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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2022.25.4.010</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-915</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TOPICAL THEME</subject></subj-group></article-categories><title-group><article-title>Клинические особенности коронавирусной инфекции COVID-19 у пациентов с артериальной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features of coronavirus infection COVID-19 in patients with arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Demina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демина Ирина Алексеевна, врач</p><p>125284, Москва, 2-й Боткинский пр-д, 5</p></bio><bio xml:lang="en"><p>Irina A. Demina, Doctor</p><p>5 2nd Botkin Ave., Moscow, 125284</p></bio><email xlink:type="simple">doctor.demira@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комарова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Комарова Анна Григорьевна, заместитель главного врача по медицинской части (по Региональному сосудистому центру)</p><p>125284, Москва, 2-й Боткинский пр-д, 5</p></bio><bio xml:lang="en"><p>Anna G. Komarova, Deputy Chief Medical Officer (Regional Vascular Center)</p><p>5 2nd Botkin Ave., Moscow, 125284</p></bio><email xlink:type="simple">zambotk@botkinmoscow.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilyina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ильина Мария Валерьевна, врач функциональной диагностики</p><p>125284, Москва, 2-й Боткинский пр-д, 5</p></bio><bio xml:lang="en"><p>Maria V. Ilina, Doctor of functional diagnostics</p><p>5 2nd Botkin Ave., Moscow, 125284</p></bio><email xlink:type="simple">maria467i@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3612-1889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плоскирева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ploskireva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плоскирева Антонина Александровна, д.м.н., профессор кафедры педиатрии с инфекционными болезнями у детей факультета дополнительного профессионального образования; заместитель директора по клинической работе</p><p>Scopus: 56848285800</p><p>117997, Москва, ул. Островитянова, 1</p><p>111123, Москва, ул. Новогиреевская, 3а</p></bio><bio xml:lang="en"><p>Antonina A. Ploskireva, Dr. of Sci. (Med.), Professor of the Department of Pediatrics with infectious diseases in children of the Faculty of Additional Professional Education; Deputy Director for Clinical Work</p><p>Scopus: 56848285800</p><p>1 Ostrovityanov str., Moscow, 117997</p><p>3a Novogireevskaya str., Moscow, 111123</p></bio><email xlink:type="simple">antonina@ploskireva.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственное бюджетное учреждение здравоохранения Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Budgetary Healthcare Institution S. P. Botkin City Clinical Hospital of the Moscow Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования Российский национальный исследовательский медицинский университет имени Н. И. Пирогова Министерства здравоохранения Российской Федерации; Федеральное бюджетное учреждение науки Центральный научно-иследовательский институт эпидемиологии Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education Pirogov Russian National Research Medical University Ministry of Health of the Russian Federation; Federal Budgetary Institution of Science Central Research Institute of Epidemiology of Rospotrebnadzor</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>4</issue><fpage>54</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Демина И.А., Комарова А.Г., Ильина М.В., Плоскирева А.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Демина И.А., Комарова А.Г., Ильина М.В., Плоскирева А.А.</copyright-holder><copyright-holder xml:lang="en">Demina I.A., Komarova A.G., Ilyina M.V., Ploskireva A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/915">https://journal.lvrach.ru/jour/article/view/915</self-uri><abstract><p>Пандемия коронавирусной инфекции COVID-19 по-прежнему остается значимой для современной медицинской науки и практики. В условиях пандемии COVID-19 пациенты с сопутствующей патологией, в частности артериальной гипертензией, требуют особого внимания, так как являются одними из самых уязвимых групп при этой инфекции. Это также диктует необходимость соблюдения оптимизации диагностических и клинических подходов к оказанию помощи пациентам с этой патологией. В этой связи научный и практический интерес представляет изучение течения инфекционного процесса COVID-19 у больных артериальной гипертензией. На базе Государственного бюджетного учреждения здравоохранения Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы находились под наблюдением 145 пациентов, перенесших COVID-19, у 91 из которых коронавирусная инфекция сочеталась с артериальной гипертензией, у 54 больных