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Иммунологические аспекты эндометриоза: обзор литературы

https://doi.org/10.26295/OS.2020.29.10.007

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Аннотация

Обзор направлен на то, чтобы свести воедино современное понимание патогенеза эндометриоза с особым акцентом на механизмы, лежащие в основе васкуляризации очагов поражения, и вклад иммунных факторов в формирования очага эндометриоза. Также проведен обзор роли гормонов, иммунных клеток и цитокинов в формировании эндометриоза и варианты фармакологической терапии.

Об авторах

Л. В. Адамян
ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ
Россия


К. Н. Арсланян
ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ
Россия


О. Н. Логинова
ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ
Россия


Л. М. Манукян
ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ
Россия


Э. И. Харченко
ФГБОУ ВО МГМСУ им. А. И. Евдокимова МЗ РФ
Россия


Список литературы

1. Cramer D. W., Missmer S. A. The epidemiology of endometriosis // Annals of the New York Academy of Sciences. 2002; 955:11-22, 34-36, 396-406.

2. Dunselman G. A. J., Vermeulen N., Becker C., et al. ESHRE guideline: management of women with endometriosis // Human Reproduction. 2014; 29 (3): 400-412. DOI: 10.1093/humrep/det457.

3. Keettel W. C., Stein R. J. The viability of the cast-off menstrual endometrium // American Journal of Obstetrics & Gynecology. 1951; 61 (2): 440-442.

4. Sampson J. A. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity // American Journal of Obstetrics & Gynecology. 1927; 14: 422-469.

5. Halme J., Hammond M. G., Hulka J. F., Raj S. G., Talbert L. M. Retrograde menstruation in healthy women and in patients with endometriosis // Obstetrics and Gynecology. 1984; 64 (2): 151-154.

6. Liu D. T. Y., Hitchcock A. Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology // British Journal of Obstetrics and Gynaecology. 1986; 93 (8): 859-862. DOI: 10.1111/j.1471-0528.1986.tb07995.x.

7. Barbieri R. L. Stenosis of the external cervical os: an association with endometriosis in women with chronic pelvic pain // Fertility and Sterility. 1998; 70 (3): 571-573. DOI: 10.1016/s0015-02829800189-7.

8. Sanfilippo J. S., Wakim N. G., Schikler K. N., Yussman M. A. Endometriosis in association with uterine anomaly // American Journal of Obstetrics & Gynecology. 1986; 154 (1): 39-43. DOI: 10.1016/0002-93788690389-3.

9. D’Hooghe T. M., Bambra C. S., Suleman M. A., Dunselman G. A., Evers H. L., Koninckx P. R. Development of a model of retrograde menstruation in baboons (Papio anubis) // Fertility and Sterility. 1994; 62 (3): 635-638.

10. D’Hooghe T. M., Bambra C. S., Raeymaekers B. M., de Jonge I., Lauweryns J. M., Koninckx P. R. Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis) // American Journal of Obstetrics & Gynecology. 1995; 173 (1): 125-134. DOI: 10.1016/0002-93789590180-9.

11. Overto C., Davis C., McMillan L., Shaw R. W., Koh C. An Atlas of Endometriosis. 3rd. Informa Healthcare; 2007.

12. Sasson I. E., Taylor H. S. Stem cells and the pathogenesis of endometriosis // Annals of the New York Academy of Sciences. 2008; 1127: 106-115. DOI: 10.1196/annals.1434.014.

13. Burney R. O., Giudice L. C. Pathogenesis and pathophysiology of endometriosis // Fertility and Sterility. 2012; 98 (3): 511-519. DOI: 10.1016/j.fertnstert.2012.06.029.

14. Leyendecker G., Herbertz M., Kunz G., Mall G. Endometriosis results from the dislocation of basal endometrium // Human Reproduction. 2002; 17 (10): 2725-2736. DOI: 10.1093/humrep/17.10.2725.

