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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2025.28.1.004</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-1345</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>УРОНЕФРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>URONEPHROLOGY</subject></subj-group></article-categories><title-group><article-title>Сравнение уровня качества жизни пациентов после трансплантации почки при различных схемах иммуносупрессивной терапии</article-title><trans-title-group xml:lang="en"><trans-title>Comparison of quality of life in patients after kidney transplantation under different regimens of immunosuppressive therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4520-8705</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парабина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Parabina</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Парабина Елена Валерьевна - нефролог, заведующая нефрологическим отделением Клиник.</p><p>443099, Самара, ул. Чапаевская, 89</p></bio><bio xml:lang="en"><p>Elena V. Parabina - nephrologist, Head of the Nephrology Department of the Clinics at the Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">parabinaev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4928-5989</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фатенков</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fatenkov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фатенков Олег Вениаминович - д.м.н., доцент, заведующий кафедрой факультетской терапии.</p><p>443099, Самара, ул. Чапаевская, 89</p></bio><bio xml:lang="en"><p>Oleg V. Fatenkov - Dr. of Sci. (Med.), Associate Professor, Head of the Head of the Department of Faculty Therapy, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">o.v.fatenkov@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4328-2090</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Светлова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Svetlova</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлова Галина Николаевна - к.м.н., доцент кафедры факультетской терапии.</p><p>443099, Самара, ул. Чапаевская, 89</p></bio><bio xml:lang="en"><p>Galina N. Svetlova - Cand. of Sci. (Med.), Associate Professor of the Department of Faculty therapy, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">g.n.svetlova@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1826-5237</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кувшинова</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuvshinova</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кувшинова Наталья Юрьевна - к.псих.н., доцент кафедры педагогики, психологии и психолингвистики.</p><p>443099, Самара, ул. Чапаевская, 89</p></bio><bio xml:lang="en"><p>Natalya Yu. Kuvshinova - Cand. of Sci. (Psy.), Associate Professor of the Department of Pedagogy, Psychology and Psycholinguistics, Federal State Budgetary Educational Institution of Higher Education Samara State Medical University of the Ministry of Health of the Russian Federation.</p><p>89 Chapaevskaya str., Samara, 443099</p></bio><email xlink:type="simple">n.yu.kuvshinova@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>25</day><month>01</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>26</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Парабина Е.В., Фатенков О.В., Светлова Г.Н., Кувшинова Н.Ю., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Парабина Е.В., Фатенков О.В., Светлова Г.Н., Кувшинова Н.Ю.</copyright-holder><copyright-holder xml:lang="en">Parabina E.V., Fatenkov O.V., Svetlova G.N., Kuvshinova N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/1345">https://journal.lvrach.ru/jour/article/view/1345</self-uri><abstract><sec><title>Введение</title><p>Введение. Пациенты с хронической болезнью почек, в том числе находящиеся на диализе, испытывают значительные физические и психические нагрузки, что в конечном итоге приводит к нарушению физического и психосоциального состояния здоровья. Все это существенно влияет на качество жизни. Трансплантация почки является наиболее перспективным направлением оказания медицинской помощи больным с терминальной почечной недостаточностью, поскольку обеспечивает значительное улучшение качества жизни по сравнению с диализной терапией. Понимание специфики качества жизни пациентов, перенесших успешную трансплантацию почки, может дать ценную информацию для принятия дальнейших терапевтических решений.</p></sec><sec><title>Цель работы</title><p>Цель работы. Проведение анализа качества жизни реципиентов почки при различных режимах иммуносупрессивной терапии.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проводили анкетирование 176 реципиентов почки по опроснику SF-36. Респонденты были разделены на две группы. В первую группу вошли реципиенты, получающие иммуносупрессивную терапию в стандартных дозах, во вторую – реципиенты, получающие иммуносупрессивную терапию в уменьшенных дозах.</p></sec><sec><title>Результаты</title><p>Результаты. Исследование показало достоверное улучшение качества жизни реципиентов почки через 12 месяцев после трансплантации. Уменьшение дозировки иммуносупрессивных препаратов приводит к значительному улучшению качества жизни пациентов. Это обусловлено снижением частоты и тяжести дозозависимых побочных эффектов иммуносупрессивной терапии.</p></sec><sec><title>Заключение</title><p>Заключение. Трансплантация почки делает возможным поддержание достаточно высоких показателей как физической, так и психологической составляющей качества жизни.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Patients with chronic kidney disease, including dialysis patients, experience significant physical and mental stress, which ultimately leads to impaired physical and psychosocial health. All this significantly affects the quality of life. Kidney transplantation is the most promising direction in providing medical care to patients with end-stage renal disease, since it provides a significant improvement in the quality of life compared to dialysis therapy. Understanding the specifics of the quality of life of patients who have undergone successful kidney transplantation can provide valuable information for making further therapeutic decisions.</p></sec><sec><title>Objective</title><p>Objective. Analysis of the quality of life of kidney recipients under various regimens of immunosuppressive therapy.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A survey of 176 kidney recipients was conducted using the SF-36 questionnaire. The respondents were divided into 2 groups. The first group included recipients receiving immunosuppressive therapy at standard doses, the second group included recipients receiving immunosuppressive therapy at reduced doses.</p></sec><sec><title>Results</title><p>Results. The study showed a significant improvement in the quality of life in kidney transplant recipients 12 months after transplantation. Reducing the dosage of immunosuppressive drugs leads to a significant improvement in the quality of life of patients. This is due to a decrease in the frequency and severity of dose-dependent side effects of immunosuppressive therapy.</p></sec><sec><title>Conclusion</title><p>Conclusion. Kidney and liver transplantation makes it possible to maintain sufficiently high rates of both the physical and psychological components of the quality of life.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>качество жизни</kwd><kwd>трансплантация почки</kwd><kwd>иммуносупрессивная терапия</kwd><kwd>хроническая болезнь почек</kwd></kwd-group><kwd-group xml:lang="en"><kwd>quality of life</kwd><kwd>kidney transplantation</kwd><kwd>immunosuppressive therapy</kwd><kwd>chronic kidney disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева И. А. Качество жизни реципиентов почечного трансплантата. Нефрология. 2018; 22 (4): 74-80. DOI: 10.24884/1561-6274-2018-22-4-74-80.</mixed-citation><mixed-citation xml:lang="en">Vasilieva I. A. Quality of life in renal transplant recipients. Nephrology (Saint-Petersburg). 2018; 22 (4): 74-80. (In Russ.) 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