ее не было. Всем пациентам проводилось комплексное клинико-лабораторное обследование и осуществлялось клиническое наблюдение в динамике. Течение коронавирусной инфекции COVID-19 у пациентов с артериальной гипертензией характеризуется развитием более тяжелых пневмоний (у 5,5% пациентов с артериальной гипертензией при компьютерной томографии диагностируются поражения легких более III степени) и более выраженной дыхательной недостаточности у большего числа пациентов (у 8,8% больных с артериальной гипертензией инфекция сопровождалась развитием дыхательной недостаточности II и более степени). У пациентов с артериальной гипертензией отмечались более высокие показатели С-реактивного белка, ферритина и глюкозы, при этом изменения в лейкоцитарной формуле были сопоставимы между группами. Динамика уровня постинфекционных антител класса IgG характеризовалась постепенным снижением их уровня в течение года, при этом у больных, у которых COVID-19 протекал на фоне артериальной гипертензии, отмечались в среднем более высокие показатели постинфекционных антител класса IgG в первые месяцы после перенесенной инфекции. Развитие новой коронавирусной инфекции у пациентов с сопутствующей патологией, в частности артериальной гипертонией, требует от врача особого внимания ввиду риска развития тяжелой формы COVID-19.</p></abstract><trans-abstract xml:lang="en"><p>The COVID-19 coronavirus pandemic is significant for modern medical science and practice. Patients with concomitant pathology during the COVID-19 pandemic, in particular arterial hypertension, require special attention, as they are among the most vulnerable groups to this infection. This requires optimization of diagnostic and clinical approaches to helping patients with this pathology. In this regard, the study of the course of the infectious process COVID-19 in patients with hypertension is of scientific and practical interest. On the basis of the State Budgetary Healthcare Institution S. P. Botkin City Clinical Hospital of the Moscow Department of Health 145 patients with COVID-19 were under observation, 91 of whom had a coronavirus infection combined with arterial hypertension, 54 patients had no arterial hypertension. All patients underwent a comprehensive clinical and laboratory examination and clinical follow-up in dynamics. The course of COVID-19 coronavirus infection in patients with arterial hypertension is characterized by the development of more severe pneumonia (in 5,5% of patients with hypertension, lung lesions are diagnosed with computed tomography of more than 3 degrees) and more pronounced respiratory failure in a larger number of patients (in 8,8% with hypertension, infection was accompanied by the development of respiratory failure of 2 or more degrees). Patients with hypertension had higher rates of CRP, ferritin and glucose, while changes in the leukocyte formula were comparable between the groups. The dynamics of the level of postinfectious IgG class antibodies was characterized by a gradual decrease in their level during the year, while in patients with COVID-19 occurring against the background of hypertension, higher rates of postinfectious IgG class antibodies were observed on average in the first months after infection. The development of coronavirus infection COVID-19 in patients with particular arterial hypertension requires special attention from the doctor, due to the risk of developing a severe form of infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>SARS-CoV-2</kwd><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>артериальная гипертония</kwd><kwd>ренин-ангиотензин-альдостероновая система</kwd><kwd>клинические особенности COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SARS-CoV-2</kwd><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>arterial hypertension</kwd><kwd>renin-angiotensin-aldosterone system</kwd><kwd>clinical features of COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Li W., Moore M., Vasilieva N., et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus // Nature. 2003; 426: 450-454. DOI: https://doi.org/10.1038/nature02145.</mixed-citation><mixed-citation xml:lang="en">Li W., Moore M., Vasilieva N., et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus // Nature. 2003; 426: 450-454. DOI: https://doi.org/10.1038/nature02145.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lan J., Ge J., Yu J., et al. Structure of the SARS-CoV-2 spike receptorbinding domain bound to the ACE2 receptor // Nature. 2020; 581: 215-220. DOI: https://doi.org/10.1038/s41586-020-2180-5.</mixed-citation><mixed-citation xml:lang="en">Lan J., Ge J., Yu J., et al. Structure of the SARS-CoV-2 spike receptorbinding domain bound to the ACE2 receptor // Nature. 2020; 581: 215-220. DOI: https://doi.org/10.1038/s41586-020-2180-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Walls A. C., et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein // Cell. 2020; 181: 281-292. DOI: https://doi.org/10.1016/j.cell.2020.02.058.