Current treatment of pharyngeal diseases

Background. Pathology of ENT organs has an important medical and social significance, which is explained by the impact on a number of indicators characterizing the level of quality of life. The increase in life expectancy of the population leads to the fact that otolaryngological complaints come to the forefront in the practice of doctors. Analysis of ENT diseases, conducted by a number of domestic and foreign researchers, indicates a high level of both acute and chronic diseases: in 1st place – diseases of the throat, in 2nd place – diseases of the nose and paranasal sinuses, in 3rd place – diseases of the ear, in 4th place – diseases of the larynx. A tendency was noted for more frequent registration of diseases of the ear, throat, nose in men compared to women. Most often, patients who received medical care were in the age range of 18-30 years. Thus, diseases of the throat occupy the first place in the structure of ENT diseases. There is an annual increase in infectious and inflammatory diseases of the pharynx, and despite the fact that most of these diseases do not require systemic antibacterial therapy, they significantly reduce the quality of life of patients and require treatment. Local drugs for the treatment of sore throat are preferable for both patients and doctors due to their ease of use and fewer side effects. A separate large group consists of patients who have undergone surgical treatment of pharyngeal diseases (tonsillectomy, adenotomy, various types of uvulopalatoplasty), who have severe pain syndrome persists in the early postoperative period and who need local treatment.

Conclusion. This article discusses the main diseases of the pharynx, diagnostic and treatment methods. Particular attention is paid to promising new methods of topical treatment. The pharmacological properties, mechanism of action, indications for use, as well as clinical aspects and prospects for the use of the topical antiseptic ambazone monohydrate in the practice of an otolaryngologist are considered.

1. Atagulova G. Zh. Treatment and prevention of chronic tonsillitis. Meditsina i ekologiia. 2012; 2: 93-96. URL: https://cyberleninka.ru/article/n/lechenie-iprofilaktika-hronicheskogo-tonzillita. (In Russ.)

2. Drozdova M. V., Preobrazhenskaya Yu. S., Ryazantsev S. V., Pavlova S. S. Inflammatory diseases of the pharynx in children. Meditsinskii sovet. 2022; 16 (1): 51-57. URL: https://cyberleninka.ru/article/n/vospalitelnyezabolevaniya-glotki-u-detey. (In Russ.)

3. Karpishchenko S. A., Baranskaya S. V. Use of topical combined antiseptic and analgesic drugs in the treatment of pharyngitis. Consilium Medicum. 2015; 3: 75-78. URL: https://cyberleninka.ru/article/n/primenenie-topicheskih-kombinirovannyhantisepticheskih-i-analgeziruyuschih-preparatov-pri-lechenii-faringita. (In Russ.)

4. Shevchik E. A., Nikiforova G. N., Bidanova D. B. Topical therapy of inflammatory diseases of the pharynx. Meditsinskii Sovet. 2016; (18): 121-123. URL: https://cyberleninka.ru/article/n/topicheskaya-terapiya-vospalitelnyh-zabolevaniy-glotki. (In Russ.)

5. Kondrashev P. A., Ertel A. I. Local complications of chronic tonsillitis and their place in the structure of urgent pathology of ENT organs. Rossiiskaia otorinolaringologiia. 2015; 2 (75): 40-42. URL: https://cyberleninka.ru/article/n/mestnye-oslozhneniya-hronicheskogo-tonzillita-i-ih-mesto-v-strukture-urgentnoypatologii-lororganov. (In Russ.)

6. Mirhonov, Zh. A., Usmanova, N. A. Local complications of chronic tonsillitis. Ekonomika i sotsium. 2023; 6 (109)-2: 843-847. URL: https://cyberleninka.ru/article/n/mestnye-oslozhneniya-hronicheskogo-tonzillita. (In Russ.)

7. Karapetyan L. S., Gafurova L. G., Starostina S. V. Prevention of infectious and inflammatory diseases in early postoperative management of patients after uvulopalatoplasty. Meditsinskii sovet. 2025; 19 (7): 124-128. https://doi.org/10.21518/ms2025-181. (In Russ.)

