The effectiveness of the combined preparation of NSAIDs with B vitamins in diseases of the musculoskeletal system

The purpose of this open, not comparative study was to evaluate the efficacy and safety of pain therapy for diseases of the musculoskeletal system. The study included 30 patients with joint pain of different localization who are hospitalized in the therapeutic department, receiving a fixed combination of diclofenac sodium with B vitamins. The severity of pain was assessed using a visual analogue scale (VAS) for day activity (VAS-am) before taking the drug and 3 hours after, for three days. In patients with gonarthrosis and coxarthrosis, the WOMAC pain index scale (The Western Ontario and McMaster Universities Osteoarthritis Index) was additionally evaluated. A statistically significant clinical efficacy of a fixed combination of diclofenac sodium with B vitamins in patients with pain was revealed, verified by the positive dynamics of VAS and WOMAC indices: after three doses, the severity of pain on the VAS scale decreased by 84% (p ≤ 0.01). According to the WOMAC scale (pain) in patients with gonarthrosis and coxarthrosis, pain for the first indicators decreased by 75% (p ≤ 0.01). The maximum effect is achieved on the first day of taking a fixed combination of diclofenac sodium with B vitamins and lasts for 3 days. Patients did not reveal unwanted adverse reactions. The rapid analgesic effect of the drug and the absence of side effects increases the patient's adherence to the drug. 

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