The use of oxygenated saline enteral solution in the complex intensive care of severe community-acquired pneumonia caused by COVID-19
https://doi.org/10.26295/OS.2020.71.86.003
Abstract
COVID-19 is an acute respiratory tract infection caused by SARS-CoV-2 coronavirus. Genetic sequencing of the virus has shown that it belongs to beta-coronaviruses related to the SARS virus. In most cases, COVID-19 has a mild course without complications, but 14–20% of patients develop a severe course that requires hospitalization and oxygen support.
The effect of oxygenated saline enteral solution (OSES) in complex intensive care on the possibility of correcting gastrointestinal dysfunction and systemic oxygenation in severe community-acquired pneumonia caused by COVID-19 was determined. Our goal is to capture the attention of specialists to the prevention and treatment of intestinal insufficiency syndrome and enterogenic intoxication due to hypoxic damage to the intestine with the probable translocation of microorganisms in patients with severe respiratory failure developed against the background of community-acquired viral pneumonia COVID-19. The article describes the first experience with the use of OSES in complex intensive care in this category of patients.
The results obtained suggest the pathogenetic validity and feasibility of using oxygenated saline enteral solution in the complex intensive care of community-acquired viral pneumonia with COVID-19.
The use of OSES, in the authors’ opinion, is of particular scientific and practical interest in the current epidemiological situation and deserves the attention of various specialists, and also requires further in-depth study of the effectiveness of this method in the combination therapy of COVID-19.
About the Authors
M. V. BykovРоссия
PhD in Medicine,
Moscow
D. V. Chernyshev
Россия
Moscow
Yu. A. Loptev
Россия
Moscow
S. V. Krasnova
Россия
PhD in Medicine,
Moscow
N. A. Tsvetkova
Россия
Moscow
Zh. B. Ponezheva
Россия
Doctor of Medicine,
Moscow
V. G. Akimkin
Россия
Doctor of Medicine, Professor, RAS academician,
Moscow
References
1. WHO. Clinical guidelines for the management of severe acute respiratory syndrome (SARS, SARI, SARI) due to a new coronavirus infection (COVID-19) — WHO/2019-nCoV/Clinical/2020.4.
2. Intensivnaya terapiya natsionalnoe rukovodstvo: v 2 t. [Intensive care: national leadership: in 2 volumes] / Ed. I. B. Zabolotskikh, D. N. Protsenko. 2nd ed., Revised. and additional. Moscow: GOETAR-Media, 2020. T. 2. 1056 s.: ill. DOI: 10.33029/9704-5018-5-ICNG-2020-1-1056.
3. Phua J., Badia J. R. Has Mortality from Acute Respiratory Distress Syndrome Decreased over Time // Am. J. of Resp. and Crit. Care Med. 2009; 179: 220–227.
4. Belikov V. L. Enteralnaya oksigenoterapiya pri enteropatiyakh kriticheskikh sostoyanii [Enteral oxygen therapy for enteropathy of critical conditions]. Abstract. Diss. Ph.D. St. Petersburg, 2016. 34 p. https://rusneb.ru/catalog/000199_000009_006663778/.
5. Mazurok V. A., Golovkin A. S., Bautin A. E., Gorelov I. I., Belikov V. L., Slivin O. A. Zheludochno-kishechnyi trakt pri kriticheskikh sostoyaniyakh: pervyi stradaet, poslednyi, komu udelyajut vnimanie [Gastrointestinal tract in critical conditions: the first suffers, the latter, to whom attention is paid] // Vestnik intensivnoi terapii. 2016. № 2. Рр. 28–37.
6. Bykov M. V. and coauthors. Patent No. 2709113 RU. from 12.16.2019 Sposob lecheniya intestinalnoi nedostatochnosti oksigenirovannym solevym enteralnym rastvorom [A method for the treatment of intestinal insufficiency with oxygenated saline enteral solution]. https://yandex.ru/patents/doc/RU2709113C1_20191216.
7. Mazurok V. A. Patent No. 2505323 RU. from 01/27/2014. Sposob vnelegochnoi oksigenatsii krovi [Method for extrapulmonary blood oxygenation].