15. Du H., Taylor H. S. Contribution of bone marrow-derived stem cells to endometrium and endometriosis // Stem Cells. 2007; 25 (8): 2082-2086. DOI: 10.1634/stemcells.2006-0828.

16. Wingfield M., Macpherson A., Healy D. L., Rogers P. A. W. Cell proliferation is increased in the endometrium of women with endometriosis // Fertility and Sterility. 1995; 64 (2): 340-346.

17. Bulun S. E., Cheng Y.-H., Yin P., et al. Progesterone resistance in endometriosis: link to failure to metabolize estradiol // Molecular and Cellular Endocrinology. 2006; 248 (1-2): 94-103. DOI: 10.1016/j.mce.2005.11.041.

18. Simpson J. L., Elias S., Malinak L. R., Buttram V. C., Jr. Heritable aspects of endometriosis. I. Genetic studies // American Journal of Obstetrics & Gynecology. 1980; 137 (3): 327-331.

19. Oosterlynck D. J., Cornillie F. J., Waer M., Vandeputte M., Koninckx P. R. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium // Fertility and Sterility. 1991; 56 (1): 45-51.

20. Nap A. W., Groothuis P. G., Demir A. Y., et al. Tissue integrity is essential for ectopic implantation of human endometrium in the chicken chorioallantoic membrane // Human Reproduction. 2003; 18 (1): 30-34. DOI: 10.1093/humrep/deg033.

21. Somigliana E., Vigan? P., Gaffuri B., et al. Modulation of NK cell lytic function by endometrial secretory factors: potential role in endometriosis // American Journal of Reproductive Immunology. 1996; 36 (5): 295-300. DOI: 10.1111/j.1600-0897.1996.tb00179.x.

22. Gilabert-Estelles J., Estelles A., Gilabert J., Castello R., Espana F., Falco C. Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis // Human Reproduction. 2003; 18: 1516-1522.

23. May K. E., Villar J., Kirtley S., Kennedy S. H., Becker C. M. Endometrial alterations in endometriosis: a systematic review of putative biomarkers // Human Reproduction Update. 2011; 17 (5): 637-653. DOI: 10.1093/humupd/dmr013.dmr013.

24. Bruse C., Bergqvist A., Carlstr?m K., Fianu-Jonasson A., Lecander I., ?stedt B. Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women // Fertility and Sterility. 1998; 70 (5): 821-826. DOI: 10.1016/s0015-02829800285-4.

25. Bulun S. E. Endometriosis // The New England Journal of Medicine. 2009; 360: 268-279.

26. Sharpe-Timms K. L. Endometrial anomalies in women with endometriosis // Annals of the New York Academy of Sciences. 2001; 943: 131-147.

27. Noble L. S., Takayama K., Zeitoun K. M., et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells // Journal of Clinical Endocrinology and Metabolism. 1997; 82 (2): 600-606. DOI: 10.1210/jc.82.2.600.

28. Attar E., Bulun S. E. Aromatase and other steroidogenic genes in endometriosis: Translational aspects // Human Reproduction Update. 2006; 12 (1): 49-56. DOI: 10.1093/humupd/dmi034.

29. Vercellini P., Cortesi I., Crosignani P. G. Progestins for symptomatic endometriosis: a critical analysis of the evidence // Fertility and Sterility. 1997; 68 (3): 393-401. DOI: 10.1016/s0015-02829700193-3.

30. Surrey E. S. The role of progestins in treating the pain of endometriosis // Journal of Minimally Invasive Gynecology. 2006; 13 (6): 528-534. DOI: 10.1016/j.jmig.2006.06.008.

31. Abushahin F., Goldman K. N., Barbieri E., Milad M., Rademaker A., Bulun S. E. Aromatase inhibition for refractory endometriosis-related chronic pelvic pain // Fertility and Sterility. 2011; 96 (4): 939-942. DOI: 10.1016/j.fertnstert.2011.07.1136.

32. Li X., O’Malley B. W. Unfolding the action of progesterone receptors // The Journal of Biological Chemistry. 2003; 278 (41): 39261-39264. DOI: 10.1074/jbc.r300024200.

