<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">lvrach</journal-id><journal-title-group><journal-title xml:lang="ru">Лечащий Врач</journal-title><trans-title-group xml:lang="en"><trans-title>Lechaschi Vrach</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-5175</issn><issn pub-type="epub">2687-1181</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">lvrach-595</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Мукоактивная терапия кашля: что за горизонтом?</article-title><trans-title-group xml:lang="en"><trans-title>Mucoactive cough therapy: what is behind the horizon?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaitsev</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">a-zaicev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГКУ ГВКГ им. акад. Н. Н. Бурденко</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>10</issue><fpage>22</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайцев А.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Зайцев А.А.</copyright-holder><copyright-holder xml:lang="en">Zaitsev A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.lvrach.ru/jour/article/view/595">https://journal.lvrach.ru/jour/article/view/595</self-uri><abstract><p>Обсуждены общие лечебные подходы к ведению пациента с кашлем, рассмотрены медикаментозные методы лечения пациентов с кашлем, особое внимание уделено мукоактивным препаратам.</p></abstract><trans-abstract xml:lang="en"><p>General therapeutic approaches to management of patients with cough were discussed, drug methods of treatment of patients with cough were considered, with special emphasize on mucoactive preparations. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>Симпозиум</kwd><kwd>Бронхопульмонология</kwd><kwd>Лор-заболевания</kwd><kwd>Кашель</kwd><kwd>Фармакотерапия кашля</kwd><kwd>Мукоактивные вещества</kwd><kwd>Эффективность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cough</kwd><kwd>cough pharmacotherapy</kwd><kwd>mucoactive preparations</kwd><kwd>efficiency</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Morice A. Epidemiology of cough // Pulm Pharmacol Ther. 2002; 15: 253–259.</mixed-citation><mixed-citation xml:lang="en">Morice A. Epidemiology of cough // Pulm Pharmacol Ther. 2002; 15: 253–259.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Morice A., McGarvey L., Pavord I. et al. Recommendations for the management of cough in adults // Thorax. 2006; 61: 1–24.</mixed-citation><mixed-citation xml:lang="en">Morice A., McGarvey L., Pavord I. et al. Recommendations for the management of cough in adults // Thorax. 2006; 61: 1–24.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А. Г., Амбросимов В. Н. Кашель. М.: Изд. «Эхо», 2012. 128 с.</mixed-citation><mixed-citation xml:lang="en">Чучалин А. Г., Амбросимов В. Н. Кашель. М.: Изд. «Эхо», 2012. 128 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А. А., Оковитый С. В. Кашель: дифференциальный диагноз и рациональная фармакотерапия // Терапевтический архив. 2014. Т. 86. № 12. С. 85–91.</mixed-citation><mixed-citation xml:lang="en">Зайцев А. А., Оковитый С. В. Кашель: дифференциальный диагноз и рациональная фармакотерапия // Терапевтический архив. 2014. Т. 86. № 12. С. 85–91.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cullinan P. Persistent cough and sputum: prevalence and clinical characteristics in south east England // Respir Med. 1992; 86: 143–149.</mixed-citation><mixed-citation xml:lang="en">Cullinan P. Persistent cough and sputum: prevalence and clinical characteristics in south east England // Respir Med. 1992; 86: 143–149.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lundback B., Nystrom L., Rosenhall L. et al. Obstructive lung disease in northern Sweden: respiratory symptoms assessed in a postal survey // Eur Respir J. 1991; 4: 257–266.</mixed-citation><mixed-citation xml:lang="en">Lundback B., Nystrom L., Rosenhall L. et al. Obstructive lung disease in northern Sweden: respiratory symptoms assessed in a postal survey // Eur Respir J. 1991; 4: 257–266.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cerveri I., Accordini S., Corsico A. et al. Chronic cough and phlegm in young adults // Eur Respir J. 2003; 22 (3): 413–417.</mixed-citation><mixed-citation xml:lang="en">Cerveri I., Accordini S., Corsico A. et al. Chronic cough and phlegm in young adults // Eur Respir J. 2003; 22 (3): 413–417.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018. Доступно на http://goldcopd.org/gold-reports/.</mixed-citation><mixed-citation xml:lang="en">Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018. Доступно на http://goldcopd.org/gold-reports/.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fuhrman C., Delmas M. Epidemiology of chronic obstructive pulmonary disease in France // Rev Mal Respir. 