8. Petrova L. G. Principles of treatment of inflammatory diseases of the pharynx. Meditsinskie novosti. 2021; 4: 19-22. URL: https://cyberleninka.ru/article/n/printsipy-lecheniya-vospalitelnyh-zabolevaniy-glotki. (In Russ.)

9. Luchsheva Yu. V., Kunelskaya N. L., Izotova G. N. Local therapy for various forms of pharyngitis. Meditsinskii sovet. 2012; 12: 88-92. URL: https://cyberleninka.ru/article/n/mestnaya-terapiya-pri-razlichnyh-formah-faringita. (In Russ.)

10. Gostry A. V., Simonova A. V., Mikhailova N. A., Snimshchikova I. A., et al. Chronic pharyngitis: etiology, pathogenesis, treatment. New approaches to assessing etiopathogenesis. Arkhiv vnutrennei meditsiny. 2019; 9 (1): 32-43. URL: https://cyberleninka.ru/article/n/hronicheskiy-faringit-etiologiyapatogenez-lechenie-novye-podhody-k-otsenke-etiopatogeneza. (In Russ.)

11. Nacherov P., Ryazantsev S. Etiological and pathogenetic diagnosis of chronic tonsillitis. Vrach. 2018; 29 (3): 26-29. URL: https://cyberleninka.ru/article/n/etiologicheskaya-i-patogeneticheskaya-diagnostika-hronicheskogo-tonzillita. (In Russ.)

12. Goffman V. V., Pluzhnikov N. N. Current views on the etiopathogenesis of chronic tonsillitis. Rossiiskaia otorinolaringologiia. 2014; 3 (70): 34-39. URL: https:// cyberleninka.ru/article/n/sovremennye-predstavleniya-ob-etiopatogenezehronicheskogo-tonzillita. (In Russ.)

13. Zaitseva S. V., Zastrozhina A. K., Kulikova E. V. Acute tonsillitis in pediatric practice. Meditsinskii sovet. 2019; 2: 113-119. URL: https://cyberleninka.ru/article/n/ostryy-tonzillit-v-praktike-vracha-pediatra. (In Russ.)

14. Chronic tonsillitis. Clinical guidelines of the Ministry of Health of the Russian Federation. 2024. National Medical Association of Otorhinolaryngologists. Interregional public organization "Alliance of Clinical Chemotherapists and Microbiologists." Interregional public organization "Association of ENT Pediatricians." (In Russ.)

15. Acute tonsillitis and pharyngitis (acute tonsillopharyngitis). Clinical guidelines of the Ministry of Health of the Russian Federation. 2023. National Medical Association of Otorhinolaryngologists, Interregional Public Organization "Alliance of Clinical Chemotherapists and Microbiologists," Interregional Public Organization “Association of ENT Pediatricians." (In Russ.)

16. Tilis S. Yu. Stomatites. Meditsinskaia sestra. 2010; 2: 22-23. URL: https://cyberleninka.ru/article/n/stomatity. (In Russ.)

17. Bakhramova F., Absalamova N., Abdukadirova N. Features of the course and treatment of stomatitis in pregnant women. CARJIS. 2024; 1 (2): 23-30. URL: https://cyberleninka.ru/article/n/osobennosti-techeniya-i-lecheniyastomatitov-u-beremennyh-1. (In Russ.)

18. Khodzhamova E. B., Gulgeldiyev M. M. Conservative treatment of chronic tonsillitis. Vestnik nauki. 2025; 3 (84): 588-591. URL: https://cyberleninka.ru/article/n/konservativnoe-lechenie-hronicheskogo-tonzillita-1. (In Russ.)

19. Gurov A. V., Muzhichkova A. V., Kelemetov A. A. Current issues in the treatment of chronic tonsillitis. Meditsinskii sovet. 2021; 6: 67-73. URL: https://cyberleninka.ru/article/n/aktualnye-voprosy-lecheniya-hronicheskogo-tonzillita. (In Russ.)

20. Volkov E. A., Butova V. G., Pozdnyakova T. I., Dzugaeva I. I. Clinical recommendations (treatment protocol) for chronic recurrent aphthous stomatitis. Rossiiskii stomatologicheskii zhurnal. 2014; 5: 35-49. URL: https://cyberleninka.ru/article/n/klinicheskie-rekomendatsii-protokollecheniya-hronicheskiy-retsidiviruyuschiy-aftoznyy-stomatit. (In Russ.)

