Whooping cough in children under one year of age

Background. Treatment of whooping cough in children includes antibiotics that can inactivate the pathogen causing the disease. Early initiation of antibiotic therapy can help prevent complications and shorten the duration of the disease.

Objective. To study and analyze the course of whooping cough in children, depending on their vaccination. Materials and methods. We analyzed the medical records of children under the age of 1 who were undergoing inpatient treatment at the Regional Infectious Diseases Clinical Hospital named after A. M. Nichoga.

Results. In total, 437 children in the Astrakhan region had whooping cough in 2023, of which 25.6% (156 people) were under the age of 1 year. The disease was registered in all administrative territories of the Astrakhan region, with the largest number of cases of whooping cough reported in children living in the Volga, Volodarsky and Ikryaninsky districts of the region – 16, 14 and 13 cases. When clarifying the vaccination history, it was revealed that only 44.2% (69 people) were vaccinated with the DPT vaccine according to the national preventive vaccination calendar. The remaining 55.8% (87 people) were not vaccinated. The cause of the disease in all sick children is contact with the direct source of infection: family members – 90.8% (79 people), while walking with other children – 9.2% (8 people). In the observed small patients, there was a dry cough and mucous discharge from the nose. A special feature of this period was the persistence of cough: despite treatment, it gradually intensified and became paroxysmal, which meant a transition to the next period – the period of spasmodic cough.

Conclusions. Recently, the incidence of whooping cough among children has been steadily increasing. The disease is registered in all age groups. The most severe disease is manifested in unvaccinated children. The main cause of the disease is contact with the source of infection. The main complaints of all children were paroxysmal cough at night and sputum discharge.

1. Gasilina E. U. Whooping cough in children is a clinical and epidemic characteristic in the Samara region. Zhurnal infektologii. 2018; 10 (3): 54-60. (In Russ.)

2. Krasnov B. B., Ilyanenkov C. F., Pavlovich L. R., Kuzmicheva M. V. Whooping cough in infants. Detskie infektsii. 2018; 17 (1): 12-17. (In Russ.)

3. Babachenko I. V., Tyan N. S., Nesterova S. W. Whooping cough and whooping cough-like syndrome in infants. Detskie infektsii. 2021; 20. 4 (77): 53-59. (In Russ.)

4. Nikolskaya M. V., Kurmayeva D. U., Soldatkina A. E., Timofeev D. M. Clinical and epidemiological features of whooping cough in hospitalized children. Vestnik Penzenskogo gosudarstvennogo universiteta. 2019; 4 (28): 61-64. (In Russ.)

5. Basov A. A., Tsvirkun O. V., Gerasimova A. G., Zekoreeva A. H. The problem of whooping cough in some regions of the world. Infektsiya i immunitet. 2019; 9-2: 354-362. (In Russ.)

6. Sizov D. A. Features of the current course of whooping cough in children Current issues of modern medicine. Materials of the II Far Eastern Medical Youth Forum. Edited by E. N. Sazonova. 2019. С. 87-89. (In Russ.)

7. Popova O. P., Mazankova L. N., Skirda T. A., Bunin S. V., Vlasov E. V. Clinical and diagnostic features of whooping cough in older children. Rossiiskii vestnik perinatologii i pediatrii. 2019; 64-4: 70-75. (In Russ.)

8. Ovchinnikova Yu. A., Pushkareva A. S. Clinical features of whooping cough in children. Forcipe. 2019; 2-S1: 451. (In Russ.)

9. Kramarev S. A., Buckwheat E. O. Whooping cough, diphtheria and tetanus: everything new is well-forgotten old (review of modern international recommendations). Aktualnaya infektologiya. 2020; 8-1: 54-61. (In Russ.)

10. Biryukova A. A. Parents' attitude to vaccine prevention of whooping cough in children. Byulleten Severnogo gosudarstvennogo meditsinskogo universiteta. 2017; 2-1 (37): 22-23. (In Russ.)

11. Korneeva V. V., Guseva P. M. Features of the course of whooping cough in children under one year old. In the collection: Scientific session of the Russian State Medical University named after Academician E. A. Wagner. materials of a scientific and practical conference with international participation of students, residents, postgraduates, and young scientists (under 35 years of age). Perm, 2024. Р. 198-199. (In Russ.)

12. Madzhonova M. J., Khodzhaeva N. M. Characteristics of clinical and laboratory parameters in whooping cough in children. Vestnik mediko-sotsialnogo instituta Tadzhikistana. 2021; 1 (1): 33-42. (In Russ.)

13. Shipilova N. A., Stulova M. V. Whooping cough in children in the Astrakhan region. Tverskoi meditsinskii zhurnal. 2023; 6: 106-109. (In Russ.)

14. Akhmedova N. Y. The structure of the incidence of whooping cough among young children. In the collection: The best research paper of 2024. collection of articles of the VII International Scientific Research Competition. Penza, 2024. Р. 108-113. (In Russ.)

15. Penkov A. S., Denisyuk N. B., Kaikova O. V. Clinical and epidemiological features of whooping cough in children in Orenburg. Meditsinskii almanakh. 2016; 2 (42): 74-76. (In Russ.).