Preview

Lechaschi Vrach

Advanced search

Bronchial asthma and obesity are a pathological tandem: the role of nutrition

https://doi.org/10.51793/OS.2021.35.60.001

Abstract

Recently, the influence of malnutrition on the occurrence and progression of bronchial asthma and obesityhas been increasingly studied. Obesity is a 21st century pandemic. Now, there is evidence of the effect of obesity on the risk of developing bronchial asthma. An increased intake of saturated fat leads to an increase in circulating free fatty acids in the body. This induces pro-inflammatory processes, including in the respiratory tract, which leads to a deterioration in the functioning of the lungs, an aggravation of the course of bronchial asthma, an increase in exacerbations of this disease, an increase in the number of hospitalizations due to the severity of the course of asthma. In addition, scientists have found that a diet low in dietary fiber also contributes to the development of systemic inflammation, thereby worsening the course of bronchial asthma. There is evidence of the effect of vitamin D deficiency on the development, progression and deterioration of control of chronic and autoimmune diseases, which also include bronchial asthma, on the deterioration of the state of lipid metabolism in the subjects. An increase in the level of vitamin D in the body of patients leads to an improvement in certain characteristics of the course and manifestation of these diseases. The use of a Mediterranean diet reduces the likelihood and progression of bronchial asthma, bronchial obstruction, and allergic reactions. Adequate intake of vitamins A, C, E leads to a decrease in inflammatory reactions in the bronchial tree, an improvement in lung function indicators, a decrease in exacerbations of bronchial asthma and the frequency of hospitalizations associated with a deterioration in the control of this pathology. Thus, it is relevant and expedient to carry out scientific and clinical work to determine and in-depth study of the influence of nutrition on the development and course of obesity and bronchial asthma, and to identify the relationship between these diseases.

About the Authors

L. V. Tribuntseva
Voronezh State Medical University named after N. N. Burdenko
Россия

Voronezh



V. T. Burlachuk
Voronezh State Medical University named after N. N. Burdenko
Россия

Voronezh



E. A. Raskina
Voronezh State Medical University named after N. N. Burdenko
Россия

Voronezh



S. A. Kozhevnikova
Voronezh State Medical University named after N. N. Burdenko
Россия

Voronezh



References

1. Finucane M. M., Stevens G. A., Cowan M. J. et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants // Lancet. 2011; 377 (9765): 557-567.

2. Taylor B., Mannino D., Brown C. et al. Body mass index and asthma severity in the National Asthma Survey // Thorax. Jan. 2008, 63 (1): 14-20.

3. Mosen D. M., Schatz M., Magid D. J. et al. The relationship between obesity and asthma severity and control in adults // J Allergy Clin Immunol. 2008, 122 (3): 507-511.

4. Sideleva O., Suratt B. T., Black K. E. et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway // Am J Respir Crit Care Med. 2012; (7): 598-605.

5. Rathmell J. C. Metabolism and autophagy in the immune system: immunometabolism comes of age // Immunol Rev. 2012; 249 (1): 5-13.

6. Dixon A. E., Pratley R. E., Forgione P. M. et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation // J Allergy Clin Immunol. 2011; 128 (3): 508-515.

7. Holguin F., Bleecker E. R., Busse W. W. et al. Obesity and asthma: an association modified by age of asthma onset // J Allergy Clin Immunol. 2011; 127 (6): 1486-1493.

8. Ермолова А. В., Будневский А. В., Малыш Е. Ю., Овсянников Е. С., Дробышева Е. С. Клинико-функциональные особенности бронхиальной астмы у больных с метаболическим синдромом // Клиническая медицина. 2015. Т. 93. № 6. С. 44-49. [Yermolova A. V., Budnevskiy A. V., Malysh Ye. Yu., Ovsyannikov Ye. S., Drobysheva Ye. S. Kliniko-funktsional'nyye osobennosti bronkhial'noy astmy u bol'nykh s metabolicheskim sindromom [Clinical and functional features of bronchial asthma in patients with metabolic syndrome] // Klinicheskaya meditsina. 2015. T. 93. № 6. Pp. 44-49.]

