Alternative introduction of milk formulas based on goat milk: discoveries and prospects
https://doi.org/10.51793/OS.2022.25.6.008
Abstract
The optimal source of nutrition for a child of 1 year old is breast milk, which provides him physical and neuropsychic development. Human milk is known to contain high concentrations (5-20 g/l in mature milk) and a wide variety of oligosaccharides. A number of studies have shown that human milk oligosaccharides effectively stimulate the growth of bifidobacteria and shape the composition of the intestinal microbiota, reducing the risk of infections, as well as modulating immune cell function and providing nutrients for the development of the child. However, there are a number of reasons for transferring a baby to mixed or artificial feeding. In case of insufficient amount of milk or its complete absence from the mother, as well as with absolute contraindications to breastfeeding, the introduction of infant formula will be an effective alternative. It is necessary to make the right choice of the milk formula in order to prevent or correct the functional disorders of the gastrointestinal tract that have arisen earlier, which can be characterized as violations of the complex twoway connection between the central and enteral nervous system. Many studies have shown that goat's milk is more similar in composition to women's milk than cow's milk. Goat milk contains high levels of oligosaccharides compared to milk from other mammals and lower levels of αs1 casein. Goat milk is also reported to have significant lactoferrin N-glycan homology with human milk. Since 1906, goat's milk has been recognized as the best natural substitute for human milk and a source of proteins for various milk formulas, and since 2013 it has been included in the Directive of the European Commission. As a result of studies during 150 years, a large number of various oligosaccharides have been identified in goat milk, many of which are similar to breast milk oligosaccharides. Modern mixtures based on goat milk has a new formula now. The changes affected the protein and fat components of the formula. In all products the total amount of protein is reduced and the proportion of the serum fraction of protein is increased.
About the Authors
N. A. GeppeРоссия
Nataliya A. Geppe, Dr. of Sci. (Med.), Professor, Head of the Department of Children's Diseases
19, b. 1 Bolshaya Pirogovskaya str., Moscow, 119435
M. D. Velikoretskaya
Россия
Marina D. Velikoretskaya, MD, Associate Professor of the Department of Children's Diseases
19, b. 1 Bolshaya Pirogovskaya str., Moscow, 119435
S. I. Shatalina
Россия
Svetlana I. Shatalina, MD, assistant of the Department of Children's Diseases
19, b. 1 Bolshaya Pirogovskaya str., Moscow, 119435
M. B. Aksenova
Россия
Marianna B. Aksenova, MD, Associate Professor of the Department of Hospital Therapy No. 1
11, b. 2 Rossolimo str., Moscow, 119021
A. A. Venerin
Россия
Andrey A. Venerin, 5th year student
11, b. 2 Rossolimo str., Moscow, 119021
A. V. Polyanskaya
Россия
Angelina V. Polyanskaya, MD, Associate Professor
19, b. 1 Bolshaya Pirogovskaya str., Moscow, 119435
S. N. Chebysheva
Россия
Svetlana N. Chebysheva, MD, Associate Professor
9, b. 1 Bolshaya Pirogovskaya str., Moscow, 119435
References
1. WHO (World Health Organisation). Report of the Expert Consultation on the Optimal Duration of Exclusive Breastfeeding; WHO: Geneva, Switzerland, 2001.
2. Iacono G., Merolla R., D’Amico D. at al. Gastrointestinal symptoms in infancy: a population-based prospective study // Dig Liver Dis. 2005; 6 (37): 432-438.
3. Benninga T. M. A., Nurko S., Faure C., Hyman P. E., Roberts I. St. J., Childhood N. L Functional Gastrointestinal Disorders: Neonate // Schechter Gastroenterology. 2016; (150): 1443-1455.
4. Khavkin A. I., Komarova O. N. Constipation in children of the first year of life in the structure of functional disorders of the gastrointestinal tract. Basic approaches to treatment // RMJ. 2015; 3: 152-157.
5. Donovan S. M., Comstock S. S. Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity // Ann. Nutr. Metab. 2016. Vol. 69. Suppl. 2. P. 42-51. DOI: 10.1159/000452818.
