Can detox nutrition be an adjunct in the treatment and rehabilitation of patients infected with the COVID-19 virus?

The article analyzes the rationale for the use and the results of the use of detoxification nutritional support in patients with COVID-19 viral infection. Data from a number of publications indicate that when infected with COVID-19, hemotoxic and metabolic effects occur, similar to those that occur with the accumulation of heavy metals. Intoxication of the body in coronavirus pathology is accompanied by violations of oxidative processes and overproduction, mainly of cytokines («cytokine storm»), which is largely due to a deficit in the consumption and accumulation of micronutrients and biologically active substances in the body with pronounced antioxidant, antiinflammatory, hepatoprotective and other activities ... The results of previous studies to assess the detoxification activity of the dietary food product suggested that this product may be effective in cases of intoxication caused by viral infections, in particular COVID-19 coronavirus. Thus, the use of jelly in a group of workers working in hazardous working conditions led to an increase in urinary excretion of nickel, copper and cobalt, an improvement in oxidative stress indicators: a decrease in malondialdehyde to 4,3 ± 0,06 μmol/l, increase in catalase activity from 417,2 ± 20,6 to 564,2 ± 20,1 μkat/L, superoxide dismutase from 13,7 ± 0,1 up to 15,3 ± 0,08 a.u., ceruloplasmin from 287,4 ± 6,1 to 331,2 ± 8,5 mg/ml. The obtained data, as well as knowledge about the peculiarities of the pathogenesis and course of COVID-19 infection, made it possible to include jelly in the maintenance therapy of patients with this disease. A survey of 283 people who have had a coronavirus infection showed the presence of symptoms of severe intoxication. Nutritional support for a month with detoxification jelly contributed to a significant reduction in symptoms of intoxication: weakness and fatigue, temperature fluctuations, fears, anxiety, suspiciousness, etc. disappeared. The authors recommend longer (at least 3-6 months) nutritional support by specialized detoxification food products for the full recovery of the body and further prevention of the development of post Сovid complications.

1. Пилат Т. Л., Кузьмина Л. П., Коляскина М. М., Радыш И. В., Ханферьян Р. А. Специализированная нутритивная поддержка пациентов с СOVID-19 диетическими лечебными продуктами питания в условиях стационара // Терапия. 2021; 2: 112-118. DOI: https://dx.doi.org/10.18565/therapy.2021.2.112-118. [Pilat T. L., Kuz'mina L. P., Kolyaskina M. M., Radysh I. V., Khanfer'yan R. A. Spetsializirovannaya nutritivnaya podderzhka patsiyentov s SOVID-19 diyeticheskimi lechebnymi produktami pitaniya v usloviyakh statsionara [Specialized nutritional support for patients with COVID-19 with dietary medicinal food in a hospital setting] // Terapiya. 2021; 2: 112-118. DOI: https://dx.doi.org/10.18565/therapy.2021.2.112-118.]

2. Пилат Т. Л., Кузьмина Л. П., Измерова Н. И. Детоксикационное питание / Под ред. Т. Л. Пилат. М.: ГЭОТАР-Медиа, 2012. 688 с. [Pilat T. L., Kuz'mina L. P., Izmerova N. I. Detoksikatsionnoye pitaniye [Detoxification nutrition] Pod red. T. L. Pilat. M.: GEOTAR-Media, 2012. 688 p.]

3. Пилат Т. Л., Безрукавникова Л. М., Коляскина М. М. с соавт. Исследование эффективности детоксицирующего влияния комплексной программы питания DETOX на функциональные показатели организма // Терапия. 2020; 2: 156-163. [Pilat T. L., Bezrukavnikova L. M., Kolyaskina M. M. s soavt. Issledovaniye effektivnosti detoksitsiruyushchego vliyaniya kompleksnoy programmy pitaniya DETOX na funktsional'nyye pokazateli organizma [Study of the effectiveness of the detoxifying effect of the DETOX complex nutrition program on the functional indicators of the body] // Terapiya. 2020; 2: 156-163.]