9. Anderson W. J., Lipworth B. J. Does body mass index influence responsiveness to inhaled corticosteroids in persistent asthma? // Ann Allergy Asthma Immunol. 2012; 108 (4): 237-242.

10. Peters-Golden M., Swern A., Bird S. S. et al. Influence of body mass index on the response to asthma controller agents // Eur Respir J. 2006; 27 (3): 495-503.

11. Telenga E. D., Tideman S. W., Kerstjens H. A. et al. Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response // Allergy. 2012; 67 (8): 1060-1068.

12. Sutherland E. R., Goleva E., Strand M. et al. Body mass and glucocorticoid response in asthma // Am J Respir Crit Care Med. 2008; 178 (7): 682-687.

13. Adeniyi F. B., Young T. Weight loss interventions for chronic asthma // Cochrane Database Syst Rev. 2012; 7: CD009339.

14. Juniper E. F., O’Byrne P. M., Guyatt G. H. et al. Development and validation of a questionnaire to measure asthma control // Eur Respir J. 1999; 14 (4): 902-907.

15. Dandona P., Ghanim H., Chaudhuri A. et al. Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance // Exp Mol Med. 2010, 42 (4): 245-253.

16. Pradeepan S., Garrison G., Dixon A. E. Obesity in Asthma: Approaches to Treatment // Curr Allergy Asthma Rep. 2013; 13 (5): 434-442. DOI: 10.1007/s11882-013-0354-z.

17. Vimaleswaran K. S. APOA5 genotype influences the association between 25- hydroxyvitamin D and high density lipoprotein cholesterol // Atherosclerosis. 2013. V. 228. № 1. P. 188-192.

18. Brehm J. M. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study // Journal of Allergy and Clinical Immunology. 2010. V. 126. № 1. P. 52-58.

19. Huang H. Vitamin D in asthma and future perspectives // Drug Design, Development and Therapy. 2013. V. 7. P. 1003-1013.

20. Li J., Xun P., Zamora D. et al. Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study // Am J Clin Nutr. 2013; 97 (1): 173-178.

21. Wood L. G., Garg M. L., Smart J. M. et al. Manipulating antioxidant intake in asthma: a randomized controlled trial // Am J Clin Nutr. 2012, 96 (3): 534-543.

22. Romieu I., Barraza-Villarreal A., Escamilla-Nunez C. et al. Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants // Respir Res. 2009; 10: 122.

23. Allen S., Britton J. R., Leonardi-Bee J. A. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis // Thoraх. 2009, 64: 610-619.

24. Romieu I., Sienra-Monge J. J., Ramirez-Aguilar M. et al. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants // Am J Respir Crit Care Med. 2002, 166: 703-709.

25. Греф А., Раутиайнен С., Грузиева О. и др. Диетическая общая антиоксидантная способность в раннем школьном возрасте и последующее аллергическое заболевание // Clin Exp Аллергия. 2017, 47: 751-759. [Gref A., Rautiaynen S., Gruziyeva O. i dr. Diyeticheskaya obshchaya antioksidantnaya sposobnost' v rannem shkol'nom vozraste i posleduyushcheye allergicheskoye zabolevaniye [Dietary total antioxidant capacity in early school age and subsequent allergic disease] Clin Exp Allergiya. 2017, 47: 751-759.]

26. Wood L. G., Garg M. L., Smart J. M. et al. Manipulating antioxidant antioxidant intake in asthma: a randomized controlled trial // Am J Clin Nutr. 2012; 96: 534-543.


Review

For citations:


Tribuntseva L.V., Burlachuk V.T., Raskina E.A., Kozhevnikova S.A. Bronchial asthma and obesity are a pathological tandem: the role of nutrition. Lechaschi Vrach. 2021;(4):7-11. (In Russ.) https://doi.org/10.51793/OS.2021.35.60.001

Views: 248

JATS XML

ISSN 1560-5175 (Print)
ISSN 2687-1181 (Online)