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Лечащий Врач

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Кишечный микробиом как терапевтическая мишень в лечении хронической неалкогольной болезни печени

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Аннотация

Поскольку стандартные диетические изменения и изменения образа жизни и патогенно-ориентированные методы лечения неалкогольной жировой болезни печени часто неэффективны, необходимы новые подходы, направленные на другие мишени. В условиях, связанных с поврежденным кишечным барьером («протекающая кишка»), оси «кишка–печень» можно улучшить естественные взаимодействия между кишечными бактериями и пептическими рецепторами, тем самым способствуя следующему каскаду событий: окислительный стресс, резистентность к инсулину, воспаление печени и фиброз. В статье также обсуждается возможность модуляции микробиоты кишечника пробиотиками.

Об авторах

Е. Ю. Плотникова
ФГБОУ ВО КемГМУ МЗ РФ
Россия


Ю. В. Захарова
ФГБОУ ВО КемГМУ МЗ РФ
Россия


Т. Ю. Грачева
ФГБОУ ВО КемГМУ МЗ РФ
Россия


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Рецензия

Для цитирования:


Плотникова Е.Ю., Захарова Ю.В., Грачева Т.Ю. Кишечный микробиом как терапевтическая мишень в лечении хронической неалкогольной болезни печени. Лечащий Врач. 2018;(8):38.

For citation:


Plotnikova E.Yu., Zakharova Yu.V., Gracheva T.Yu. Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease. Lechaschi Vrach. 2018;(8):38. (In Russ.)

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