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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">lvrach-711</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Ожирение, антибиотики и кишечная микробиота — какова связь?</article-title><trans-title-group xml:lang="en"><trans-title>Obesity, antibiotics and intestinal microbiota — how are they connected?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотникова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikova</surname><given-names>E. Yu.</given-names></name></name-alternatives><email xlink:type="simple">eka-pl@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краснов</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnov</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО КемГМУ МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>3</issue><fpage>84</fpage><lpage>84</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Плотникова Е.Ю., Краснов О.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Плотникова Е.Ю., Краснов О.А.</copyright-holder><copyright-holder xml:lang="en">Plotnikova E.Y., Krasnov O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/711">https://journal.lvrach.ru/jour/article/view/711</self-uri><abstract><p>Ожирение прогрессирует в ряде стран мира со скоростью настоящей эпидемии. Новые эпидемиологические исследования показали, что воздействие антибиотиков связано с повышенным риском набора избыточного веса и ожирения. Нарушения микрофлоры кишечника происходят не только из-за лечения антибиотиками. Антибиотики широко используются в качестве стимуляторов роста в сельском хозяйстве, они накапливаются в мясе животных и птицы, которые мы употребляем в пищу. Пробиотики являются агентами, способными модулировать и улучшать кишечную микрофлору при антибиотикотерапии.</p></abstract><trans-abstract xml:lang="en"><p>In some countries, obesity is growing at the rate of a real epidemics. New epidemiologic studies have shown that antibiotic exposure is connected to increased risk of overweight and obesity. Intestinal microflora disorders take place not only due to antibiotic therapy. Antibiotics are widely used as growth stimulators in agriculture, they are accumulated in animal and poultry meat, and we use it as food. Probiotics are the agents which can modulate and restore intestinal microflora in antibiotic therapy. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Актуальная тема</kwd><kwd>Антибактериальная терапия</kwd><kwd>Антибиотики</kwd><kwd>Гастроэнтерология</kwd><kwd>Ожирение</kwd><kwd>Пробиотики</kwd><kwd>Терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>antibiotics</kwd><kwd>antibiotic therapy</kwd><kwd>probiotics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ng M., Fleming T., Robinson M. et al. Global, regional and national prevalence of overweight and obesity in children and adults 1980–2013: a systematic analysis // Lancet (London, England). 2014; 384 (9945): 766–781.</mixed-citation><mixed-citation xml:lang="en">Ng M., Fleming T., Robinson M. et al. Global, regional and national prevalence of overweight and obesity in children and adults 1980–2013: a systematic analysis // Lancet (London, England). 2014; 384 (9945): 766–781.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Collaboration NCDRF. Trends in adult body?mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants // Lancet. 2016; 387 (10026): 1377–1396.</mixed-citation><mixed-citation xml:lang="en">Collaboration NCDRF. Trends in adult body?mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants // Lancet. 2016; 387 (10026): 1377–1396.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">NCD Risk Factor Collaboration (NCD-RisC): Mariachiara Di Cesare, James Bentham, Gretchen A. Stevens, Bin Zhou, Goodarz Danaei, Yuan Lu, Honor Bixby, Melanie J. Cowan, Leanne M. Riley, Kaveh Hajifathalian, L?a Fortunato, Cristina Taddei, James E. Bennett, Nayu Ikeda, Young Ho Khang, Catherine Kyobutungi, Avula Laxmaiah, Yanping Li, Hsien Ho Lin &amp; 31 others. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants // Lancet. 2016 Apr 2; 387 (10026): 1377–1396.</mixed-citation><mixed-citation xml:lang="en">NCD Risk Factor Collaboration (NCD-RisC): Mariachiara Di Cesare, James Bentham, Gretchen A. Stevens, Bin Zhou, Goodarz Danaei, Yuan Lu, Honor Bixby, Melanie J. Cowan, Leanne M. Riley, Kaveh Hajifathalian, L?a Fortunato, Cristina Taddei, James E. Bennett, Nayu Ikeda, Young Ho Khang, Catherine Kyobutungi, Avula Laxmaiah, Yanping Li, Hsien Ho Lin &amp; 31 others. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants // Lancet. 2016 Apr 2; 387 (10026): 1377–1396.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">DeSalle R., Perkins S. L., Wynne P. J. Welcome to the Microbiome: Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You. 2015. Yale University Press: New Haven, 264 p.</mixed-citation><mixed-citation xml:lang="en">DeSalle R., Perkins S. L., Wynne P. J. Welcome to the Microbiome: Getting to Know the Trillions of Bacteria and Other Microbes In, On, and Around You. 2015. Yale University Press: New Haven, 264 p.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tremaroli V., Backhed F. Functional interactions between the gut microbiota and host metabolism // Nature. 2012; 489 (7415): 242–249.</mixed-citation><mixed-citation xml:lang="en">Tremaroli V., Backhed F. Functional interactions between the gut microbiota and host metabolism // Nature. 2012; 489 (7415): 242–249.