The use of certain ABs is accompanied by the development of AAD (not only during the administration of drugs, but also within 2 months after its completion), which reduces the compliance rate of the treatment and increases the frequency of violation of the schedule of AB drugs and can negatively affect the effectiveness of the prescribed therapy. The preventive use of butyric acid and inulin together with AB can reduce the relative risk of developing AAD and increase the compliance of the treatment; and due to these effects, it is possible to increase the frequency of elimination of pathogenic and conditionally pathogenic microorganisms in the treatment of inflammatory infectious diseases and reduce the likelihood of developing antibiotic resistance. 

The best results of in vitro fertilization (IVF) and embryo transfer programs are observed in patients younger than 35 years old with tubo-peritoneal infertility factor in the absence of male factor. Difficulties in terms of reducing the effectiveness of IVF programs and / or the occurrence of complications arise in patients at risk for these complications, in patients of the late stage of the reproductive period and in infertility associated with certain gynecological diseases. To achieve the desired results in these groups of patients, non-standard approaches are required, which allow not only to increase the effectiveness of IVF programs, but also improve the rate of live births. 

Reactive oxygen forms (ROF) play an important role in modulating many physiological functions of the reproductive system, including the formation of endometriosis, are involved in the pathogenesis of infertility; There is a fine balance between ROF and antioxidants in the female reproductive process, which supports redox homeostasis. Oxidative stress occurs under conditions where the balance between ROF production and antioxidant protection is disturbed, and this may be due either to insufficient antioxidant protection or to excessive ROF production. Various data confirm the role of oxidative stress in the development and progression of endometriosis. This observation may open the way to assessment of therapeutic approaches aimed at correcting oxidative imbalance: the status of oxidative stress may be the key to treatment and, ultimately, to the prevention of endometriosis. In particular, in the future, clinical trials will help to better clarify the effectiveness of antioxidants as a potential therapy for endometriosis. 

This article presents the results of use of pump insulin therapy in type 1 diabetes mellitus in children. The collected data characterize the method of pump insulin therapy as an excellent instrument for achieving glycemic targets and improving the quality of life for children of all age groups. 

The basis for this study was the high incidence of vitamin D deficiency among children and adults of the Russian Federation. We examined 127 children and adolescents with obesity and 64 healthy children and adolescents. Normal serum vitamin D was diagnosed in 11% of subjects with obesity and in 8% of healthy subjects. A “clinical portrait” of a child with obesity and a prediction of the greatest metabolic and cardiovascular disorders was compiled: a teenager with advancing puberty, with severe obesity with a BMI > +3 SDS, having a vitamin D deficiency (25(OH)D < 20 ng/ml). 

Retrospective study of changes in metabolic status indicators (carbon and lipid metabolism, body mass) in patients at the 3rd stage of cardio-rehabilitation after acute coronary syndrome was conducted. 

This is a review of rehabilitation options for children with cerebral palsy. The article provides a detailed analysis of the types, methods of treatment and rehabilitation, intended for rehabilitation therapists, general practitioners, and subject-matter specialists. 

One of the important issues in the organization of nursing of children with intrauterine growth retardation (IUGR) is the issue of organizing enteral feeding. Enteral nutrition approaches in children differ depending on the degree of maturity of the child. Currently, the most detailed approaches to enteral feeding in premature infants with IUGR are reflected. In the diet of such children, as a rule, special therapeutic products are used: breast milk fortifiers and/or mixtures for premature and low-weight babies. In modern literature, there is little data on the characteristics of the organization of enteral feeding in full-term children with IUGR. The article discusses the issues of feeding full-term newborns with IUGR with a lack of breast milk, as well as the possibility of using a specialized mixture for low-weight children for feeding in such children. 

Influenza is of great socio-economic importance due to the widespread prevalence and high mortality, especially among patients at risk. Vaccination is important in reducing the incidence and mortality from influenza. The article describes the indications for vaccination, risk groups, features of modern vaccines. The article presents recommendations for the treatment of various forms of influenza. 

The analysis of the evaluation of the effectiveness of vitamin D3 (cholecalciferol) in the correction of cognitive disorders, anxiety, depression and improving the quality of life in patients with cerebrovascular disease. It was found that in patients taking vitamin D3 (cholecalciferol), the level of 25(OH) D in the peripheral blood increased, and the level of inflammatory response markers decreased, as well as improved cognitive function, reduced anxiety and depression, and improved quality of life.