21. Shilenkova V. V. Tonsillopharyngitis: the role of local anti-inflammatory therapy. Meditsinskii sovet. 2018; 6: 56-60. URL: https://cyberleninka.ru/article/n/tonzillofaringity-rol-mestnoy-protivovospalitelnoy-terapii. (In Russ.)

22. Filippova O. V. Acute tonsillopharyngitis: possibilities of combined treatment. RMZh. Meditsinskoe obozrenie. 2024; 8 (8): 477-483. DOI: 10.32364/2587-6821-2024-8-8-6. (In Russ.)

23. Local therapy for pain syndrome in the throat. MS. 2015; 15: 50-53. URL: https://cyberleninka.ru/article/n/sredstva-mestnoy-terapii-pri-bolevomsindrome-v-glotke (In Russ.)

24. Instructions for medical use of Faringazon from the Ministry of Health of the Russian Federation – https://faringazon.ru/upload/iblock/32f/paz1ert34kghl0lxlu8nvh3k8w8as8rs.pdf (In Russ.)

25. Gergiev V. F., Svistushkin V. M., Nikiforova G. N., Timurzieva A. B. Acute infectious and inflammatory diseases of the pharynx: some aspects of diagnosis and possibilities for drug correction. MS. 2018; 8: 20-22. URL: https://cyberleninka.ru/article/n/ostrye-infektsionno-vospalitelnye-zabolevaniya-glotki-nekotoryeaspekty-diagnostiki-i-vozmozhnosti-medikamentoznoy-korrektsi. (In Russ.)

26. Svistushkin V. M., Mokoyan Zh. T., Karpova O. Yu. Possibilities of effective topical monotherapy for patients with acute tonsillopharyngitis. Consilium Medicum. 2018; 20 (11): 8-12. URL: https://cyberleninka.ru/article/n/vozmozhnosti-effektivnoytopicheskoy-monoterapii-patsientov-s-ostrym-tonzillofaringitom. (In Russ.)

27. Kharina D. V., Macharadze D. Sh. Acute tonsillopharyngitis. Rational choice of pharmacotherapy. Voprosy sovremennoi pediatrii 2013; 12 (5): 49-53. URL: https://cyberleninka.ru/article/n/ostryy-tonzillofaringit-ratsionalnyyvybor-farmakoterapii. (In Russ.)

28. Chen J. K., Niddam D. M., Tung T. H., Li L. P. Topical Triamcinolone on "Sweet Spots" to Block Dynamic Pain after Tonsillectomy and UvuloPalato-Pharyngo-Plasty. Ann OtolRhinolLaryngol. 2021; 130 (4): 382-388. DOI: 10.1177/0003489420953602. Epub 2020 Sep 10. PMID: 32909450.

29. Kladova O. V., Shamsheva O. V. Clinically proven efficacy of the antiseptic agent Faringosept (AmbaZone) over many years of use in medical practice. Praktika pediatra. 2017; 6: 66-70. (In Russ.)

30. Ryabova M. A., Ulupov M. Yu., Faizova A. R., Volchkov E. A. Selection of topical therapy in the early period after uvulopalatoplasty. Effektivnaia farmakoterapiia. 2023; 19 (49): 30-32. DOI 10.33978/2307-3586-2023-19-49-30-32. (In Russ.)

31. Zakharova I. N., Berezhnaya I. V., Kuznetsova I. V., Dubovets N. F. Possibilities of using ambazon (Faringosept) in infectious and inflammatory diseases of the oropharynx. Pediatrics. Consilium Medicum. 2024; 1: 37-42. DOI: 10.26442/26586630.2024.1.202596. (In Russ.)

32. Daikhes N. A., Baranov A. A., Lobzin Yu. V., et al. Current clinical guidelines for the management of patients with acute tonsillitis and pharyngitis. PF. 2025; 2: 164-174. URL: https://cyberleninka.ru/article/n/sovremennye-klinicheskie-rekomendatsiipo-vedeniyu-patsientov-s-ostrymi-tonzillitom-i-faringitom. (In Russ.)