<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">lvrach-632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Кожные реакции на лекарства. Как распознать?</article-title><trans-title-group xml:lang="en"><trans-title>Drug reactions with skin manifestations. How to discover?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиулин</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Haliulin</surname><given-names>Yu. G.</given-names></name></name-alternatives><email xlink:type="simple">yuriy.khaliulin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мачарадзе</surname><given-names>Д. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Macharadze</surname><given-names>D. Sh.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГАОУ ВО РУДН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>11</issue><fpage>79</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Халиулин Ю.Г., Мачарадзе Д.Ш., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Халиулин Ю.Г., Мачарадзе Д.Ш.</copyright-holder><copyright-holder xml:lang="en">Haliulin Y.G., Macharadze D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/632">https://journal.lvrach.ru/jour/article/view/632</self-uri><abstract><p>Рассмотрены причины возникновения и клинические проявления токсикодермий. Указывается, что реакции на лекарства с проявлениями на коже чрезвычайно разнообразны. В некоторых случаях врач не может отменить лекарство, и тогда задача врача — назначить лечение с целью сгладить побочные эффекты лекарства или найти замену данному препарату. Регресс высыпаний после отмены препарата тоже помогает найти причину заболевания.</p></abstract><trans-abstract xml:lang="en"><p>Reasons of appearance and clinical manifestations of toxicodermia were considered. It was indicated that drug reactions with skin manifestations are extremely versatile. In some cases, the doctor cannot cancel the drug, and then the doctor should prescribe the treatment in order to mitigate the side effects of the drug, or find a substitute for this preparation. Regression in the eruptions after the preparation is cancelled also helps find the reason of the disease. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Актуальная тема</kwd><kwd>Дерматоз</kwd><kwd>Токсикодермия</kwd><kwd>Высыпания</kwd><kwd>Реакции на лекарства</kwd><kwd>Фармакология</kwd><kwd>Дерматовенерология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dermatosis</kwd><kwd>toxicodermia</kwd><kwd>eruption</kwd><kwd>drug reactions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gerogianni K., Tsezou A., Dimas K. Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention // Mol Diagn Ther. 2018, Jun; 22 (3): 297–314.</mixed-citation><mixed-citation xml:lang="en">Gerogianni K., Tsezou A., Dimas K. Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention // Mol Diagn Ther. 2018, Jun; 22 (3): 297–314.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">C. de la Torre, Oh H. J. Suh. Advances in the diagnosis of drug eruptions // Actas Dermosifiliogr. 2013, Nov; 104 (9): 782–788.</mixed-citation><mixed-citation xml:lang="en">C. de la Torre, Oh H. J. Suh. Advances in the diagnosis of drug eruptions // Actas Dermosifiliogr. 2013, Nov; 104 (9): 782–788.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">James W. D., Berger T. G., Elston D. M. Andrews Diseases of the Skin. Clinical Dermatology // Saunders Elsevier. 2006, 10 th edit.: 123.</mixed-citation><mixed-citation xml:lang="en">James W. D., Berger T. G., Elston D. M. Andrews Diseases of the Skin. Clinical Dermatology // Saunders Elsevier. 2006, 10 th edit.: 123.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider J. A., Cohen P. R. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Concise Review with a Comprehensive Summary of Therapeutic Interventions Emphasizing Supportive Measures // Adv Ther. 2017; 34 (6): 1235–1244.</mixed-citation><mixed-citation xml:lang="en">Schneider J. A., Cohen P. R. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Concise Review with a Comprehensive Summary of Therapeutic Interventions Emphasizing Supportive Measures // Adv Ther. 2017; 34 (6): 1235–1244.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Renn C. N., Straff W., Dorfm?ller A., Al-Masaoudi T., Merk H. F., Sachs B. Amoxicillin-induced Exanthema in Young Adults with Infectious Mononucleosis: Demonstration of Drug-specific Lymphocyte Reactivity // Br J Dermatol. 2002, Dec; 147 (6): 1166–1170.</mixed-citation><mixed-citation xml:lang="en">Renn C. N., Straff W., Dorfm?ller A., Al-Masaoudi T., Merk H. F., Sachs B. Amoxicillin-induced Exanthema in Young Adults with Infectious Mononucleosis: Demonstration of Drug-specific Lymphocyte Reactivity // Br J Dermatol. 2002, Dec; 147 (6): 1166–1170.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ramirez A., Perez-Perez L., Fernandez-Redondo V., Toribio J. Photoallergic Dermatitis Induced by Diltiazem // Contact Dermatitis. 2007: 56: 118–119.</mixed-citation><mixed-citation xml:lang="en">Ramirez A., Perez-Perez L., Fernandez-Redondo V., Toribio J. Photoallergic Dermatitis Induced by Diltiazem // Contact Dermatitis. 2007: 56: 118–119.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Weyers W., Metze D. Histopathology of Drug Eruptions — General Criteria, Common Patterns, and Differential Diagnosis // Dermatol Pract Concept. 2011; 1 (1): 9: 33–47.</mixed-citation><mixed-citation xml:lang="en">Weyers W., Metze D. Histopathology of Drug Eruptions — General Criteria, Common Patterns, and Differential Diagnosis // Dermatol Pract Concept. 2011; 1 (1): 9: 33–47.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ackerman A. B., Chongchitnant N., Sanchez J. et al. Histologic Diagnosis of Inflammatory Skin Diseases. 2 nd ed. Baltimore: Williams&amp;Wilkins, 1997: 317.</mixed-citation><mixed-citation xml:lang="en">Ackerman A. B., Chongchitnant N., Sanchez J. et al. Histologic Diagnosis of Inflammatory Skin Diseases. 2 nd ed. Baltimore: Williams&amp;Wilkins, 1997: 317.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Majdy N., Weyers W., Metze D. Histopathologic Features of Exanthematous Drug Eruptions of the Macular and Papular Type // Am J Dermatopathol. 2011; 33 (7): 695–704.</mixed-citation><mixed-citation xml:lang="en">Majdy N., Weyers W., Metze D. Histopathologic Features of Exanthematous Drug Eruptions of the Macular and Papular Type // Am J Dermatopathol. 2011; 33 (7): 695–704.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Busam K. J. Dermatopathology E-Book: A Volume in the Series: Foundations in Diagnostic Pathology (Expert Consult — Online), 2 nd ed, 2016. Elsevier/Saunders. Chapter 14. Hematopoetic Neoplasms: 603.</mixed-citation><mixed-citation xml:lang="en">Busam K. J. Dermatopathology E-Book: A Volume in the Series: Foundations in Diagnostic Pathology (Expert Consult — Online), 2 nd ed, 2016. Elsevier/Saunders. Chapter 14. Hematopoetic Neoplasms: 603.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Goldberg I., Hanson M., Chodick G., Shirazi I., Brenner S. In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions // Clin Dev Immunol. 2012: 687532.</mixed-citation><mixed-citation xml:lang="en">Goldberg I., Hanson M., Chodick G., Shirazi I., Brenner S. In Vitro Release of Interferon-Gamma from Peripheral Blood Lymphocytes in Cutaneous Adverse Drug Reactions // Clin Dev Immunol. 2012: 687532.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Barbaud A. Drug Patch Testing in Systemic Cutaneous Drug Allergy // Toxicology. 2005; 209 (2): 209–216.</mixed-citation><mixed-citation xml:lang="en">Barbaud A. Drug Patch Testing in Systemic Cutaneous Drug Allergy // Toxicology. 2005; 209 (2): 209–216.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Schulz J. T., Sheridan R. L., Ryan C. M., MacKool B., Tompkins R. G. A 10-Year Experience with Toxic Epidermal Necrolysis // J Burn Care Rehabil. 2000; 21 (3): 199–204.