2010; 27 (2): 160–168.</mixed-citation><mixed-citation xml:lang="en">Fuhrman C., Delmas M. Epidemiology of chronic obstructive pulmonary disease in France // Rev Mal Respir. 2010; 27 (2): 160–168.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Buist A. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study // Lancet. 2007; 370 (9589): 741–750.</mixed-citation><mixed-citation xml:lang="en">Buist A. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study // Lancet. 2007; 370 (9589): 741–750.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Menezes A. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study // Lancet. 2005; 366 (9500): 1875–1881.</mixed-citation><mixed-citation xml:lang="en">Menezes A. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study // Lancet. 2005; 366 (9500): 1875–1881.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chuchalin A., Khaltaev N., Аntonov N. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation // Int J COPD. 2014; 9: 963–974.</mixed-citation><mixed-citation xml:lang="en">Chuchalin A., Khaltaev N., Аntonov N. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation // Int J COPD. 2014; 9: 963–974.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А. А., Оковитый С. В., Крюков Е. В. Кашель. Практическое пособие для врачей. М.: Главный военный клинический госпиталь им. Н. Н. Бурденко, 2015.</mixed-citation><mixed-citation xml:lang="en">Зайцев А. А., Оковитый С. В., Крюков Е. В. Кашель. Практическое пособие для врачей. М.: Главный военный клинический госпиталь им. Н. Н. Бурденко, 2015.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А. А. Направления фармакотерапии и профилактики острых респираторных вирусных инфекций // РМЖ. 2009; Т. 17. № 23: 1525–1529.</mixed-citation><mixed-citation xml:lang="en">Зайцев А. А. Направления фармакотерапии и профилактики острых респираторных вирусных инфекций // РМЖ. 2009; Т. 17. № 23: 1525–1529.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А. А., Синопальников А. И. Рациональная фармакотерапия острых респираторных вирусных инфекций // Consilium Medicum. 2008; Т. 10. № 10: 80–86.</mixed-citation><mixed-citation xml:lang="en">Зайцев А. А., Синопальников А. И. Рациональная фармакотерапия острых респираторных вирусных инфекций // Consilium Medicum. 2008; Т. 10. № 10: 80–86.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Оковитый С. В., Анисимова Н. А. Фармакологические подходы к противокашлевой терапии // Русский медицинский журнал. 2011; № 23: 1150–1158.</mixed-citation><mixed-citation xml:lang="en">Оковитый С. В., Анисимова Н. А. Фармакологические подходы к противокашлевой терапии // Русский медицинский журнал. 2011; № 23: 1150–1158.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Клячкина И. Л. Выбор лекарственных препаратов при продуктивном кашле // Consilium Medicum. 2007; т. 9, № 1.</mixed-citation><mixed-citation xml:lang="en">Клячкина И. Л. Выбор лекарственных препаратов при продуктивном кашле // Consilium Medicum. 2007; т. 9, № 1.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Beeh K. M., Beier J., Esperester A., Paul L. D. Antiinflammatory properties of ambroxol // Eur J Med Res. 2008; 13: 12: 557–562.</mixed-citation><mixed-citation xml:lang="en">Beeh K. M., Beier J., Esperester A., Paul L. D. Antiinflammatory properties of ambroxol // Eur J Med Res. 2008; 13: 12: 557–562.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А. А., Моисеев С. В. Бронхоэктазы, не обусловленные муковисцидозом: эпидемиология, диагностика и лечение // Клиническая фармакология и терапия. 2017. Т. 26. № 5. С. 19–24.</mixed-citation><mixed-citation xml:lang="en">Зайцев А. А., Моисеев С. В. Бронхоэктазы, не обусловленные муковисцидозом: эпидемиология, диагностика и лечение // Клиническая фармакология и терапия. 2017. Т. 26. № 5. С. 19–24.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Balsamo R., Lanata L., Egan C. G. Mucoactive drugs // Eur. Respir. Rev. 2010. Vоl. 19. № 116. P. 127–133.</mixed-citation><mixed-citation xml:lang="en">Balsamo R., Lanata L., Egan C. G. Mucoactive drugs // Eur. Respir. Rev. 2010. Vоl. 19. № 116. P. 127–133.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Moretti M. Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease // Expert Rev Respir Med. 2007; 1: 307–316.</mixed-citation><mixed-citation xml:lang="en">Moretti M. Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease // Expert Rev Respir Med. 2007; 1: 307–316.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Moretti M. Erdosteine: its relevance in COPD treatment // Expert Opin Drug Metab Toxicol. 2009. Vol. 5. Р. 333–343.</mixed-citation><mixed-citation xml:lang="en">Moretti M. Erdosteine: its relevance in COPD treatment // Expert Opin Drug Metab Toxicol. 