Participation of ERM proteins in the regulation of the cell cytoskeleton and the role of the moesin protein in the path ogenesis of adenomyosis

Data on new biological markers of adenomyosis are presented. The role of ERM proteins in the development and progression of endometriosis is described. An in-depth study of the structure, mass, localization of ERM proteins and their functional relationship with the signaling pathways Rho, RhoA, Rhoc, RhocK1, leading to increased migration and adhesion of ectopic endometrial cells. It describes which cell adhesion proteins are involved in binding to the moesin protein domain and function as crosslinkers between membrane proteins and the cytoskeleton. Data on the regulation of the function of ERM proteins as crosslinkers are presented. In order to study the functional role of ERM proteins, the phenotypes of mice with the presence and removal of the protein moesin, radixin and ezrin separately were described. Various methods of studying the expression of ERM proteins in ectopic and eutopic endometrial cells are considered. The role of the protein moesin and ezrin in the pathogenesis of adenomyosis and in the progression of the pathological process is described separately. The expression of moesin in ectopic endometrial cells in adenomyosis, leading to the progression of the pathological process, was studied. Markers involved in phosphorylation of the moesin protein and markers that inhibit moesin activity are described, which favorably affects the outcome of the disease. The expression of the ezrin protein in ectopic endometrial cells in the proliferative and secretory phases of the menstrual cycle was studied, its role in the development and progression of adenomyosis was described, as well as markers that activate and inhibit this protein were studied. It describes the forms of cancer diseases in which the expression of ERM system proteins is increased, which contributes to more active metastasis of cancer cells and leads to a worse prognosis of the disease. We have studied which biological markers inhibit the activity of ERM proteins, which helps to reduce cancer cell metastasis. 

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