8. Matkevich V. A., Luzhnikov E. A., Ilyashenko K. K. et al. Kishechnyi lavazh pri tkzo- i endotoksikoze. Metodichesrie rekomendatsii [Intestinal lavage with exo- and endotoxemia. Guidelines]. DZ of Moscow, 2010. 20 s.
9. Matkevich V. A. Kishechnyi lavazh [Intestinal lavage]. In: Medical toxicology: national guidelines / Ed. E. A. Luzhnikov. M.: GEOTAR-Medicine, 2012. Ch. 4. S. 162–186.
10. Bykov M. V., Ivanova T. F., Bagaev V. G., Amcheslavsky V. G., Lazarev V. V. Polozhitelnyi effekt metoda kishechnogo lavazha v kompleksnoi terapii reperfuzionnogo oteka legkikh [The positive effect of the method of intestinal lavage in the treatment of reperfusion pulmonary edema] // Detskaya bolnitsa. 2014. № 4 (58). P. 57–59.
11. Hill L. T. Gut dysfunction in the critically ill - mechanisms and clinical. implications // J. Crit. Care. 2013; 29 (1): 11-15.
12. Leaphert C. L., Tapes J. J. The gut is a motor of organ system disfunction // Surgery. 2007; (141): 563–569.
13. Klingensmith N. J., Coopersmith С. М. The gut as the motor of multiple organ disfunction in critical illness // CCC. 2016; 32 (2): 203212.
14. Matkevich V. A., Luzhnikov E. A., Belova M. V., Syromyatnikova E. D., Kurilkin Yu. A. Rol kishechnoi translokatsii v geneze endotiksemii pri ostrykh otravleniyakh I detoksikatsionnyi effekt kishechnogo lavazha [The role of intestinal translocation in the genesis of endotoxemia in acute poisoning and the detoxifying effect of intestinal lavage] // Neotlozhnaya meditsinskaya pomosch. 2015. № 4. P. 16–21.
15. Ugolev A. M., Eckert L. G., Gromova L. V. Yavlenie dvustoronnego dykhaniya enterotsitov mlekopitayuschikh v normalnykh usloviyakh [The phenomenon of bilateral respiration of mammalian enterocytes under normal conditions] Application for discovery No. A-147 of January 19, 1998 (International assoc. Authors of scientific discoveries). Diploma No. 129.
16. Rybakov A. S., Tyagun V. S., Vetoshkin V. A. et al. Primenenie enteralnoi oksigenatsii v kompleksnom lechenii OKN [The use of enteral oxygenation in the complex treatment of OKN] / Man and his health: theses of the XXI International medical biol. conferences of young researchers. SPb, 2018. Vol. 21. S. 369–370.
17. Slivin O. A., Tarnovskaya D. S., Mazurok V. A., Belikov V. L., Gorelov I. I. Intestinalnaya oksigenatsiya v sostave intensivnoi terapii beremennoi s grippom a (H1N1). Klinicheskaya demonstratsiya [Intestinal oxygenation as part of intensive care in a pregnant woman with influenza a (H1N1). Clinical demonstration] // Vestnik intensivnoi terapii. 2017; 3: 69–75.
18. Gelman S., Paz M., Levy E. Influence of enteral oxygen administration on the slow electrical activity of the intestine and stomach // Arch. Surg. 1976; 111 (5): 566–574.
19. Mazurok V. A., Belikov V. L., Slivin O. A., Lobach S. M. Vozmozhnosti povysheniya sistemnoi oksigenatsii posredstvom enteralnoi oksigenoterapii [Possibilities of increasing systemic oxygenation through enteral oxygen therapy] // Anesteziologiya i reanimatologiya. 2014. № 5. Рр. 21–26.
Review
For citations:
Bykov M.V., Chernyshev D.V., Loptev Yu.A., Krasnova S.V., Tsvetkova N.A., Ponezheva Zh.B., Akimkin V.G. The use of oxygenated saline enteral solution in the complex intensive care of severe community-acquired pneumonia caused by COVID-19. Lechaschi Vrach. 2020;(7):58-63. (In Russ.) https://doi.org/10.26295/OS.2020.71.86.003
JATS XML


















