Disease course, obstetric and perinatal outcomes in pregnant women with COVID-19 (literature review)
https://doi.org/10.51793/OS.2022.25.6.003
Abstract
At the end of 2019, a new acute respiratory disease, caused by the SARS-CoV-2 coronavirus, emerged for the first time in Wuhan, Hubei province, China. Due to its high contagiousness, the infection quickly spread to all continents and was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. To write a review article, materials from the submitted databases were studied: PubMed and Google Scholar, using keywords corresponding to the medical thematic heading (MeSH), «pregnancy» and «COVID-19», «coronavirus» or «SARS-CoV-2». Physiological changes associated with pregnancy increase the mother's susceptibility to infections in general, therefore, during pregnancy, the course of the disease may have its own characteristics. The most important issues in this case are the impact of the new coronavirus infection on the fetus, approaches to delivery. The findings reported that adverse outcomes included early and late spontaneous miscarriages, low birth weight infants for gestational age, and prematurity. Caesarean section was the main method of delivery in all cases of premature births against the background of a new coronavirus infection, while stillbirth and neonatal mortality compared with the general population, according to the above study results, do not increase. In general, I would like to hope that over time, the scientific community will receive the necessary information on the features of the course of pregnancy, possible complications and approaches to delivery in pregnant women with a new coronavirus infection, depending on the severity, we will learn to predict complications, which is an excellent prospect for further study.
About the Authors
M. D. Sanaeva
Regional State Budgetary Healthcare Institution Altai Regional Clinical Perinatal Center
Россия
Россия
Sanaeva Mariia Dmitrievna, obstetrician-gynecologist, doctor of ultrasound diagnostics
154 Fomina str., Barnaul, 656045
Yu. A. Dudareva
Federal State Budgetary Educational Institution of Higher Education Altai State Medical University of the Ministry of Health of the Russian Federation
Россия
Россия
Dudareva Yulia Alekseevna, Dr. of Sci. (Med.), Associate Professor, Professor of the Department of Obstetrics and Gynecology
40 ave. Lenin, Barnaul, 656038
References
1. Wang C., Horby P. W., Hayden F. G., Gao G. F. A novel coronavirus outbreak of global health concern // Lancet. 2020; 395 (10223): 470-473. https://doi.org/10.1016/S0140-6736(20)30185-9.
2. WHO Director-General’s opening remarks at the media briefing on COVID-19; 11 March 2020. https://www.who.int/dg/speeches/detail/who-director-general-sopening-remarks-at-the-media-briefing-on-covid-19-11-march-2020 (Accessed September 29, 2020).
3. Mathad J. S., Gupta A. Pulmonary infections in pregnancy // Semin Respir Crit Care Med. 2017; 38 (2): 174-184. https://doi.org/10.1055/s-0037-1602375.
4. Perlman S. Another decade, another coronavirus // N Engl J Med. 2020; 382 (8): 760-762. https://doi.org/10.1056/NEJMe2001126.
5. Galang R. R., Chang K., Strid P., et al. Severe coronavirus infections in pregnancy: a systematic review // Obstet Gynecol. 2020; 136 (2): 262-272. https://doi.org/10.1097/AOG.0000000000004011.
6. Diriba K., Awulachew E., Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical Fig. 1. Algorithm for the disposition of pregnant patients with COVID-19. M. N. Boushra, A. Koyfman and B. Long American Journal of Emergency Medicine xxx (2020) xxx 5 maternal-fetal transmission: a systematic review and meta-analysis // Eur J Med Res. 2020; 25 (1): 39. https://doi.org/10.1186/s40001-020-00439-w.
7. Allotey J., Stallings E., Bonet M., et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis // BMJ. 2020; 370. https://doi.org/10.1136/bmj.m3320.
8. Cohen J., Vignaux O., Jacquemard F. Covid-19 in pregnant women: general data from a French national survey // Eur J Obstet Gynecol Reprod Biol. 2020; 251 (1): 267-268. https://doi.org/10.1016/j.ejogrb.2020.06.002.
9. Liu D., Li L., Wu X., et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis // Am J Roentgenol. 2020; 215 (1): 127-132. https://doi.org/10.2214/AJR.20.23072.
10. Gabriel Marín, Miguel A., Mar Reyne Vergeli, Sonia Caserío Carbonero, Sole Laia, Tamara Carrizosa Molina, et al. Maternal, perinatal, and neonatal outcomes with COVID-19: a multicenter study of 242 pregnances and their 248 infant newborns during their first month of life // The Pediatric Infectious Disease Journal. 2020. https://doi.org/10.1097/INF.0000000000002902 Still in print.
11. Turan O., Hakim A., Dashraath P., Jeslyn W. J. L., Wright A., Abdul-Kadir R. Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS-CoV-2 infection among hospitalized pregnant women: A systematic review // Int J Gynecol Obstet. 2020; 151 (1). https://doi.org/10.1002/ijgo.13329ijgo.13329.
12. Hirshberg A., Kern-Goldberger A. R., Levine L. D., et al. Care of critically ill pregnant patients with coronavirus disease 2019: a case series // Am J Obstet Gynecol. 2020; 223 (2): 286-290. https://doi.org/10.1016/j.ajog.2020.04.029.