4. Авдеев С. Н. Неинвазивная вентиляция легких при новой коронавирусной инфекции COVID-19 // Пульмонология. 2020; 30 (5): 679-687. [Avdeyev S. N. Neinvazivnaya ventilyatsiya legkikh pri novoy koronavirusnoy infektsii COVID-19 [Non-invasive ventilation of the lungs with a new coronavirus infection COVID-19] // Pul'monologiya. 2020; 30 (5): 679-687.]

5. Торшин И. Ю., Громова О. А., Чучалин А. Г. Микронутриенты против коронавирусов. М.: ГЭОТАР-медиа, 2020, 112 с. [Torshin I. YU., Gromova O. A., Chuchalin A. G. Mikronutriyenty protiv koronavirusov. [Micronutrients against coronaviruses] M.: GEOTAR-media, 2020, 112 p]

6. Barazzoni R., Bischoff S. C., Breda J., Wickramasinghe K., Krznaric Z., Nitzan D., Pirlich M., Singer P. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection // Clin. Nutr. (Edinb. Scotl.). 2020; 39: 1631–1638.

7. Chacko S. A., Song Y., Nathan L., Tinker L., de Boer I. H., Tylavsky F., Wallace R., Liu S. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women // Diabetes Care. 2010; 33: 304–310. DOI: 10.2337/dc09-1402.

8. George S. M., Neuhouser M. L., Mayne S. T., Irwin M. L., Albanes D., Gail M. H., Alfano C. M., Bernstein L., McTiernan A., Reedy J., et al. Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors // Cancer Epidemiol. Biomark. Prev. 2010; 19: 2220–2228. DOI: 10.1158/1055-9965.EPI-10-0464.

9. Ma Y., Hebert J. R., Li W., Bertone-Johnson E. R., Olendzki B., Pagoto S. L., Tinker L., Rosal M. C., Ockene I. S., Ockene J. K., et al. Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study // Nutrition. 2008; 24: 941–949. DOI: 10.1016/j.nut.2008.04.005.

10. Mozaffarian D., Pischon T., Hankinson S. E., Rifai N., Joshipura K., Willett W. C., Rimm E. B. Dietary intake of trans fatty acids and systemic inflammation in women // Am. J. Clin. Nutr. 2004; 79: 606–612. DOI: 10.1093/ajcn/79.4.606.

11. North C. J., Venter C. S., Jerling J. C. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease // Eur. J. Clin. Nutr. 2009; 63: 921–933. DOI: 10.1038/ejcn.2009.8.

12. Jahns L., Conrad Z., Johnson L. K., Whigham L. D., Wu D., Claycombe-Larson K. J. A diet high in carotenoid-rich vegetables and fruits favorably impacts inflammation status by increasing plasma concentrations of IFN-α2 and decreasing MIP-1β and TNF-α in healthy individuals during a controlled feeding trial // Nutr. Res. 2018; 52: 98–104. DOI: 10.1016/j.nutres.2018.02.005.

13. Rodríguez L., Cervantes E., Ortiz R. Malnutrition and gastrointestinal and respiratory infections in children: A public health problem // Int. J. Environ. Res. Public Health. 2011; 8: 1174-1205. DOI: 10.3390/ijerph8041174.

14. Gabriele M., Pucci L. Diet Bioactive Compounds: Implications for Oxidative Stress and Inflammation in the Vascular System // Endocr. Metab. Immune Disord. Drug Targets. 2017; 17: 264–275. DOI: 10.2174/1871530317666170921142055.

15. Bouayed J., Bohn T. Exogenous antioxidants – Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses // Oxid. Med. Cell Longev. 2010; 3: 228-237.

16. Pohanka M. Role of oxidative stress in infectious diseases. A review // Folia Microbiol. 2013; 58: 503–513. DOI: 10.1007/s12223-013-0239-5.

