The article describes the course of the cholestatic variant of congenital cytomegalovirus infection in children with an assessment of the obstetric and gynecological history of mothers and the characteristics of the newbornneonatal period. Pregnancy in women proceeded with signs of fetal-placental insufficiency, which led to the birth of children with a low gestational age, since cytomegalovirus infection developed in an acute form. The newborns had a low Apgar score and signs of hypotrophy of I-II degrees. The clinical picture of congenital cytomegalovirus hepatitis was characterized by a protracted course and had an undulating character, a complete recovery of mass-growth parameters, a symptom of jaundice took place within 3 months. It was revealed that a longer cholestasis syndrome was observed in children who had both congenital cytomegalovirus infection and impaired bilirubin uptake, in particular, Gilbert's syndrome. Ursodeoxycholic acid is the only generally accepted starting drug for the drug effect on cholestasis syndrome in children with liver disease. Complex therapy with the use of the drug Ursodeoxycholic acid at a dose of 15-20 mg/kg per day, at the early stages of treatment, this infectious pathology made it possible to stabilize the clinical and laboratory parameters. In the absence of complaints and clinical manifestations, the levels of ALT, AST and ALP were restored for a long period within 5-6 months, while the cholesterol values returned to normal by 3 months. The chosen scheme of therapy with Ursodeoxycholic acid at a dose of 15-20 mg/kg per day contributed to the prevention of severe complications from the biliary tract, such as chronic cholecystocholangitis, primary biliary cirrhosis. The use of therapeutic tactics, taking into account the individual characteristics of young children, was not accompanied by the presence of side effects.