Influence of a hydrogel antiseptic dressing based on collagen hydrolysate and sodium alginate on the course of the wound process in mine-blast trauma and diabetic foot syndrome

Background. Treatment of wounds in mine blast trauma and diabetic foot syndrome (DFS) remains a clinical challenge. Mine blast trauma is associated with extensive tissue damage and a high risk of infection. Diabetic foot syndrome leads to ulcerative defects in 20% of diabetic patients, and up to 85% of lower limb amputations result from wound infection against the background of impaired microcirculation. The growing problem of antimicrobial resistance necessitates the use of topical antiseptics that also stimulate regeneration. Combined hydrogel dressings are promising, but their clinical potential requires further clarification.

Objective. To evaluate the effect of a combined antiseptic hydrogel dressing on the wound healing process in patients with mine blast trauma and diabetic foot syndrome.

Materials and methods. A prospective single center study was conducted at the Odintsovo Regional Hospital (2022-2025). We analyzed 200 medical records divided into four groups of 50 patients each: main groups ( diabetic foot syndrome and mine blast trauma treated with the hydrogel hydrogel containing collagen hydrolysate, sodium alginate and antiseptics) and control groups (standard therapy). We assessed wound size dynamics, pH, leukocyte count, C reactive protein, microbiology, length of hospital stay, and number of surgical debridements. Statistical analysis used Student's t test, Mann – Whitney U test, and Pearson correlation.

Results. The use of the hydrogel resulted in significant clinical benefits. In the diabetic foot syndrome group, wound pH shifted from 5.05 to 5.90 (p < 0.001); a pH increase > 0.5 by day 10 predicted a favorable outcome with 85% specificity. In the mine blast trauma group, C reactive protein decreased from 109.5 to 50.2 mg/L (p < 0.001). In the diabetic foot syndrome group, hospital stay was reduced by 4.6 days (18.2 vs 22.7; p < 0.001), and the number of surgical debridements decreased from 2.1 to 0.8. In the mine blast trauma group, the rate of autodermoplasty increased from 32% to 72%. The hydrogel was effective against E. coli, K. pneumoniae, E. faecalis, and P. aeruginosa. No adverse events related to the hydrogel were recorded.

Conclusion. The hydrogel containing collagen hydrolysate, sodium alginate and antiseptic exhibits combined antimicrobial, anti inflammatory, and regenerative effects. Its use in diabetic foot syndrome patients significantly reduces hospital stay and the number of surgical interventions. Wound pH dynamics (an increase > 0.5 by day 10) can serve as a prognostic criterion for favorable healing.

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