The influence of changes in intestinal microbiota on the course of inflammatory intestinal diseases
Abstract
An important role in the development and progression of inflammatory bowel diseases belongs to environmental factors, in particular, the intestinal microbiota. Advances in the technology of genomic sequencing made it possible to establish that it is the change in the composition of the intestinal microbiota that triggers the inflammation in the intestine, and not vice versa, as it was previously thought.
About the Authors
O. V. GausRussian Federation
V. A. Akhmedov
Russian Federation
References
1. Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению язвенного колита [электронный ресурс]. http://www.gastro.ru/userfiles/R_YAZVKOLIT_2017.pdf (дата обращения 01.02.2018 г).
2. Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению болезни Крона [электронный ресурс]. http://www.gastro.ru/userfiles/R_Krona_2017.pdf (дата обращения 01.02.2018 г).
3. Балунов П. А. Фармакоэкономическая оценка применения 5?СК при легком и среднетяжелом распространенном (рецидивирующем) язвенном колите // Медицинский совет. 2017. № 15. C. 122–129.
4. Weimers P., Munkholm P. The Natural History of IBD: Lessons Learned // Curr Treat Options Gastroenterol. 2018. Vol. 16 (1). P. 101–111.
5. Uhlig H. H., Booth C. A. Spectrum of Genetic Variants Contributes to Immune Defects and Pathogenesis of Inflammatory Bowel Diseases // Gastroenterology. 2018. Vol. 154 (8). P. 2022–2024.
6. Rutayisire E., Huang K., Liu Y., Tao F. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants’ life: a systematic review // BMC Gastroenterol. 2016. Vol. 16 (1). P. 86.
7. Bager P., Simonsen J., Nielsen N. M., Frisch M. Cesarean section and offspring’s risk of inflammatory bowel disease: a national cohort study // Inflamm. Bowel Dis. 2012. Vol. 18 (5). P. 857–862.
8. Barclay A. R., Russell R. K., Wilson M. L. et al. Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease // J. Pediatr. 2009. Vol. 155 (3). P. 421–426.
9. Stein D. J., Shaker R. Inflammatory Bowel Disease. A Point of Care Clinical Guide. Springer International Publishing Switzerland. 2015. 244 р.
10. Lane E. R., Zisman T. L., Suskind D. L. The microbiota in inflammatory bowel disease: current and therapeutic insights // J. Inflammation Research. 2017. Vol. 10. P. 63–73.
11. Kiesler P., Fuss I. J., Strober W. Experimental Models of Inflammatory Bowel Diseases // Cell. Molecul. Gastroenterol. Hepatol. 2015. Vol. 1 (2). P. 154–170.
12. Корниенко Е. А. Воспалительные заболевания кишечника у детей. М.: Прима Принт, 2014. 208 c.
13. Maloy K. J., Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease // Nature insight. 2011. Vol. 474 (7351). P. 298–306.
14. Vrakas S., Mountzouris K. C., Michalopoulos G. et al. Intestinal Bacteria Composition and Translocation of Bacteria in Inflammatory Bowel Disease // PLoS One. 2017. Vol. 12 (1). e0170034.
15. Matsuoka K., Kanai T. The gut microbiota and inflammatory bowel disease // Semin. Immunopathol. 2015. Vol. 37. P. 47–55.
16. Wang W., Chen L., Zhou R. et al. Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease // J. Clin. Microbiol. 2014. Vol. 52. P. 398–406.
17. Ca Y., Shen J., Ran Z. H. Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature // Gastroenterol. Res. Pract. 2014. Vol. 2014. 872725.
18. Zhang L., Lee H., Grimm M. C. et al. Campylobacter concisus and inflammatory bowel disease // World J. Gastroenterol. 2014. Vol. 20 (5). P. 1259–1267.
19. Lyu G., Li J., Liu A. L. et al. A comparison of clinical characteristics in elderly patients with ulcerative colitis and ischemic colitis // Zhonghua Nei Ke Za Zhi. 2016. Vol. 55 (6). P. 466–469.
20. Law C. C., Tariq R., Khanna S. et al. Systematic review with meta-analysis: the impact of Clostridium difficile infection on the short- and long-term risks of colectomy in inflammatory bowel disease // Aliment Pharmacol Ther. 2017. Vol. 45 (8) P. 1011–1020.
21. Cojocariu C., Stanciu C., Stoica O. et al. Clostridium difficile infection and inflammatory bowel disease // Turk. J. Gastroenterol. 2014. Vol. 25 (6). P. 603–610.
22. Buts J. P. Twenty-five years of research on Saccharomyces boulardii trophic effects: updates and perspectives // Dig. Dis. Sci. 2009. Vol. 54. P. 15–18.
23. Головенко О. В., Халиф И. Л., Головенко А. О. Роль масляной кислоты и инулина в лечении органических и функциональных заболеваний кишечника. ФГБУ «ГНЦ Колопроктологии» Минздравсоцразвития России, 2?е изд., доп. М.: 4 ТЕ АРТ, 2012. 40 с.
24. Vernia P., Annese V., Bresci G. et al. Topical butyrate improves efficacy of 5?ASA in refractory distal ulcerative colitis: results of a multicenter trial // Eur. J. Clin. Invest. 2003. Vol. 33 (3). P. 244–248.
25. Assisi R. F. Combined butyric acid/mesalazine treatment in ulcerative colitis with mild-moderate activity. Results of a multicenter pilot study // Minevra Gastroenterol. Dietol. 2008. Vol. 54 (3). P. 231–238.
26. Sabatino A. D., Morera R., Ciccocioppo R. et al. Oral Butyrate for mildly to moderately active Crohn’s disease // Aliment. Pharmacol. Ther. 2005. Vol. 22 (9). P. 789–794.
27. Jostins L., Ripke S., Weersma R. K. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease // Nature. 2012. Vol. 491. P. 119–124.
28. Lees C. W., Barrett J. C., Parkes M., Satsangi J. New IBD genetics: common pathways with other diseases // Gut. 2011. Vol. 60. P. 1739–1753.
29. Cooney R., Baker J., Brain O. et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation // Nat. Med. 2010. Vol. 16. P. 90–97.
Review
For citations:
Gaus O.V., Akhmedov V.A. The influence of changes in intestinal microbiota on the course of inflammatory intestinal diseases. Lechaschi Vrach. 2018;(8):24. (In Russ.)
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