</mixed-citation><mixed-citation xml:lang="en">Walls A. C., et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein // Cell. 2020; 181: 281-292. DOI: https://doi.org/10.1016/j.cell.2020.02.058.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Li F., Li W., Farzan M., Harrison S. C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor // Science. 2005; 309: 1864-1868. DOI: https://doi.org/10.1126/science.1116480.</mixed-citation><mixed-citation xml:lang="en">Li F., Li W., Farzan M., Harrison S. C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor // Science. 2005; 309: 1864-1868. DOI: https://doi.org/10.1126/science.1116480.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Q., Zhang Y., Wu L., Niu S., et al. Structural and functional basis of SARS-CoV-2 entry by using human ACE2 // Cell. 2020; 181 (4): 894-904. DOI: https://doi.org/10.1016/j.cell.2020.03.045.</mixed-citation><mixed-citation xml:lang="en">Wang Q., Zhang Y., Wu L., Niu S., et al. Structural and functional basis of SARS-CoV-2 entry by using human ACE2 // Cell. 2020; 181 (4): 894-904. DOI: https://doi.org/10.1016/j.cell.2020.03.045.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lei C., Qian K., Li T., Zhang S., et al. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig // Nat Commun. 2020; 11 (1): 2070. DOI: https://doi.org/10.1038/s41467-020-16048-4.</mixed-citation><mixed-citation xml:lang="en">Lei C., Qian K., Li T., Zhang S., et al. Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig // Nat Commun. 2020; 11 (1): 2070. DOI: https://doi.org/10.1038/s41467-020-16048-4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Donoghue M., Hsieh F., Baronas E., et al. A novel angiotensin-converting enzyme-relatedcarboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 // Circ Res. 2000; 87: E1-9. DOI: 10.1161/01.res.87.5.e1.</mixed-citation><mixed-citation xml:lang="en">Donoghue M., Hsieh F., Baronas E., et al. A novel angiotensin-converting enzyme-relatedcarboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 // Circ Res. 2000; 87: E1-9. DOI: 10.1161/01.res.87.5.e1.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Santos R. A. S., Sampaio W. O., Alzamora A. C., Motta-Santos D., Alenina N., Bader M., et al. The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) // Physiological Reviews. 2018; 98 (1): 505-553. DOI: 10.1152/physrev.00023.2016.</mixed-citation><mixed-citation xml:lang="en">Santos R. A. S., Sampaio W. O., Alzamora A. C., Motta-Santos D., Alenina N., Bader M., et al. The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) // Physiological Reviews. 2018; 98 (1): 505-553. DOI: 10.1152/physrev.00023.2016.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Голухова Е. З., Сливнева И. В., Рыбка М. М., Мамалыга М. Л., Алехин М. Н., Ключников И. В. и др. Легочная гипертензия как фактор оценки риска неблагоприятного исхода у пациентов с COVID-19 // Российский кардиологический журнал. 2020; 12 (25): 121-133.</mixed-citation><mixed-citation xml:lang="en">Golukhova Ye. Z., Slivneva I. V., Rybka M. M., Mamalyga M. L., Alekhin M. N., Klyuchnikov I. V. i dr. Pulmonary hypertension as a risk factor for adverse outcomes in patients with COVID -19 // Rossiyskiy kardiologicheskiy zhurnal. 2020. T. 25, № 12. P. 121-133.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Самсонова М. В., Михалева Л. М., Зайратьянц О. В., Варясин В. В., Быканова А. В., Мишнев О. Д. и др. Патология легких при COVID-19 в Москве // Архив патологии. 2020; 4 (82): 32-40. DOI: https://doi.org/10.17116/patol20208204132.</mixed-citation><mixed-citation xml:lang="en">Samsonova M. V., Mikhaleva L. M., Zayrat'yants O. V., Varyasin V. V., Bykanova A. V., Mishnev O. D. i dr. Pulmonary pathology in COVID-19 in Moscow // Arkhiv patologii. 2020. T. 82, № 4. P. 32-40.] DOI: https://doi.org/10.17116/patol20208204132</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y. Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury // Virologica Sinica. 2020; 35 (3): 256-258. DOI: 10.1007/s12250-020-00205-6.</mixed-citation><mixed-citation xml:lang="en">Wu Y. Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury // Virologica Sinica. 2020; 35 (3): 256-258. DOI: 10.1007/s12250-020-00205-6.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hamming I., Timens W., Bulthuis M., Lely A., Navis G., van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis // The Journal of Pathology. 2004; 203 (2): 631-637. DOI: 10.1002/path.1570.</mixed-citation><mixed-citation xml:lang="en">Hamming I., Timens W., Bulthuis M., Lely A., Navis G., van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis // The Journal of Pathology. 2004; 203 (2): 631-637. DOI: 10.1002/path.1570.