoms are fever, running nose and cough, which is the most common cause for calling out doctors and ambulance, especially in children. According to modern recommendations, prescription of symptomatic drugs (mucolytics, expectorants, vasoconstrictors, antihistamines, etc.) has severe limitations, especially in children 6–12 years. 

The authors shared experience of using a complex of natural terpenes to prevent respiratory tract diseases in preschool children in organized groups. A total of 7129 children aged 3–7 years were examined, which included: a pediatrician examination, anamnestic data analysis, an observation sheet filling, a polymerase chain reaction for the presence of Epstein–Barr virus in nasopharyngeal swabs before and after the examination. 

The review discusses peculiarities of secondary IgA-nephropathy, complicating Henoch–Schonlein purpura,
spondyloarthropathies, gluten enteropathy HCV infections, AIDS, liver cirrhosis, hereditary nephritis.

We considered diseases of sexual system in boys which threaten their reproductive health, the role of urinary tract infections in children and teenagers in formation of infertility, urination disorders. The methods of examination and tactics in conducting such patients were discussed. 

The aim of the study was to define structure of chronic kidney disease in children of the Orenburg region. We defined prevalence of tubulointerstitial diseases (91,3%) in structure of CKD in the Orenburg region. Our study confirms prevalence of tubulointerstitial diseases in the structure of CKD. 

The review is devoted to plasmatherapy — a relatively new approach in the regenerative medical practice. Special attention is paid to the description of the pathogenic effects, variety of the modes of its application, as well as the results of clinical studies dedicated to the plasmatherapy effectiveness in various branches of medicine. 

Risk factors for pneumonia development connected with providing medical aid to patients with oncological pathology were studied. The relevant risk factors for pneumonia development connected with providing the medical aid are the age of the patient over 60 years, oncological pathology of lymphatic and blood-forming tissues, duration of the main oncological pathology less than one year, comorbid pathology of cardiovascular system. 

The article presents information on epidermolysis bullosa, a rare genetic skin disease caused by mutations of several genes responsible for the synthesis of structural proteins of the skin. The pathogenic mechanisms causing the development of epidermolysis bullosa and deterioration of the clinical symptoms of the disease were given. The article describes the critical diagnostic criteria and options of treatment and prevention for these patients.