Clinical case of morphea associated with a malignant process with extensive skin lesions, which debuted against the background of taking anti-gouty remedy

Abstract

Background. Localized scleroderma may be associated with a malignant process occurring in the body. The onset of scleroderma does not always coincide with the onset of clinical manifestations of oncology. The process can have a primary, secondary or independent development. Authors from different countries correspond to cases of both parallel development of both conditions, as well as the development of localized scleroderma against the background of cancer treatment and oncological processes against the background of long-term localized scleroderma. In addition, some substances, apparently, can provoke the development of localized scleroderma of a non-tumor-associated form.

Results. An article presents a clinical case of morphea associated with endometrial cancer and made a debut as a result of medicine intake. A patient who underwent nerve-sparing extended extirpation of the uterus and appendages, with the upper part of the vagina and pelvic lymphadenectomy for endometrioid adenocarcinoma. After one year, increase in uric acid in the blood was found, so allopurinol was prescribed. After three weeks of the drug intake, she noticed itching and painful sensations on the skin of the back. After keeping taking the pills, rashes appeared, gradually occupying most of the skin of the trunk, upper and lower extremities.

Сonclusion. Besides the association of morphea with a malignant process and the possible involvement of allopurinol as a trigger of the skin process, the vastness of the skin lesion and the disease course become interesting. It also remains unclear whether there is a development of localized scleroderma against the background of a malignant process, the trigger was solely taking an anti-gouty drug, or whether there is a combination of all factors that led to the current condition of the patient.