13. San-Juan R., Barbero P., Fernández-Ruiz M., et al. Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: a single-Centre cohort study from Spain // E Clinical Medicine. 2020; 23: 100407. https://doi.org/10.1016/j.eclinm.2020.100407.
14. Schwartz D. A. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes // Arch Pathol Lab Med. 2020; 144 (7): 799-805. https://doi.org/10.5858/arpa.2020-0901-SA.
15. Ellington S., Strid P., Tong V. T., et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22-June 7, 2020 // MMWR Morb Mortal Wkly Rep. 2020; 69 (25): 769-775. https://doi.org/10.15585/mmwr.mm6925a1.
16. Clerkin K. J., Fried J. A., Raikhelkar J., et al. COVID-19 and cardiovascular disease // Circulation. 2020; 141 (20): 1648-1655. https://doi.org/10.1161/CIRCULATIONAHA.120.046941.
17. Thompson J. L., Nguyen L. M., Noble K. N., Aronoff D. M. COVID-19-related disease severity in pregnancy // Am J Reprod Immunol. September. 2020. https://doi.org/10.1111/aji.13339.
18. Juusela A., Nazir M., Gimovsky M. Two cases of coronavirus 2019-related cardiomyopathy in pregnancy // Am J Obstetr Gynecol MFM. 2020; 2 (2): 100113. https://doi.org/10.1016/j.ajogmf.2020.100113.
19. Kim G. U., Kim M. J., Ra S. H., et al. Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19 // Clin Microbiol Infect. 2020; 26 (7). https://doi.org/10.1016/j.cmi.2020.04.040948.e1-948.e3.
20. Ferrazzi E., Frigerio L., Savasi V., et al. Mode of delivery and clinical findings in COVID19 infected pregnant women in northern Italy // SSRN Electron J. April 2020. https://doi.org/10.2139/ssrn.3562464.
21. Flaherman V. J., Afshar Y., Boscardin J., et al. Infant outcomes following maternal infection with SARS-CoV-2: first report from the PRIORITY study // Clin Infect Dis. September 2020. https://doi.org/10.1093/cid/ciaa1411.
22. Fenizia C., Biasin M., Cetin I., et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy // Nat Commun. 2020; 11 (1): 5128. https://doi.org/10.1038/s41467-020-18933-4.
23. Carosso A., Cosma S., Serafini P., Benedetto C., Mahmood T. How to reduce the potential risk of vertical transmission of SARS-CoV-2 during vaginal delivery? // Eur J Obstet Gynecol Reprod Biol. 2020; 250: 246249. https://doi.org/10.1016/j.ejogrb.2020.04.065.
24. Baergen R. N., Heller D. S. Placental pathology in Covid-19 positive mothers: preliminary findings // Pediatr Dev Pathol. 2020; 23 (3): 177-180. https://doi.org/10.1177/1093526620925569.
25. Chen S., Huang B., Luo D. J., et al. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases // Zhonghua bing li xue za zhi = Chinese journal of Pathology. 2020; 49 (0). https://doi.org/10.3760/cma.j.cn112151-20200225-00138E005.
26. Kuhrt K., McMicking J., Nanda S., Nelson-Piercy C., Shennan A. Placental abruption in a twin pregnancy at 32 weeks’ gestation complicated by coronavirus disease 2019 without vertical transmission to the babies // Am J Obstetr Gynecol MFM. 2020; 2 (3): 100135. https://doi.org/10.1016/j.ajogmf.2020.100135.
27. Baud D., Greub G., Favre G., et al. Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection // JAMA. 2020; 323 (21): 2198-2200. https://doi.org/10.1001/jama.2020.7233.
28. Knight Dphil M., Bunch K., Vousden N., et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study // BMJ. 2020; 369: m2107. https://doi.org/10.1136/bmj.m2107.
29. What’s new | COVID-19 Treatment Guidelines; 2020. https://www.covid19treatmentguidelines.nih.gov/whats-new/ (Accessed October 18, 2020).
30. Chen H., Guo J., Wang C., et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records // Lancet. 2020; 395 (10226): 809-815. https://doi.org/10.1016/S0140-6736(20)30360-3.
31. Wei M., Yuan J., Liu Y., Fu T., Yu X., Zhang ZJ. Novel coronavirus infection in hospitalized infants under 1 year of age in China // JAMA. 2020; 323 (13): 1313-1314. https://doi.org/10.1001/jama.2020.2131.
32. Zhu H., Wang L., Fang C., et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia // Transl Pediatr. 2020; 9 (1): 51-60. https://doi.org/10.21037/tp.2020.02.06.
33. Zeng L., Xia S., Yuan W., et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China // JAMA Pediatr. 2020; 174 (7): 722-725. https://doi.org/10.1001/jamapediatrics.2020.0878.
Review
For citations:
Sanaeva M.D., Dudareva Yu.A. Disease course, obstetric and perinatal outcomes in pregnant women with COVID-19 (literature review). Lechaschi Vrach. 2022;(5-6):20-24. (In Russ.) https://doi.org/10.51793/OS.2022.25.6.003
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