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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2022.25.3.008</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-897</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Кардиометаболические нарушения при SARS-CoV-2-инфекции и постковидном синдроме</article-title><trans-title-group xml:lang="en"><trans-title>Cardiometabolic disorders in SARS-CoV-2 infection and post-covid syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8093-2371</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старичкова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starichkova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старичкова Анастасия Алексеевна, старший лаборант кафедры неотложной терапии с эндокринологией и профпатологией ФПК и ППВ</p><p>630091, Новосибирск, Красный проспект, 52; </p><p>630005, Новосибирск, ул. Семьи Шамшиных, 95а</p></bio><bio xml:lang="en"><p>Anastasiya A. Starichkova, Senior Laboratory Assistant, Department of Emergency Therapy with Endocrinology and Occupational Pathology, Faculty of Advanced Training and Professional Retraining of Physicians; doctor</p><p>52 Krasny Prospekt, Novosibirsk, 630091;</p><p>5 Semii Shamshin str., Novosibirsk, 630005</p></bio><email xlink:type="simple">nasyua94@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0207-7063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыганкова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsygankova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цыганкова Оксана Васильевна, д.м.н., профессор кафедры неотложной терапии с эндокринологией и профпатологией ФПК и ППВ; старший научный сотрудник лаборатории клинических биохимических и гормональных исследованийтерапевтических заболеваний</p><p>630091, Новосибирск, Красный проспект, 52;</p><p>630089, Новосибирск, ул. Б. Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Oksana V. Tsygankova, Dr. of Sci. (Med.), Professor, Department of Emergency Therapy with Endocrinology and Occupational Pathology, Faculty of Advanced Training and Professional Retraining of Physicians; Senior Researcher at the Laboratory ofClinical Biochemical and Hormonal Studies of Therapeutic Diseases</p><p>52 Krasny Prospekt, Novosibirsk, 630091;</p><p>175/1 B. Bogatkova str., Novosibirsk, 630089</p></bio><email xlink:type="simple">oksana_c.nsk@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1250-8798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хидирова</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Khidirova</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хидирова Людмила Даудовна, д.м.н., профессор кафедры фармакологии, клинической фармакологии и доказательной медицины</p><p>630091, Новосибирск, Красный проспект, 52</p></bio><bio xml:lang="en"><p>Lyudmila D. Khidirova, Dr. of Sci. (Med.), Professor, Department ofPharmacology, Clinical Pharmacology and Evidence-Based Medicine</p><p>52 Krasny Prospekt, Novosibirsk, 630091</p></bio><email xlink:type="simple">h_ludmila@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старичков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starichkov</surname><given-names>А. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старичков Алексей Алексеевич, д.м.н., профессор кафедры неотложной терапии с эндокринологией и профпатологией ФПК и ППВ</p><p>630091, Новосибирск, Красный проспект, 52</p></bio><bio xml:lang="en"><p>Aleksey A. Starichkov, Dr. of Sci. (Med.), Professor, Department ofEmergency Therapy with Endocrinology and Occupational Pathology, Faculty of Advanced Training and Professional Retraining of Physicians</p><p>52 Krasny Prospekt, Novosibirsk, 630091</p></bio><email xlink:type="simple">a.starichkov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвиненко</surname><given-names>П. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinenko</surname><given-names>P. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвиненко Полина Игоревна, заведующая отделением для взрослого населения с новой коронавирусной инфекцией COVID-19</p><p>630003, Новосибирск, ул. Владимировский спуск, 2А</p></bio><bio xml:lang="en"><p>Polina I. Litvinenko, Head of the Department for Adults with NovelCoronavirus Infection COVID-19</p><p>2A Vladimirovsky spusk str., Novosibirsk, 630003</p></bio><email xlink:type="simple">linalit@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Новосибирский&#13;
государственный медицинский университет Министерства здравоохранения Российской Федерации; Государственное бюджетное учреждение здравоохранения Новосибирской области Новосибирский областной госпиталь № 2 ветеранов войн</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Novosibirsk State Medical University of the Ministry of Health of the Russian Federation; State Budgetary Healthcare Institution of the Novosibirsk Region Novosibirsk Regional Hospital No. 2 for War Veterans</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Новосибирский&#13;
государственный медицинский университет Министерства здравоохранения Российской Федерации; Научно-исследовательский институт терапии и профилактической медицины – филиал Федерального государственного бюджетного научного учреждения Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Novosibirsk State Medical University of the Ministry of Health of the Russian Federation; Research Institute of Therapy and Preventive Medicine – branch of the Federal State Budgetary Scientific Institution Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования Новосибирский&#13;
государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Novosibirsk State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Частное учреждение здравоохранения «Клиническая больница «РЖД-Медицина» города Новосибирск»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Private healthcare institution Clinical Hospital RZD-Medicine Novosibirsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>49</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Старичкова А.А., Цыганкова О.В., Хидирова Л.Д., Старичков А.А., Литвиненко П.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Старичкова А.А., Цыганкова О.В., Хидирова Л.Д., Старичков А.А., Литвиненко П.И.</copyright-holder><copyright-holder xml:lang="en">Starichkova A.A., Tsygankova O.V., Khidirova L.D., Starichkov А.A., Litvinenko P.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/897">https://journal.lvrach.ru/jour/article/view/897</self-uri><abstract><p>С конца 2019 года мир охвачен пандемией новой коронавирусной инфекции, вызванной SARS-CoV-2. С первых дней интернациональное медицинское сообщество активно изучало острую фазу данной инфекции, однако постепенно пришло понимание того, что все более и более увеличивается количество людей с отдаленными последствиями, которые могут носить самый разнообразный, в том числе мультисистемный характер. В обзоре литературы отражены актуальные представления о краткосрочном и отсроченном влиянии инфицирования вирусом SARS-CoV-2 на развитие электролитных нарушений и течение сердечно-сосудистой патологии, в том числе развившейся de novo. Обсуждаются дискуссионные вопросы определения, факторов риска, патогенеза, течения постковидного синдрома с представлением официального термина «состояния после COVID-19» и его интерпретацией, согласно дефиниции Всемирной организации здравоохранения, предложенной осенью 2021 года. Отдельно освещаются проблемы нарушений сердечного ритма с акцентом на фибрилляцию предсердий и хроническую сердечную недостаточность, прежде всего диагностические, связанные с неспецифичностью одышки у таких  пациентов и частым повышением натрийуретических пептидов, обусловленным внесердечными причинами. Необходимо подчеркнуть, что информация о клинических исходах, прогнозе и патогенезе фибрилляции предсердий при COVID-19 пока остается противоречивой, что обусловлено, с одной стороны, влиянием виремии, интоксикации, лихорадки как очевидных транзиторных причин данного нарушения ритма, а с другой – лонгитудинальным протромботическим статусом, характерным для инфицирования SARS-CoV-2. Известно, что наибольшее количество госпитализаций и смертей в мире, ассоциированных с новой коронавирусной инфекцией, приходится на лиц пожилого и старческого возраста. Атипичность клинической картины, полиморбидность, полипрагмазия, наличие гериатрических синдромов занимают особое место в курации геронтологического контингента пациентов, к чему также привлекают внимание клиницистов авторы обзора.</p></abstract><trans-abstract xml:lang="en"><p>Since the end of 2019, the world has been gripped by a pandemic of a new coronavirus infection caused by SARS-CoV-2. From the first days, the international medical community has been actively studying the acute phase of this infection, but gradually the understanding has come that the number of people with long-term consequences, which can be of the most diverse, including multisystem nature, is increasing more and more. The review of the literature reflects current ideas about the short-term and long-term impact of infection with the SARS-CoV-2 virus on the development of electrolyte disorders and the course of cardiovascular pathology, including those that developed de novo. The debatable issues of definition, risk factors, pathogenesis, course of post-COVID syndrome are discussed with the introduction of the official term «states after COVID-19» and its interpretation, according to the World Health Organization definition proposed in the fall of 2021. Separately, the problems of cardiac arrhythmias are highlighted with an emphasis on atrial fibrillation and chronic heart failure, primarily diagnostic ones associated with non-specific dyspnea in such patients and a frequent increase in natriuretic peptides due to non-cardiac causes. It should be emphasized that information on the clinical outcomes, prognosis and pathogenesis of atrial fibrillation in COVID-19 remains controversial, which is due, on the one hand, to the influence of viremia, intoxication, and fever as obvious transient causes of this arrhythmia, and, on the other hand, to the longitudinal prothrombotic status characteristic of SARS-CoV-2 infection. It is known that the largest number of hospitalizations and deaths in the world associated with a new coronavirus infection occurs in elderly and senile people. The atypicality of the clinical picture, polymorbidity, polypharmacy, the presence of geriatric syndromes occupies a special place in the supervision of the gerontological contingent of patients, to which the authors of the review also draw the attention of clinicians.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>постковидный синдром</kwd><kwd>состояние после COVID-19</kwd><kwd>пожилой и старческий возраст</kwd><kwd>фибрилляция предсердий</kwd><kwd>сердечная недостаточность</kwd><kwd>гипокалиемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>new coronavirus infection</kwd><kwd>long covid</kwd><kwd>post COVID-19 condition</kwd><kwd>elderly and senile age</kwd><kwd>atrial fibrillation</kwd><kwd>heart failure</kwd><kwd>hypоkalemia</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа частично выполнена по Государственному заданию в рамках бюджетной темы № АААА-А17-117112850280-2</funding-statement><funding-statement xml:lang="en">The work was partially carried out according to the State task within the framework of the budget theme No. AAAA17-117112850280-2</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wu F., Zhao S., Yu B. et al. 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