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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51793/OS.2021.24.12.003</article-id><article-id custom-type="elpub" pub-id-type="custom">lvrach-855</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Роль недифференцированных дисплазий соединительной ткани в развитии пролапса органов малого таза</article-title><trans-title-group xml:lang="en"><trans-title>Support role undifferentiated connective tissue dysplasia in genital organ rolapse evolution</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4393-6111</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селихова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Selikhova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Селихова Марина Сергеевна – доктор медицинских наук, профессор кафедры акушерства и гинекологии.</p><p>400131, Волгоград, пл. Павших Борцов, 1.</p></bio><bio xml:lang="en"><p>Marina S. Selihova - Dr. of Sci. (Med.), Professor of the Department of Obstetrics and Gynecology at the Volgograd State Medical University of the Ministry of Health of the Russian Federation.</p><p>1 Pavshikh Bortsov Square, Volgograd, 400131.</p></bio><email xlink:type="simple">selichovamarina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2164-3537</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скворцов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skvortsov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скворцов Всеволод Владимирович - доктор медицинских наук, доцент кафедры внутренних болезней.</p><p>400131, Волгоград, пл. Павших Борцов, 1.</p></bio><bio xml:lang="en"><p>Vsevolod V. Skvortsov - Dr. of Sci. (Med.), Associate Professor of the Department of Internal Diseases at Volgograd State Medical University.</p><p>1 Pavshikh Bortsov Square, Volgograd, 400131.</p></bio><email xlink:type="simple">vskvortsov1@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ершов</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ershov</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ершов Георгий Владимирович – кандидат медицинских наук, врач высшей категории, Заслуженный врач России, заведующий гинекологическим отделением ОКБ на ст. «Волгоград-1», КБ РЖД-Медицина г. Волгоград.</p><p>400961, Волгоград, ул. Коммунистическая, 7.</p></bio><bio xml:lang="en"><p>Georgy V. Ershov - MD, doctor of the highest category, Honored Doctor of Russia, Head of the Gynecological Department Non-State Healthcare Institution «Departmental Clinical Hospital at the Volgograd-1 station of the Open Joint Stock Company “Russian Railways”», Private Founding of Health Service Clinical Hospital Russian Railroads – Medicine Volgdgrad.</p><p>7 Kommunisticheskaya str., Volgograd, 400961.</p></bio><email xlink:type="simple">info@vlg.sovamed.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ершов</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ershov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ершов Антон Георгиевич - клинический ординатор.</p><p>400131, Волгоград, пл. Павших Борцов, 1.</p></bio><bio xml:lang="en"><p>Anton G. Ershov - clinical resident at the Volgograd State Medical University of the Ministry of Health of the Russian Federation.</p><p>1 Pavshikh Bortsov Square, Volgograd, 400131.</p></bio><email xlink:type="simple">vr165@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1128-2678</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малякин</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Malyakin</surname><given-names>G. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Малякин Георгий Ильич - студент 6-го курса лечебного факультета.</p><p>400131, Волгоград, пл. Павших Борцов, 1.</p></bio><bio xml:lang="en"><p>Georgy I. Malyakin - 6th year student of the Faculty of General Medicine at the Volgograd State Medical University of the Ministry of Health of the Russian Federation.</p><p>1 Pavshikh Bortsov Square, Volgograd, 400131.</p></bio><email xlink:type="simple">manuljke@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ВолгГМУ Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>КБ РЖД-Медицина г. Волгоград</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Private Founding of Health Service Clinical Hospital Russian Railroads – Medicine Volgdgrad</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>13</day><month>01</month><year>2022</year></pub-date><volume>0</volume><issue>12</issue><fpage>22</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Селихова М.С., Скворцов В.В., Ершов Г.В., Ершов А.Г., Малякин Г.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Селихова М.С., Скворцов В.В., Ершов Г.В., Ершов А.Г., Малякин Г.И.</copyright-holder><copyright-holder xml:lang="en">Selikhova M.S., Skvortsov V.V., Ershov G.V., Ershov A.G., Malyakin G.