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Лечащий Врач

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Урсодезоксихолевая кислота и болезни печени

https://doi.org/10.26295/OS.2020.75.99.012

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Аннотация

Урсодезоксихолевая кислота (УДХК) - гидрофильная желчная кислота, которая является мощным антиоксидантом и в настоящее время используется в качестве панацеи для медикаментозного лечения широкого спектра заболеваний печени.Показана фармакокинетика УДХК, механизмы действия, среди которых выделены защита холангиоцитов от цитотоксичности гидрофобных желчных кислот; стимуляция гепатобилиарной секреции; защита гепатоцитов от апоптоза, вызванного желчными кислотами, а также использование УДХК при различных холестатических заболеваниях: первичный билиарный цирроз, склерозирующий холангит, прогрессирующие и непрогрессирующие формы семейного внутрипеченочного холестаза, муковисцидоз, внутрипеченочный холестаз беременных, лекарственно индуцированный холестаз, гипофосфолипид-ассоциированная желчнокаменная болезнь.УДХК широко используется в терапии различных заболеваний печени, а при холестатических заболеваниях она является препаратом терапии первой линии. Несмотря на то, что во многих случаях лечение УДХК не является патогенетическим, ее применение сопровождается уменьшением кожного зуда, улучшением биохимических показателей и улучшает результаты гистологических и холангиографических исследований. Поэтому проводимое лечение является благоприятным и направлено больше на купирование осложнений при холестатических заболеваниях. Все пациенты, получавшие УДХК при первичным склерозирующем холангите, имели более благоприятное течение заболевания с более редким появлением серьезных осложнений.

Об авторах

Г. В. Волынец
ФГБОУ ВО РНИМУ им. Н. И. Пирогова МЗ РФ
Россия


А. И. Хавкин
ФГБОУ ВО РНИМУ им. Н. И. Пирогова МЗ РФ
Россия


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Рецензия

Для цитирования:


Волынец Г.В., Хавкин А.И. Урсодезоксихолевая кислота и болезни печени. Лечащий Врач. 2020;(6):62-68. https://doi.org/10.26295/OS.2020.75.99.012

For citation:


Volynets G.V., Khavkin A.I. Ursodeoxycholic acid and hepatic diseases. Lechaschi Vrach. 2020;(6):62-68. (In Russ.) https://doi.org/10.26295/OS.2020.75.99.012

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