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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name>ООО «Издательство "Открытые системы"»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">lvrach-679</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Сердечно-сосудистые заболевания и первичный рак молочной железы: коморбидность и модифицируемые факторы риска</article-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular diseases and primary breast cancer: comorbidity and modified risk factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Друк</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Druk</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">drukinna@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ибрагимова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Ibragimova</surname><given-names>A. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ибрагимова</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Ibragimova</surname><given-names>M. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лялюкова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyalyukova</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радюкова</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Radyukova</surname><given-names>I. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кореннова</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Korennova</surname><given-names>O. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашвиц</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashvits</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО ОмГМУ МЗ РФ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГБУЗ ЗСМЦ ФМБА России</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>БУЗОО ООД</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>БУЗОО ГККД</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>23</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Друк И.В., Ибрагимова А.Р., Ибрагимова М.Р., Лялюкова А.С., Радюкова И.М., Кореннова О.Ю., Ашвиц И.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Друк И.В., Ибрагимова А.Р., Ибрагимова М.Р., Лялюкова А.С., Радюкова И.М., Кореннова О.Ю., Ашвиц И.В.</copyright-holder><copyright-holder xml:lang="en">Druk I.V., Ibragimova A.R., Ibragimova M.R., Lyalyukova A.S., Radyukova I.M., Korennova O.Y., Ashvits I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/679">https://journal.lvrach.ru/jour/article/view/679</self-uri><abstract><p>Рассмотрены факторы риска развития первичного рака молочной железы (РМЖ). Анализ показывает, что в женской популяции сердечно-сосудистые заболевания и РМЖ имеют общие модифицируемые факторы риска, что определяет перспективы дополнительных преимуществ немедикаментозных профилактических вмешательств.</p></abstract><trans-abstract xml:lang="en"><p>The risk factors for development of primary breast cancer (BC) were considered. The analysis shows that, within the female population of cardiovascular diseases and BC, there are common modified risk factors, which defines prospects for additional advantages of non-drug interventions. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Ангиология</kwd><kwd>Женский пол</kwd><kwd>Кардиология</kwd><kwd>Первичный рак молочной железы</kwd><kwd>Профилактика</kwd><kwd>Сердечно-сосудистые заболевания</kwd><kwd>Симпозиум</kwd><kwd>Факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary breast cancer</kwd><kwd>cardiovascular diseases</kwd><kwd>female sex</kwd><kwd>risk factors</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Здравоохранение в России. 2017: Стат. сб. Росстат. М., 2017. 170 с.</mixed-citation><mixed-citation xml:lang="en">Здравоохранение в России. 2017: Стат. сб. Росстат. М., 2017. 170 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Состояние онкологической помощи населению России в 2016 году / Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. М.: МНИОИ им. П. А. Герцена — филиал ФГБУ «НМИРЦ» Минздрава России, 2017. 236 с.</mixed-citation><mixed-citation xml:lang="en">Состояние онкологической помощи населению России в 2016 году / Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. М.: МНИОИ им. П. А. Герцена — филиал ФГБУ «НМИРЦ» Минздрава России, 2017. 236 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) // European Heart Journal. 2016; 37: 2768–2801. DOI: 10.1093/eurheartj/ehw211.</mixed-citation><mixed-citation xml:lang="en">ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) // European Heart Journal. 2016; 37: 2768–2801. DOI: 10.1093/eurheartj/ehw211.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Муромцева Г. А., Концевая А. В., Константинов В. В. и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012–2013 гг. Результаты исследования ЭССЕ-РФ // Кардиоваскулярная терапия и профилактика. 2014; 13 (6): 8.</mixed-citation><mixed-citation xml:lang="en">Муромцева Г. А., Концевая А. В., Константинов В. В. и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012–2013 гг. Результаты исследования ЭССЕ-РФ // Кардиоваскулярная терапия и профилактика. 2014; 13 (6): 8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Benjamin E. J., Blaha M. J., Chiuve S. E., Cushman M., Das S. R. et al. Оn behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics: 2017 update: a report from the American Heart Association [published corrections appear in Circulation // Circulation. 