Approaches to the therapy of acute tonsillopharyngitis, depending on the etiology of the disease, were considered. Special attention was paid to topical remedies for treatment of acute tonsillopharyngitis. Clinical cases were given. 

The article discusses the methods of therapeutic influence in the case of transport disorders and improvement of the drainage functions of the respiratory tract in acute respiratory infections in children. The mechanism of action of acetylcysteine in the treatment of acute inflammatory diseases of the respiratory tract in children is considered. 

The prospects of treating patients with chronic rhinosinusitis were discussed, as well as the possibilities of prevention and complex therapy of the exacerbations of this disease. 

General therapeutic approaches to management of patients with cough were discussed, drug methods of treatment of patients with cough were considered, with special emphasize on mucoactive preparations. 

The results of observational non-interventional prospective study of application of kagocel for prevention of ARVI and influenza during epidemic rise of morbidity among young people were presented. During epidemic rise of morbidity in 2018 in young people who didn’t receive any drugs for the prevention of ARVI and influenza, the incidence rate of ARVI or influenza was high (40%). Against the background of the 28-day course of preventive kagocel administration, the incidence of ARVI or influenza was only 16%. The index of the preventive effectiveness during the study was: (I) = 40%/16% = 2,5. 

The article introduces clinical and functional analysis of individual symptoms of acute bronchitis in infants on the background of connective tissue dysplasia. Diagnostic criteria, the peculiarity of the disease course, the program of therapeutic and rehabilitation measures under this pathology were reviewed. 

Chronic obstructive pulmonary disease (COPD) is often combined with hypertension (AH). One of the common factors in the development of this pathology is the activation of the renin-angiotensin-aldosterone system. Plasma renin activity in patients with combination of COPD and AH and patients with AH; in patients in groups with a combination of COPD and AH, separated by structural changes in lung tissue and patients with AH was studied. 

Myofascial pains is an important component of office syndrome, an occupational disease of many office workers. Efficiency of combined gel containing ibuprofen and levomenthol, was evaluated in 20 office workers with painful muscular spasm associated with the factors of working environment. Reduction of pain by 50% along with objective reduction of tonus of «indicative» muscles is revealed already in 3 days in two thirds of patients. Duration of the therapy of the painful muscular spasm with the combined gel containing ibuprofen and levomenthol, was 7 to 10 days, with complete pain reduction in 80% of patients. 

Quantitative sensory testing is one of the objective method in assessing and diagnosing chronic facial pain syndromes. 155 patients with trigeminal neuralgia, trigeminal neuropathy, myofascial pain syndrome with temporomandibular disorder were examined. Conclusions were drawn about the sensory patterns of various chronic pain syndromes in the facial area. A new term was proposed «differentiated sensory alteration» is the differentiated interest of C- and A-delta-fibers, which are responsible for assessing the organism’s thermal and cold sensitivity, in the development of chronic pain syndromes. 

The article analyzes the results of a survey of 75 men who addressed to the department of sexology and therapy of sexual dysfunctions with pains in the pelvic region with which patients associated sexual disorders. In the course of the study, the authors studied the clinical aspects of these disorders, taking into account the diagnostic complexity of the qualification of similarity and the difference of the existing symptoms from the manifestations of a physical illness. The principles and tactics of therapeutic and rehabilitation measures, developed taking into account the structure of mental and sexual pathology, are presented. 

Main types of vertigo regularly observed in child neurology are covered in the lecture. Contemporary principles of approach to its diagnostics and management in pediatric patients are considered.

The article based on the analysis of the literature data substantiates the relevance of our study of 56 female patients with coital anorgasmia. In the course of the study, the authors analyzed the relationship of these disorders with latent deviations of sexual desire, characteristics of psychosexual development and erogenous reactivity of patients. The role of bi - and homosexual tendencies of the libido in the formation of the orgasmic disorder, and disharmony in a pair. The tactics of psychotherapeutic measures for this group of patients is presented. 

11 cases of cerebral nematodoses were observed in 2014–2017 years. In all cases of nematodosis specific radiological signs tunnel and visualization of helmint were registered; in 9 of 11 cases, previously unknown sing «clew in cross-section» was observed. This sign may be considered as specific for neuroimaging diagnosis of cerebral nematodosis. 

Reasons of appearance and clinical manifestations of toxicodermia were considered. It was indicated that drug reactions with skin manifestations are extremely versatile. In some cases, the doctor cannot cancel the drug, and then the doctor should prescribe the treatment in order to mitigate the side effects of the drug, or find a substitute for this preparation. Regression in the eruptions after the preparation is cancelled also helps find the reason of the disease. 

The article presents information about one of the most common and frequently encountered benign skin tumors seborrheic keratosis. Pathogenic mechanisms of seborrheic keratosis are described in detail, histological classification of skin tumors by WHO is given. The article describes several specific forms of this disease. Differential diagnostics and methods of treatment of patients with seborrheic keratosis are given. 

Traditionally, increase of activity of creatine kinase MB-fraction (CK‑MB) is a diagnostic marker of acute myocardial infarction, but also registered in other diseases, when there are no lesions of coronary arteries. In some patients, the values of CK-MB exceed total creatine kinase indices (CK), which is related to formation of macrocomplexes. Diagnostic and forecasting value of CK-MB increase, with possible macrocomplex formation, in patients with extracardiac pathology, were evaluated. 

Clinical observation of a rare bullous autoimmune dermatosis — bullous pemphigoid — in a patient with concomitant polyorganic somatic pathology is given. The main literature information about etiopathogenesis, clinical picture, diagnostics, differential diagnostics and treatment of Lever bullous pemphigoid are given. 

The article deals with the results of foreign studies and data from the Russian pharmacovigilance database of spontaneous reports that characterize side effects of all fluoroquinolone antibiotics for systemic use — dysglycemia and psychical disorders. 

Clinical features of 30 adult patients suffering from mastocytosis with skin lesion were compared with the duration of the disease, severity of skin and systemic symptoms, involvement of the internals in the pathologic process, level of tryptase in the blood serum and presence of marrow lesion. Presence of skin and systemic symptoms, as well as the level of tryptase, can be useful for assessment of internal lesion in mastocytosis in adults.