Comparison of quality of life in patients after kidney transplantation under different regimens of immunosuppressive therapy
https://doi.org/10.51793/OS.2025.28.1.004
Abstract
Background. Patients with chronic kidney disease, including dialysis patients, experience significant physical and mental stress, which ultimately leads to impaired physical and psychosocial health. All this significantly affects the quality of life. Kidney transplantation is the most promising direction in providing medical care to patients with end-stage renal disease, since it provides a significant improvement in the quality of life compared to dialysis therapy. Understanding the specifics of the quality of life of patients who have undergone successful kidney transplantation can provide valuable information for making further therapeutic decisions.
Objective. Analysis of the quality of life of kidney recipients under various regimens of immunosuppressive therapy.
Materials and methods. A survey of 176 kidney recipients was conducted using the SF-36 questionnaire. The respondents were divided into 2 groups. The first group included recipients receiving immunosuppressive therapy at standard doses, the second group included recipients receiving immunosuppressive therapy at reduced doses.
Results. The study showed a significant improvement in the quality of life in kidney transplant recipients 12 months after transplantation. Reducing the dosage of immunosuppressive drugs leads to a significant improvement in the quality of life of patients. This is due to a decrease in the frequency and severity of dose-dependent side effects of immunosuppressive therapy.
Conclusion. Kidney and liver transplantation makes it possible to maintain sufficiently high rates of both the physical and psychological components of the quality of life.
About the Authors
E. V. Parabina
Samara State Medical University
Россия
Россия
Elena V. Parabina - nephrologist, Head of the Nephrology Department of the Clinics at the Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.
89 Chapaevskaya str., Samara, 443099
O. V. Fatenkov
Samara State Medical University
Россия
Россия
Oleg V. Fatenkov - Dr. of Sci. (Med.), Associate Professor, Head of the Head of the Department of Faculty Therapy, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.
89 Chapaevskaya str., Samara, 443099
G. N. Svetlova
Samara State Medical University
Россия
Россия
Galina N. Svetlova - Cand. of Sci. (Med.), Associate Professor of the Department of Faculty therapy, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.
89 Chapaevskaya str., Samara, 443099
N. Yu. Kuvshinova
Samara State Medical University
Россия
Россия
Natalya Yu. Kuvshinova - Cand. of Sci. (Psy.), Associate Professor of the Department of Pedagogy, Psychology and Psycholinguistics, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.
89 Chapaevskaya str., Samara, 443099
References
1. Vasilieva I. A. Quality of life in renal transplant recipients. Nephrology (Saint-Petersburg). 2018; 22 (4): 74-80. (In Russ.) DOI: 10.24884/1561-6274-2018-22-4-74-80.
2. Iqbal M. M., Rahman N., Alam M., Deb Nath P. K., et al. Quality of life is improved in renal transplant recipients versus that shown in patients with chronic kidney disease with or without dialysis. Exp Clin Transplant. 2020; 18: 64-67. DOI: 10.6002/ect.TOND-TDTD2019.P11.
3. Ryu J.-H., Koo T. Y., Ro H., Cho J.-H., et al. Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function. PLoS ONE. 2021; 16 (10): e0257981. DOI: 10.1371/journal.pone.0257981.
4. Kostro J. Z., Hellmann A., Kobiela J., et al. Quality of life after kidney transplantation: a prospective study. Transplant Proc. 2016; 48 (1): 50-54.
5. Аbaeva O. P., Romanov S. V., Ryabova Е. N. Quality of life of patients who underwent kidney and liver transplant surgery. The Russian Journal of Preventive Medicine. 2020; 23 (1): 121-126. (In Russ.) DOI: 10.17116/profmed202023011121.
6. Shevchenko A. O., Khalilulin T. A., Mironkov B. L., Saitgareev R. S., et al. Quality of life assessment in cardiac transplant recipients. Russian Journal of Transplantology and Artificial Organs. 2014; 16 (4): 11-16. (In Russ.) DOI:10.15825/1995-1191-2014-4-11-16.
7. Wang Y., Hemmelder M. H., Bos W. J. W., Snoep J. D. Mapping health-related quality of life after kidney transplantation by group comparisons: a systematic review. Nephrol Dial Transplant. 2021; 36: 2327-2339. DOI: 10.1093/ndt/gfab232.
8. Tsarpali V., Midtvedt K., Lønning K., Bernklev T., et al. Quality of life in older kidney transplant recipients: a national cohort study of shortand longer-term outcomes. Kidney Med. 2021; 3 (6): 974-983. DOI: 10.1016/j.xkme.2021.05.007.
9. Tucker E. L., Smith A. R., Daskin M. S., Schapiro H., et al. Life and expectations postkidney transplant: a qualitative analysis of patient responses. BMC Nephrology. 2019; 20: 175. DOI: 10.1186/s12882-019-1368-0.
10. Sarhan A. L., Jarareh R. H., Sarhan M. S., et al. Quality of life for kidney transplant recipients and hemodialysis patients in Palestine: a crosssectional study. BMC Nephrology. 2021; 22: 210. DOI: 10.1186/s12882-021-02412-z.
11. Gulov M. K., Abdulloev S. M., Rofiev H. K. Quality of life in patients with chronic kidney disease. IP Pavlov Russian Medical Biological Herald. 2018; 26 (4): 493-499. (In Russ.) DOI: 10.23888/PAVLOVJ2018264493-499.
Review
For citations:
Parabina E.V., Fatenkov O.V., Svetlova G.N., Kuvshinova N.Yu. Comparison of quality of life in patients after kidney transplantation under different regimens of immunosuppressive therapy. Lechaschi Vrach. 2025;(1):26-31. (In Russ.) https://doi.org/10.51793/OS.2025.28.1.004
Views:
124
JATS XML
Email this article 