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ley R. E., Backhed F., Turnbaugh P., Lozupone C. A., Knight R. D., Gordon J. I. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. 2005; 102 (31): 11070–11075.</mixed-citation><mixed-citation xml:lang="en">Ley R. E., Backhed F., Turnbaugh P., Lozupone C. A., Knight R. D., Gordon J. I. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. 2005; 102 (31): 11070–11075.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Плотникова Е. Ю., Краснов О. А. Метаболический синдром и кишечная микрофлора; что общего? // Экспериментальная и клиническая гастроэнтерология. 2015; 112 (12): 64–73.</mixed-citation><mixed-citation xml:lang="en">Плотникова Е. Ю., Краснов О. А. Метаболический синдром и кишечная микрофлора; что общего? // Экспериментальная и клиническая гастроэнтерология. 2015; 112 (12): 64–73.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nieuwdorp M., Gilijamse P. W., Pai N., Kaplan L. M. Role of the microbiome in energy regulation and metabolism // Gastroenterology. 2014; 146 (6): 1525–1533.</mixed-citation><mixed-citation xml:lang="en">Nieuwdorp M., Gilijamse P. W., Pai N., Kaplan L. M. Role of the microbiome in energy regulation and metabolism // Gastroenterology. 2014; 146 (6): 1525–1533.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cani P. D., Lecourt E., Dewulf E. M. et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal // Am J Clin Nutr. 2009; 90 (5): 1236–1243.</mixed-citation><mixed-citation xml:lang="en">Cani P. D., Lecourt E., Dewulf E. M. et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal // Am J Clin Nutr. 2009; 90 (5): 1236–1243.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sayin S. I., Wahlstrom A., Felin J. et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro?beta?muricholic acid, a naturally occurring FXR antagonist // Cell Metab. 2013; 17 (2): 225–235.</mixed-citation><mixed-citation xml:lang="en">Sayin S. I., Wahlstrom A., Felin J. et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro?beta?muricholic acid, a naturally occurring FXR antagonist // Cell Metab. 2013; 17 (2): 225–235.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Watanabe M., Morimoto K., Houten S. M. et al. Bile acid binding resin improves metabolic control through the induction of energy expenditure // PLoS One. 2012; 7 (8): e38286.</mixed-citation><mixed-citation xml:lang="en">Watanabe M., Morimoto K., Houten S. M. et al. Bile acid binding resin improves metabolic control through the induction of energy expenditure // PLoS One. 2012; 7 (8): e38286.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Гриневич В. Б., Сас Е. И. Физиологические эффекты желчных кислот // РМЖ «Медицинское обозрение». 2017; 2: 87–91.</mixed-citation><mixed-citation xml:lang="en">Гриневич В. Б., Сас Е. И. Физиологические эффекты желчных кислот // РМЖ «Медицинское обозрение». 2017; 2: 87–91.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Alcock J., Maley C. C., Aktipis C. A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms // Bioessays. 2014; 36 (10): 940–949.</mixed-citation><mixed-citation xml:lang="en">Alcock J., Maley C. C., Aktipis C. A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms // Bioessays. 2014; 36 (10): 940–949.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Blaser, Martin J. Missing microbes: How the overuse of antibiotics is fueling our modern plagues. Henry Holt and Company, LLC, New York, NY, USA, 2014. 288 р.</mixed-citation><mixed-citation xml:lang="en">Blaser, Martin J. Missing microbes: How the overuse of antibiotics is fueling our modern plagues. Henry Holt and Company, LLC, New York, NY, USA, 2014. 288 р.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cho I., Yamanishi S., Cox L., Methe B. A., Zavadil J., Li K., Gao Z., Mahana D., Raju K., Teitler I. et al. Antibiotics in early life alter the murine colonic microbiome and adiposity // Nature. 2012; 488: 621–626.</mixed-citation><mixed-citation xml:lang="en">Cho I., Yamanishi S., Cox L., Methe B. A., Zavadil J., Li K., Gao Z., Mahana D., Raju K., Teitler I. et al. Antibiotics in early life alter the murine colonic microbiome and adiposity // Nature. 2012; 488: 621–626.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Bello M. G., Blaser M. J., Ley R. E., Knight R. Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing // Gastroenterology. 2011; 140: 1713–1719.</mixed-citation><mixed-citation xml:lang="en">Dominguez-Bello M. G., Blaser M. J., Ley R. E., Knight R. Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing // Gastroenterology. 2011; 140: 1713–1719.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Blaser M. J., Falkow S. What are the consequences of the disappearing human microbiota? // Nat Rev Micro. 2009; 7: 887–894.</mixed-citation><mixed-citation xml:lang="en">Blaser M. J., Falkow S. What are the consequences of the disappearing human microbiota? // Nat Rev Micro. 2009; 7: 887–894.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Trasande L., Blustein J., Liu M., Corwin E., Cox L. M., Blaser M. J. Infant antibiotic exposures and early-life body mass // Int J Obes. 2013; 37: 16–23.</mixed-citation><mixed-citation xml:lang="en">Trasande L., Blustein J., Liu M., Corwin E., Cox L. M., Blaser M. J. Infant antibiotic exposures and early-life body mass // Int J Obes. 2013; 37: 16–23.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Blustein J. et al. Association of caesarean delivery with child adiposity from age 6 weeks to 15 years // Int J Obes. 2013; 37: 900–906.