Preview

Lechaschi Vrach

Advanced search

Non-alcoholic fatty hepatic disease in children with obesity and metabolic syndrome

Abstract

Features of functional state of liver in children with obesity were studied, and its connection with main components of metabolic syndrome was assessed. 483 children with obesity were studied (285 boys and 198 girls) at the age of 6 to 15 years old. The complex study included anamnesis collection, anthropometrics, clinical studies of the blood, biochemical study of the blood serum, study of the lipid spectrum, hormone profile, ultrasonic study of the abdominal cavity organs and retroperitoneal space, CT of the abdominal cavity. 

About the Author

T. A. Bokova
ГБУЗ МО МОНИКИ им. М. Ф. Владимирского
Россия


References

1. Younossi Z. M., Koenig A. B., Abdelatif D. et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes // Hepatology. 2016. Vol. 64 (1). P. 73–84.

2. Loomba R., Sanyal A. J. The global NAFLD epidemic // Nat Rev Gastroenterol Hepatol. 2013. Vol. 10 (11). P. 686–690.

3. Алешина Е. И., Гурова М. М., Новикова В. П., Гурьева В. А., Усыченко Е. А. Особенности гепатобилиарной системы при ожирении у детей // Профилактическая и клиническая медицина. 2012. № 1. С. 10–15.

4. Бокова Т. А. Метаболический синдром у детей: подходы к профилактике и патогенетической терапии // Лечащий Врач. 2018. № 9, с. 74–76.

5. Ogawa W., Takashima M. Hepatic insulin resistance and energy homeostasis // Nippon Rinsho. 2010. Vol. 68. № 2. Р. 330–334.

6. Youssef J., Badr M. Z. PPARs: history and advances // Methods Mol. Biol. 2013; 952: 1–6.

7. Герок В., Блюм Ф. Заболевания печени и желчевыделительной системы / Пер. с немец. М.: МЕДпресс-информ, 2009. 199 с.

8. Harisson S. A. Повышение активности печеночных ферментов и жировая дистрофия печени // Клиническая гастроэнтерология и гепатология. 2009. Т. 2. № 3. С. 26–31.

9. Burt A. D., Mullon A., Day C. P. Diagnosis and interpretation of steatosis and steatohepatitis // Seminars in Diagnostic Pathology. 1998. № 15. Р. 246–258.

10. Zimmet P., Alberti G., Kaufman F. et al. The metabolic syndrome in children and adolescents — an IDF consensus report // Pediatric Deabetes. 2007. Vol. 8. № 5. Р. 299–306.


Review

For citations:


Bokova T.A. Non-alcoholic fatty hepatic disease in children with obesity and metabolic syndrome. Lechaschi Vrach. 2019;(1):28. (In Russ.)

Views: 192

JATS XML

ISSN 1560-5175 (Print)
ISSN 2687-1181 (Online)