Clinical cases of effective use of combined lipid-lowering therapy (statin and ezetimibe) in patients with extremely high risk, who failed to achieve the target values of the level of low-density lipoprotein cholesterol were presented. Use of this drug combination allowed to achieve the target values of lipid spectrum in patients safely and effectively, and to reduce the risk of repeated cardiovascular events. 

Approaches to the therapy of arterial hypertension for women in menopause with climacteric syndrome were considered, as well as features of hypotensive therapy application, main groups of hypotensive drugs, and possibilities of rational combined therapy. 

We studied hypotensive effects, as well as short-term, daily and long-term variability of arterial pressure against the background of treatment with angiotensin-transforming ferment inhibitor and angiotensin-ferment blockers II in patients with arterial hypertension in comorbidity with chronic obstructive pulmonary disease. 

The article is devoted to analysis of relationship of left ventricular remodeling, plasma renin level, glomerular filtration rate in patients with arterial hypertension and renal additional arteries. It is shown that hormonal and hemodynamic factors in young patients with arterial hypertension of 1–2 degrees with renal additional arteries create a load on left ventricle, contributing to pathological myocardial remodeling in the form of eccentric hypertrophy and concentric remodeling. 

The article is a review of the literature, which presents the results of clinical studies on the effect of sleep disorders on the course of hypertension and the relationship between sleep duration and risk of occurrence and progression of the disease. In addition, the mechanisms of melatonin on the body and related effects are described. 

In the course of the case follow-up, clinical-expert analysis of validity of diagnosing «stenocardia» and «chronic heart insufficiency with retained and medium ejection fraction» was presented, as well as the strategies of management of the patients affected by acute coronary syndrome and x-ray-endovascular intervention on the coronary arteries. 

Derangements of hemostatic system after cardiac surgery with cardiopulmonary bypass are described in detail, but predictors of thrombotic complication in this group of children are still not detected. It was suggested that fibrin-monomer level and von Willebrand factor concentrations could be used as predictors of thrombosis in infants with congenital heart diseases. 

The article presents a review of mechanisms, diagnostics and possible predictors of atrial fibrillation recurrence, as well as the analysis of available scientifically proved therapeutic approaches to the treatment of patients with this arrhythmia. The role of anticoagulant therapy both in the context of the strategy of «rate control» and in the use of the strategy of «rhythm control» is examined. 

The article analyzes literature data on the diagnostics of diastolic function condition in young patients with signs of connective tissue dysplasia. The problem of diagnostics of pre-clinical left-ventricular diastolic dysfunction was discussed, as well as possible influence of peculiarities of connective-tissue cardiac frame in patients with connective tissue dysplasia on functional condition of auricles and left-ventricular diastolic function. 

The review article presents current data on water-electrolyte balance in healthy and pathological state. The diseases and conditions which occur in insipidary syndrome are described. The features of the clinical picture, diagnostic methods and treatment principles are considered. 

The results of prospective comparative study on application of the traditional therapy, and the one combined with butyric acid and inulin in patients with irritable intestine syndrome were presented, with the follow-up period of one year. This study has demonstrated authentically high therapeutic effect of butyric acid and inulin in patients with irritable intestine syndrome and low level of the disease recurrence, according to the results of the prospective study. 

We assessed clinical efficiency of application of topical-action preparations, in order to reduce frequency of infectious and postoperative complications, enhance regeneration of vaginal tissues, by inclusion of modern topical antibacterial combined and estrogenic preparations in the complex before and after the management. 

The article presents data on papillomavirus infection caused by human papilloma virus (HPV). The etiological and pathogenic mechanisms leading to the development of the disease are given, the risk factors for HPV infection, the clinical picture of different forms of the disease are described in detail. The article reveals information about the diagnosis of papillomavirus infection and tactics of treatment of patients with HPV infection. 

A review of modern literature on the role of intestinal microbiota in the pathogenesis of obesity is presented. New ways of influence of intestinal microbiota and products of its fermentation on metabolism are considered: through imbalance of Firmicutes and Bacteroidetes, by influence of short-chain fatty acids, and also as a result of activity of methanogenic archaea. 

The article highlights the information about the etiopathogenesis of acne, the features of the clinical course of various forms of the disease and possible treatments. The features of acne treatment in adolescents are considered in detail. The article describes the features of the treatment of late acne in women and combined therapy in acne patients of different levels of severity. 

The problem of polymorbidity in dermatological practice conditions the need for careful compliance with the diagnostic algorithm and analysis to identify the possibility of etiopathogenetic interconnection of diseases and their impact on each other. In this article we present a case of rare combined pathology — atopic dermatitis and porokeratosis. We want to draw the attention of practitioners to the fact that in this clinical observation the fact of establishing the final clinical diagnosis was delayed for 20 years, which led to the development of mental disorders in the patient.