6. Drossman D. A., Hasler W. L. Rome IV – Functional GI disorders: disorders of GutBrain interaction // Gastroenterology. 2016; 6 (150): 1262-1279.
7. Meleshkina A. V., Kudryashova M. A., Chebysheva S. N. What is important to know about intestinal colic in children during the first months of life // Pediatriya (Pril. k zhurn. Consilium Medicum). 2018; 2: 38-42.
8. Savino F. Focus on infantile colic // Acta Paediatr. 2007; 9 (96): 1259-1264. DOI: 10.1111/j.1651-2227.2007.00428.x.
9. Shamir R., St James-Roberts I., Di Lorenzo C., Burns A. J., Thapar N., Indrio F. et al. Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms // J Pediatr Gastroenterol Nutr. 2013. Vol. 57. Suppl. 1. P. 1-45. DOI: 10.1097/MPG.0b013e3182a154ff.
10. Räihä H., Lehtonen L., Huhtala V., Saleva K., Korvenranta H. Excessively crying infant in the family: mother-infant, father-infant and motherfather interaction // Child Care Health Dev. 2002; 5 (28): 419-429. DOI: 10.1046/j.1365-2214.2002.00292.x.
11. Akman I., Kusçu K., Ozdemir N., Yurdakul Z., Solakoglu M., Orhan L. et al. Mothers’ postpartum psychological adjustment and infantile colic // Arch Dis Child. 2006; 5 (91): 417-419. DOI: 10.1136/adc.2005.083790.
12. National program for optimizing the feeding of children in the first year of life in the Russian Federation. M.: Soyuz pediatrov Rossii, 2019. P. 68.
13. Website «ThisGreece». URL: https://thisgreece.ru/turizm/gastronomicheskij/1083-koze (data obrashcheniya: 15.05.2022).
14. Frolova N. I., Buldakova L. R. Elixir of Health // Prakticheskaya diyetologiya. 2012; 3: 58-63.
15. Kazyukova T. V., Il'yenko L. I., Kotlukov V. K. Goat milk in the nutrition of infants and young children // Pediatriya. 2017; 1 (96): 75-82.
16. Issues of feeding young children (review of the scientific and practical seminar) // Pediatriya (Pril. k zhurn. Consilium Medicum). 2018; 4: 25-31.
17. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the suitability of goat milk protein as a source of protein in infant formulae and in follow-on formulae // EFSA Journal. 2012; 3 (10): 18. DOI: 10.2903/j.efsa.2012.2603. Available online: www.efsa.europa.eu/efsajournal.
18. Zakharova I. N., Kholodova I. N., Nechayeva V. V. Infant formula from goat milk: are there any advantages? // Meditsinskiy Sovet. 2016; 1: 22-26.
19. Urashima T., Taufik E. Oligosaccharides in milk: their benefits and future utilization // Media Peternakan. 2011; (33): 189-197.
20. Sanz Ceballos L., Morales E. R., de la Torre Adarve G., et al. Composition of goat and cow milk produced under similar conditions and analyzed by identical methodology // J Food Comp Anal. 2009; (22): 322-329.
21. Lönnerdal B. Infant formula and infant nutrition: Bioactive proteins of human milk and implications for composition of infant formulas // J. Clin. Nutr. 2014; (99): 712-717.
22. Gallier S., Vocking K., Post J. A., Van De Heijning B., Acton D., Van Der Beek E. M., Van Baalen T. A novel infant milk formula concept: Mimicking the human milk fat globule structure // Colloid Surf. 2015; (136): 329-339. [CrossRef] [PubMed].
23. Innis S. M. Dietary Triacylglycerol Structure and Its Role in Infant Nutrition // Adv. Nutr. 2011; (2): 275-283.
24. Asakuma S., Hatakeyama E., Urashima T., et al. Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria // J Biol Chem. 2011; 40 (286): 83-92.
25. Bode L. Recent advances on structure, metabolism, and function of human milk oligosaccharides // J Nutr. 2006; (136): 2127-2130.
26. Bode L. Human milk oligosaccharides: every baby needs a sugar mama // Glycobiology. 2012; (22): 1147-1162.
27. Gopal P. K., Gill H. Oligosaccharides and glycoconjugates in bovine milk and colostrum // Br J Nutr. 2000. Vol. 84, Suppl. 1. P. 69-74.
