Safe approaches to modulating the immune response in recurrent acute respiratory infections in young children

The article presents materials on the effectiveness and safety of food products enriched with pre – and probiotic components, vitamins and trace elements for the prevention of acute respiratory infections (ARI) and as a therapeutic food in young children. Data on the role of bifidobacteria BB-12, inulin, vitamins and trace elements in the formation of the immune response are presented. The results of modern studies confirming the importance of these components in childhood are shown. Data on products enriched with components necessary for the prevention of acute respiratory infections are presented. It was shown that preventive intake of food products enriched with bifidobacteria BB-12, inulin, vitamins, macro-and microelements calcium, D3, safely modulates the activity of the immune system, which provides prevention of repeated episodes of ari in young children. The inclusion in the diet of foods enriched with probiotics, vitamins and trace elements in ARI significantly accelerates recovery and the period of convalescence. Fermented milk drink immunobaby for children older than 8 months, enriched with prebiotic (inulin), sourdough of lactic acidophilus bacilli, probiotic (bifidobacteria BB-12), vitamin and mineral complex containing Zn and vitamin D3, can be recommended for permanent, preventive and therapeutic nutrition of young children. Juice-containing drink for children older than 12 months enriched with prebiotic – inulin, minerals (calcium, iron) and vitamins (C, E, A, D3) is an additional source of necessary trace elements both during the period of ARI disease and during convalescence. The effectiveness of the drink is clinically proven. The composition of drinking yoghurts for children older than 8 months, enriched with prebiotic – inulin, and probiotic (bifidobacteria BB-12) can provide natural aid to digestion both in the acute period of infection, with pronounced antibiotic therapy, and for preventive purposes. The effectiveness is clinically proven. 

1. Ruzhenсova T. A., Abdrashitov D. R., Meshkova N. A., Gorelov A. V. Ispol`zovanie probiotikov v profilaktike sezonny`x ostry`x respiratorny`x infekcij [Use of probiotics in the prevention of seasonal acute respiratory infections] // Russkij medicinskij zhurnal. 2019; 3: 22-24.

2. Evsiutina Iu. V. Probiotiki v profilaktike i lechenii zabolevanii zheludochno-kishechnogo trakta [Probiotics in the prevention and treatment of diseases of the gastrointestinal tract] // Russkiy meditsinskiy zhurnal. Meditsinskoe obozrenie. 2018; 2 (3): 18-22. https://www.rmj.ru/articles/gastroenterologiya/Probiotiki_vprofilaktikeilechenii_zabolevaniygheludochno-kishechnogo_trakta/.

3. Guarner F., Sanders M. E., Eliakim R. et al. World Gastroenterology Organization practice guideline: Probiotics and prebiotics. 2017. Режим доступа: https: //www.worldgastroenterology.org/UserFiles/ file/guidelines/probiotics-and-prebiotics-russian-2017.pdf.

4. Ruzhentsova T. A. Rol' probiotikov v formirovanii immuniteta [The role of probiotics in the formation of immunity] The Lechaschy Vrach Journal. 2018; (4): 27-30. Rezhim dostupa: https://www.lvrach.ru/2018/04/15436940/.

5. Andreeva I. V., Dovgan E. V., Stetsyuk O. U. Sovremennye podkhody k profilakticheskomu i lechebnomu ispolzovaniyu probiotikov pri infektsionnykh zabolevaniyakh v pediatricheskoi praktike [Modern approaches to preventive and therapeutic use of probiotics in infectious diseases in pediatric practice] // Meditsinskiy alfavit. 2017; 2 (19): 16-21. (In Russ.) Available at: https://www.elibrary.ru/item.asp?id=30674757.

6. Andreyeva I. V. Dokazatel'noye obosnovaniye primeneniya probiotikov dlya lecheniya i profilaktiki zabolevaniy ZHKT [Evidence-based substantiation of the use of probiotics for the treatment and prevention of gastrointestinal diseases] Meditsinskiy sovet. 2007; (3): 60-63. Rezhim dostupa: https://cyberleninka.ru/article/n/dokazatelnoeobosnovanie-primeneniya-probiotikov-dlya-lecheniya-i-profilaktikizabolevaniy-zhkt/viewer.

7. Lohner S., Jakobik V., Mihályi K., Soldi S., Vasileiadis S., Theis S., Sailer M., Sieland C., Berényi K., Boehm G. // The Journal of Nutrition. 2018; 148 (8): 1300-1308. https://doi.org/10.1093/jn/nxy120.