2009. Vol. 5. Р. 333–343.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Savu S., Mitrea M., Silvestro L., Mancini C. HPLC with on-line mass spectrometry detection applicable to elucidate erdosteine metabolism // Int J Clin Pharm Ther. 2000. Vol. 38. Р. 415–417.</mixed-citation><mixed-citation xml:lang="en">Savu S., Mitrea M., Silvestro L., Mancini C. HPLC with on-line mass spectrometry detection applicable to elucidate erdosteine metabolism // Int J Clin Pharm Ther. 2000. Vol. 38. Р. 415–417.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ricevuti G., Nazzone A., Uccelli E. et al. Influence of erdosteine, a mucolytic agent, on amoxicillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis // Thorax. 1988. Vоl. 43. P. 585–590.</mixed-citation><mixed-citation xml:lang="en">Ricevuti G., Nazzone A., Uccelli E. et al. Influence of erdosteine, a mucolytic agent, on amoxicillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis // Thorax. 1988. Vоl. 43. P. 585–590.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Braga P. C., Zuccotti T., Dal Sasso M. Bacterial aghesiveness: effects of the SH metabolite of erdosteine (mucoactive drug) plus clarithromycin versus clarithromycin alone // Chemotherapy. 2001. Vоl. 47. P. 208–214.</mixed-citation><mixed-citation xml:lang="en">Braga P. C., Zuccotti T., Dal Sasso M. Bacterial aghesiveness: effects of the SH metabolite of erdosteine (mucoactive drug) plus clarithromycin versus clarithromycin alone // Chemotherapy. 2001. Vоl. 47. P. 208–214.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dal Negro R. Erdosteine: antitussive and anti-inflammatory effects // Lung. 2008; 186: 70–73.</mixed-citation><mixed-citation xml:lang="en">Dal Negro R. Erdosteine: antitussive and anti-inflammatory effects // Lung. 2008; 186: 70–73.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD // Biochim. Biophys. Acta. 2012. Vоl. 1822. № 5. P. 714–728.</mixed-citation><mixed-citation xml:lang="en">Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD // Biochim. Biophys. Acta. 2012. Vоl. 1822. № 5. P. 714–728.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cogo R. Erdosteine: a new therapeutic weapon beyond the PEACE // Trends in Medicine. 2012. Vоl. 12. № 3. P. 133–142.</mixed-citation><mixed-citation xml:lang="en">Cogo R. Erdosteine: a new therapeutic weapon beyond the PEACE // Trends in Medicine. 2012. Vоl. 12. № 3. P. 133–142.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Moretti M., Marchioni C. An overview of erdosteine antioxidant activity in experimental research // Pharmacol Res. 2007; 55: 249–254.</mixed-citation><mixed-citation xml:lang="en">Moretti M., Marchioni C. An overview of erdosteine antioxidant activity in experimental research // Pharmacol Res. 2007; 55: 249–254.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Braga P. C., Dal Sasso M., Sala M. T., Gianelle V. Effects of erdosteine and its metabolites on bacterial adhesiveness // Arzneimittelforschung. 1999. Vоl. 49. № 4. P. 344–350.</mixed-citation><mixed-citation xml:lang="en">Braga P. C., Dal Sasso M., Sala M. T., Gianelle V. Effects of erdosteine and its metabolites on bacterial adhesiveness // Arzneimittelforschung. 1999. Vоl. 49. № 4. P. 344–350.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ricevuti G., Nazzone A., Uccelli E. et al. Influence of erdosteine, a mucolytic agent, on amoxicillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis // Thorax. 1988. Vоl. 43. P. 585–590.</mixed-citation><mixed-citation xml:lang="en">Ricevuti G., Nazzone A., Uccelli E. et al. Influence of erdosteine, a mucolytic agent, on amoxicillin penetration into sputum in patients with an infective exacerbation of chronic bronchitis // Thorax. 1988. Vоl. 43. P. 585–590.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Floriani I., Page C. P. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data // Pulm. Pharmacol. Ther. 2010. Vоl. 23. № 2. P. 135–144.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Floriani I., Page C. P. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data // Pulm. Pharmacol. Ther. 2010. Vоl. 23. № 2. P. 135–144.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Bisetti A., Mancini C. Mucolytic activity of erdosteine double blind clinical trial vs placebo // Arch. Med. Inter. 1995; 47: 89–97.</mixed-citation><mixed-citation xml:lang="en">Bisetti A., Mancini C. Mucolytic activity of erdosteine double blind clinical trial vs placebo // Arch. Med. Inter. 1995; 47: 89–97.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi B., Ballabio M., Moretti M. Effects of erdosteine on serum biomarker concentrations at COPD exacerbation // Eur. Respir. J. 2010; 36: 378.