2017; 135: e146–e603. DOI: 10.1161/CIR.0000000000000485.</mixed-citation><mixed-citation xml:lang="en">Benjamin E. J., Blaha M. J., Chiuve S. E., Cushman M., Das S. R. et al. Оn behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics: 2017 update: a report from the American Heart Association [published corrections appear in Circulation // Circulation. 2017; 135: e146–e603. DOI: 10.1161/CIR.0000000000000485.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gernaat S. A. M., Ho P. J., Rijnberg N. et al. Risk of death from cardiovascular disease following breast cancer: a systematic review // Breast Cancer Research and Treatment. 2017; 164 (3): 537–555. DOI: 10.1007/s10549–017–4282–9.</mixed-citation><mixed-citation xml:lang="en">Gernaat S. A. M., Ho P. J., Rijnberg N. et al. Risk of death from cardiovascular disease following breast cancer: a systematic review // Breast Cancer Research and Treatment. 2017; 164 (3): 537–555. DOI: 10.1007/s10549–017–4282–9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bradshaw P. T., Stevens J., Khankari N., Teitelbaum S. L. et al. Cardiovascular Disease Mortality Among Breast Cancer Survivors // Epidemiology (Cambridge, Mass). 2016; 27 (1): 6–13. DOI: 10.1097/EDE.0000000000000394.</mixed-citation><mixed-citation xml:lang="en">Bradshaw P. T., Stevens J., Khankari N., Teitelbaum S. L. et al. Cardiovascular Disease Mortality Among Breast Cancer Survivors // Epidemiology (Cambridge, Mass). 2016; 27 (1): 6–13. DOI: 10.1097/EDE.0000000000000394.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta L. S., Watson K. E., Barac A., Beckie Th. M. et al. Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association // Circulation. 2018, February 20, 137 (8): e30-e66. DOI: 10.1161/CIR.0000000000000556.</mixed-citation><mixed-citation xml:lang="en">Mehta L. S., Watson K. E., Barac A., Beckie Th. M. et al. Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association // Circulation. 2018, February 20, 137 (8): e30-e66. DOI: 10.1161/CIR.0000000000000556.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mozaffarian D., Benjamin E. J., Go A. S., Arnett D. K. et al. On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics: 2016 update: a report from the American Heart Association [published correction appears in Circulation. 2016; 133: e599] // Circulation. 2015; 133: e38–e360. DOI: 10.1161/CIR.0000000000000350.</mixed-citation><mixed-citation xml:lang="en">Mozaffarian D., Benjamin E. J., Go A. S., Arnett D. K. et al. On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics: 2016 update: a report from the American Heart Association [published correction appears in Circulation. 2016; 133: e599] // Circulation. 2015; 133: e38–e360. DOI: 10.1161/CIR.0000000000000350.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Кардиоваскулярная профилактика 2017. Национальные рекомендации. Комитет экспертов. 2017; 289 с. http://scardio.ru/content/Guidelines/Cardiovascular-prof-2017.pdf.</mixed-citation><mixed-citation xml:lang="en">Кардиоваскулярная профилактика 2017. Национальные рекомендации. Комитет экспертов. 2017; 289 с. http://scardio.ru/content/Guidelines/Cardiovascular-prof-2017.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Heidemann C., Schulze M. B., Franco O. H., van Dam R. M., Mantzoros C. S., Hu F. B. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women // Circulation. 2008; 118: 230–237. DOI: 10.1161/CIRCULATIONAHA.108.771881.</mixed-citation><mixed-citation xml:lang="en">Heidemann C., Schulze M. B., Franco O. H., van Dam R. M., Mantzoros C. S., Hu F. B. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women // Circulation. 2008; 118: 230–237. DOI: 10.1161/CIRCULATIONAHA.108.771881.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mozaffarian D. Nutrition and cardiovascular and metabolic disease. In: Bonow R. O., Mann D. L., Zipes D. P., Libby P. Braunwald’s heart disease: a textbook of cardiovascular medicine. Elsevier Saunders; Philadelphia: 2015.</mixed-citation><mixed-citation xml:lang="en">Mozaffarian D. Nutrition and cardiovascular and metabolic disease. In: Bonow R. O., Mann D. L., Zipes D. P., Libby P. Braunwald’s heart disease: a textbook of cardiovascular medicine. Elsevier Saunders; Philadelphia: 2015.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Heidemann C., Schulze M. B., Franco O. H., van Dam R. M., Mantzoros C. S., Hu F. B. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women // Circulation. 2008; 118: 230–237. DOI: 10.1161/CIRCULATIONAHA.108.771881.</mixed-citation><mixed-citation xml:lang="en">Heidemann C., Schulze M. B., Franco O. H., van Dam R. M., Mantzoros C. S., Hu F. B. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women // Circulation. 2008; 118: 230–237. DOI: 10.1161/CIRCULATIONAHA.108.771881.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation><mixed-citation xml:lang="en">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng J. S., Hu X. J., Zhao Y. M., Yang J., Li D Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies // BMJ. 2013; 346: f3706.</mixed-citation><mixed-citation xml:lang="en">Zheng J. S., Hu X. J., Zhao Y. M., Yang J., Li D Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies // BMJ. 2013; 346: f3706.