</mixed-citation><mixed-citation xml:lang="en">Blustein J. et al. Association of caesarean delivery with child adiposity from age 6 weeks to 15 years // Int J Obes. 2013; 37: 900–906.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Huh S. Y., Rifas-Shiman S. L., Zera C. A., Edwards J. W. R., Oken E., Weiss S. T., Gillman M. W. Delivery by caesarean section and risk of obesity in preschool age children: a prospective cohort study // Arch Dis Childhood. 2012; 97: 610–616.</mixed-citation><mixed-citation xml:lang="en">Huh S. Y., Rifas-Shiman S. L., Zera C. A., Edwards J. W. R., Oken E., Weiss S. T., Gillman M. W. Delivery by caesarean section and risk of obesity in preschool age children: a prospective cohort study // Arch Dis Childhood. 2012; 97: 610–616.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Coates M. E., Fuller R., Harrison G. F., Lev M., Suffolk S. F. A comparison of the growth of chicks in the Gustafsson germ-free apparatus and in a conventional environment, with and without dietary supplements of penicillin // Br J Nutr. 1963; 17: 141–150.</mixed-citation><mixed-citation xml:lang="en">Coates M. E., Fuller R., Harrison G. F., Lev M., Suffolk S. F. A comparison of the growth of chicks in the Gustafsson germ-free apparatus and in a conventional environment, with and without dietary supplements of penicillin // Br J Nutr. 1963; 17: 141–150.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dethlefsen L., Huse S., Sogin M. L., Relman D. A. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing // PLoS Biol. 2008; 6: e280.</mixed-citation><mixed-citation xml:lang="en">Dethlefsen L., Huse S., Sogin M. L., Relman D. A. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing // PLoS Biol. 2008; 6: e280.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Dethlefsen L., McFall-Ngai M., Relman D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease // Nature. 2007; 449: 811–818.</mixed-citation><mixed-citation xml:lang="en">Dethlefsen L., McFall-Ngai M., Relman D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease // Nature. 2007; 449: 811–818.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Sullivan A., Edlund C., Nord C. E. Effect of antimicrobial agents on the ecological balance of human microflora // Lancet Infect Dis. 2001; 1: 101–114.</mixed-citation><mixed-citation xml:lang="en">Sullivan A., Edlund C., Nord C. E. Effect of antimicrobial agents on the ecological balance of human microflora // Lancet Infect Dis. 2001; 1: 101–114.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Beaugerie L., Petit J. C. Microbial-gut interactions in health and disease. Antibiotic-associated diarrhoea // Best Pract Res Clin Gastroenterol. 2004; 18: 337–352.</mixed-citation><mixed-citation xml:lang="en">Beaugerie L., Petit J. C. Microbial-gut interactions in health and disease. Antibiotic-associated diarrhoea // Best Pract Res Clin Gastroenterol. 2004; 18: 337–352.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wilcox M. H. Gastrointestinal disorders and the critically ill. Clostridium difficile infection and pseudomembranous colitis // Best Pract Res Clin Gastroenterol. 2003; 17: 475–493.</mixed-citation><mixed-citation xml:lang="en">Wilcox M. H. Gastrointestinal disorders and the critically ill. Clostridium difficile infection and pseudomembranous colitis // Best Pract Res Clin Gastroenterol. 2003; 17: 475–493.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Marra F., Lynd L., Coombes M., Richardson K., Legal M. et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis // Chest. 2006; 129: 610–618.</mixed-citation><mixed-citation xml:lang="en">Marra F., Lynd L., Coombes M., Richardson K., Legal M. et al. Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis // Chest. 2006; 129: 610–618.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Noverr M. C., Huffnagle G. B. The ‘microflora hypothesis’ of allergic diseases // Clin Exp Allergy. 2005; 35: 1511–1520.</mixed-citation><mixed-citation xml:lang="en">Noverr M. C., Huffnagle G. B. The ‘microflora hypothesis’ of allergic diseases // Clin Exp Allergy. 2005; 35: 1511–1520.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Prioult G., Nagler-Anderson C. Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation // Immunol Rev. 2005; 206: 204–218.</mixed-citation><mixed-citation xml:lang="en">Prioult G., Nagler-Anderson C. Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation // Immunol Rev. 2005; 206: 204–218.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Nicholson J. K., Holmes E., Wilson I. D. Gut microorganisms, mammalian metabolism and personalized health care // Nat Rev Microbiol. 2005; 3: 431–438.</mixed-citation><mixed-citation xml:lang="en">Nicholson J. K., Holmes E., Wilson I. D. Gut microorganisms, mammalian metabolism and personalized health care // Nat Rev Microbiol. 2005; 3: 431–438.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">O’Keefe S. J., Chung D., Mahmoud N., Sepulveda A. R., Manafe M. et al. Why do African Americans get more colon cancer than Native Africans // J Nutr. 2007; 137: 175S-182S.</mixed-citation><mixed-citation xml:lang="en">O’Keefe S. J., Chung D., Mahmoud N., Sepulveda A. R., Manafe M. et al. Why do African Americans get more colon cancer than Native Africans // J Nutr. 2007; 137: 175S-182S.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">McGarr S. E., Ridlon J. M., Hylemon P. B. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature // J Clin Gastroenterol. 