Preclinical studies of Russian biological drugs based on technologically processed antibodies: review of foreign publications
https://doi.org/10.51793/OS.2023.26.10.010
Abstract
Background. The effectiveness, safety and mechanism of action of biological drugs manufactured on the basis of gradual technology, is an object of growing interest in scientific circles. To date, more than 500 articles have been published in the scientific literature, which are devoted to the results of the study of their pharmacological activity, mechanisms of action, and safety. At the same time, the results of a number of studies, ranging from the mechanism of action and ending with the effectiveness of drugs manufactured using the above mentioned technology (technologically processed antibodies) in vitro, ex vivo and in vivo, have been published in international highly rated journals. Using experimental and clinical approaches generally accepted for modern evidence-based medicine, it was shown that drugs based on technologically processed antibodies are not inferior in effectiveness and safety to modern drugs in the corresponding therapeutic groups and open up new opportunities in the treatment of widespread and some socially significant diseases.
Objective. This article is devoted to the review of the results of preclinical studies of technologically processed antibodies to various targets.
Results. A study of the content of a number of papers covering studies of the effectiveness and mechanism of action for drugs based on technologically processed antibodies to various targets has been conducted.
Conclusion. Publications in highly-rated peer-reviewed scientific journals with high requirements for the quality of research help demonstrate new results on this issue, which is especially important for topics related to the research of technologically processed antibodies.
About the Authors
N. F. Bunkin
Federal State Budgetary Educational Institution of Higher Education Bauman Moscow State Technical University
Россия
Россия
Nikolai F. Bunkin, Dr. of Sci. (Phys.&Math.), Professor of the Department of basic sciences
5 b. 1 2nd Baumanskaya str., Moscow, 105005
V. L. Voeikov
Federal State Budget Educational Institution of Higher Education M. V. Lomonosov Moscow State University
Россия
Россия
Vladimir L. Voeikov, Dr. of Sci. (Biol.), Professor of the Department of Bioorganic Chemisry of the Faculty of Biology
1 b. 12 Leninskie gory, Moscow, 119234
References
1. Tarasov S. A., Gorbunov E. A., Don E. S., et al. Insights into the mechanism of action of highly diluted biologics. The Journal of Immunology. 2020; 205 (5): 1345-1354. DOI: 10.4049/jimmunol.2000098.
2. Meager A. The interferons: characterization and application. Wiley-Blackwell: 2006. 460 рр.
3. Penkov N. Antibodies processed using high dilution technology distantly change structural properties of IFNγ aqueous solution. Pharmaceutics. 2021; 13 (11): 1864. DOI: 10.3390/pharmaceutics13111864.
4. Woods K. N. Modeling of protein hydration dynamics is supported by THz spectroscopy of highly diluted solutions. Frontiers in Chemistry. 2023; 11: 1131935. doi.org/10.3389/fchem.2023.1131935.
5. Jerman I., Ogrizek L., Periček Krapež V., Jan L. Physicochemical study of the molecular signal transfer of ultra-high diluted antibodies to interferon-gamma. International Journal of Molecular Sciences. 2023; 24 (15): 11961. doi.org/10.3390/ijms241511961.
6. Bunkin N., Shkirin A., Ninham B., et al. Shaking-induced aggregation and flotation in immunoglobulin dispersions: differences between water and water − ethanol mixtures. ACS Omega. 2020; 5: 14689-14701. doi.org/10.1021/acsomega.0c01444.
7. Gorbunov E. А., Nicoll J., Kachaeva E. V., et al. Subetta increases phosphorylation of insulin receptor β-subunit alone and in the presence of insulin. Nutrition & Diabetes. 2015; 5 (7): e169. DOI: 10.1038/nutd.2015.20.
8. Nicoll J., Gorbunov E. A., Tarasov S. A., Epstein O. I. Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro. International Journal of Endocrinology. 2013; 2013: 925874. DOI: 10.1155/2013/925874.
9. Petrova N. V., Tarasov S. A., Epstein O. I., et al. Highly diluted antibodies to eNOS restore endothelium function in aortic rings from hypertensive rats. Dose-Response: An International Journal. 2022; 20 (2): 15593258221099281. DOI: 10.1177/15593258221099281.
10. Don Е. S., Emelyanova A. G., Yakovleva N. N., et al. Dose-Dependent Antiviral Activity of Released-Active Form of Antibodies to Interferon-Gamma against influenza A/California/07/09(H1N1) in Murine Model. Journal of Medical Virology. 2017; 89 (5): 759-766. DOI: 10.1002/jmv.24717.
11. Еmelianova A. G., Petrova N. V., Fremez C., et al. Therapeutic potential of highly diluted antibodies in antibiotic-resistant infection. European Journal of Pharmaceutical Sciences. 2022; 173: 106161. DOI: 10.1016/j.ejps.2022.106161.
12. Bailbé D., Philippe E., Gorbunov E., et al. The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone. Journal of Diabetes Research. 2013; 2013: 763125. DOI: 10.1155/2013/763125.
13. Castagne V., Lemaire M., Kheyfets I., et al. Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat. Journal of Pharmacy and Pharmacology. 2008; 60(3):309-316.
14. Andrianov V. V., Epstein O. I., Gainutdinova T. Kh., et al. Antibodies to calciumbinding S100B protein block the conditioning of long-term sensitization in the terrestrial snail. Pharmacology, biochemistry, and behavior. 2009; 94: 37-42.
15. Chu X., Zhavbert E. S., Dugina J. L., et al. Sildenafil and a Compound Stimulating Endothelial NO Synthase Modify Sexual Incentive Motivation and Copulatory Behavior in Male Wistar and Fisher 344 Rats. The Journal of Sexual Medicine. 2008; 5: 2085-2099.
16. Chu X., Agmo A. Sexual incentive motivation in old male rats: The effects of sildenafil and a compound (Impaza) stimulating endothelial NO synthase. Pharmacology, biochemistry, and behavior. 2008; 89: 209-217.
17. Don E. S., Bobrovnik S. А., Sherriff G., et al. Advanced approach to activity evaluation for released-active forms of antibodies to interferon-gamma by enzyme-linked immunoassay. Journal of Immunoassay and Immunochemistry. 2019; 40 (3): 250-268. DOI: 10.1080/15321819.2019.1567536.
18. Mkrtumyan A., Ametov A., Demidova T., et al. A new approach to overcome insulin resistance in patients with impaired glucose tolerance: the results of a multicenter, double-blind, placebo-controlled, randomized clinical trial of efficacy and safety of Subetta. Journal of Clinical Medicine. 2022; 11 (5): 1390. DOI: 10.3390/jcm11051390.
19. Shapovalov A. V., Obukhov V. V. Some aspects of nonlinearity and self-organization In biosystems on examples of localized excitations in the DNA molecule and generalized Fisher – KPP model. Symmetry. 2018; 10 (3): 53. DOI: 10.3390/sym10030053.
Review
For citations:
Bunkin N.F., Voeikov V.L. Preclinical studies of Russian biological drugs based on technologically processed antibodies: review of foreign publications. Lechaschi Vrach. 2023;(10):66-70. (In Russ.) https://doi.org/10.51793/OS.2023.26.10.010
Views:
203
JATS XML
Email this article 
