References

lvrach

Лечащий Врач

Lechaschi Vrach

1560-51752687-1181

10.51793/OS.2021.11.97.010

lvrach-752

Research Article

ДЕРМАТОВЕНЕРОЛОГИЯ

DERMATOVENEROLOGY

Метотрексат в дерматологии: от теории к практике

Methotrexate in dermatology: from theory to practice

Галлямова

Ю. А.

Gallyamova

Yu. A.

доктор медицинских наук, профессор

Москва

Moscow

Асоскова

А. В.

Asoskova

A. V.

Москва

Moscow

stasya.asoskova@mail.ru

ФГБОУ ДПО РМАНПО Минздрава РоссииРоссияFSBEI FPE «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of the RussiaRussian Federation

2021

21072021

054651

2021

Галлямова Ю.А., Асоскова А.В.

Gallyamova Y.A., Asoskova A.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.lvrach.ru/jour/article/view/752

Метотрексат зарекомендовал себя как высокоэффективное средство для лечения псориаза с 1953 г. Эффективность метотрексата обусловлена его цитотоксическим и противовоспалительным действием. Согласно проекту клинических рекомендаций Российского общества дерматовенерологов и косметологов применение метотрексата обосновано при многих заболеваниях кожи. Длительная история и накопленный практический опыт применения не вызывают сомнения в эффективности метотрексата, обусловленной его уникальными фармакологическими свойствами, а именно противовоспалительным, иммуномодулирующим и кумулятивным эффектами, которые позволяют препарату занимать лидирующие позиции в терапии многих кожных заболеваний. В статье подробно раскрыты метаболизм метотрексата и его фармакодинамика. Согласно обзору современных данных мировой литературы авторы представили рекомендации по лечению метотрексатом, применению его у детей, мониторингу во время лечения, а также обратили внимание на показания при особых ситуациях (инфекции, прививки, контрацепция и т. д.).

Methotrexate has established itself as a highly effective treatment for psoriasis since 1953. The effectiveness of methotrexate is due to its cytotoxic and anti-inflammatory effects. According to the draft clinical guidelines of the Russian Society of Dermatovenereologists and Cosmetologists, the use of methotrexate is justified in many skin diseases. A long history and accumulated practical experience of application do not raise doubts about the effectiveness of methotrexate due to its unique pharmacological properties, namely, antiinflammatory, immunomodulatory and cumulative effects, which allow the drug to occupy a leading position in the treatment of many skin diseases. The article describes in detail the metabolism of methotrexate and its pharmacodynamics. According to a review of modern data from the world literature, the authors presented recommendations for treatment with methotrexate, its use in children, monitoring during treatment, and also drew attention to the indications in special situations (infections, vaccinations, contraception, etc.).

псориазметотрексатмеханизм действиятоксичностьбезопасностьмониторинг безопасности

psoriasismethotrexatemechanism of actiondrug toxicitydrug safetysafety monitoring

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The authors declare that there are no conflicts of interest present.