</mixed-citation><mixed-citation xml:lang="en">Bianchi B., Ballabio M., Moretti M. Effects of erdosteine on serum biomarker concentrations at COPD exacerbation // Eur. Respir. J. 2010; 36: 378.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С. Н. Перспективы применения современных мукоактивных препаратов в терапии пациентов с хронической обструктивной болезнью легких // Пульмонология. 2014. № 2. С. 100–108.</mixed-citation><mixed-citation xml:lang="en">Авдеев С. Н. Перспективы применения современных мукоактивных препаратов в терапии пациентов с хронической обструктивной болезнью легких // Пульмонология. 2014. № 2. С. 100–108.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Burgel P.-R., Nesme-Meyer P., Chanez P. et al. Cough and spu- tum production are associated with frequent exacerbations and hospitalizations in COPD subjects // Chest. 2009; 135: 975–982.</mixed-citation><mixed-citation xml:lang="en">Burgel P.-R., Nesme-Meyer P., Chanez P. et al. Cough and spu- tum production are associated with frequent exacerbations and hospitalizations in COPD subjects // Chest. 2009; 135: 975–982.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Speizer F. E., Fay M. E., Dockery D. W. et al. Chronic obstructive pulmonary disease mortality in six U. S. cities // Am. Rev. Respir. Dis. 1989; 140 (3): 49–S55.</mixed-citation><mixed-citation xml:lang="en">Speizer F. E., Fay M. E., Dockery D. W. et al. Chronic obstructive pulmonary disease mortality in six U. S. cities // Am. Rev. Respir. Dis. 1989; 140 (3): 49–S55.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Prescott E., Lange P., Vestbo J. Chronic mucus hypersecretion in COPD and death from pulmonary infection // Eur. Respir. J. 1995; 8: 1333–1338.</mixed-citation><mixed-citation xml:lang="en">Prescott E., Lange P., Vestbo J. Chronic mucus hypersecretion in COPD and death from pulmonary infection // Eur. Respir. J. 1995; 8: 1333–1338.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., Prescott E., Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group // Am. J. Respir. Crit. Care Med. 1996; 153: 1530–1535.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., Prescott E., Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group // Am. J. Respir. Crit. Care Med. 1996; 153: 1530–1535.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">De Marco R., Accordini S., Cerveri I. et al. Incidence of chron- ic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm // Am. J. Respir. Crit. Care Med. 2007; 175: 32–39.</mixed-citation><mixed-citation xml:lang="en">De Marco R., Accordini S., Cerveri I. et al. Incidence of chron- ic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm // Am. J. Respir. Crit. Care Med. 2007; 175: 32–39.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Dal Negro R., Visconti M., Tognella S., Micheletto C. Erdosteine affects eicosanoid production in COPD // Int J Clin Pharmacol Ther. 2011; 49: 41–45.</mixed-citation><mixed-citation xml:lang="en">Dal Negro R., Visconti M., Tognella S., Micheletto C. Erdosteine affects eicosanoid production in COPD // Int J Clin Pharmacol Ther. 2011; 49: 41–45.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Fioretti M., Bandera M. Prevention of exacerbation in chronic bronchitis patients with erdosteine // Med. Praxis. 1991. Vоl. 12. № 4. P. 219–227.</mixed-citation><mixed-citation xml:lang="en">Fioretti M., Bandera M. Prevention of exacerbation in chronic bronchitis patients with erdosteine // Med. Praxis. 1991. Vоl. 12. № 4. P. 219–227.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Moretti M., Bottrighi P., Dallari R. et al. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: The equalife study // Drugs Exp. Clin. Res. 2004, 30: 143–152.</mixed-citation><mixed-citation xml:lang="en">Moretti M., Bottrighi P., Dallari R. et al. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: The equalife study // Drugs Exp. Clin. Res. 2004, 30: 143–152.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Синопальников А. И., Зайцев А. А. Современный взгляд на фармакотерапию обострений хронической обструктивной болезни легких // Лечащий Врач. 2009. № 10. С. 45–49.</mixed-citation><mixed-citation xml:lang="en">Синопальников А. И., Зайцев А. А. Современный взгляд на фармакотерапию обострений хронической обструктивной болезни легких // Лечащий Врач. 2009. № 10. С. 45–49.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Dal Negro R., Wedzicha J., Iversen M. et al. Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study // Eur Respir J. 2017; 12; 50 (4).</mixed-citation><mixed-citation xml:lang="en">Dal Negro R., Wedzicha J., Iversen M. et al. Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study // Eur Respir J. 2017; 12; 50 (4).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