2005; 39: 98–109.</mixed-citation><mixed-citation xml:lang="en">McGarr S. E., Ridlon J. M., Hylemon P. B. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature // J Clin Gastroenterol. 2005; 39: 98–109.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ley R. E., Backhed F., Turnbaugh P., Lozupone C. A., Knight R. D. et al. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. 2005; 102: 11070–11075.</mixed-citation><mixed-citation xml:lang="en">Ley R. E., Backhed F., Turnbaugh P., Lozupone C. A., Knight R. D. et al. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. 2005; 102: 11070–11075.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">B?ckhed F., Ding H., Wang T., Hooper L. V., Koh G. Y. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. 2004; 101: 15718–15723.</mixed-citation><mixed-citation xml:lang="en">B?ckhed F., Ding H., Wang T., Hooper L. V., Koh G. Y. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. 2004; 101: 15718–15723.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart C. S., Duncan S. H., Cave D. R. Oxalobacter formigenes and its role in oxalate metabolism in the human gut // FEMS Microbiol Lett. 2004; 230: 1–7.</mixed-citation><mixed-citation xml:lang="en">Stewart C. S., Duncan S. H., Cave D. R. Oxalobacter formigenes and its role in oxalate metabolism in the human gut // FEMS Microbiol Lett. 2004; 230: 1–7.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Lofmark S., Jernberg C., Billstrom H., Andersson D. I., Edlund C. Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestine // Anaerobe. 2008; 14: 157–160.</mixed-citation><mixed-citation xml:lang="en">Lofmark S., Jernberg C., Billstrom H., Andersson D. I., Edlund C. Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestine // Anaerobe. 2008; 14: 157–160.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sjolund M., Wreiber K., Andersson D. I., Blaser M. J., Engstrand L. Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori // Ann Intern Med. 2003; 139: 483–487.</mixed-citation><mixed-citation xml:lang="en">Sjolund M., Wreiber K., Andersson D. I., Blaser M. J., Engstrand L. Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori // Ann Intern Med. 2003; 139: 483–487.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">B?ckhed F., Ley R. E., Sonnenburg J. L., Peterson D. A., Gordon J. I. Host-bacterial mutualism in the human intestine // Science. 2005; 307: 1915–1920.</mixed-citation><mixed-citation xml:lang="en">B?ckhed F., Ley R. E., Sonnenburg J. L., Peterson D. A., Gordon J. I. Host-bacterial mutualism in the human intestine // Science. 2005; 307: 1915–1920.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Parikh N. I., Pencina M. J., Wang T. J., Lanier K. J., Fox C. S., D’Agostino R. B., Vasan R. S. Increasing trends in incidence of overweight and obesity over 5 decades // Am J Med. 2007 Mar; 120 (3): 242–250.</mixed-citation><mixed-citation xml:lang="en">Parikh N. I., Pencina M. J., Wang T. J., Lanier K. J., Fox C. S., D’Agostino R. B., Vasan R. S. Increasing trends in incidence of overweight and obesity over 5 decades // Am J Med. 2007 Mar; 120 (3): 242–250.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Nestle, Marion. Food Politics: How the Food Industry Influences Nutrition and Health. Berkeley: U of California, 2002. 457 р.</mixed-citation><mixed-citation xml:lang="en">Nestle, Marion. Food Politics: How the Food Industry Influences Nutrition and Health. Berkeley: U of California, 2002. 457 р.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Eric Andrew Finkelstein, Wan Chen Kang Graham, Rahul Malhotra. Lifetime Direct Medical Costs of Childhood Obesity // Pediatrics. 2014, April. 133: 1–9.</mixed-citation><mixed-citation xml:lang="en">Eric Andrew Finkelstein, Wan Chen Kang Graham, Rahul Malhotra. Lifetime Direct Medical Costs of Childhood Obesity // Pediatrics. 2014, April. 133: 1–9.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hayes A., Chevalier A., D’Souza M., Baur L., Li Ming Wen, Judy Simpson. Early childhood obesity: Association with healthcare expenditure in Australia // Obesity. 2016; 24 (8): 1752–1758.</mixed-citation><mixed-citation xml:lang="en">Hayes A., Chevalier A., D’Souza M., Baur L., Li Ming Wen, Judy Simpson. Early childhood obesity: Association with healthcare expenditure in Australia // Obesity. 2016; 24 (8): 1752–1758.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Moriarty J. P., Branda M. E., Olsen K. D., Shah N. D., Borah B. J., Wagie A. E., Egginton J. S., Naessens J. M. The Effects of Incremental Costs of Smoking and Obesity on Health Care Costs Among Adults // Journal of Occupational and Environmental Medicine, 2012; 54 (3): 286.</mixed-citation><mixed-citation xml:lang="en">Moriarty J. P., Branda M. E., Olsen K. D., Shah N. D., Borah B. J., Wagie A. E., Egginton J. S., Naessens J. M. The Effects of Incremental Costs of Smoking and Obesity on Health Care Costs Among Adults // Journal of Occupational and Environmental Medicine, 2012; 54 (3): 286.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Broe A., Potteg?rd A., Lamont R. F., J?rgensen J. S., Damkier P. Increasing use of antibiotics in pregnancy during the period 2000–2010: prevalence, timing, category, and demographics // BJOG. 2014; 121: 988–996.</mixed-citation><mixed-citation xml:lang="en">Broe A., Potteg?rd A., Lamont R. F., J?rgensen J. S., Damkier P. Increasing use of antibiotics in pregnancy during the period 2000–2010: prevalence, timing, category, and demographics // BJOG. 2014; 121: 988–996.