33. Attia G. R., Zeitoun K., Edwards D., Johns A., Carr B. R., Bulun S. E. Progesterone receptor isoform A but not B is expressed in endometriosis // Journal of Clinical Endocrinology and Metabolism. 2000; 85 (8): 2897-2902. DOI: 10.1210/jc.85.8.2897.

34. Cheng Y.-H., Imir A., Fenkci V., Yilmaz M. B., Bulun S. E. Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17?-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism // American Journal of Obstetrics & Gynecology. 2007; 196 (4): 391.e1-391.e8. DOI: 10.1016/j.ajog.2006.12.014.

35. Folkman J., Shing Y. Angiogenesis // Journal of Biological Chemistry. 1992; 267 (16): 10931-10934.

36. Risau W. Mechanisms of angiogenesis // Nature. 1997; 386 (6626): 671-674. DOI: 10.1038/386671a0.

37. Ferrara N. VEGF and the quest for tumour angiogenesis factors // Nature Reviews Cancer. 2002; 2 (10): 795-803. DOI: 10.1038/nrc909.

38. Nisolle M., Casanas-Roux F., Anaf V., Mine J.-M., Donnez J. Morphometric study of the stromal vascularization in peritoneal endometriosis // Fertility and Sterility. 1993; 59 (3): 681-684.

39. Shifren J. L., Tseng J. F., Zaloudek C. J., et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis // The Journal of Clinical Endocrinology and Metabolism. 1996; 81 (8): 3112-3118. DOI: 10.1210/jc.81.8.3112.

40. Hoeben A., Landuyt B., Highley M. S., Wildiers H., van Oosterom A. T., de Bruijn E. A. Vascular endothelial growth factor and angiogenesis // Pharmacological Reviews. 2004; 56 (4): 549-580. DOI: 10.1124/pr.56.4.3.

41. Sharkey A. M., Day K., McPherson A., et al. Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia // Journal of Clinical Endocrinology and Metabolism. 2000; 85 (1): 402-409. DOI: 10.1210/jc.85.1.402.

42. McLaren J., Prentice A., Charnock-Jones D. S., Smith S. K. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis // Human Reproduction. 1996; 11 (1): 220-223. DOI: 10.1093/oxfordjournals.humrep.a019023.

43. Bourlev V., Volkov N., Pavlovitch S., Lets N., Larsson A., Olovsson M. The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor-A and its receptors in eutopic endometrium and endometriotic lesions // Reproduction. 2006; 132 (3): 501-509. DOI: 10.1530/rep.1.01110.

44. Donnez J., Smoes P., Gillerot S., Casanas-Roux F., Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis // Human Reproduction. 1998; 13 (6): 1686-1690. DOI: 10.1093/humrep/13.6.1686.

45. McLaren J., Prentice A., Charnock-Jones D. S., et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids // The Journal of Clinical Investigation. 1996; 98 (2): 482-489. DOI: 10.1172/jci118815.

46. Ribatti D., Vacca A., Nico B., Roncali L., Dammacco F. Postnatal vasculogenesis // Mechanisms of Development. 2001; 100 (2): 157-163. DOI: 10.1016/S0925-4773 (00)00522-0.

47. Asahara T., Masuda H., Takahashi T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization // Circulation Research. 1999; 85 (3): 221-228. DOI: 10.1161/01.RES.85.3.221.

48. Becker C. M., Beaudry P., Funakoshi T., et al. Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis // The American Journal of Pathology. 2011; 178 (4): 1782-1791. DOI: 10.1016/j.ajpath.2010.12.037.

49. Laschke M. W., Giebels C., Menger M. D. Vasculogenesis: a new piece of the endometriosis puzzle // Human Reproduction Update. 2011; 17 (5): 628-636. DOI: 10.1093/humupd/dmr023.dmr023.