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/855">https://journal.lvrach.ru/jour/article/view/855</self-uri><abstract><p>Одним из наиболее  значимых факторов риска формирования опущений и выпадений внутренних половых органов являются заболевания соединительной ткани. Неуклонный рост числа женщин, страдающих пролапсом органов малого таза, привел к тому, что данная патология стала как медицинской, так и социально-экономической проблемой во многих странах. В то же время данные о роли недифференцированных дисплазий соединительной ткани в развитии пролапса органов малого таза и в формировании недостаточности тазового дна и возможности использования ее с целью прогнозирования данной патологии разноречивы. С целью определения взаимосвязи проявления недифференцированных дисплазий соединительной ткани с развитием пролапса органов малого таза был проведен ретроспективный анализ 157 историй болезни пациенток с пролапсом гениталий. У 27,39% пациенток были отмечены проявления дисплазий соединительной ткани. В 39,53% случаев было выявлено сочетание проявления недифференцированных дисплазий соединительной ткани с родовым травматизмом. У 16,28% от количества случаев с родовым травматизмом и пролапсом органов малого таза выявлены  выраженные формы дисплазии соединительной ткани (варикозное расширение вен нижних конечностей, полипоз кишечника, пролапс митрального клапана), потребовавшие хирургической коррекция до беременности или после родов. Выявленная у каждой третьей пациентки, оперированной по поводу несостоятельности тазового дна, недифференцированная дисплазия соединительной ткани позволяет рассматривать ее как фактор риска развития пролапса органов малого таза, особенно в сочетании с травматизацией промежности в родах. Однако для оценки роли и значимости патологии соединительной ткани в прогнозировании формирования опущения и выпадения внутренних половых органов малого таза у женщин необходимы проспективные рандомизированные исследования.</p></abstract><trans-abstract xml:lang="en"><p>One of the most significant risk factors for the formation  of internal  genital organs is connective  tissue diseases. The steady increase in the number of women suffering from pelvic organ prolapse has led to the fact that this pathology has become both a medical and socio-economic problem in many countries. At the same time, the data on the role of undifferentiated connective tissue dysplasias in the development of pelvic organ prolapse and in the formation of pelvic floor insufficiency and the possibility of using it to predict this pathology are contradictory.  To determine the relationship between the manifestation of undifferentiated connective tissue dysplasia and the development of pelvic organ prolapse, a retrospective analysis of 157 case histories of patients with genital prolapse was carried out. In 27,39% of patients, manifestations of connective tissue dysplasia were noted. In 39,53% of cases, a combination of the manifestation of undifferentiated  connective tissue dysplasias with birth traumatism was revealed. Severe forms of connective tissue dysplasia (varicose veins of the lower extremities, intestinal polyposis, mitral valve prolapse) were found in 16,28% of the number of cases with birth traumatism and pelvic organ prolapse, which required surgical correction  before pregnancy or after childbirth. Revealed in every third patient operated on for pelvic floor incompetence, undifferentiated connective tissue dysplasias allows us to consider it as a risk factor for pelvic organ prolapse, especially in combination with perineal trauma during childbirth. However, to assess the role and significance of connective tissue pathology in predicting the formation of prolapse and prolapse of the internal genital organs of the small pelvis in a woman, prospective randomized  studies are needed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>генитальный пролапс</kwd><kwd>дисплазии соединительной ткани</kwd><kwd>факторы  риска</kwd><kwd>социально-активный возраст</kwd><kwd>хирургическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>genital prolapse</kwd><kwd>connective tissue dysplasia</kwd><kwd>risk factors</kwd><kwd>social-active age</kwd><kwd>surgical treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The Population Division Department of Economic and Social Affairs United Nations Secretariat The Ageing of the World's Population, www.un.org 2005 January [cited 2006 May 10].</mixed-citation><mixed-citation xml:lang="en">The Population Division Department of Economic and Social Affairs United Nations Secretariat The Ageing of the World's Population, www.un.org 2005 January [cited 2006 May 10].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Milsom I., Gyhagen M. 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