Experience in the use of wound-healing collagen dressings in the complex treatment of venous trophic ulcers

Background. Venous trophic ulcers are a typical manifestation of decompensation of chronic venous insufficiency of the lower extremities. The causes of venous trophic ulcers are chronic vein diseases such as varicose veins of the lower limbs, pelvis, post-thrombotic disease of the lower limbs, angiodysplasias (phlebodysplasias), phlebopathies. The launch in the body of these diseases can be due to many factors: genetic, advanced age, obesity, hypodynamia, use of contraceptives, deep vein thrombosis, severe trauma to the lower extremities and so on. All these diseases and factors lead to the development of chronic venous insufficiency, accompanied by prolonged venous stasis of blood. With the progression of chronic venous disease, the appearance of trophic ulcer is a consequence of decompensation of chronic venous insufficiency. Collagen dressings have proved to be a convenient and effective wound covering capable of accelerating healing time, reducing the level of local inflammation in the wound, reducing the size of the postoperative scar. Collagen wound coverings are biodegradable porous preparations, the main component of which is collagen, usually obtained from bovine dermis. The mechanism of collagen action in wound healing is due to its stimulating effect on the proliferation of fibroblasts and their synthesis of endogenous connective tissue proteins, its ability to absorb wound secretion and turn into a soft gel on the wound surface, which is an optimal environment for reproduction and migration of wound cells.

Results. The issues of pathogenesis, manifestations and therapeutic approaches to conservative therapy of venous trophic ulcers are high-lighted, the mechanisms of the therapeutic action of collagen dressings are emphasized. A clinical example of recovery of an outpatient with a trophic ulcer against the background of post-thrombotic disease using the collagen wound healing dressing is given, and the features of dressings using collagen sponges are discussed.

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