</mixed-citation><mixed-citation xml:lang="en">Schulz J. T., Sheridan R. L., Ryan C. M., MacKool B., Tompkins R. G. A 10-Year Experience with Toxic Epidermal Necrolysis // J Burn Care Rehabil. 2000; 21 (3): 199–204.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bastuji-Garin S., Fouchard N., Bertocchi M., Roujeau J. C., Revuz J., Wolkenstein P. SCORTEN: a Severity-of-illness Score for Toxic Epidermal Necrolysis // J. Invest. Dermatol. 2000; 115: 149–153.</mixed-citation><mixed-citation xml:lang="en">Bastuji-Garin S., Fouchard N., Bertocchi M., Roujeau J. C., Revuz J., Wolkenstein P. SCORTEN: a Severity-of-illness Score for Toxic Epidermal Necrolysis // J. Invest. Dermatol. 2000; 115: 149–153.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ruble J., Matsuo F. Anticonvulsant-Induced Cutaneous Reactions. Incidence, Mechanisms and Management // CNS Drugs. 1999, Sep; 12 (3): 215–236.</mixed-citation><mixed-citation xml:lang="en">Ruble J., Matsuo F. Anticonvulsant-Induced Cutaneous Reactions. Incidence, Mechanisms and Management // CNS Drugs. 1999, Sep; 12 (3): 215–236.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh S. A., Creamer D. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a Clinical Update and Review of Current Thinking // Clinical and Experimental Dermatology. 36: 6–11.</mixed-citation><mixed-citation xml:lang="en">Walsh S. A., Creamer D. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a Clinical Update and Review of Current Thinking // Clinical and Experimental Dermatology. 36: 6–11.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sheikh J. S., Farah S., Mohd A. Drug Reaction with Eosinophilia and Systemic Symptoms: Manifestations, Treatment, and Outcome in 17 Patients // Int J Dermatol. 2015, 54: 537–542.</mixed-citation><mixed-citation xml:lang="en">Sheikh J. S., Farah S., Mohd A. Drug Reaction with Eosinophilia and Systemic Symptoms: Manifestations, Treatment, and Outcome in 17 Patients // Int J Dermatol. 2015, 54: 537–542.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Shiohara T., Inaoka M., Kano Y. Drug-induced Hypersensitivity Syndrome (DIHS): A Reaction Induced by a Complex Interplay among Herpesviruses and Antiviral and Antidrug Immune Responses // Allergol. Int. 2006; 55: 1–8.</mixed-citation><mixed-citation xml:lang="en">Shiohara T., Inaoka M., Kano Y. Drug-induced Hypersensitivity Syndrome (DIHS): A Reaction Induced by a Complex Interplay among Herpesviruses and Antiviral and Antidrug Immune Responses // Allergol. Int. 2006; 55: 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Koumantaki-Mathioudaki E., Papadavid E., Katsambas A. Generalized pustular drug eruptions // JADV. 1999, 12: 196–197.</mixed-citation><mixed-citation xml:lang="en">Koumantaki-Mathioudaki E., Papadavid E., Katsambas A. Generalized pustular drug eruptions // JADV. 1999, 12: 196–197.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ardeshna K. P., Rohatgi S., Jerajani H. R. Fixed Drug Eruption to Cetirizine: An Unusual Villain // Indian Dermatol Online J. 2018, Jan-Feb; 9 (1): 55–57.</mixed-citation><mixed-citation xml:lang="en">Ardeshna K. P., Rohatgi S., Jerajani H. R. Fixed Drug Eruption to Cetirizine: An Unusual Villain // Indian Dermatol Online J. 2018, Jan-Feb; 9 (1): 55–57.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mi-Yeong K., Eun-Jung J., Yoon-Seok C., Sang-Heon C., Kyung-Up M., Sae-Hoon K. A Case of Levocetirizine-induced Fixed Drug Eruption and Cross-reaction with Piperazine Derivatives // Asia Pac Allergy. 2013, Oct; 3 (4): 281–284.</mixed-citation><mixed-citation xml:lang="en">Mi-Yeong K., Eun-Jung J., Yoon-Seok C., Sang-Heon C., Kyung-Up M., Sae-Hoon K. A Case of Levocetirizine-induced Fixed Drug Eruption and Cross-reaction with Piperazine Derivatives // Asia Pac Allergy. 2013, Oct; 3 (4): 281–284.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Drucker A. M., Rosen C. F. Drug-Induced Photosensitivity. Culprit Drugs, Management and Prevention // Drug Safety. 2011; 34 (10): 821–837.