Possibilities of modern probiotic therapy in the treatment of patients with post-infectious irritable bowel syndrome
https://doi.org/10.51793/OS.2022.25.2.005
Abstract
Irritable bowel syndrome is a chronic disease of the gastrointestinal tract, with such characteristic symptoms as pain and discomfort in the abdomen in the absence of an organic pathological process, the frequency of which in recent years has begun to increase due to post-COVID-19 postinfectious irritable bowel syndrome. Purpose of the study was to evaluate the effectiveness of including the probiological drug in the therapy of patients with post-infectious irritable bowel syndrome after a previous COVID-19 infection. We examined 70 patients with postinfectious irritable bowel syndrome that developed after a previous infection with COVID-19. The patients were divided into 2 groups. The main group consisted of 35 people who were treated with irritable bowel syndrome based on the latest recommendations of the Russian Gastroenterological Association, including antispasmodics, antidiarrheals. Additionally, the patients of the main group were included in the combined probiotic enteric capsules for 2 weeks at a dose of 3 capsules per day. In patients of the main group, whom included the probiotic in therapy, there was a more pronounced relief from the clinical manifestations of the disease with an overall assessment of the effectiveness of treatment of 82,7% in the main group and 56,9% in the comparison group. When assessing the indicators in points according to the IBS-SSS test and the IBS-QOL scale, both groups of patients showed statistically significant improvements in indicators (p < 0.001), however, the best indicators of intestinal symptoms and quality of life were in the main group. The combined probiotic is an interesting combination in the treatment of patients with post-COVID-19 postinfectious irritable bowel syndrome, contributing to a more pronounced regression of the clinical manifestations of the disease and improving the quality of life of patients.
About the Authors
V. A. Akhmedov
Federal State Budgetary Educational Institution of Higher Education Omsk State Medical University of the Ministry of Health of the Russian Federation
Россия
Россия
Vadim A. Akhmedov, Dr. of Sci. (Med.), Professor, Head of the Department of Medical Rehabilitation of Additional Professional Education
5 Petr Nekrasov str., Omsk, 644037
O. V. Gaus
Federal State Budgetary Educational Institution of Higher Education Omsk State Medical University of the Ministry of Health of the Russian Federation
Россия
Россия
Olga V. Gaus, MD, Associate Professor of the Department of Internal Medicine, Gastroenterology
5 Petr Nekrasov str., Omsk, 644037
References
1. Гаус О. В., Ливзан М. А. Синдром раздраженного кишечника: что нового? (обзор материалов UEG Week Virtual 2020) // Медицинский алфавит. 2021; 6: 41-47. [Gaus O. V., Livzan M. A. Irritable bowel syndrome: what's new? (review of UEG Week Virtual 2020 materials) // Medical Alphabet. 2021; 6: 41-47 // Meditsinskiy alfavit. 2021; 6: 41-47.]
2. Гаус О. В., Ливзан М. А. «Гастроинтестинальная» коморбидность при синдроме раздраженного кишечника // Экспериментальная и клиническая гастроэнтерология. 2021; 6 (190): 104-111. [Gaus O. V., Livzan M. A. «Gastrointestinal» comorbidity in irritable bowel syndrome // Eksperimental'naya i klinicheskaya gastroenterologiya. 2021; 6 (190): 104-111.]
3. Гаус О. В., Ливзан М. А., Турчанинов Д. В. и др. Абдоминальная боль у лиц молодого возраста // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021; 31 (3): 25-35. [Gaus O. V., Livzan M. A., Turchaninov D. V. i dr. Abdominal pain in young people // Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2021; 31 (3): 25-35.]
4. Benjak Horvat I., Gobin I., Kresović A. et al. How can probiotic improve irritable bowel syndrome symptoms? // World J Gastrointest Surg. 2021; 13 (9): 923-940.
5. Lozupone C. A., Stombaugh J. I., Gordon J. I. et al. Diversity, stability and resilience of the human gut microbiota // Nature. 2012; 489: 220-230.
6. Grenham S., Clarke G., Cryan J. F. et al. Brain-gut-microbe communication in health and disease // Front Physiol. 2011; 2: 94.