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kushi L. H., Doyle C., McCullough M., Rock C. L. et al. American Cancer Society guidelines on nutrition and physical activity for cancer prevention // CA: A Cancer Journal for Clinicians. 2012; 62: 30–67. DOI: 10.3322/caac.20140.</mixed-citation><mixed-citation xml:lang="en">Kushi L. H., Doyle C., McCullough M., Rock C. L. et al. American Cancer Society guidelines on nutrition and physical activity for cancer prevention // CA: A Cancer Journal for Clinicians. 2012; 62: 30–67. DOI: 10.3322/caac.20140.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Papaioannou M. D., Koufaris C., Gooderham N. J. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylim-idazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells // Toxicol Lett. 2014; 229 (1): 9–16.</mixed-citation><mixed-citation xml:lang="en">Papaioannou M. D., Koufaris C., Gooderham N. J. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylim-idazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells // Toxicol Lett. 2014; 229 (1): 9–16.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Knott C. S., Coombs N., Stamatakis E., Biddulph J. P. All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts // BMJ. 2015; 350: h384. DOI: 10.1136/bmj. h384.</mixed-citation><mixed-citation xml:lang="en">Knott C. S., Coombs N., Stamatakis E., Biddulph J. P. All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts // BMJ. 2015; 350: h384. DOI: 10.1136/bmj. h384.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jimenez M., Chiuve S. E., Glynn R. J., Stampfer M. J. et al. Alcohol consumption and risk of stroke in women // Stroke. 2012; 43: 939–945. DOI: 10.1161/STROKEAHA.111.639435.</mixed-citation><mixed-citation xml:lang="en">Jimenez M., Chiuve S. E., Glynn R. J., Stampfer M. J. et al. Alcohol consumption and risk of stroke in women // Stroke. 2012; 43: 939–945. DOI: 10.1161/STROKEAHA.111.639435.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Roerecke M., Rehm J. The cardioprotective association of average alcohol consumption and ischaemic heart disease: a systematic review and meta-analysis // Addiction. 2012; 107: 1246–1260. DOI: 10.1111/j.1360–0443.2012.03780. x.</mixed-citation><mixed-citation xml:lang="en">Roerecke M., Rehm J. The cardioprotective association of average alcohol consumption and ischaemic heart disease: a systematic review and meta-analysis // Addiction. 2012; 107: 1246–1260. DOI: 10.1111/j.1360–0443.2012.03780. x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Roerecke M., Rehm J. Alcohol consumption, drinking patterns, and ischemic heart disease: a narrative review of meta-analyses and a systematic review and meta-analysis of the impact of heavy drinking occasions on risk for moderate drinkers // BMC Med. 2014; 12: 182. DOI: 10.1186/s12916–014–0182–6.</mixed-citation><mixed-citation xml:lang="en">Roerecke M., Rehm J. Alcohol consumption, drinking patterns, and ischemic heart disease: a narrative review of meta-analyses and a systematic review and meta-analysis of the impact of heavy drinking occasions on risk for moderate drinkers // BMC Med. 2014; 12: 182. DOI: 10.1186/s12916–014–0182–6.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Roerecke M., Tobe S. W., Kaczorowski J. et al. Sex-Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies. Journal of the American Heart Association // Cardiovascular and Cerebrovascular Disease. 2018; 7 (13): e008202. DOI: 10.1161/JAHA.117.008202.</mixed-citation><mixed-citation xml:lang="en">Roerecke M., Tobe S. W., Kaczorowski J. et al. Sex-Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies. Journal of the American Heart Association // Cardiovascular and Cerebrovascular Disease. 2018; 7 (13): e008202. DOI: 10.1161/JAHA.117.008202.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Shield K. D., Soerjomataram I., Rehm J. Alcohol Use and reast Cancer: A Critical Review. Alcoholism // Clinical and Experimental Research. 2016; 40 (6), 1166–1181. DOI: 10.1111/acer.13071.</mixed-citation><mixed-citation xml:lang="en">Shield K. D., Soerjomataram I., Rehm J. Alcohol Use and reast Cancer: A Critical Review. Alcoholism // Clinical and Experimental Research. 2016; 40 (6), 1166–1181. DOI: 10.1111/acer.13071.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Howell A., Anderson A. S., Clarke R. B., Duffy S. W. et al. Risk determination and prevention of breast cancer // Breast Cancer Res. 2014; 16: 446. DOI: 10.1186/s13058–014–0446–2.</mixed-citation><mixed-citation xml:lang="en">Howell A., Anderson A. S., Clarke R. B., Duffy S. W. et al. Risk determination and prevention of breast cancer // Breast Cancer Res. 2014; 16: 446. DOI: 10.1186/s13058–014–0446–2.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Schwedhelm C., Boeing H., Hoffmann G., Aleksandrova K., Schwingshackl L. Effect of diet on mortality and cancer recurrence among cancer survivors: a systematic review and meta-analysis of cohort studies // Nutrition Reviews. 2016; 74 (12): 737–748. DOI: 10.1093/nutrit/nuw045.</mixed-citation><mixed-citation xml:lang="en">Schwedhelm C., Boeing H., Hoffmann G., Aleksandrova K., Schwingshackl L. Effect of diet on mortality and cancer recurrence among cancer survivors: a systematic review and meta-analysis of cohort studies // Nutrition Reviews. 