Povidone-iodine capabilities in the local therapy of urogenital infectious and inflammatory diseases
https://doi.org/10.51793/OS.2026.29.1.009
Abstract
Background. Povidone-iodine is a water – soluble iodine formulation with antimicrobial effect against a wide range of microorganisms (bacteria, fungi, protozoa, viruses). No acquired microbial resistance has been reported for povidone-iodine over the decades of its use due to its multiple-targeted action. Povidone-iodine has been used for a long time in surgical, gynecological and dermatological practice; it is highly effective in different forms and concentrations and retains its antimicrobial activity even when diluted 1:100 or more. Due to the high safety profile of lower concentration povidone-iodine solutions (while maintaining their effectiveness), they can also be used on the skin and mucous membranes of the genitourinary system, so these solutions may be considered as a promising addition to the main therapy (or in some cases as a variant of the main therapy) of bacterial vaginosis or sexually transmitted infections.
Conclusion. The range of povidone-iodine formulations is registered in the Russian Federation in the form of a 10.0% ointment and a 7.5% solution; it has a declared antimicrobial effect and is indicated for use in dermatovenereology. Ural Scientific Research Institute of Dermatovenerology and Immunopathology has scheduled a study of using povidone-iodine solution in patients with urogenital infectious and inflammatory diseases in addition to the systemic treatment indicated for these diagnoses in accordance with current guidelines.
About the Authors
N. V. Zilberberg
Ural Scientific Research Institute of Dermatovenerology and Immunopathology
Россия
Россия
Natalia V. Zilberberg, Dr. of Sci. (Med.), Professor, Deputy Director
8 Shcherbakova str., Yekaterinburg, 620076
A. I. Polishchuk
Ural Scientific Research Institute of Dermatovenerology and Immunopathology
Россия
Россия
Anton I. Polishchuk, Cand. of Sci. (Med.), Senior Researcher of Scientific research Department of Dermatology
8 Shcherbakova str., Yekaterinburg, 620076
References
1. Lepelletier D., Maillard J. Y., Pozzetto B., et al. Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization. Antimicrob Agents Chemother. 2020; 64 (9): e00682-20. DOI: 10.1128/AAC.00682-20.
2. Steins A., Carroll C., Choong F. J., et al. Cell death and barrier disruption by clinically used iodine concentrations. Life Sci Alliance. 2023; 6 (6): e202201875. DOI: 10.26508/lsa.202201875. LECHASCHI VRACH, VOL. 29, № 1, 2026, https://journal.lvrach.ru/
3. Benevento W. J., Murray P., Reed C. A., et al. The sensitivity of Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex type II to АКТУАЛЬНАЯ ТЕМА disinfection with povidone-iodine. Am J Ophthalmol. 1990; 109 (3): 329-333. PMID: 2155533.
4. Wewalka G., Stary A., Bosse B., et al. Efficacy of povidone-iodine vaginal suppositories in the treatment of bacterial vaginosis. Dermatology. 2002; 204 (Suppl 1): 79-85. PMID: 12011527.
5. Bigliardi P. L., Alsagoff S. A. L., El-Kafrawi H. Y., et al. Povidone iodine in wound healing: a review of current concepts and practices. Int J Surg. 2017; 44: 260-268. DOI: 10.1016/j.ijsu.2017.06.073.
6. Yu H., Tak-Yin M. The efficacy of povidone-iodine pessaries in a short, low-dose treatment regime on candidal, trichomonal and non-specific vaginitis. Postgrad Med J. 1993; 69 (Suppl 3): S58-S61. PMID: 8290459.
7. Petersen E. E., Weissenbacher E. R., Hengst P., et al. Local treatment of vaginal infections of varying etiology with dequalinium chloride or povidone-iodine: a randomized, double-blind, active-controlled, multicentric clinical study. Arzneimittelforschung. 2002; 52 (9): 706-715. DOI: 10.1055/s-0031-1299955.
8. Párducz L., Eszik I., Wagner G., et al. Impact of antiseptics on Chlamydia trachomatis growth. Lett Appl Microbiol. 2016; 63 (4): 260-267. DOI: 10.1111/lam.12625.
9. Reeve P. The inactivation of Chlamydia trachomatis by povidone-iodine. J Antimicrob Chemother. 1976; 2 (1): 77-80. DOI: 10.1093/jac/2.1.77.
10. Kawana R., Kitamura T., Nakagomi O., et al. Inactivation of human viruses by povidone-iodine in comparison with other antiseptics. Dermatology. 1997; 195 (Suppl 2): 29-35. DOI: 10.1159/000246027.
11. Sokal D. C., Hermonat P. L. Inactivation of papillomavirus by low concentrations of povidone-iodine. Sex Transm Dis. 1995; 22 (1): 22-24. DOI: 10.1097/00007435-199501000-00004.
12. Friedrich E. G. Jr, Masukawa T. Effect of povidone-iodine on Herpes genitalis. Obstet Gynecol. 1975; 45 (3): 337-339. PMID: 1113955.
13. Capriotti K., Stewart K., Pelletier J., et al. Molluscum Contagiosum Treated with Dilute Povidone-Iodine: A Series of Cases. J Clin Aesthet Dermatol. 2017; 10 (3): 41-45. PMID: 28360968.
14. Meza-Romero R., Navarrete-Dechent C., Downey C. Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment. Clin Cosmet Investig Dermatol. 2019; 12: 373-381. DOI: 10.2147/CCID.S187224.
15. Dela Cruz F., Brown D. H., Leikin J. B., et al. Iodine absorption after topical administration. West J Med. 1987; 146 (1): 43-45. PMID: 3825108.
16. Ertan M. B., Başarır K., Kocaoğlu H., et al. Systemic iodine levels increase with povidone-iodine irrigation, but does this affect thyroid functions? A case-control study. J Orthop Surg Res. 2024; 19 (1): 636. DOI: 10.1186/s13018-024-04877-8.
17. Pfokreni L., Kaushal A., Aishwarya Rao H., et al. Povidone-iodine induced chemical injury in a neurosurgical patient: A case report. JCA Advances. 2025; 2 (2) 100103; 1-2. doi.org/10.1016/j.jcadva.2025.100103.
18. Lowe D. O., Knowles S. R., Weber E. A., et al. Povidone-iodine-induced burn: case report and review of the literature. Pharmacotherapy. 2006; 26 (11): 1641-1645. DOI: 10.1592/phco.26.11.1641.
19. Van den Broek P. J., Buys L. F., Van Furth R. Interaction of povidoneiodine compounds, phagocytic cells, and microorganisms. Antimicrob Agents Chemother. 1982; 22: 593-597. DOI: 10.1128/aac.22.4.593.
20. Meehan J. P. Dilute Povidone-Iodine Irrigation: The Science of Molecular Iodine (I2) Kinetics and Its Antimicrobial Activity. J Am Acad Orthop Surg. 2025; 33 (2): 65-73. DOI: 10.5435/JAAOS-D-24-00471.
21. Instruction for medical use of the drug Braunodin B. Braun [website]. https://bbraun.ru; 2025 [updated December 10, 2025; cited December 11, 2025]. Available from: https://bbraun.ru/wp-content/uploads/2024/04/ instrukcziya-po-primeneniyu-braunodin-r-r.pdf (In Russ.)
Review
For citations:
Zilberberg N.V., Polishchuk A.I. Povidone-iodine capabilities in the local therapy of urogenital infectious and inflammatory diseases. Lechaschi Vrach. 2026;(1):64-68. (In Russ.) https://doi.org/10.51793/OS.2026.29.1.009
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