Comparative evaluation of changes in pain sensitivity and behavior in experimental animals under the influence of some drugs with psychotropic effect on the model of chronic alcoholism

Drugs used in the treatment of alcohol intoxication can have a toxic effect on the cardiovascular, central nervous and digestive systems, which can lead to death, most often occurring at night, which is caused by the predominant tone of the parasympathetic division of the autonomic nervous system, and needs experimental study using chronopharmacological methods. The inclusion of antioxidants in the scheme for the relief of alcohol intoxication contributes to a significant reduction in the pathological effects of depressants used in the standards of treatment of alcoholic disease. The study examined the effect of two groups of drugs and their combinations on pain sensitivity and behavioral reactions of aggression in rats with a formed model of chronic alcoholism. The process of selecting the most rational combinations of drugs for the treatment of patients with alcohol dependence has been carried out. Purpose of the study: To reveal the chronopharmacological features of the effects of certain psychotropic drugs and their combinations on the CNS of laboratory animals in a model of chronic alcoholism. Animals, after 10 days of alcoholization, received saturation with two drugs with a psychotropic effect and their combinations (droperidol, ethylmethyldihydrooxypyridine succinate (hereinafter, ethylmethyldihydrooxypyridine succinate), droperidol + ethylmethyldihydrooxypyridine succinate). Animal behavior was studied using the Hot Plate method. When studying the rhythm of sensitivity to electrothermal stimulation, desynchronization was noted against the background of Mexiprim, which has a direct physiological effect on the sensitivity of laboratory animals to changed conditions, bringing it closer to normal (as in intact animals), due to the fact that it refers to stimulants of the central nervous system, the fact of which is confirmed by the literature data. It was noted that droperidol has a depressant effect on the central nervous system, synchronizing pain sensitivity and aggression reactions, aggravating this process against the background of alcoholism. When conducting a histomorphological study of liver tissue, a negative effect on hepatocytes of droperidol was established against the background of chronic alcohol intoxication, in contrast to its use in combination with ethylmethyldihydrooxypyridine succinate, when a decrease in the affected areas of liver tissue can be observed with its gradual recovery and approach to a healthy structure.

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