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Alcocer-Díaz-Barreiro L., Cossio-Aranda J., Verdejo-Paris J., Odinde-Los-Ríos M., Galván-Oseguera H., Álvarez-López H. et al. COVID-19 and the renin, angiotensin, aldosterone system. A complex relationship // Arch. Cardiol. Mex. 2020. Vol. 90, suppl. P. 19-25. DOI: https://doi.org/10.24875/ACM.M20000063.</mixed-citation><mixed-citation xml:lang="en">Alcocer-Díaz-Barreiro L., Cossio-Aranda J., Verdejo-Paris J., Odinde-Los-Ríos M., Galván-Oseguera H., Álvarez-López H. et al. COVID-19 and the renin, angiotensin, aldosterone system. A complex relationship // Arch. Cardiol. Mex. 2020. Vol. 90, suppl. P. 19-25. DOI: https://doi.org/10.24875/ACM.M20000063.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S., Qin M., Cai Y., Liu T., Shen B., Yang F. et al. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 // European Heart Journal. 2020; 41 (22): 2070-2079. DOI: 10.1093/eurheartj/ehaa408.</mixed-citation><mixed-citation xml:lang="en">Shi S., Qin M., Cai Y., Liu T., Shen B., Yang F. et al. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 // European Heart Journal. 2020; 41 (22): 2070-2079. DOI: 10.1093/eurheartj/ehaa408.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sala S., Peretto G., Gramegna M., Palmisano A., Villatore A., Vignale D. et al. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection // European Heart Journal. 2020; 41 (19): 1861-1862. DOI: 10.1093/eurheartj/ehaa286.</mixed-citation><mixed-citation xml:lang="en">Sala S., Peretto G., Gramegna M., Palmisano A., Villatore A., Vignale D. et al. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection // European Heart Journal. 2020; 41 (19): 1861-1862. DOI: 10.1093/eurheartj/ehaa286.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ueki Y., Otsuka T., Windecker S., Räber L. ST-elevation myocardial infarction and pulmonary embolism in a patient with COVID-19 acute respiratory distress syndrome // European Heart Journal. 2020; 41 (22): 2134. DOI: 10.1093/eurheartj/ehaa399.</mixed-citation><mixed-citation xml:lang="en">Ueki Y., Otsuka T., Windecker S., Räber L. ST-elevation myocardial infarction and pulmonary embolism in a patient with COVID-19 acute respiratory distress syndrome // European Heart Journal. 2020; 41 (22): 2134. DOI: 10.1093/eurheartj/ehaa399.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Erquicia P., Dobarro D., Raposeiras-Roubín S., Bastos Fernandez G., Iñiguez-Romo A. Multivessel coronary thrombosis in a patient with COVID-19 pneumonia // European Heart Journal. 2020; 41 (22): 2132. DOI: 10.1093/eurheartj/ehaa393.</mixed-citation><mixed-citation xml:lang="en">Dominguez-Erquicia P., Dobarro D., Raposeiras-Roubín S., Bastos Fernandez G., Iñiguez-Romo A. Multivessel coronary thrombosis in a patient with COVID-19 pneumonia // European Heart Journal. 2020; 41 (22): 2132. DOI: 10.1093/eurheartj/ehaa393.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandez Gasso L., Maneiro Melon N. M., Sarnago Cebada F., Solis J., Garcia Tejada J. Multivessel spontaneous coronary artery dissection presenting in a patient with severe acute SARS-CoV-2 respiratory infection // European Heart Journal. 2020; 41 (32): 3100-3101. DOI: 10.1093/eurheartj/ehaa400.</mixed-citation><mixed-citation xml:lang="en">Fernandez Gasso L., Maneiro Melon N. M., Sarnago Cebada F., Solis J., Garcia Tejada J. Multivessel spontaneous coronary artery dissection presenting in a patient with severe acute SARS-CoV-2 respiratory infection // European Heart Journal. 2020; 41 (32): 3100-3101. DOI: 10.1093/eurheartj/ehaa400.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // The Lancet. 2020; 395 (10229): 1054-1062. DOI: 10.1016/S0140-6736(20)30566-3.</mixed-citation><mixed-citation xml:lang="en">Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // The Lancet. 2020; 395 (10229): 1054-1062. DOI: 10.1016/S0140-6736(20)30566-3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time // The Lancet Infectious Diseases. 2020; 20 (5): 533-534. DOI: 10.1016/S1473-3099(20)30120-1.</mixed-citation><mixed-citation xml:lang="en">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time // The Lancet Infectious Diseases. 2020; 20 (5): 533-534. DOI: 10.1016/S1473-3099(20)30120-1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Clerkin K. J., Fried J. A., Raikhelkar J., Sayer G., Griffin J. M., Masoumi A. et al. COVID-19 and Cardiovascular Disease // Circulation. 2020; 141 (20): 1648-1655. DOI: 10.1161/CIRCULATIONAHA.120.04694.</mixed-citation><mixed-citation xml:lang="en">Clerkin K. J., Fried J. A., Raikhelkar J., Sayer G., Griffin J. M., Masoumi A. et al. COVID-19 and Cardiovascular Disease // Circulation. 2020; 141 (20): 1648-1655. DOI: 10.1161/CIRCULATIONAHA.120.04694.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Li X., Xu S., Yu M., Wang K., Tao Y., Zhou Y. et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan // Journal of Allergy and Clinical Immunology. 