17. Khomich O. A., Kochetkov S. N., Bartosch B., Ivanov A. V. Redox biology of respiratory viral infections // Viruses. 2018; 10 (8): 392. DOI: 10.3390/v10080392.

18. Van den Brand J. M. A., Haagmans B. L., van Riel D. et al. The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models // J Comp. Pathol. 2014; 151 (1): 83-112. DOI: 10.1016/j.jcpa.2014.01.004.

19. Shivappa N., Steck S. E., Hurley T. G., Hussey J. R., Hebert J. R. Designing and developing a literature-derived, population-based dietary inflammatory index // Public Health Nutr. 2014; 17: 1689-1696. DOI: 10.1017/s1368980013002115.

20. Calder P. C. Omega-3 fatty acids and inflammatory processes // Nutrients. 2010; 2: 355-374. DOI: 10.3390/nu203035.

21. Rubin L. P., Ross A. C., Stephensen C. B., Bohn T., Tanumihardjo S. A. Metabolic effects of inflammation on vitamin A and carotenoids in humans and animal models // Adv. Nutr. 2017; 8: 197-212. DOI: 10.3945/an.116.014167.

22. Wannamethee S. G., Lowe G. D., Rumley A., Bruckdorfer K. R., Whincup P. H. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis // Am. J. Clin. Nutr. 2006; 83: 567-574. DOI: 10.1093/ajcn.83.3.567.

23. Khan N., Khymenets O., Urpi-Sarda M., Tulipani S., Garcia-Aloy M., Monagas M., Mora-Cubillos X., Llorach R., Andres-Lacueva C. Cocoa polyphenols and inflammatory markers of cardiovascular disease // Nutrients. 2014; 6: 844-880. DOI: 10.3390/nu6020844.

24. Kaulmann A., Bohn T. Carotenoids, inflammation, and oxidative stress-- implications of cellular signaling pathways and relation to chronic disease prevention // Nutr. Res. 2014; 34: 907-929. DOI: 10.1016/j.nutres.2014.07.010.

25. Sanson G., Bertocchi L., Dal Bo E., Di Pasquale C. L., Zanetti M. Identifying reliable predictors of protein-energy malnutrition in hospitalized frail older adults: A prospective longitudinal study // Int J Nurs Stud. 2018; 82: 40-48.

26. Hunter J. V., Goerner L. Infections // Handb Clin Neurol. 2016; 136: 1173-1198.

27. Kim D. E., Jang M. J., Kim Y. R., Lee J. Y., Cho E. B., Kim E., et al. Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells // Toxicology. 2017; 387: 1-9.

28. De Riccardis L., Buccolieri A., Muci M., Pitotti E., De Robertis F., Trianni G., et al. Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects // Biochim Biophys Acta. 2018; 1864: 1828-1838.

29. Calder P. C. Nutrition, immunity and COVID-19 // BMJ Nutrition, Prevention & Health. 2020; 3. DOI: 10.1136/bmjnph-2020-000085.

30. George S. M., Neuhouser M. L., Mayne S. T., Irwin M. L., Albanes D., Gail M. H., Alfano C. M., Bernstein L., McTiernan A., Reedy J., et al. Postdiagnosis diet quality is inversely related to a biomarker of inflammation among breast cancer survivors // Cancer Epidemiol. Biomark. Prev. 2010; 19: 2220-2228.

31. Лодягин А. Н., Бытоцыренов Б. В., Шикалова И. А., Вознюк И. А. Ацидоз и токсический гемолиз-цели патогенетического лечения патологии при COVID-19 // Вестник восстановительной медицины. 2020. [Lodyagin A. N., Bytotsyrenov B. V., Shikalova I. A., Voznyuk I. A. Atsidoz i toksicheskii gemoliz – tseli patogeneticheskogo lecheniya patologii pri COVID-19 [Acidosis and toxic hemolysis – targets of pathogenetic treatment of pathology in COVID-19] // Vestnik vosstanovitelnoi meditsiny. 2020]