2016; 74 (12): 737–748. DOI: 10.1093/nutrit/nuw045.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Colditz G. A., Rosner B., Berkey C. S. et al. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk // J Natl Cancer Inst. 2013; 105 (20): 1571–1578. DOI: 10.1093/jnci/djt213.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Colditz G. A., Rosner B., Berkey C. S. et al. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk // J Natl Cancer Inst. 2013; 105 (20): 1571–1578. DOI: 10.1093/jnci/djt213.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong M. E., Green J., Reeves G. K., Beral V., Cairns B. J. On behalf of the Million Women Study Collaborators. Frequent physical activity may not reduce vascular disease risk as much as moderate activity: large prospective study of women in the United Kingdom // Circulation. 2015; 131: 721–729. DOI: 10.1161/CIRCULATIONAHA.114.010296.</mixed-citation><mixed-citation xml:lang="en">Armstrong M. E., Green J., Reeves G. K., Beral V., Cairns B. J. On behalf of the Million Women Study Collaborators. Frequent physical activity may not reduce vascular disease risk as much as moderate activity: large prospective study of women in the United Kingdom // Circulation. 2015; 131: 721–729. DOI: 10.1161/CIRCULATIONAHA.114.010296.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation><mixed-citation xml:lang="en">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Boeke C. E., Eliassen A. H., Oh H., Spiegelman D., Willett W. C., Tamimi R. M. Adolescent physical activity in relation to breast cancer risk // Breast Cancer Res Treat. 2014; 145: 715–724. DOI: 10.1007/s10549–014–2919–5.</mixed-citation><mixed-citation xml:lang="en">Boeke C. E., Eliassen A. H., Oh H., Spiegelman D., Willett W. C., Tamimi R. M. Adolescent physical activity in relation to breast cancer risk // Breast Cancer Res Treat. 2014; 145: 715–724. DOI: 10.1007/s10549–014–2919–5.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Tamimi R. M., Spiegelman D., Smith-Warner S. A., Wang M. et al. Population Attributable Risk of Modifiable and Nonmodifiable Breast Cancer Risk Factors in Postmenopausal Breast Cancer // Am J Epidemiol. 2016 Dec 15; 184 (12): 884–893. DOI: 10.1093/aje/kww145.</mixed-citation><mixed-citation xml:lang="en">Tamimi R. M., Spiegelman D., Smith-Warner S. A., Wang M. et al. Population Attributable Risk of Modifiable and Nonmodifiable Breast Cancer Risk Factors in Postmenopausal Breast Cancer // Am J Epidemiol. 2016 Dec 15; 184 (12): 884–893. DOI: 10.1093/aje/kww145.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson H. D., Zakher B., Cantor A., Fu R. et al. isk Factors for Breast Cancer for Women Age 40 to 49: A Systematic Review and Meta-analysis // Ann Intern Med. 2012, May 1; 156 (9): 635–648. DOI: 10.1059/0003–4819–156–9–201205010–00006.</mixed-citation><mixed-citation xml:lang="en">Nelson H. D., Zakher B., Cantor A., Fu R. et al. isk Factors for Breast Cancer for Women Age 40 to 49: A Systematic Review and Meta-analysis // Ann Intern Med. 2012, May 1; 156 (9): 635–648. DOI: 10.1059/0003–4819–156–9–201205010–00006.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation><mixed-citation xml:lang="en">Hashemi S. H. B., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electronic Physician. 2014; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Brenner D. R., Brockton N. T., Kotsopoulos J. et al. Breast cancer survival among young women: a review of the role of modifiable lifestyle factors // Cancer Causes &amp; Control. 2016; 27: 459–472. DOI: 10.1007/s10552–016–0726–5.</mixed-citation><mixed-citation xml:lang="en">Brenner D. R., Brockton N. T., Kotsopoulos J. et al. Breast cancer survival among young women: a review of the role of modifiable lifestyle factors // Cancer Causes &amp; Control. 2016; 27: 459–472. DOI: 10.1007/s10552–016–0726–5.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bruno E., Roveda E., Vitale J. et al. Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women // Eur J Cancer Care. 2018; 27: e12617. https://doi. org/10.1111/ecc.12617.</mixed-citation><mixed-citation xml:lang="en">Bruno E., Roveda E., Vitale J. et al. Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women // Eur J Cancer Care. 2018; 27: e12617. https://doi. org/10.1111/ecc.12617.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Муромцева Г. А., Концевая А. В., Константинов В. В. и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012–2013 гг. Результаты исследования ЭССЕ-РФ // Кардиоваскулярная терапия и профилактика. 2014; 13 (6): 8.</mixed-citation><mixed-citation xml:lang="en">Муромцева Г. А., Концевая А. В., Константинов В. В. и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012–2013 гг. Результаты исследования ЭССЕ-РФ // Кардиоваскулярная терапия и профилактика. 2014; 13 (6): 8.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rosner B., Eliassen A. H., Toriola A. T., Hankinson S. E., Willett W. C., Natarajan L., Colditz G. A. Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women // Breast Cancer Res Treat. 2015; 150: 643–653. DOI: 10.1007/s10549-015-3344-0.</mixed-citation><mixed-citation xml:lang="en">Rosner B., Eliassen A. H., Toriola A. T., Hankinson S. E., Willett W. C., Natarajan L., Colditz G. A. Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women // Breast Cancer Res Treat. 2015; 150: 643–653. DOI: 10.1007/s10549-015-3344-0.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemi S. H., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electron Physician. 2014 Jul 1; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation><mixed-citation xml:lang="en">Hashemi S. H., Karimi S., Mahboobi H. Lifestyle changes for prevention of breast cancer // Electron Physician. 2014 Jul 1; 6 (3): 894–905. DOI: 10.14661/2014.894–905.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Keum N., Greenwood D. C., Lee D. H., Kim R., Aune D., Ju W., Hu F. B., Giovannucci E. L. Adult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies // J Natl Cancer Inst. 2015; 107: djv088. DOI: 10.1093/jnci/djv088.</mixed-citation><mixed-citation xml:lang="en">Keum N., Greenwood D. C., Lee D. H., Kim R., Aune D., Ju W., Hu F. B., Giovannucci E. L. Adult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies // J Natl Cancer Inst. 2015; 107: djv088. DOI: 10.1093/jnci/djv088.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Проект Стратегии формирования здорового образа жизни населения, профилактики и контроля неинфекционных заболеваний на период до 2025 года. Дата публикации 26.06.2017 г. https://www.gnicpm.ru/UserFiles/Strategy_draft_26062017.pdf.</mixed-citation><mixed-citation xml:lang="en">Проект Стратегии формирования здорового образа жизни населения, профилактики и контроля неинфекционных заболеваний на период до 2025 года. Дата публикации 26.06.2017 г. https://www.gnicpm.ru/UserFiles/Strategy_draft_26062017.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gray J. M., Rasanayagam S., Engel C., Rizzo J. State of the evidence 2017: an update on the connection between breast cancer and the environment // Environmental Health. 2017; 16: 94. DOI: 10.1186/s12940-017-0287-4.</mixed-citation><mixed-citation xml:lang="en">Gray J. M., Rasanayagam S., Engel C., Rizzo J. State of the evidence 2017: an update on the connection between breast cancer and the environment // Environmental Health. 2017; 16: 94. DOI: 10.1186/s12940-017-0287-4.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Parada H., Bradshaw P. T., Steck S. E. et al. Postdiagnosis Changes in Cigarette Smoking and Survival Following Breast Cancer // JNCI cancer spectrum. 2017; 1 (1): pkx001. DOI: 10.1093/jncics/pkx001.</mixed-citation><mixed-citation xml:lang="en">Parada H., Bradshaw P. T., Steck S. E. et al. Postdiagnosis Changes in Cigarette Smoking and Survival Following Breast Cancer // JNCI cancer spectrum. 2017; 1 (1): pkx001. DOI: 10.1093/jncics/pkx001.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kawai M., Malone K. E., Tang M.-T. C., Li C. I. Active smoking and risk of estrogen receptor positive and triple-negative breast cancer among women 20–44 years of age // Cancer. 2014; 120 (7): 1026–1034. DOI: 10.1002/cncr.28402.</mixed-citation><mixed-citation xml:lang="en">Kawai M., Malone K. E., Tang M.-T. C., Li C. I. Active smoking and risk of estrogen receptor positive and triple-negative breast cancer among women 20–44 years of age // Cancer. 2014; 120 (7): 1026–1034. DOI: 10.1002/cncr.28402.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Butler E. N., Tse C.-K., Bell M. E., Conway K., Olshan A. F., Troester M. A. Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study // Cancer causes &amp; control: CCC. 2016; 27 (6): 775–786. DOI: 10.1007/s10552-016-0754-1.</mixed-citation><mixed-citation xml:lang="en">Butler E. N., Tse C.-K., Bell M. E., Conway K., Olshan A. F., Troester M. A. Active smoking and risk of Luminal and Basal-like breast cancer subtypes in the Carolina Breast Cancer Study // Cancer causes &amp; control: CCC. 2016; 27 (6): 775–786. DOI: 10.1007/s10552-016-0754-1.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Jones M. E., Schoemaker M. J., Wright L. B., Ashworth A., Swerdlow A. J. Smoking and risk of breast cancer in the Generations Study cohort // Breast Cancer Res. 2017, Nov 22; 19 (1): 118. DOI: 10.1186/s13058–017–0908–4.</mixed-citation><mixed-citation xml:lang="en">Jones M. E., Schoemaker M. J., Wright L. B., Ashworth A., Swerdlow A. J. Smoking and risk of breast cancer in the Generations Study cohort // Breast Cancer Res. 2017, Nov 22; 19 (1): 118. DOI: 10.1186/s13058–017–0908–4.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Nyante S. J., Gierach G. L., Dallal C. M. et al. Cigarette smoking and postmenopausal breast cancer risk in a prospective cohort // British Journal of Cancer. 2014; 110 (9): 2339–2347. DOI: 10.1038/bjc.2014.132.</mixed-citation><mixed-citation xml:lang="en">Nyante S. J., Gierach G. L., Dallal C. M. et al. Cigarette smoking and postmenopausal breast cancer risk in a prospective cohort // British Journal of Cancer. 2014; 110 (9): 2339–2347. DOI: 10.1038/bjc.2014.132.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Дефицит витамина D у взрослых: диагностика, лечение и профилактика. Клинические рекомендации РАЭ, МЗ РФ // Проблемы эндокринологии. 2016, 4, с. 60–84. DOI: 10.14341/probl201662460–84.</mixed-citation><mixed-citation xml:lang="en">Дефицит витамина D у взрослых: диагностика, лечение и профилактика. Клинические рекомендации РАЭ, МЗ РФ // Проблемы эндокринологии. 