Chronic tick-borne encephalitis
https://doi.org/10.51793/OS.2021.69.42.002
Abstract
The article is devoted to Kozhevnikov's epilepsy, one of the most common and, in fact, pathognomonic manifestations of the chronic course of tick-borne encephalitis. The stages in its development, the types of the course of the formed Kozhevnikovskaya epilepsy, and approaches to therapy are described. This material presents a unique case of chronic tick-borne encephalitis (TBE) (47 years from the beginning of the disease and more than 30 years after vaccination). It is shown that the delayed development of severe neurological symptoms and disease progression occur against the background of dysimmunoglobulinemia. The strain isolated from the patient had high neurovirulence for white mice, was highly neuroinvasive, and belong to the Siberian subtype of tick-borne encephalitis virus (TBEV). As TBE progressed, a polystrain immune response and a stressed immune response with high antibody avidity developed (30-32 years after vaccination). In the neurological status – pecular postencephalitic changes with elements of cortical motor epilepsy. No significant cognitive defect was detected.
About the Authors
E. G. Demianovskaia
Clinical Hospital of Infectious Diseases No. 1, Moscow Healthcare Agency; Central state medical Academy of Department of President Affairs
Россия
Россия
Moscow
V. V. Pogodina
Chumakov Federal Scientific Center for Research and Development of Immune-And-Biological Products, Russian Academy of Sciences
Россия
Россия
Moscow
N. G. Bochkova
Chumakov Federal Scientific Center for Research and Development of Immune-And-Biological Products, Russian Academy of Sciences
Россия
Россия
Moscow
E. I. Naumov
Aldan Central Hospital
Россия
Россия
Aldan (Saha Yakutia)
T. A. Snitur
Aldan Central Hospital
Россия
Россия
Aldan (Saha Yakutia)
L. S. Levina
Chumakov Federal Scientific Center for Research and Development of Immune-And-Biological Products, Russian Academy of Sciences
Россия
Россия
Moscow
M. S. Szherbinina
Chumakov Federal Scientific Center for Research and Development of Immune-And-Biological Products, Russian Academy of Sciences
Россия
Россия
Moscow
A. S. Vasiliev
Central state medical Academy of Department of President Affairs
Россия
Россия
Moscow
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Review
For citations:
Demianovskaia E.G., Pogodina V.V., Bochkova N.G., Naumov E.I., Snitur T.A., Levina L.S., Szherbinina M.S., Vasiliev A.S. Chronic tick-borne encephalitis. Lechaschi Vrach. 2021;(5):10-13. (In Russ.) https://doi.org/10.51793/OS.2021.69.42.002
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