Endothelial dysfunction in acute renal injury in children with hemolytic-uremic syndrome (literature review)

Hemolytic uremic syndrome (HUS) is a major cause of acute kidney injury (AKI) in children and one of the causes of the progression of kidney damage in childhood. Endothelial dysfunction is the central pathogenetic mechanism of kidney damage in this pathology. Early detection of endothelial dysfunction in kidney damage is of great interest, since timely correction can help slow the progression of kidney damage. The presence of a direct correlation between the glomerular filtration rate and biomarkers of endothelial dysfunction in patients with impaired renal function has been proven. Due to damage to the endothelium of the renal glomeruli, glomerular filtration decreases until the formation of AKI. It is promising to identify early and sensitive biomarkers of AKI in children with HUS for the development of new diagnostic approaches, which will optimize the early diagnosis and progression of renal damage in this category of patients. The study of the effect of endothelial dysfunction on the course and outcome of HUS is relevant and requires further research in this direction. 

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