The article presents modern data on complete treatment of psoriasis with genetically engineered biological preparations in Krasnodar region. Clinical cases of successful treatment of patients with psoriasis vulgaris and nail psoriasis with secukinumab are presented in this publication. 

The article describes a clinical case of alopecia mucinosa, manifested in hair loss on the scalp. The diagnosis was confirmed on the basis of histological examination. Clinical, anamnestic and laboratory data allowed to establish the correct diagnosis.

The data of Immunohistochemical and Morphometric studies of skin biopsy images of 30 patients with I, II and III stages of Mycosis Fungoides were analyzed. Diagnostically relevant threshold values of the volume fraction of positive staining cells of the dermal infiltrate with MCA CD3, CD4, CD8 and Ki67 were evaluated. These data allow to build a mathematical model which allows effectively to distinguish between early (I-IIA) and late (IIB-III) stages of Mycosis Fungoides. Clinical examples of use of this model are given. 

The article presents analysis of the effectiveness of using interval hypoxi-hyperoxic training (IHHT) technology in aesthetic cosmetology. It is shown that the hypoxi-hyperoxic therapy improves parameters of gas exchange and hemodynamics in patients at systemic level. In the face and neck area, the condition of capillary network is improved, the microcirculation and the local blood concentration are increased. The obtained results allow to recommend IHHT technology for activating of complex rejuvenation of aged patients’ organism and correction of adverse changes in the skin of the face and neck. 

The article describes the clinical cases of patients with nevus Ota, Mongolian spot. Many of dermal melanosis can be associated with a risk of damage to the organs of hearing, vision, nervous system and melanoma development. Therefore, such patients need dispensary observation and examination by narrow specialists. Methods of laser therapy for dermal melanocytosis are described. 

An open, single-site, controlled, randomized clinical study on the effectiveness and safety of administration of a new locally produced topical cream with azelaic acid and organosilicon glycerhydrogel in acne patients during the interrecurrent period was performed. The undertaken study has shown that the new cream administration leads to positive dynamics of IGA and BASI, VAS of skin oiliness and the quality of life before and after the cream administration. The results of the study make it possible to recommend the new cream for administration during acne interrecurrent period as an alternative to standard skin-care products. 

The scientific analysis of organization of medical-social work in the area of preventive maintenance, timely therapy of influenza, anti-epidemic actions, optimization of rehabilitation of workers are presented. The medical-social approach to revealing probable risk of the noncompliance is reflected in infection of influenza. Methods: theoretical research, scientific observation (method of «field» observation), opinion polls (questioning and interviewing), content analysis- were used. In informal collective employment, not less than in self-employment, a certain failure of commitment of the patient to treatment of influenza, concerning administration pharmaceutical preparations, and other medical purposes used in basic diagrams is supposed. 

The article presents a modern understanding of measles — the epidemiology of the disease, brief data on the tactics of treatment of pathogenesis, clinic and patient management. A clinical example of measles in an adult is presented. The article reflects the modern approaches to the diagnosis and prevention of this highly contagious infection. 

Febrile seizures are common in children, in some cases, they are associated with Human betaherpesvirus 6A/V infection (HHV6А/В). This condition can recur, leading to the hospitalization of the patient. Cases of clinical observation of children with recurrent febrile seizure and active infection of HHV-6A/V are presented. The effectiveness of antiviral treatment of HHV-6A/V as prevention of recurrent febrile seizure has been demonstrated. 

The frequency, nature and duration of extra-intestinal manifestations depending on the therapy in children with norovirus infection were studied. It was found that in norovirus infection in children, in addition to gastrointestinal symptoms, there are often other symptoms that affect the upper respiratory tract, pancreas, hepatobiliary and urinary systems and heart. An effective drug that relieves the symptoms of norovirus infection, prevents the development of extra-intestinal manifestations and complications, is colloidal silicon dioxide. 

HIV infection and chronic viral hepatitis modify the classical clinical picture of dermatoses. In most cases, they are atypical, prone to widespread and resistant to standard treatment. In this case, the development and course of dermatoses can also be influenced by the ongoing antiretroviral therapy. Comorbidity of dermatoses with chronic infections can lead to tactical and diagnostic errors, which subsequently lengthens and complicates the therapeutic process. In this regard, the article describes clinical observations of dermatological patients with combined HIV infection and chronic viral hepatitis C. 

The problem of infectious endocarditis (IE) is significant in many countries of the world. According to the data of numerous foreign studies, occurrence of IE is 3–10 cases for 100 000 people per year. During the last decades, the number of risk factors for this disease has increased, and their correlation has changed. Injective drug-addiction, cardio-surgical operations, and invasive medical manipulations (prolonged intravenous line, hemodialysis) are playing the key role now. 

Acute tonsillitis (quinsy) has different etiology, and prescription of antibiotics is not always proved. The purpose of the article is to provide modern algorithm of diagnostics and treatment in syndrome of acute tonsillitis. In the article, optimum tactics of clinical assessment, including use of special scales, microbiological research is discussed in detail, and diagnostic algorithms and tactics of therapy in acute tonsillitis (including Streptococcal tonsillitis) are also suggested. 

The aspects of medical support of children with connective tissue dysplasia, including individual non-drug effects and basic drugs aimed at the correction of metabolic disorders in connective tissue are considered. The principles of dispensary observation of this category of children are presented. 

The issues of life quality of patients with endometriosis were considered, the methods of patients’ quality of life were discussed, the results of international studies being given. 

This article presents a literature review dedicated to modern methods of noninvasive evaluation of efficacy of thrombolytic therapy in patients with ST-segment elevation in myocardial infarction. D-dimer as a probable marker of myocardial reperfusion and its role in thrombolytic therapy efficacy evaluation is under discussion. 

Reasons of appearance and clinical manifestations of toxicodermia were considered. It was indicated that drug reactions with skin manifestations are extremely versatile. In some cases, the doctor cannot cancel the drug, and then the doctor should prescribe the treatment in order to mitigate the side effects of the drug, or find a substitute for this preparation. Regression in the eruptions after the preparation is cancelled also helps find the reason of the disease. 

The article is devoted to the therapeutic characteristics of pharmacopuncture (otherwise, biopuncture) — a method based on the administration of medications in the area of reflexotherapy points. The presented material is the result of many years of own research, built on the use of a «model» of vertebrogenic pathology.