50. Yamaguchi J.-I., Kusano K. F., Masuo O., et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization // Circulation. 2003; 107 (9): 1322-1328. DOI: 10.1161/01.cir.0000055313.77510.22.

51. Virani S., Edwards A. K., Thomas R., Childs T., Tayade C. Blocking of stromal cell-derived factor-1 reduces neoangiogenesis in human endometriosis lesions in a mouse model // American Journal of Reproductive Immunology. 2013; 70 (5): 386-397. DOI: 10.1111/aji.12134.

52. Taylor R. N., Lebovic D. I., Mueller M. D. Angiogenic factors in endometriosis // Annals of the New York Academy of Sciences. 2002; 955: 89-100, 118, 396-406.

53. Lin Y.-J., Lai M.-D., Lei H.-Y., Wing L.-Y. C. Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model // Endocrinology. 2006; 147 (3): 1278-1286. DOI: 10.1210/en.2005-0790.

54. Fainaru O., Adini A., Benny O., et al. Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis // The FASEB Journal. 2008; 22 (2): 522-529. DOI: 10.1096/fj.07-9034com.

55. Stanic A. K., Kim M., Styer A. K., Rueda B. R. Dendritic cells attenuate the early establishment of endometriosis-like lesions in a murine model // Reproductive Sciences. 2014; 21: 1228-1236.

56. Chen G. Y., Nunez G. Sterile inflammation: sensing and reacting to damage // Nature Reviews Immunology. 2010; 10: 826-837.

57. Beste M. T., Pfaffle-Doyle N., Prentice E. A., et al. Endometriosis: Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation // Science Translational Medicine. 2014; 6 (222) DOI: 10.1126/scitranslmed.3007988.222ra16

58. Koch A. E., Polverini P. J., Kunkel S. L., et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis // Science. 1992; 258 (5089): 1798-1801. DOI: 10.1126/science.1281554.

59. Bacci M., Capobianco A., Monno A., et al. Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease // The American Journal of Pathology. 2009; 175 (2): 547-556. DOI: 10.2353/ajpath.2009.081011.

60. Kwak J.-Y., Park S.-W., Kim K.-H., Na Y.-J., Lee K.-S. Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis // Human Reproduction. 2002; 17 (3): 595-600. DOI: 10.1093/humrep/17.3.595.

61. Banchereau J., Steinman R. M. Dendritic cells and the control of immunity // Nature. 1998; 392 (6673): 245-252. DOI: 10.1038/32588.

62. Schulke L., Berbic M., Manconi F., Tokushige N., Markham R., Fraser I. S. Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis // Human Reproduction. 2009; 24 (7): 1695-1703. DOI: 10.1093/humrep/dep071.

63. Pencovich N., Luk J., Hantisteanu S., Hornstein M. D., Fainaru O. The development of endometriosis in a murine model is dependent on the presence of dendritic cells // Reproductive BioMedicine Online. 2014; 28 (4): 515-521. DOI: 10.1016/j.rbmo.2013.12.011

64. Ho H.-N., Chao K.-H., Chen H.-F., Wu M.-Y., Yang Y.-S., Lee T.-Y. Peritoneal natural killer cytotoxicity and CD25+CD3+ lymphocyte subpopulation are decreased in women with stage III-IV endometriosis // Human Reproduction. 1995; 10 (10): 2671-2675.

65. Kang Y. J., Jeung I. C., Park A., et al. An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression // Human Reproduction. 2014; 29: 2176-2189. DOI: 10.1093/humrep/deu172.

66. Antsiferova Y. S., Sotnikova N. Y., Posiseeva L. V., Shor A. L. Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis // Fertility and Sterility. 2005; 84 (6): 1705-1711. DOI: 10.1016/j.fertnstert.2005.05.066.

67. Gorai I., Ishikawa M., Onose R., Hirahara F., Minaguchi H. Antiendometrial autoantibodies are generated in patients with endometriosis //. American Journal of Reproductive Immunology. 1993; 29 (2): 116-123. DOI: 10.1111/j.1600-0897.1993.tb00575.x.