7. Bellini M., Gambaccini D., Stasi C. et al. Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy // World J Gastroenterol. 2014; 20: 8807-8820.
8. Tap J., Derrien M., Törnblom H. et al. Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome // Gastroenterology. 2017; 152: 111-123.
9. Rajilić-Stojanović M., Biagi E., Heilig H. G. et al. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome // Gastroenterology. 2011; 141: 1792-1801.
10. Гаус О. В., Ливзан М. А., Гавриленко Д. А. Постинфекционный синдром раздраженного кишечника: время ренессанса? // Медицинский алфавит. 2021; 35: 50-56. [Gaus O. V., Livzan M. A., Gavrilenko D. A. Post-infectious irritable bowel syndrome: time for a renaissance? // Meditsinskiy alfavit. 2021; 35: 50-56.]
11. Федорин М. М., Гаус О. В., Ливзан М. А. и др. Лица с избыточной массой тела и СРК имеют характерные пищевые привычки и повышенный уровень кишечной проницаемости // Экспериментальная и клиническая гастроэнтерология. 2021; 6 (190): 50-56. [Fedorin M. M., Gaus O. V., Livzan M. A. i dr. Persons with overweight and IBS have characteristic eating habits and an increased level of intestinal permeability // Eksperimental'naya i klinicheskaya gastroenterologiya. 2021; 6 (190): 50-56.]
12. Ахмедов В. А., Гаус О. В. COVID-19 и кишечная микробиота: учебное пособие. М.: Прима Принт, 2022. 72 с. [Akhmedov V. A., Gaus O. V. COVID-19 and intestinal microbiota: a textbook. M.: Prima Print, 2022. p 72]
13. Ивашкин В. Т., Маев И. В., Шелыгин Ю. А. и др. Диагностика и лечение синдрома раздраженного кишечника (Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России) // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021; 31 (5): 74-95. [Ivashkin V. T., Mayev I. V., Shelygin Yu. A. i dr. Diagnosis and treatment of irritable bowel syndrome (Clinical recommendations of the Russian Gastroenterological Association and the Association of Coloproctologists of Russia) // Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2021; 31 (5): 74-95.]
14. Didari T., Mozaffari S., Nikfar S. et al. Effectiveness of probiotics in irritable bowel syndrome: updated systematic review with meta-analysis // World J Gastroenterol. 2015; 21: 3072-3084.
15. Johnsen P. H., Hilpüsch F., Valle P. C. et al. The effect of fecal microbiota transplantation on IBS related quality of life and fatigue in moderate to severe non-constipated irritable bowel: secondary endpoints of a double blind, randomized, placebo-controlled trial // EBioMedicine. 2020; 51: 102562.
16. Marlicz W., Skonieczna-Żydecka K., Krynicka P. et al. Probiotics in irritable bowel syndrome – is the quest for the right strain over? Rapid review of existing guidelines and recommendations // G. Prz Gastroenterol. 2021; 16 (4): 369-382.
17. Wollny T., Daniluk T., Piktel E. et al. Targeting the Gut Microbiota to Relieve the Symptoms of Irritable Bowel Syndrome // Pathogens. 2021; 10 (12): 1545.
18. Rivière A., Gagnon M., Weckx S. et al. Mutual cross-feeding interactions between Bifidobacterium longum subsp. longum NCC2705 and Eubacterium rectale ATCC 33656 explain the bifidogenic and butyrogenic effects of arabinoxylan oligosaccharides // Appl Environ Microbiol. 2015; 81: 7767-7781.
19. Le Morvan de Sequeira C., Kaeber M., Cekin S. E. et al. The Effect of Probiotics on Quality of Life, Depression and Anxiety in Patients with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis // J Clin Med. 2021; 10 (16): 3497.
Review
For citations:
Akhmedov V.A., Gaus O.V. Possibilities of modern probiotic therapy in the treatment of patients with post-infectious irritable bowel syndrome. Lechaschi Vrach. 2022;(2):32-35. (In Russ.) https://doi.org/10.51793/OS.2022.25.2.005
Views:
267
JATS XML
Email this article 
