Mitral valve prolapse: clinical variants, current understanding
Abstract
The article covers clinical diversity of mitral prolapse, deliberating ambiguous prognosis in patients with mitral valve prolapse (MVP) and different tactics of their management. The greatest attention is paid to primary MVP as the only variant of mitral prolapse claiming nosological independence. The origin of a primary MVP as a consequence of congenital mesenchymal inferiority in the framework of hereditary connective tissue disorders is considered.
References
1. Freed L. A., Levy D., Levine R. A. et al. Prevalence and clinical outcome of mitral-valve prolapse // N. Engl. J. Med. 1999; 341 (1): р. 1-7.
2. Sainger R., Grau J. B., Branchetti E. et al. Human myxomatous mitral valve prolapse: role of bone protein 4 in valvular interstitial cell activation // J. Cell. Physiol. 2012; 227 (6): р. 2595-2604.
3. Boudoulas K. D., Boudoulas H. Floppy mitral valve (FMV)/mitral valve prolapse (MVP) and the FMV/MVP syndrome: pathophysiologic mechanisms and pathogenesis of symptoms // Cardiology. 2013; 126 (2): р. 69-80.
4. Delling F. N., Vasan R. S. Epidemiology and pathophysiology of mitral valve prolapse: new insights into diseaseprogression, genetics and molecular basis // Circulation. 2014; 129 (21): р. 2158-2170.
5. Мартынов А. И., Акатова Е. В., Николин О. П. Результаты длительной терапии оротатом магния у пациентов с пролапсом митрального клапана // Кардиоваскулярная терапия и профилактика. 2012; 11 (3): с. 30-35.
6. Taub C. C., Stoler J. M., Perez-Sanz T. et al. Mitral valve prolapse in Marfan syndrome: an old topic revisited // Echocardiography. 2009; 26 (4): р. 357-364.
7. Dolan A. L., Mishra M. B., Chambers J. B., Grahame R. Clinical and echocardiographic survey of the Ehlers-Danlos syndrome // Br. J. Rheumatol. 1997; 36 (4): р. 459-462.
Review
For citations:
Klemenov A.V. Mitral valve prolapse: clinical variants, current understanding. Lechaschi Vrach. 2019;(9):65. (In Russ.)
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