2016, 4, с. 60–84. DOI: 10.14341/probl201662460–84.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Forman J. P., Giovannucci E., Holmes M. D. et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension // Hypertension. 2007; 49: 1063–1069.</mixed-citation><mixed-citation xml:lang="en">Forman J. P., Giovannucci E., Holmes M. D. et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension // Hypertension. 2007; 49: 1063–1069.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Shekarriz-Foumani R., Khodaie F. The correlation of plasma 25-hydroxyvitamin D deficiency with risk of breast neoplasms: a systematic review // Iran J Cancer Prev. 2016; 9: e4469. DOI: 10.17795/ijcp-4469.</mixed-citation><mixed-citation xml:lang="en">Shekarriz-Foumani R., Khodaie F. The correlation of plasma 25-hydroxyvitamin D deficiency with risk of breast neoplasms: a systematic review // Iran J Cancer Prev. 2016; 9: e4469. DOI: 10.17795/ijcp-4469.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J. S., Haule C. C., Kim J. H. et al. Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy // Journal of Breast Cancer. 2018; 21 (2): 134–141. DOI: 10.4048/jbc.2018.21.2.134.</mixed-citation><mixed-citation xml:lang="en">Kim J. S., Haule C. C., Kim J. H. et al. Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy // Journal of Breast Cancer. 2018; 21 (2): 134–141. DOI: 10.4048/jbc.2018.21.2.134.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Welsh J. Function of the vitamin D endocrine system in mammary gland and breast cancer // Mol Cell Endocrinol. 2017 Sep 15; 453: 88–95. DOI: 10.1016/j. mce.2017.04.026.</mixed-citation><mixed-citation xml:lang="en">Welsh J. Function of the vitamin D endocrine system in mammary gland and breast cancer // Mol Cell Endocrinol. 2017 Sep 15; 453: 88–95. DOI: 10.1016/j. mce.2017.04.026.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Sergeev I. N. Vitamin D and cellular Ca2+ signaling in breast cancer // Anticancer Res. 2012; 32: 299–302.</mixed-citation><mixed-citation xml:lang="en">Sergeev I. N. Vitamin D and cellular Ca2+ signaling in breast cancer // Anticancer Res. 2012; 32: 299–302.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Iqbal M. U. N., Khan T. A. Association between vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: a systematic review and meta-analysis // Tumour Biol. 2017; 39: 1010428317731280. DOI: 10.1177/1010428317731280.</mixed-citation><mixed-citation xml:lang="en">Iqbal M. U. N., Khan T. A. Association between vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: a systematic review and meta-analysis // Tumour Biol. 2017; 39: 1010428317731280. DOI: 10.1177/1010428317731280.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D., V?lez de-la-Paz O. I., Zhai J. X. et al. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies // Tumor Biol. 2013, 34: 3509. https://doi. org/10.1007/s13277–013–0929–2.</mixed-citation><mixed-citation xml:lang="en">Wang D., V?lez de-la-Paz O. I., Zhai J. X. et al. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies // Tumor Biol. 2013, 34: 3509. https://doi. org/10.1007/s13277–013–0929–2.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Shekarriz-Foumani R., Khodaie F. The Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review // Iran J Cancer Prev. 2016, Jun; 9 (3): e4469. DOI: 10.17795/ijcp-4469.</mixed-citation><mixed-citation xml:lang="en">Shekarriz-Foumani R., Khodaie F. The Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review // Iran J Cancer Prev. 2016, Jun; 9 (3): e4469. DOI: 10.17795/ijcp-4469.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Stoll F., Akladios C. Y., Mathelin C. Vitamin D and breast cancer: is there a link? // Gynecol Obstet Fertil. 2013; 41: 242–50.</mixed-citation><mixed-citation xml:lang="en">Stoll F., Akladios C. Y., Mathelin C. Vitamin D and breast cancer: is there a link? // Gynecol Obstet Fertil. 2013; 41: 242–50.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Ord??ez-Mena J. M., Sch?ttker B., Fedirko V., Jenab M. et al. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium // Eur J Epidemiol. 2016 Mar; 31 (3): 311–23. DOI: 10.1007 / s10654–015–0040–7.</mixed-citation><mixed-citation xml:lang="en">Ord??ez-Mena J. M., Sch?ttker B., Fedirko V., Jenab M. et al. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium // Eur J Epidemiol. 2016 Mar; 31 (3): 311–23. DOI: 10.1007 / s10654–015–0040–7.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Welsh J. E. Vitamin D and Breast Cancer: Past and Present // Journal of Steroid Biochemistry and Molecular Biology 2018; 177: 15–20. http://dx. doi. org/10.1016/j. jsbmb.2017.07.025.</mixed-citation><mixed-citation xml:lang="en">Welsh J. E. Vitamin D and Breast Cancer: Past and Present // Journal of Steroid Biochemistry and Molecular Biology 2018; 177: 15–20. http://dx. doi. org/10.1016/j. jsbmb.2017.07.025.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Chiriac V. F., Baban A., Dumitrascu D. L. Psychological stress and breast cancer incidence: a systematic review // Clujul Med. 2018; 91 (1): 18–26. DOI: 10.15386/cjmed-924.</mixed-citation><mixed-citation xml:lang="en">Chiriac V. F., Baban A., Dumitrascu D. L. Psychological stress and breast cancer incidence: a systematic review // Clujul Med. 2018; 91 (1): 18–26. DOI: 10.15386/cjmed-924.