Use of ozone therapy at the stage of periconceptional preparation within the program of rehabilitation of women with chronic endometritis

One of the topical issues of modern obstetrics is the search for ways to improve the morphofunctional state of the endometrium. The importance of this problem is determined, first of all, as a reserve possibility to reduce the frequency of premature births and, consequently, perinatal morbidity and mortality. The use of ozone therapy in the complex treatment of chronic endometritis in combination with reduced blood flow in the uterus and ovaries opens up prospects for more effective pre-implantation preparation. Aims were to improve the effectiveness of treatment of chronic endometritis in complex periconceptional preparation in women with miscarriage. This prospective cohort controlled study included patients with confirmed chronic endometritis with a history of miscarriage. In total, 81 patients participated in the study. The study was conducted from January 2004 to August 2006. Patients of the main group received systemic ozone therapy at the stage of rehabilitation in complex treatment, the control group underwent traditional treatment. The effectivenesswas evaluated using clinical and paraclinical examination methods. The patients examined with morphologically confirmed chronic endometritis showed a decrease in blood flow in the uterine and ovarian arteries, which significantly affected the reproductive potential of women. Significant differences were obtained in different approaches to treatment. In the main group, against the background of ozone therapy, there was an improvement in blood flow in the uterus and ovaries, which positively affected the increase in the midline echo, improvement of characteristics of the yellow body; the changes were slightly expressed in the control group. In the main group, in patients who underwent periconceptional preparation, the course of pregnancy and outcomes were significantly better than in the control group, with no adverse effects observed in either group. The use of ozone therapy in patients with chronic endometritis significantly improves the effectiveness of periconceptional preparation. 

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