2020; 146 (1): 110-118. DOI: 10.1016/j.jaci.2020.04.006.</mixed-citation><mixed-citation xml:lang="en">Li X., Xu S., Yu M., Wang K., Tao Y., Zhou Y. et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan // Journal of Allergy and Clinical Immunology. 2020; 146 (1): 110-118. DOI: 10.1016/j.jaci.2020.04.006.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Cai Q., Chen F., Wang T., Luo F., Liu X., Wu Q. et al. Obesity and CO-VID-19 Severity in a Designated Hospital in Shenzhen, China // Diabetes Care. 2020; 43 (7): 1392-1398. DOI: 10.2337/dc20-0576.</mixed-citation><mixed-citation xml:lang="en">Cai Q., Chen F., Wang T., Luo F., Liu X., Wu Q. et al. Obesity and CO-VID-19 Severity in a Designated Hospital in Shenzhen, China // Diabetes Care. 2020; 43 (7): 1392-1398. DOI: 10.2337/dc20-0576.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Simonnet A., Chetboun M., Poissy J., Raverdy V., Noulette J., Duhamel A. et al. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation // Obesity. 2020; 28 (7): 1195-1199. DOI: 10.1002/oby.22831.</mixed-citation><mixed-citation xml:lang="en">Simonnet A., Chetboun M., Poissy J., Raverdy V., Noulette J., Duhamel A. et al. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation // Obesity. 2020; 28 (7): 1195-1199. DOI: 10.1002/oby.22831.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Shi Y., Yu X., Zhao H., Wang H., Zhao R., Sheng J. Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan // Critical Care. 2020; 24 (1): 108. DOI: 10.1186/s13054-020-2833-7.</mixed-citation><mixed-citation xml:lang="en">Shi Y., Yu X., Zhao H., Wang H., Zhao R., Sheng J. Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan // Critical Care. 2020; 24 (1): 108. DOI: 10.1186/s13054-020-2833-7.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S. et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China // JAMA Internal Medicine. 2020; 180 (7): 934-43. DOI: 10.1001/jamainternmed.2020.0994.</mixed-citation><mixed-citation xml:lang="en">Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S. et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China // JAMA Internal Medicine. 2020; 180 (7): 934-43. DOI: 10.1001/jamainternmed.2020.0994.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">European Society of Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Last updated on 10 June 2020. URL: https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance (дата обращения: 18.02.2022).</mixed-citation><mixed-citation xml:lang="en">European Society of Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Last updated on 10 June 2020. URL: https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance (дата обращения: 18.02.2022).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Centers for Disease Control and Prevention. People at Increased Risk for Severe Illness. 2020. URL: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/index.html (дата обращения: 18.02.2022).</mixed-citation><mixed-citation xml:lang="en">Centers for Disease Control and Prevention. People at Increased Risk for Severe Illness. 2020. URL: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/index.html (дата обращения: 18.02.2022).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shibata S., Arima H., Asayama K., Hoshide S., Ichihara A., Ishimitsu T. et al. Hypertension and related diseases in the era of COVID-19: are port from the Japanese Society of Hypertension Task Force on COVID-19 // Hypertension Research. 2020; 43 (10): 1028-1046. DOI: 10.1038/s41440-020-0515-0.</mixed-citation><mixed-citation xml:lang="en">Shibata S., Arima H., Asayama K., Hoshide S., Ichihara A., Ishimitsu T. et al. Hypertension and related diseases in the era of COVID-19: are port from the Japanese Society of Hypertension Task Force on COVID-19 // Hypertension Research. 2020; 43 (10): 1028-1046. DOI: 10.1038/s41440-020-0515-0.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Петри А., Сэбин К. Наглядная медицинская статистика. М.: ГЭОТАР-МЕД, 2010. 169 с.</mixed-citation><mixed-citation xml:lang="en">A. Petri, K. Sebin. Visual medical statistics. M.: GEOTAR-MED, 2010. P. 16.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Swiahb J. N., Motiwala M. A. Upper respiratory tract and otolaryngological manifestations of coronavirus disease 2019 (COVID-19): A systemic review // SAGE Open Med. 2021 May 20; 9: 20503121211016965. DOI: 10.1177/20503121211016965. PMID: 34094558; PMCID: PMC8141987.</mixed-citation><mixed-citation xml:lang="en">Al-Swiahb J. N., Motiwala M. A. Upper respiratory tract and otolaryngological manifestations of coronavirus disease 2019 (COVID-19): A systemic review // SAGE Open Med. 2021 May 20; 9: 20503121211016965. DOI: 10.1177/20503121211016965. PMID: 34094558; PMCID: PMC8141987.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