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Heikkil? K., Nyberg S. T., Theorell T., Fransson E. I., Alfredsson L., Bjorner J. B. et al. Work stress and risk of cancer: Meta-analysis of 5700 incident cancer events in 116,000 European men and women // BMJ. 2013; 346: f165.</mixed-citation><mixed-citation xml:lang="en">Heikkil? K., Nyberg S. T., Theorell T., Fransson E. I., Alfredsson L., Bjorner J. B. et al. Work stress and risk of cancer: Meta-analysis of 5700 incident cancer events in 116,000 European men and women // BMJ. 2013; 346: f165.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Schoemaker M. J., Jones M. E., Wright L. B., Griffin J. et al. Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom // Breast Cancer Res. 2016, Jul 15; 18 (1): 72. DOI: 10.1186/s13058–016–0733–1.</mixed-citation><mixed-citation xml:lang="en">Schoemaker M. J., Jones M. E., Wright L. B., Griffin J. et al. Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom // Breast Cancer Res. 2016, Jul 15; 18 (1): 72. DOI: 10.1186/s13058–016–0733–1.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Sun H. L., Dong X. X., Cong Y. J., Gan Y. et al. Depression and the risk of breast cancer: A meta-analysis of cohort studies // Asian Pac J Cancer Prev. 2015; 16: 3233–3239.</mixed-citation><mixed-citation xml:lang="en">Sun H. L., Dong X. X., Cong Y. J., Gan Y. et al. Depression and the risk of breast cancer: A meta-analysis of cohort studies // Asian Pac J Cancer Prev. 2015; 16: 3233–3239.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Aky?rek ?., Akbal E., G?ne? F. Increase in the risk of ST elevation myocardial infarction is associated with homocysteine level // Arch Med Res. 2014; 45: 501–506.</mixed-citation><mixed-citation xml:lang="en">Aky?rek ?., Akbal E., G?ne? F. Increase in the risk of ST elevation myocardial infarction is associated with homocysteine level // Arch Med Res. 2014; 45: 501–506.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Y., Huang Y., Hu Y., Zhong J. et al. Hyperhomocysteinemia is an independent risk factor in young patients with coronary artery disease in southern China // Herz. 2013; 38: 779–784.</mixed-citation><mixed-citation xml:lang="en">Wu Y., Huang Y., Hu Y., Zhong J. et al. Hyperhomocysteinemia is an independent risk factor in young patients with coronary artery disease in southern China // Herz. 2013; 38: 779–784.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Alam N., Khan H. I., Chowdhury A. W., Haque M. S. et al. Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction // Bangladesh Med Res Counc Bull. 2012; 38: 9–13.</mixed-citation><mixed-citation xml:lang="en">Alam N., Khan H. I., Chowdhury A. W., Haque M. S. et al. Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction // Bangladesh Med Res Counc Bull. 2012; 38: 9–13.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // JAMA. 2002; 288: 2015–2022.</mixed-citation><mixed-citation xml:lang="en">Homocysteine Studies Collaboration Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // JAMA. 2002; 288: 2015–2022.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Humphrey L. L., Fu R., Rogers K., Freeman M., Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis // Mayo Clin Proc. 2008; 83: 1203–1212.</mixed-citation><mixed-citation xml:lang="en">Humphrey L. L., Fu R., Rogers K., Freeman M., Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis // Mayo Clin Proc. 2008; 83: 1203–1212.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson K. Low cir culating folate and vitamin b6 concentrations risk factors for stroke, peripheral vascular disease, and coronary artery disease // Circulation. 1998. Vol. 97. P. 437–443.</mixed-citation><mixed-citation xml:lang="en">Robinson K. Low cir culating folate and vitamin b6 concentrations risk factors for stroke, peripheral vascular disease, and coronary artery disease // Circulation. 1998. Vol. 97. P. 437–443.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Van Beynum I. M. Hyperhomocysteinemia: a risk factor for ischemic stroke in children // Circulation. 1999. Vol. 99. P. 2070–2072.</mixed-citation><mixed-citation xml:lang="en">Van Beynum I. M. Hyperhomocysteinemia: a risk factor for ischemic stroke in children // Circulation. 1999. Vol. 99. P. 2070–2072.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Virtanen J. K. Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the kuopio ischaemic heart disease risk factors (KIHD) study // Intl. med. 2005. Vol. 257. P. 255–262.</mixed-citation><mixed-citation xml:lang="en">Virtanen J. K. Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the kuopio ischaemic heart disease risk factors (KIHD) study // Intl. med. 2005. Vol. 257. P. 255–262.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Veeranna V., Zalawadiya S. K., Niraj A. et al. Homocysteine and reclassification of cardiovascular disease risk // J Am Coll Cardiol. 2011, Aug 30; 58 (10): 1025–1033.</mixed-citation><mixed-citation xml:lang="en">Veeranna V., Zalawadiya S. K., Niraj A. et al. Homocysteine and reclassification of cardiovascular disease risk // J Am Coll Cardiol. 2011, Aug 30; 58 (10): 1025–1033.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // J Am Med Assoc. 