</mixed-citation><mixed-citation xml:lang="en">Drucker A. M., Rosen C. F. Drug-Induced Photosensitivity. Culprit Drugs, Management and Prevention // Drug Safety. 2011; 34 (10): 821–837.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sehgal V. N., Jain S., Bhattacharya S. N. Cutaneous drug reactions // JEADV. 1993, 2: 281–295.</mixed-citation><mixed-citation xml:lang="en">Sehgal V. N., Jain S., Bhattacharya S. N. Cutaneous drug reactions // JEADV. 1993, 2: 281–295.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Frigas E., Nzeako U. C. Angioedema. Pathogenesis, differential diagnosis, and treatment // Clin Rev Allergy Immunol. 2002; 23 (2): 217–231.</mixed-citation><mixed-citation xml:lang="en">Frigas E., Nzeako U. C. Angioedema. Pathogenesis, differential diagnosis, and treatment // Clin Rev Allergy Immunol. 2002; 23 (2): 217–231.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lasser E. C. Chasing Contrast Molecules: A 45 Year Quixotic Quest // Acad Radiol. 2004; 11: 1190–1196.</mixed-citation><mixed-citation xml:lang="en">Lasser E. C. Chasing Contrast Molecules: A 45 Year Quixotic Quest // Acad Radiol. 2004; 11: 1190–1196.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bush W. H., Segal A. J. Recognition and Treatment of Acute Contrast Reactions // Appl Radiol December. 2009: 21,16–21.</mixed-citation><mixed-citation xml:lang="en">Bush W. H., Segal A. J. Recognition and Treatment of Acute Contrast Reactions // Appl Radiol December. 2009: 21,16–21.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Brenner S., Bialy-Golan A., Ruocco V. Drug-induced Pemphigus // Clin Dermatol. 1998; 6 (3): 393–397.</mixed-citation><mixed-citation xml:lang="en">Brenner S., Bialy-Golan A., Ruocco V. Drug-induced Pemphigus // Clin Dermatol. 1998; 6 (3): 393–397.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Халиулин Ю. Г., Урбанский А. С. Современные подходы к диагностике и медикаментозной терапии дерматозов. Учебное пособие для системы послевузовского и дополнительного профессионального образования врачей. Кемерово: КемГМА, 2011. 165 с.</mixed-citation><mixed-citation xml:lang="en">Халиулин Ю. Г., Урбанский А. С. Современные подходы к диагностике и медикаментозной терапии дерматозов. Учебное пособие для системы послевузовского и дополнительного профессионального образования врачей. Кемерово: КемГМА, 2011. 165 с.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Valeyrie-Allanore L., Sassolas B., Roujeau J.-C. Drug-Induced Skin, Nail and Hair Disorders // Drug Safety. 2007; 30 (11): 1011–1030.</mixed-citation><mixed-citation xml:lang="en">Valeyrie-Allanore L., Sassolas B., Roujeau J.-C. Drug-Induced Skin, Nail and Hair Disorders // Drug Safety. 2007; 30 (11): 1011–1030.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Virendra N. S., Sanjiv J., Sambit N. B. Cutaneous drug reactions // JEADV. 1993, 2: 281–295.</mixed-citation><mixed-citation xml:lang="en">Virendra N. S., Sanjiv J., Sambit N. B. Cutaneous drug reactions // JEADV. 1993, 2: 281–295.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Femiano F., Lanza A., Buonaiuto C. et al. Oral Manifestations of Adverse Drug Reactions: Guidelines // JEADV. 2008, 22: 681–691.</mixed-citation><mixed-citation xml:lang="en">Femiano F., Lanza A., Buonaiuto C. et al. Oral Manifestations of Adverse Drug Reactions: Guidelines // JEADV. 2008, 22: 681–691.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Tack D. A., Rogers R. S. Oral Drug Reactions // Dermatologic Therapy 2002, 15: 236–250.</mixed-citation><mixed-citation xml:lang="en">Tack D. A., Rogers R. S. Oral Drug Reactions // Dermatologic Therapy 2002, 15: 236–250.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Moore D. E. Drug-Induced Cutaneous Photosensitivity. Incidence, Mechanism, Prevention and Management // Drug Safety. 2002; 25 (5), p. 356.</mixed-citation><mixed-citation xml:lang="en">Moore D. E. Drug-Induced Cutaneous Photosensitivity. Incidence, Mechanism, Prevention and Management // Drug Safety. 2002; 25 (5), p. 356.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