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Vidal A. C. et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring // Int J Obes. 2013; 37: 907–913.</mixed-citation><mixed-citation xml:lang="en">Vidal A. C. et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring // Int J Obes. 2013; 37: 907–913.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Jepsen P. et al. A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark // British Journal Of Clinical Pharmacology. 2003; 55: 216–221.</mixed-citation><mixed-citation xml:lang="en">Jepsen P. et al. A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark // British Journal Of Clinical Pharmacology. 2003; 55: 216–221.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hicks L. A., Taylor T. H., Hunkler R. J. U. S. Outpatient Antibiotic Prescribing, 2010 // New Engl J Med. 2013; 368: 1461–1462.</mixed-citation><mixed-citation xml:lang="en">Hicks L. A., Taylor T. H., Hunkler R. J. U. S. Outpatient Antibiotic Prescribing, 2010 // New Engl J Med. 2013; 368: 1461–1462.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">McCaig L. F., Besser R. E., Hughes J. M. Trends in antimicrobial prescribing rates for children and adolescents // JAMA: The Journal of the American Medical Association. 2002; 287: 3096–3102.</mixed-citation><mixed-citation xml:lang="en">McCaig L. F., Besser R. E., Hughes J. M. Trends in antimicrobial prescribing rates for children and adolescents // JAMA: The Journal of the American Medical Association. 2002; 287: 3096–3102.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Grijalva C. G., Nuorti J., Griffin M. R. Antibiotic prescription rates for acute respiratory tract infections in us ambulatory settings // JAMA. 2009; 302: 758–766.</mixed-citation><mixed-citation xml:lang="en">Grijalva C. G., Nuorti J., Griffin M. R. Antibiotic prescription rates for acute respiratory tract infections in us ambulatory settings // JAMA. 2009; 302: 758–766.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Слайд-шоу из лекции «Антибиотики и ожирение» Blaser M. J. https://www.amnh.org/explore/science-topics/health-and-our-microbiome/meet-your-microbiome.</mixed-citation><mixed-citation xml:lang="en">Слайд-шоу из лекции «Антибиотики и ожирение» Blaser M. J. https://www.amnh.org/explore/science-topics/health-and-our-microbiome/meet-your-microbiome.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ternhag A, Hellman J. More on U. S. Outpatient Antibiotic Prescribing, 2010 // New Engl J Med. 2013; 369: 1175–1176.</mixed-citation><mixed-citation xml:lang="en">Ternhag A, Hellman J. More on U. S. Outpatient Antibiotic Prescribing, 2010 // New Engl J Med. 2013; 369: 1175–1176.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hersh A. L., Jackson M. A., Hicks L. A. DISEASES, t.C.O.I. Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics // Pediatrics. 2013; 132: 1146–1154.</mixed-citation><mixed-citation xml:lang="en">Hersh A. L., Jackson M. A., Hicks L. A. DISEASES, t.C.O.I. Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics // Pediatrics. 2013; 132: 1146–1154.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Fridkin S. et al. Vital signs: improving antibiotic use among hospitalized patients // MMWR. Morbidity and mortality weekly report. 2014; 63: 194–200.</mixed-citation><mixed-citation xml:lang="en">Fridkin S. et al. Vital signs: improving antibiotic use among hospitalized patients // MMWR. Morbidity and mortality weekly report. 2014; 63: 194–200.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Lee G. C. et al. Outpatient antibiotic prescribing in the United States: 2000 to 2010 // BMC medicine. 2014; 12: 96.</mixed-citation><mixed-citation xml:lang="en">Lee G. C. et al. Outpatient antibiotic prescribing in the United States: 2000 to 2010 // BMC medicine. 2014; 12: 96.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Gerber J. S. et al. Variation in Antibiotic Prescribing Across a Pediatric Primary Care Network // J Pediatric Infect Dis Soc. 2014. In press, DOI: 10.1093/jpids/piu086.</mixed-citation><mixed-citation xml:lang="en">Gerber J. S. et al. Variation in Antibiotic Prescribing Across a Pediatric Primary Care Network // J Pediatric Infect Dis Soc. 2014. In press, DOI: 10.1093/jpids/piu086.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Ajslev T. A., Andersen C. S., Gamborg M., S?rensen T. I. A., Jess T. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics // Int J Obes. 2011; 35: 522–529.</mixed-citation><mixed-citation xml:lang="en">Ajslev T. A., Andersen C. S., Gamborg M., S?rensen T. I. A., Jess T. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics // Int J Obes. 2011; 35: 522–529.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Azad M. B., Bridgman S. L., Becker A. B., Kozyrskyj A. L. Infant antibiotic exposure and the development of childhood overweight and central adiposity // Int J Obes. 2014: 1–9.</mixed-citation><mixed-citation xml:lang="en">Azad M. B., Bridgman S. L., Becker A. B., Kozyrskyj A. L. Infant antibiotic exposure and the development of childhood overweight and central adiposity // Int J Obes. 2014: 1–9.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey L. C. et al. Association of Antibiotics in Infancy With Early Childhood Obesity // JAMA Pediatr. 2014; 168 (11): 1063–1069.</mixed-citation><mixed-citation xml:lang="en">Bailey L. C. et al. Association of Antibiotics in Infancy With Early Childhood Obesity // JAMA Pediatr. 