2002; 288: 2015–2022.</mixed-citation><mixed-citation xml:lang="en">Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis // J Am Med Assoc. 2002; 288: 2015–2022.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Wald D. S., Law M., Morris J. K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis // BMJ. 2002; 325: 1202–1208.</mixed-citation><mixed-citation xml:lang="en">Wald D. S., Law M., Morris J. K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis // BMJ. 2002; 325: 1202–1208.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Kim Y. I. Folate and carcinogenesis: Evidence, mechanisms, and implications // J Nutr Biochem. 1999; 10: 66–88.</mixed-citation><mixed-citation xml:lang="en">Kim Y. I. Folate and carcinogenesis: Evidence, mechanisms, and implications // J Nutr Biochem. 1999; 10: 66–88.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Blount B. C., Mack M. M., Wehr C. M., MacGregor J. T. et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neural damage // Proc Natl Acad Sci USA. 1997; 94: 3290–3295.</mixed-citation><mixed-citation xml:lang="en">Blount B. C., Mack M. M., Wehr C. M., MacGregor J. T. et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neural damage // Proc Natl Acad Sci USA. 1997; 94: 3290–3295.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Lin J., Lee I. M., Song Y., Cook N. R. et al. Plasma homocysteine and cysteine and risk of breast cancer in women // Cancer Res. 2010; 70, 2397–2405.</mixed-citation><mixed-citation xml:lang="en">Lin J., Lee I. M., Song Y., Cook N. R. et al. Plasma homocysteine and cysteine and risk of breast cancer in women // Cancer Res. 2010; 70, 2397–2405.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis S. Yu., Harbor R. M., Harris R., Smith G. D. Meta-analyzes of the observational and genetic associations of ies ve ve ve veir cancer of breast and breast cancer // J. Natl Cancer Inst. 2006. V. 98. № 22. P. 1607–1622.</mixed-citation><mixed-citation xml:lang="en">Lewis S. Yu., Harbor R. M., Harris R., Smith G. D. Meta-analyzes of the observational and genetic associations of ies ve ve ve veir cancer of breast and breast cancer // J. Natl Cancer Inst. 2006. V. 98. № 22. P. 1607–1622.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Lissowska J., Gaudet M. M., Brinton L. A. et al. genetic polymorphisms in a single-carbon pathway of metabolism-and the risk of breast cancer: a control study and a meta-analysis // Int. J. Cancer. V. 120. № 12. P. 2696–2703.</mixed-citation><mixed-citation xml:lang="en">Lissowska J., Gaudet M. M., Brinton L. A. et al. genetic polymorphisms in a single-carbon pathway of metabolism-and the risk of breast cancer: a control study and a meta-analysis // Int. J. Cancer. V. 120. № 12. P. 2696–2703.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">BrAvatara V. The controversial roles of methylene tetrahydro-polymorphisms of folateductase and folic acid in the mammary gland of cancerdisease // Int. J. Food. Sci. Nutr. 2015. V. 66. № 1. P. 43–49.</mixed-citation><mixed-citation xml:lang="en">BrAvatara V. The controversial roles of methylene tetrahydro-polymorphisms of folateductase and folic acid in the mammary gland of cancerdisease // Int. J. Food. Sci. Nutr. 2015. V. 66. № 1. P. 43–49.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Babyshkina N., Malinovskaya E., Nazarenko M. et al. Effect of folate-associated SNP on clinical function, response to neoadjuvant treatment and survival in pre- and postmenopauser of the breast patients // Gene. 2013. V. 518. № 2. P. 397–404.</mixed-citation><mixed-citation xml:lang="en">Babyshkina N., Malinovskaya E., Nazarenko M. et al. Effect of folate-associated SNP on clinical function, response to neoadjuvant treatment and survival in pre- and postmenopauser of the breast patients // Gene. 2013. V. 518. № 2. P. 397–404.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Ding X. P., Feng L., Ma L. MTHFR C677T полиморфно-физм и риск рака яичников: метаанализ. Азиатский Пак // J. Cancer Prev. 2012. V. 13. № 8. P. 3937–3942.</mixed-citation><mixed-citation xml:lang="en">Ding X. P., Feng L., Ma L. MTHFR C677T полиморфно-физм и риск рака яичников: метаанализ. Азиатский Пак // J. Cancer Prev. 2012. V. 13. № 8. P. 3937–3942.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Naushad S. M., Pavani A., Rupasri Y. et al. association of aberrations in a single-carbon metabolism, a molecular phenotype and cancer of breast cancer // Mol. Carcinog. 2012. V. 51. Appendix 1: E32–41.</mixed-citation><mixed-citation xml:lang="en">Naushad S. M., Pavani A., Rupasri Y. et al. association of aberrations in a single-carbon metabolism, a molecular phenotype and cancer of breast cancer // Mol. Carcinog. 2012. V. 51. Appendix 1: E32–41.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki T., Matsuo K., Hirose K. et al. One-carbon me-polymorphisms associated with tabolism, and the risk of developing breast cancer // Carcinogenesis. V. 29. № 2. P. 356–362.</mixed-citation><mixed-citation xml:lang="en">Suzuki T., Matsuo K., Hirose K. et al. One-carbon me-polymorphisms associated with tabolism, and the risk of developing breast cancer // Carcinogenesis. V. 29. № 2. P. 356–362.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