68. Ho H.-N., Wu M.-Y., Chao K.-H., Chen C.-D., Chen S.-U., Yang Y.-S. Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometriosis // Human Reproduction. 1997; 12 (11): 2528-2533. DOI: 10.1093/humrep/12.11.2528.

69. Szyllo K., Tchorzewski H., Banasik M., Glowacka E., Lewkowicz P., Kamer-Bartosinska A. The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis // Mediators of Inflammation. 2003; 12 (3): 131-138. DOI: 10.1080/0962935031000134842.

70. Hever A., Roth R. B., Hevezi P., et al. Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator // Proceedings of the National Academy of Sciences of the United States of America. 2007; 104 (30): 12451-12456. DOI: 10.1073/pnas.0703451104.

71. Cameron M. J., Kelvin D. J. Cytokines and chemokines - their receptors and their genes: an overview // Advances in Experimental Medicine and Biology. 2003; 520: 8-32. DOI: 10.1007/978-1-4615-0171-82.

72. Na Y.-J., Jin J.-O., Lee M.-S., Song M.-G., Lee K.-S., Kwak J.-Y. Peritoneal fluid from endometriosis patients switches differentiation of monocytes from dendritic cells to macrophages // Journal of Reproductive Immunology. 2008; 77 (1): 63-74. DOI: 10.1016/j.jri.2007.03.013.

73. Kondera-Anasz Z., Sikora J., Mielczarek-Palacz A., Jo?ca M. Concentrations of interleukin (IL)-1?, IL-1 soluble receptor type II (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra) in the peritoneal fluid and serum of infertile women with endometriosis //. European Journal of Obstetrics & Gynecology & Reproductive Biology. 2005; 123 (2): 198-203. DOI: 10.1016/j.ejogrb.2005.04.019.

74. Sikora J., Mielczarek-Palacz A., Kondera-Anasz Z. Imbalance in cytokines from interleukin-1 family-role in pathogenesis of endometriosis // The American Journal of Reproductive Immunology. 2012; 68 (2): 138-145. DOI: 10.1111/j.1600-0897.2012.01147.x.

75. Cheong Y. C., Shelton J. B., Laird S. M., et al. IL-1, IL-6 and TNF-? concentrations in the peritoneal fluid of women with pelvic adhesions // Human Reproduction. 2002; 17 (1): 69-75.

76. Kharfi A., Boucher A., Akoum A. Abnormal interleukin-1 receptor type II gene expression in the endometrium of women with endometriosis // Biology of Reproduction. 2002; 66 (2): 401-406. DOI: 10.1095/biolreprod66.2.401.

77. Harada T., Yoshioka H., Yoshida S., et al. Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis // American Journal of Obstetrics & Gynecology. 1997; 176 (3): 593-597. DOI: 10.1016/s0002-93789770553-2.

78. Pizzo A., Salmeri F. M., Ardita F. V., Sofo V., Tripepi M., Marsico S. Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis // Gynecologic and Obstetric Investigation. 2002; 54 (2): 82-87. DOI: 10.1159/000067717.

79. Wu M. H., Lu C. W., Chuang P. C., Tsai S. J. Prostaglandin E2: the master of endometriosis? // Experimental Biology and Medicine (Maywood). 2010; 235 (6): 668-677. DOI: 10.1258/ebm.2010.009321.

80. Wu M.-H., Sun H. S., Lin C.-C. et al. Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis // Molecular Human Reproduction. 2002; 8 (12): 1103-1110. DOI: 10.1093/molehr/8.12.1103.

81. Kalu E., Sumar N., Giannopoulos T., et al. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis // Journal of Obstetrics and Gynaecology Research. 2007; 33 (4): 490-495. DOI: 10.1111/j.1447-0756.2007.00569.x.

82. Bergqvist A., Bruse C., Carlberg M., Carlstr?m K. Interleukin 1?, interleukin-6, and tumor necrosis factor-? in endometriotic tissue and in endometrium // Fertility and Sterility. 2001; 75 (3): 489-495. DOI: 10.1016/S0015-0282 (00)01752-0.

