IgA nephropathy and celiac disease: pathogenetic relationship of diseases and the possibility of a gluten-free diet
https://doi.org/10.51793/OS.2021.24.8.003
Abstract
According to the world literature IgA nephropathy is most often considered as an idiopathic form of primary glomerulonephritis, however, in some cases, the disease can be secondary and pathogenetically associated with liver diseases (cirrhosis of any etiology), lung diseases (sarcoidosis, etc.), systemic and autoimmune diseases (hemorrhagic vasculitis, systemic lupus erythematosus, etc.), as well as inflammatory bowel diseases (Crohn's disease, ulcerative colitis, celiac disease). In the context of possible improvement in the outcomes of nephropathy, as well as new treatment methods the association of IgA nephropathy with celiac disease is particularly noteworthy. There is evidence of potential pathogenetic links between these diseases, where gluten in some patients is probably a trigger factor in the development of glomerulonephritis. According to the world literature, the prevalence of celiac disease in the general population is 0,5-1%, depending on the geographical region, and increases to 4% in patients with IgA nephropathy. The influence of celiac disease on the clinical course of IgA nephropathy, the study of possible pathogenetic mechanisms of the relationship, the prospects and possibilities of the gluten-free diet in the treatment of IgA nephropathy determine the relevance of the review topic.
About the Authors
M. E. Mantsaeva
Russian Medical Academy of continuous education
Russian Federation
Russian Federation
Moscow
A. G. Borisov
Russian Medical Academy of continuous education; Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Moscow
M. A. Smirnova
Russian Medical Academy of continuous education
Russian Federation
Russian Federation
Moscow
A. A. Stremouhov
Russian Medical Academy of continuous education
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Mantsaeva M.E., Borisov A.G., Smirnova M.A., Stremouhov A.A. IgA nephropathy and celiac disease: pathogenetic relationship of diseases and the possibility of a gluten-free diet. Lechaschi Vrach. 2021;(8):18-24. (In Russ.) https://doi.org/10.51793/OS.2021.24.8.003
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