Plant-derived exosome-like nanoparticles: characteristics and their potential for use in dermatological and cosmetological practice
https://doi.org/10.51793/OS.2024.27.10.008
Abstract
Introduction. The article discusses a new trend in dermatological and cosmetological practice – the use of plant-derived exosomes. Exosomes are microscopic extracellular vesicles that can transfer bioactive molecules between cells. The article describes in detail the characteristics of plant exosomes, as well as their potential applications in clinical practice of a dermatovenerologist, cosmetologist.
Objective. The aim of the study was to investigate the therapeutic efficacy of Melissa officinalis exosome-based composition in correcting age-related skin changes (visible wrinkles and skin texture).
Materials and methods. 30 patients with type II photoaging according to Glogau (the average age was about 41.2 years) and skin phototype III or IV according to Fitzpatrick were under observation. The patients were divided into two groups: the main group (n = 15) received local therapy preparation based on M. оfficinalis exosomes using a mesoroller; the control group (n = 15), where the patients underwent only с therapy without adding exosomes. The course consisted of 3 procedures with an interval of 14-20 days. To assess clinical effectiveness, a three-dimensional analysis of the skin surface was performed and statistical analysis.
Results. The cumulative assessment of the regression of clinical manifestations of visible skin folds (wrinkles) and skin texture (pores) showed the advantages of procedures using M. оfficinalis exosomes. With microneedling without the use of exosomes, the reduction in the depth index was 79.64%, and with the addition of M. оfficinalis exosomes – 53.35%. When assessing skin texture (pores), the reduction in the index was 73.25% without adding exosomes, and with addition – the decrease was 54.58%.
Conclusion. A correlation has been revealed between the use of exosomal therapy based on M. officinalis and external age-related changes accompanying the aging process.
About the Authors
T. V. Doronina
Lomonosov Moscow State University
Россия
Россия
Tatiana V. Doronina, Сand. of Sci. (Biol.), Junior Researcher, Cell Biology and Histology Department, Faculty of Biology, Federal State Educational Institution of Higher Professional Education
1, p. 12 Leninskie Gory str., Moscow, 119234
M. V. Koshkina
Melis Cosmetology and Dentistry Clinic
Россия
Россия
Mariya V. Koshkina, Сand. of Sci. (Med.), dermatovenerologist, cosmetologist, Melis Cosmetology and Dentistry Clinic
1/1 Pokryshkina str., Moscow, 119571
D. I. Znatdinov
Hyaluronic Acid Research Center
Россия
Россия
Damir I. Znatdinov, Junior Researcher, Autonomous Non-profit Organization for the implementation of research programs Scientific
38/16 Komsomolsky Ave., Moscow, 119146
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Review
For citations:
Doronina T.V., Koshkina M.V., Znatdinov D.I. Plant-derived exosome-like nanoparticles: characteristics and their potential for use in dermatological and cosmetological practice. Lechaschi Vrach. 2024;(10):55-61. (In Russ.) https://doi.org/10.51793/OS.2024.27.10.008
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