28. Triantis V., Bode L., Van Neerven R. Immunological effects of human milk oligosaccharides // Front Pediatr. 2018; (6): 190.
29. Sela D. A., Mills D. A. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides // Trends Microbiol. 2010; (18): 298-307.
30. Institute of Medicine. Infant Formula: Evaluating the Safety of New Ingredients. The National Academies Press, 2004. P. 41-54.
31. Jandal J. M. Comparative aspects of goat and sheep milk // Small Rumin Res. 1996; (22): 177-185.
32. Park Y. W., Juárez M., Ramos M., et al. Physico-chemical characteristics of goat and sheep milk // Small Rumin Res. 2007; (68): 88-113.
33. Kiskini A., Difilippo E. Oligosaccharides in goat milk: structure, health effects and isolation // Cell MolBiol (Noisy-legrand). 2013; (59): 25-30.
34. Raynal-Ljutovac K., Lagriffoul G., Paccard P., et al. Composition of goat and sheep milk products: an update // Small Rumin Res. 2008; (79): 57-72.
35. Martinez-Ferez A., Rudloff S., Guadix A., et al. Goats’ milk as a natural source of lactose-derived oligosaccharides: isolation by membrane technology // Int Dairy J. 2006; (16): 173-181.
36. Moro G. E., Stahl B., Fanaro S., et al. Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants // ActaPaediatr. 2005; (94): 27-30.
37. Oozeer R., van Limpt K., Ludwig T., et al. Intestinal microbiology in early life:specific prebiotics can have similar functionalities as human-milk oligosaccharides // Am J ClinNutr. 2013; (98): 561-571.
38. Sousa Y. R. F., et al. Composition and isolation of goat cheese whey oligosaccharides by membrane technology // Int J BiolMacromol. 2019; (139): 57-62.
39. Leong A., et al. Oligosaccharides in goats’ milk-based infant formula and their prebiotic and anti-infection properties // Br J Nutr. 2019; 4 (122): 441-449.
40. Gallier S., Tolenaars L., Prosser C. Whole Goat Milk as a Source of Fat and Milk Fat Globule Membrane in Infant Formula // Nutrients. 2020; 11 (12): 34-86. DOI: 10.3390/nu12113486.
41. Thurl S., Munzert M., Boehm G., et al. Systematic review of the concentrations of oligosaccharides in human milk // Nutr Rev. 2017; (75): 920-933.
42. Newburg D. S., Ruiz-Palacios G. M., Altaye M., et al. Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants // Glycobiology. 2004; (14): 253-263.
43. LoCascio R. G., Desai P., Sela D. A., et al. Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization // Appl Environ Microbio. 2010; (76): 7373-7381.
44. Strum J. S., Kim J., Wu S., et al. Rapid identification and accurate quantitation of biological oligosaccharide mixtures // Anal Chem. 2012; (84): 7793-7801.
45. Thongaram T., Hoeflinger J. L., Chow J., et al. Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli // J Dairy Sci. 2017; (100): 7825-7833.
46. Ebersbach T., Andersen J. B., Bergstrom A., et al. Xylo-oligosaccharides inhibit pathogen adhesion to enterocytes in vitro // Res Microbiol. 2012; (163): 22-27.
47. Newburg D. S. Do the binding properties of oligosaccharides in milk protect human infants from gastrointestinal bacteria? // J Nutr. 1997; (127): 980-984.
48. Neveu C., Riaublanc A., Miranda G., Chich J. F., Martin P. Is the apocrine milk secretion process observed in the goat species rooted in the perturbation of the intracellular transport mechanism induced by defective alleles at the αs1-Cn locus? // Reprod. Nutr. Dev. 2002; (42): 163-172.
49. Hodgkinson A. J., Wallace O. A. M., Boggs I., Broadhurst M., Prosser C. G. Gastric digestion of cow and goat milk: Impact of infant and young child in vitro digestion conditions // Food Chem. 2017; (245): 275-281.
50. Maathuis A., Havenaar R., He T., Bellmann S. Protein digestion and quality of goat and cow milk infant formula and human milk under simulated infant conditions // J. Pediatr. Gastroenterol. Nutr. 2017; (65): 661-666.