83. Keenan J. A., Chen T. T., Chadwell N. L., Torry D. S., Caudle M. R. Interferon-gamma (IFN-?) and interleukin-6 (IL-6) in peritoneal fluid and macrophage-conditioned media of women with endometriosis // The American Journal of Reproductive Immunology. 1994; 32 (3): 180-183. DOI: 10.1111/j.1600-0897.1994.tb01111.x.

84. Mahnke J. L., Yusoff Dawood M., Huang J.-C. Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis // Fertility and Sterility. 2000; 73 (1): 166-170. DOI: 10.1016/s0015-02829900466-5.

85. Topley N., Jorres A., Luttmann W., et al. Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1? and TNF? // Kidney International. 1993; 43 (1): 226-233. DOI: 10.1038/ki.1993.36.

86. Suen J. L., Chang Y., Chiu P. R., et al. Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model // The American Journal of Pathology. 2014; 184 (2): 464-471. DOI: 10.1016/j.ajpath.2013.10.023.

87. Mukaida N., Harada A., Matsushima K. Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions // Cytokine and Growth Factor Reviews. 1998; 9 (1): 9-23. DOI: 10.1016/S1359-6101 (97)00022-1.

88. Arici A., Tazuke S. I., Attar E., Kliman H. J., Olive D. L. Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells // Molecular Human Reproduction. 1996; 2 (1): 40-45. DOI: 10.1093/molehr/2.1.40.

89. Rafet Gazvani M., Christmas S., Quenby S., Kirwan J., Johnson P. M., Kingsland C. R. Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease // Human Reproduction. 1998; 13 (7): 1957-1961. DOI: 10.1093/humrep/13.7.1957.

90. Ryan I. P., Tseng J. F., Schriock E. D., Khorram O., Landers D. V., Taylor R. N. Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis // Fertility and Sterility. 1995; 63 (4): 929-932.

91. Akoum A., Lawson C., McColl S., Villeneuve M. Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro // Molecular Human Reproduction. 2001; 7 (9): 859-866. DOI: 10.1093/molehr/7.9.859.

92. Li A., Dubey S., Varney M. L., Dave B. J., Singh R. K. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis // Journal of Immunology. 2003; 170 (6): 3369-3376. DOI: 10.4049/jimmunol.170.6.3369.

93. Arici A., Tazuke S. I., Oral E., Olive D. L., Attar E. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells // Fertility and Sterility. 1997; 67 (6): 1065-1072. DOI: 10.1016/S0015-0282 (97)81440-9.

94. Akoum A., Kong J., Metz C., Beaumont M.-C. Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with and without endometriosis // Fertility and Sterility. 2002; 77 (5): 989-994. DOI: 10.1016/S0015-0282 (02)03082-0.

95. Yih S., Katabuchi H., Araki M., et al. Expression of monocyte chemoattractant protein-1 in peritoneal endometriotic cells // Virchows Archiv. 2001; 438 (1): 70-77. DOI: 10.1007/s004280000263.

96. Arici A., Senturk L. M., Seli E., Bahtiyar M. O., Kim G. Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone // Biology of Reproduction. 1999; 61 (1): 85-90. DOI: 10.1095/biolreprod61.1.85.


Рецензия

Для цитирования:


Адамян Л.В., Арсланян К.Н., Логинова О.Н., Манукян Л.М., Харченко Э.И. Иммунологические аспекты эндометриоза: обзор литературы. Лечащий Врач. 2020;(4):37. https://doi.org/10.26295/OS.2020.29.10.007

For citation:


Adamyan L.V., Arslanyan K.N., Loginova O.N., Manukyan L.M., Kharchenko E.I. Immunological aspects of endometriosis: review of the literature. Lechaschi Vrach. 2020;(4):37. (In Russ.) https://doi.org/10.26295/OS.2020.29.10.007

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