2014; 168 (11): 1063–1069.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy R. et al. Antibiotic treatment during infancy and increased body mass index in boys: an international cross-sectional study // Int J Obes. 2013; 38: 115–119.</mixed-citation><mixed-citation xml:lang="en">Murphy R. et al. Antibiotic treatment during infancy and increased body mass index in boys: an international cross-sectional study // Int J Obes. 2013; 38: 115–119.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Cox L. M., Blaser M. J. Antibiotics in early life and obesity // Nat Rev Endocrinol. 2015, Mar; 11 (3): 182–190.</mixed-citation><mixed-citation xml:lang="en">Cox L. M., Blaser M. J. Antibiotics in early life and obesity // Nat Rev Endocrinol. 2015, Mar; 11 (3): 182–190.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Hooper L. V., Littman D. R., Macpherson A. J. Interactions between the microbiota and the immune system // Science. 2012; 336: 1268–1273.</mixed-citation><mixed-citation xml:lang="en">Hooper L. V., Littman D. R., Macpherson A. J. Interactions between the microbiota and the immune system // Science. 2012; 336: 1268–1273.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller N. T., Whyatt R., Hoepner L., Oberfield S., Dominguez-Bello M. G., Widen E. M., Hassoun A., Perera F., Rundle A. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity // Int J Obes (Lond). 2015, Apr; 39 (4): 665–670.</mixed-citation><mixed-citation xml:lang="en">Mueller N. T., Whyatt R., Hoepner L., Oberfield S., Dominguez-Bello M. G., Widen E. M., Hassoun A., Perera F., Rundle A. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity // Int J Obes (Lond). 2015, Apr; 39 (4): 665–670.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Dethlefsen L., Relman D. A. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation // Proc Natl Acad Sci USA. 2011, 108 (Suppl 1): 4554–6110.</mixed-citation><mixed-citation xml:lang="en">Dethlefsen L., Relman D. A. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation // Proc Natl Acad Sci USA. 2011, 108 (Suppl 1): 4554–6110.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Thuny F., Richet H., Casalta J.-P., Angelakis E., Habib G., Raoult D. Vancomycin Treatment of Infective Endocarditis Is Linked with Recently Acquired Obesity // PLoS One. 2010; 5 (2): e9074.</mixed-citation><mixed-citation xml:lang="en">Thuny F., Richet H., Casalta J.-P., Angelakis E., Habib G., Raoult D. Vancomycin Treatment of Infective Endocarditis Is Linked with Recently Acquired Obesity // PLoS One. 2010; 5 (2): e9074.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Jakobsson H. E., Jernberg C., Andersson A. F., Sjolund-Karlsson M., Jansson J. K., Engstrand L. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome // PLoS One. 2010; 5: e9836.</mixed-citation><mixed-citation xml:lang="en">Jakobsson H. E., Jernberg C., Andersson A. F., Sjolund-Karlsson M., Jansson J. K., Engstrand L. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome // PLoS One. 2010; 5: e9836.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Jernberg C., Lofmark S., Edlund C., Jansson J. K. Long-term impacts of antibiotic exposure on the human intestinal microbiota // Microbiology. 2010; 156: 3216–3223.</mixed-citation><mixed-citation xml:lang="en">Jernberg C., Lofmark S., Edlund C., Jansson J. K. Long-term impacts of antibiotic exposure on the human intestinal microbiota // Microbiology. 2010; 156: 3216–3223.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Jess T. Microbiota, antibiotics, and obesity // N Engl J Med. 2014; 371: 2526–2528.</mixed-citation><mixed-citation xml:lang="en">Jess T. Microbiota, antibiotics, and obesity // N Engl J Med. 2014; 371: 2526–2528.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Riley L. W., Raphael E., Faerstein E. Obesity in the United States — dysbiosis from exposure to low-dose antibiotics? // Front Public Health. 2013; 1: 69.</mixed-citation><mixed-citation xml:lang="en">Riley L. W., Raphael E., Faerstein E. Obesity in the United States — dysbiosis from exposure to low-dose antibiotics? // Front Public Health. 2013; 1: 69.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Alang N., Kelly C. R. Weight gain after fecal microbiota transplantation // Send to Open Forum Infect Dis. 2015, Feb 4; 2 (1): ofv004.</mixed-citation><mixed-citation xml:lang="en">Alang N., Kelly C. R. Weight gain after fecal microbiota transplantation // Send to Open Forum Infect Dis. 2015, Feb 4; 2 (1): ofv004.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Vrieze A., Van Nood E., Holleman F., Saloj?rvi J., Kootte R. S., Bartelsman J. F., Dallinga-Thie G. M., Ackermans M. T., Serlie M. J., Oozeer R., Derrien M., Druesne A., van Hylckama Vlieg J. E., Bloks V. W., Groen A. K., Heilig H. G., Zoetendal E. G., Stroes E. S., de Vos W. M., Hoekstra J. B., Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome // Gastroenterology. 2012, Oct; 143 (4): 913–6.e7.</mixed-citation><mixed-citation xml:lang="en">Vrieze A., Van Nood E., Holleman F., Saloj?rvi J., Kootte R. S., Bartelsman J. F., Dallinga-Thie G. M., Ackermans M. T., Serlie M. J., Oozeer R., Derrien M., Druesne A., van Hylckama Vlieg J. E., Bloks V. W., Groen A. K., Heilig H. G., Zoetendal E. G., Stroes E. S., de Vos W. M., Hoekstra J. B., Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome // Gastroenterology. 2012, Oct; 143 (4): 913–6.e7.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Feighner S. D., Dashkevicz M. P. Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity // Appl Environ Microbiol. 1987; 53: 331–336.</mixed-citation><mixed-citation xml:lang="en">Feighner S. D., Dashkevicz M. P. Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity // Appl Environ Microbiol. 1987; 53: 331–336.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Backhed F., Ding H., Wang T., Hooper L. V., Koh G. Y. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. 2004; 101: 15718–15723.</mixed-citation><mixed-citation xml:lang="en">Backhed F., Ding H., Wang T., Hooper L. V., Koh G. Y. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. 2004; 101: 15718–15723.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Andrade M. J., Jayaprakash C., Bhat S., Evangelatos N., Brand A., Satyamoorthy K. Antibiotics-Induced Obesity: A Mitochondrial Perspective // Public Health Genomics. 2017; 20: 257–273.</mixed-citation><mixed-citation xml:lang="en">Andrade M. J., Jayaprakash C., Bhat S., Evangelatos N., Brand A., Satyamoorthy K. Antibiotics-Induced Obesity: A Mitochondrial Perspective // Public Health Genomics. 2017; 20: 257–273.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Angelakis E. Weight gain by gut microbiota manipulation in productive animals // Microb Pathog. 2017, May; 106: 162–170.</mixed-citation><mixed-citation xml:lang="en">Angelakis E. Weight gain by gut microbiota manipulation in productive animals // Microb Pathog. 2017, May; 106: 162–170.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Acar J., Casewell M., Freeman J., Friis C., Goossens H. Avoparcin and virginiamycin as animal growth promoters: a plea for science in decision-making // Clin Microbiol Infect. 2000; 6: 477–482.</mixed-citation><mixed-citation xml:lang="en">Acar J., Casewell M., Freeman J., Friis C., Goossens H. Avoparcin and virginiamycin as animal growth promoters: a plea for science in decision-making // Clin Microbiol Infect. 2000; 6: 477–482.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Dyer I. A., Koes R. M., Herlugson M. L., Ojikutu L. B., Preston R. L. et al. Effect of avoparcin and monensin on performance of finishing heifers // J Anim Sci. 1980; 51: 843–846.</mixed-citation><mixed-citation xml:lang="en">Dyer I. A., Koes R. M., Herlugson M. L., Ojikutu L. B., Preston R. L. et al. Effect of avoparcin and monensin on performance of finishing heifers // J Anim Sci. 1980; 51: 843–846.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Война миров: антибиотики в сельском хозяйстве. На сайте The DairyNews http://www.dairynews.ru/dairyfarm/voyna-mirov-antibiotiki-v-selskom-khozyaystve.html.</mixed-citation><mixed-citation xml:lang="en">Война миров: антибиотики в сельском хозяйстве. На сайте The DairyNews http://www.dairynews.ru/dairyfarm/voyna-mirov-antibiotiki-v-selskom-khozyaystve.html.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Marshall B. M., Levy S. B. Food Animals and Antimicrobials: Impacts on Human Health // Clin Microbiol Rev. 2011; 24: 718–733.</mixed-citation><mixed-citation xml:lang="en">Marshall B. M., Levy S. B. Food Animals and Antimicrobials: Impacts on Human Health // Clin Microbiol Rev. 2011; 24: 718–733.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Donoghue D. J. Antibiotic residues in poultry tissues and eggs: human health concerns? // Poultry Sci. 2003; 82: 618–621.</mixed-citation><mixed-citation xml:lang="en">Donoghue D. J. Antibiotic residues in poultry tissues and eggs: human health concerns? // Poultry Sci. 2003; 82: 618–621.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Ternak G. Antibiotics may act as growth/obesity promoters in humans as an inadvertent result of antibiotic pollution? // Medical Hypotheses. 2005; 64: 14–16.</mixed-citation><mixed-citation xml:lang="en">Ternak G. Antibiotics may act as growth/obesity promoters in humans as an inadvertent result of antibiotic pollution? // Medical Hypotheses. 2005; 64: 14–16.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Riley L. W. Obesity in the United States — dysbiosis from exposure to low-dose antibiotics? 2013: 1–8.</mixed-citation><mixed-citation xml:lang="en">Riley L. W. Obesity in the United States — dysbiosis from exposure to low-dose antibiotics? 2013: 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor J. H., Gordon W. S. Growth-promoting activity for pigs of inactivated penicillin // Nature. 1955; 176: 312–313.</mixed-citation><mixed-citation xml:lang="en">Taylor J. H., Gordon W. S. Growth-promoting activity for pigs of inactivated penicillin // Nature. 1955; 176: 312–313.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Jukes T. H., Williams W. L. Nutritional effects of antibiotics // Pharmacol Rev. 1953; 5: 381–420.</mixed-citation><mixed-citation xml:lang="en">Jukes T. H., Williams W. L. Nutritional effects of antibiotics // Pharmacol Rev. 1953; 5: 381–420.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Gaskins H., Collier C., Anderson D. Antibiotics as growth promotants: mode of action // Anim Biotechnol. 2002; 13: 29–42.</mixed-citation><mixed-citation xml:lang="en">Gaskins H., Collier C., Anderson D. Antibiotics as growth promotants: mode of action // Anim Biotechnol. 2002; 13: 29–42.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Butaye P., Devriese L., Haesebrouck F. Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria // Clin Microbiol Rev. 2003; 16: 175–188.</mixed-citation><mixed-citation xml:lang="en">Butaye P., Devriese L., Haesebrouck F. Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria // Clin Microbiol Rev. 2003; 16: 175–188.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Van Boeckel T. P., Brower C., Gilbert M., Grenfell B. T., Levin S. A., Robinson T. P., Teillant A., Laxminarayan R. Global trends in antimicrobial use in food animals // PNAS. 2015. March 19, 201503141. http://www.pnas.org/content/pnas/early/2015/03/18/1503141112.full.pdf.</mixed-citation><mixed-citation xml:lang="en">Van Boeckel T. P., Brower C., Gilbert M., Grenfell B. T., Levin S. A., Robinson T. P., Teillant A., Laxminarayan R. Global trends in antimicrobial use in food animals // PNAS. 2015. March 19, 201503141. http://www.pnas.org/content/pnas/early/2015/03/18/1503141112.full.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Muir L. A. Mode of action of exogenous substances on animal growth — an overview // Journal of animal science. 1985; 61: 154–180.</mixed-citation><mixed-citation xml:lang="en">Muir L. A. Mode of action of exogenous substances on animal growth — an overview // Journal of animal science. 1985; 61: 154–180.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Chatelier E., Nielsen T., Qin J., Prifti E., Hildebrand F., Falony G. Richness of human gut microbiome correlates with metabolic markers // Nature. 2013; 500.</mixed-citation><mixed-citation xml:lang="en">Chatelier E., Nielsen T., Qin J., Prifti E., Hildebrand F., Falony G. Richness of human gut microbiome correlates with metabolic markers // Nature. 2013; 500.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Cotillard A., Kennedy S. P., Kong L. C. et al. Dietary intervention impact on gut microbial gene richness // Nature. 2013; 500 (7464): 585–588.</mixed-citation><mixed-citation xml:lang="en">Cotillard A., Kennedy S. P., Kong L. C. et al. Dietary intervention impact on gut microbial gene richness // Nature. 2013; 500 (7464): 585–588.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Turnbaugh P. J., Ley R. E., Mahowald M. A., Magrini V., Mardis E. R., Gordon J. I. An obesity?associated gut microbiome with increased capacity for energy harvest // Nature 2006; 444 (7122): 1027–1031.</mixed-citation><mixed-citation xml:lang="en">Turnbaugh P. J., Ley R. E., Mahowald M. A., Magrini V., Mardis E. R., Gordon J. I. An obesity?associated gut microbiome with increased capacity for energy harvest // Nature 2006; 444 (7122): 1027–1031.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Mingqian He, Bingyin Shi. Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics // Cell Biosci. 2017; 7: 54.</mixed-citation><mixed-citation xml:lang="en">Mingqian He, Bingyin Shi. Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics // Cell Biosci. 2017; 7: 54.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Sanders M. E. Probiotics and microbiota composition // BMC Med. 2016; 14 (1): 82.</mixed-citation><mixed-citation xml:lang="en">Sanders M. E. Probiotics and microbiota composition // BMC Med. 2016; 14 (1): 82.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Eloe-Fadrosh E. A., Brady A., Crabtree J. et al. Functional dynamics of the gut microbiome in elderly people during probiotic consumption. MBio 2015; 6(2): 1–12.</mixed-citation><mixed-citation xml:lang="en">Eloe-Fadrosh E. A., Brady A., Crabtree J. et al. Functional dynamics of the gut microbiome in elderly people during probiotic consumption. MBio 2015; 6(2): 1–12.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">McNulty N. P., Yatsunenko T., Hsiao A. et al. The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins // Sci Transl Med. 2011; 3 (106): 106ra.</mixed-citation><mixed-citation xml:lang="en">McNulty N. P., Yatsunenko T., Hsiao A. et al. The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins // Sci Transl Med. 2011; 3 (106): 106ra.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Drissi F., Raoult D., Merhej V. Metabolic role of lactobacilli in weight modification in humans and animals // Microb Pathog. 2016; 106: 182–194.</mixed-citation><mixed-citation xml:lang="en">Drissi F., Raoult D., Merhej V. Metabolic role of lactobacilli in weight modification in humans and animals // Microb Pathog. 2016; 106: 182–194.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Q., Wu Y., Fei X. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials // Int J Food Sci Nutr. 2015; 67 (5): 571–580.</mixed-citation><mixed-citation xml:lang="en">Zhang Q., Wu Y., Fei X. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials // Int J Food Sci Nutr. 2015; 67 (5): 571–580.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Borgeraas H., Johnson L. K., Skattebu J., Hertel J. K., Hjelmes?th J. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials // Obes Rev. 2018 Feb; 19 (2): 219–232.</mixed-citation><mixed-citation xml:lang="en">Borgeraas H., Johnson L. K., Skattebu J., Hertel J. K., Hjelmes?th J. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials // Obes Rev. 2018 Feb; 19 (2): 219–232.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Kadooka Y., Sato M., Imaizumi K., Ogawa A., Ikuyama K., Akai Y., Okano M., Kagoshima M., Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial // Eur J Clin Nutr. 2010; 64 (6): 636–643.</mixed-citation><mixed-citation xml:lang="en">Kadooka Y., Sato M., Imaizumi K., Ogawa A., Ikuyama K., Akai Y., Okano M., Kagoshima M., Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial // Eur J Clin Nutr. 2010; 64 (6): 636–643.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