51. Hodgkinson A. J., McDonald N. A., Kivits L. J., Hurford D. R., Fahey S., Prosser C. G. Allergic responses induced by goat milk αs1-casein in a murine model of gastrointestinal atopy // J. Dairy Sci. 2012; (95): 83-90.
52. Wang Y., Eastwood B.,Yang Z., de Campo L., Knott R., Prosser C., Carpenter E., Hemar Y. Rheological and structural characterization of acidified skim milks and infant formulae made form cow and goat milk. // Food Hydrocoll. 2019; (96): 161-170.
53. Prentice P. M., Schoemaker M. H., Vervoort J., Hettinga K., Lambers T. T., van Tol E. A. F., Acerini C. L., Olga L., Petry C. J., Hughes I. A., et al. Human milk short-chain fatty acid composition is associated with adiposity in infants // J. Nutr. 2019; 149: 716-722.
54. Bronsky J., Campoy C., Embleton N., Fewtrell M., Mis N. F., Gerasimidis K., Hojsak I., Hulst J., Indrio F., Lapillonne A., et al. Palm Oil and Beta-palmitate in Infant Formula: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition // J. Pediatr. Gastroenterol. Nutr. 2019; (68): 742-760.
55. Iwasaki Y., Yamane T. Enzymatic synthesis of structured lipids // Adv. Biochem Eng Biotechnol. 2004; (90): 151-171. DOI: 10.1007/b94196.
56. Han Y., Chang E. Y., Kim J., Ahn K., Kim H. Y., Hwang E. M., Lowry D., Prosser C., Lee S. I. Association of infant feeding practices in the general population with infant growth and stool characteristics // Nutr. Res. Pract. 2011; (5): 308-312.
57. Infante D. D., Prosser C. G., Tormo R. Constipated patients fed goat milk protein formula: A case series study // J. Nutr. Health Sci. 2018; (5): 203.
58. Hess J. R., Greenberg N. A. The Role of nucleotides in the immune and gastrointestinal systems potential clinical applications // Nutr. Clin. Pract. 2012; 2 (27): 281-294. DOI: 10.1177/0884533611434933.
59. Buck R. H., Thomas D. L., Winship T. R., Cordle C. T., Kuchan M. J., Baggs G. E. et al. Effect of dietary ribonucleotides on infant immune status. Part 2: Immune cell development // Pediatr Res. 2004; 6 (56): 891-900. DOI: 10.1203/01.PDR.0000145577.03287.FA.
60. Yau K. I., Huang C.-B., Chen W., Chen Sh.-J., Chou Y.-H., Huang F.-Y. et al. Effect of nucleotides on diarrhea and immune responses in healthy term infants in Taiwan // J Pediatr Gastroenterol Nutr. 2003; 1 (36): 37-43. DOI: 10.1097/00005176-200301000-00009.
61. Borovik T. E., Semonova N. N., Lukoyanova O. L., Zvonkova N. G., Bushuyeva T. V., Stepanova T. N., Skvortsova V. A., Mel'nichuk O. S., Kopyl'tsova Ye. A., Semikina Ye. L., Zakharova I. N., Ryumina I. I., Narogan M. V., Grosheva Ye. V., Khanfer'yan R. A., Savchenko Ye. A., Belousova T. V., Yolkina T. N., Surovkina Ye. A., Tatarenko Yu. A. The effectiveness of the use of an adapted mixture based on goat milk in the nutrition of healthy children in the first half of life: results of a multicenter prospective comparative study // Voprosy sovremennoy pediatrii. 2017; 3 (16).
62. https://www.kabrita.ru/upload/iblock/95f/95f48d6d2864c99a28e1e71a903a4797.pdf
Review
For citations:
Geppe N.A., Velikoretskaya M.D., Shatalina S.I., Aksenova M.B., Venerin A.A., Polyanskaya A.V., Chebysheva S.N. Alternative introduction of milk formulas based on goat milk: discoveries and prospects. Lechaschi Vrach. 2022;(5-6):46-53. (In Russ.) https://doi.org/10.51793/OS.2022.25.6.008
JATS XML



















