Gamma rhythm in patients with ischemic stroke

Background. Gamma rhythm plays an important role in enabling cognitive processes. Studies confirm the association of gamma activity with visual and auditory perception, time perception, attention, consciousness and processing of semantic information, inner speech, and memory.

Objective. The purpose of the study is to evaluate gamma activity in patients with hemispheric ischemic stroke in the acute and acute periods in comparison with cognitive and anxiety-depressive disorders.

Materials and methods. A study was carried out on 32 patients with hemispheric ischemic stroke. All patients underwent comprehensive clinical-neurological, laboratory-instrumental and neurophysiological studies. The EEG was analyzed visually and using mathematical analysis. Using the method of mathematical analysis, we assessed the average values of the gamma rhythm power spectrum in the range of 30-45, 50-70 and 80-100 Hz in all leads and the peak frequency of the γ rhythm of the background EEG. The NIHSS, Rankin, Rivermead, Montreal Cognitive Assessment Scale, Hospital Anxiety and Depression Scale, Spielberger – Hanin Reactive and Personal Anxiety Scales, and Beck Depression Scales were used.

Results. Mathematical analysis of bioelectrical activity of the brain of patients with hemispheric ischemic stroke showed deviations in the gamma rhythm in the range of 30-100 Hz, compared with the control group. Statistically significant correlations were established between cognitive, anxiety-depressive disorders and the gamma rhythm index in the frontal and central-temporal regions in the frequency range of 30-100 Hz.

Conclusion. Mathematical analysis of the bioelectrical activity of the brain, along with clinical and neuropsychological studies, is recommended to be used for the diagnosis and identification of cognitive and anxiety-depressive disorders in patients with hemispheric ischemic stroke already in the acute and acute periods, which is especially important for prescribing adequate, pathogenetically based therapy and determining the prognosis of the disease.

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